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TREM2

Triggering receptor expressed on myeloid cells 2 (TREM2) is a protein that in humans is encoded by the TREM2 gene. TREM2 is expressed on macrophages, immature monocyte-derived dendritic cells, osteoclasts, and microglia, which are immune cells in the central nervous system. In the liver, TREM2 is expressed by several cell types, including macrophages…

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Aliases
TREM2, TREM-2, Trem2a, Trem2b, Trem2c, triggering receptor expressed on myeloid cells 2, PLOSL2
Band
6p21.1 · 17|17 C
Bgee
C1 segment · amniotic fluid · inferior ganglion of vagus nerve · substantia nigra · optic nerve
BioGPS
More reference expression data
Chr.
Chromosome 6 (human) · Chromosome 17 (mouse)
Databases
NCBI: entry; OMA: entry

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Overview

Gene

Structure

Function

Clinical significance

As a drug target

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TREM2

Nodes118
Edges117
Triples267
Avg. degree1.98
Density0.016949
Components1

How this topic connects Entity context

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TREM2

Top relations

Gene ontology · 88
TREM2 → amyloid-beta binding, amyloid-beta clearance, apolipoprotein A-I binding, apolipoprotein binding, apoptotic cell clearance, cellular response to amyloid-beta, cellular response to lipoteichoic acid, cellular response to peptidoglycan, complement-mediated synapse pruning, defense response to bacterium, dendritic cell differentiation, detection of lipopolysaccharide, detection of lipoteichoic acid, detection of peptidoglycan, extracellular region, high-density lipoprotein particle binding, humoral immune response, import into cell, innate immune response, integral component of membrane
related to Function · 30
TREM2 → AP1, Association, C-type, CD14, DAP10, DAP12, DNA, Engagement, ERK, Fc, FPR1, GAL1, GAL3, IFNGR1, Ig, IL1RN, ITAM, MAPK, Monocyte, Myeloid
Bgee · 20
TREM2 → amniotic fluid, C1 segment, corpus callosum, dentate gyrus of hippocampal formation granule cell, gallbladder, hippocampus proper, inferior ganglion of vagus nerve, left adrenal gland, mesenchyme, olfactory bulb, optic nerve, ovary, right coronary artery, striatum of neuraxis, substantia nigra, subthalamic nucleus, superior frontal gyrus, upper lobe of left lung, urinary bladder, white adipose tissue
RNA expression pattern · 20
TREM2 → amniotic fluid, C1 segment, corpus callosum, dentate gyrus of hippocampal formation granule cell, gallbladder, hippocampus proper, inferior ganglion of vagus nerve, left adrenal gland, mesenchyme, olfactory bulb, optic nerve, ovary, right coronary artery, striatum of neuraxis, substantia nigra, subthalamic nucleus, superior frontal gyrus, upper lobe of left lung, urinary bladder, white adipose tissue
related to Cancer · 12
TREM2 → Although TREM2, An, APOE, C1q, CD163, CD68, CSF1R, High, MAFB, TCGA, The Cancer Genome Atlas, Tumor
related to Liver disease · 12
TREM2 → Cd9, Compared, Expression, HCC, In, Kupfer, Mice, NASH, One, TAMs, The, This
related to Structure · 11
TREM2 → ADAM10, ADAM17, CSF, DAP10, DAP12, DNAX, Ig-like V-type, Part, The, The TREM2, This
related to PLOSL or Nasu–Hakola disease · 10
TREM2 → Bone, DAP12, Hakola, In, Loss, Nasu, PLOSL, Several, The, TYROBP
related to Alzheimer's disease · 7
TREM2 → AD, Alzheimer's, CD33, Expression, Loss, Missense, R47H
related to Clinical significance · 6
TREM2 → DAP12, Hakola, Nasu, PLOSL, TYROBP, Variants

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Important terminology

expressed expression cells signaling macrophages liver gene also human protein disease inflammatory microglia dap12 bp tumor associated receptor myeloid cell

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
TREM2AliasesTREM2, TREM-2, Trem2a, Trem2b, Trem2c, triggering receptor expressed on myeloid cells 2, PLOSL21.00infobox
TREM2Band6p21.11.00infobox
TREM2Band17|17 C1.00infobox
TREM2BgeeC1 segment1.00infobox
TREM2Bgeeamniotic fluid1.00infobox
TREM2Bgeeinferior ganglion of vagus nerve1.00infobox
TREM2Bgeesubstantia nigra1.00infobox
TREM2Bgeeoptic nerve1.00infobox
TREM2Bgeeright coronary artery1.00infobox
TREM2Bgeegallbladder1.00infobox
TREM2Bgeeleft adrenal gland1.00infobox
TREM2Bgeesubthalamic nucleus1.00infobox
TREM2Bgeeupper lobe of left lung1.00infobox
TREM2Bgeewhite adipose tissue1.00infobox
TREM2Bgeestriatum of neuraxis1.00infobox
TREM2Bgeehippocampus proper1.00infobox
TREM2Bgeeurinary bladder1.00infobox
TREM2Bgeedentate gyrus of hippocampal formation granule cell1.00infobox
TREM2Bgeecorpus callosum1.00infobox
TREM2Bgeesuperior frontal gyrus1.00infobox
TREM2Bgeemesenchyme1.00infobox
TREM2Bgeeovary1.00infobox
TREM2Bgeeolfactory bulb1.00infobox
TREM2BioGPSMore reference expression data1.00infobox
TREM2Chr.Chromosome 6 (human)1.00infobox
TREM2Chr.Chromosome 17 (mouse)1.00infobox
TREM2DatabasesNCBI: entry; OMA: entry1.00infobox
TREM2End41,163,186 bp1.00infobox
TREM2End48,661,175 bp1.00infobox
TREM2EnsemblENSG000000959701.00infobox

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