CD33

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CD33 topic overview

The analysis highlights Clinical significance, Structure and Alzheimer's disease as prominent areas in the source structure around CD33.

Related topics: 22
Source areas: 5
Connected nodes: 27
Extracted relationships: 118
Concept neighborhoods: 11
Bridge connections: 27

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Clinical significance · 10 topics

Overview · 6 topics

Structure · 3 topics

Alzheimer's disease · 2 topics

Function · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases: CD33, CD33 molecule, SIGLEC-3, SIGLEC3, p67
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes5IHB, 5J06, 5J0B, 6D48, 6D49, 6D4A, 6TL8, 7AW6
Band: 19q13.41 · 7 B3|7 28.25 cM
Bgee: monocyte · granulocyte · spleen · blood · bone marrow cell
BioGPS: n/a
Chr.: Chromosome 19 (human) · Chromosome 7 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How CD33 connects Entity context

The extracted context around CD33 shows recurring relationship patterns in the source. For example, CD33 → carbohydrate binding, cell adhesion, cell-cell adhesion, cell-cell signaling, external side of plasma membrane, Golgi apparatus, immune response-inhibiting signal transduction, integral component of membrane, integral component of plasma membrane, membrane, negative regulation of calcium ion transport, negative regulation of cell population proliferation, negative regulation of interleukin-1 beta production, negative regulation of interleukin-8 production, negative regulation of monocyte activation, negative regulation of tumor necrosis factor production, neutrophil degranulation, nucleus, peroxisome, plasma membrane Another extracted example is CD33 → appendix, blood, bone marrow cell, calvaria, gastrula, granulocyte, lumbar subsegment of spinal cord, monocyte, right adrenal cortex, right coronary artery, right lung, spleen, stroma of bone marrow, submandibular gland, superior frontal gyrus, tibiofemoral joint, upper lobe of left lung. Use these groups to spot repeated connection types before inspecting the individual relationships.

Top relations

Gene ontology · 30

CD33 → carbohydrate binding, cell adhesion, cell-cell adhesion, cell-cell signaling, external side of plasma membrane, Golgi apparatus, immune response-inhibiting signal transduction, integral component of membrane, integral component of plasma membrane, membrane, negative regulation of calcium ion transport, negative regulation of cell population proliferation, negative regulation of interleukin-1 beta production, negative regulation of interleukin-8 production, negative regulation of monocyte activation, negative regulation of tumor necrosis factor production, neutrophil degranulation, nucleus, peroxisome, plasma membrane

Bgee · 17

CD33 → appendix, blood, bone marrow cell, calvaria, gastrula, granulocyte, lumbar subsegment of spinal cord, monocyte, right adrenal cortex, right coronary artery, right lung, spleen, stroma of bone marrow, submandibular gland, superior frontal gyrus, tibiofemoral joint, upper lobe of left lung

RNA expression pattern · 17

related to Clinical significance · 16

CD33 → ADC, Based, Drug Administration, FDA, Food, Gemtuzumab, However, IgG4, Mylotarg, N-acetyl-γ-calicheamicin, On September, Pfizer, Pfizer's Mylotarg, Pfizer/Wyeth-Ayerst Laboratories, Several, The

related to Function · 6

CD33 → ITIM, SH2, SHP, Src, This, Upon

related to Structure · 4

CD33 → IgC2, IgV, ITIMs, The

Band · 2

CD33 → 19q13.41, 7 B3|7 28.25 cM

Chr. · 2

CD33 → Chromosome 19 (human), Chromosome 7 (mouse)

End · 2

CD33 → 43,193,852 bp, 51,243,860 bp

related to Alzheimer's disease · 2

CD33 → Alzheimer, TREM2

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

bp human chr band sialic chromosome 19 acid gene location gemtuzumab ozogamicin external binding receptor cells mouse siglec-3 siglec3 p67

CD33 relationships Subject–Predicate–Object triples

TTTA extracted 118 structured relationships around CD33. Examples in this analysis include CD33 → Aliases → CD33, CD33 molecule, SIGLEC-3, SIGLEC3, p67 and CD33 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes5IHB, 5J06, 5J0B, 6D48, 6D49, 6D4A, 6TL8, 7AW6. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
CD33	Aliases	CD33, CD33 molecule, SIGLEC-3, SIGLEC3, p67	1.00	infobox
CD33	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes5IHB, 5J06, 5J0B, 6D48, 6D49, 6D4A, 6TL8, 7AW6	1.00	infobox
CD33	Band	19q13.41	1.00	infobox
CD33	Band	7 B3\|7 28.25 cM	1.00	infobox
CD33	Bgee	monocyte	1.00	infobox
CD33	Bgee	granulocyte	1.00	infobox
CD33	Bgee	spleen	1.00	infobox
CD33	Bgee	blood	1.00	infobox
CD33	Bgee	bone marrow cell	1.00	infobox
CD33	Bgee	right coronary artery	1.00	infobox
CD33	Bgee	upper lobe of left lung	1.00	infobox
CD33	Bgee	right lung	1.00	infobox
CD33	Bgee	appendix	1.00	infobox
CD33	Bgee	right adrenal cortex	1.00	infobox
CD33	Bgee	stroma of bone marrow	1.00	infobox
CD33	Bgee	lumbar subsegment of spinal cord	1.00	infobox
CD33	Bgee	tibiofemoral joint	1.00	infobox
CD33	Bgee	gastrula	1.00	infobox
CD33	Bgee	submandibular gland	1.00	infobox
CD33	Bgee	calvaria	1.00	infobox
CD33	Bgee	superior frontal gyrus	1.00	infobox
CD33	BioGPS	n/a	1.00	infobox
CD33	Chr.	Chromosome 19 (human)	1.00	infobox
CD33	Chr.	Chromosome 7 (mouse)	1.00	infobox
CD33	Databases	NCBI: entry; OMA: entry	1.00	infobox
CD33	End	51,243,860 bp	1.00	infobox
CD33	End	43,193,852 bp	1.00	infobox
CD33	Ensembl	ENSG00000105383	1.00	infobox
CD33	Entrez	945	1.00	infobox
CD33	External IDs	OMIM: 159590; MGI: 99440; GeneCards: CD33	1.00	infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around CD33 bring nearby vocabulary together. In this analysis, examples include Binding, Portion and Acid. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

CD33
- Binding
- Portion
- Acid
- Gene
- Location
- Sialic
- Human
- Disease
- Expressed
- External
- Function
- Molecule
cd33
- Binding
- Portion
- Acid
- Gene
- Location
- Sialic
- Human
- Disease
- Expressed
- External
- Function
- Molecule
sialic acids
- Expressed
- Receptor
- B3
- Cells
- End
- External
- Function
- Molecule
- Mouse
- Myeloid
- P67
- Search
transmembrane receptor
- Expressed
- Sialic
- B3
- Cells
- End
- External
- Function
- Mouse
- Myeloid
- Search
- Siglec-3
- Siglec3
function
- Search
- Chromosome
- Gene
- Location
- Bp
- Chr
- Human
- B3
- End
- Molecule
- Mouse
- P67
clinical significance
- Disease
- External
- Function
- Molecule
- P67
- Search
- Siglec-3
- Siglec3
- Chromosome
- Gene
- Location
- Bp
alzheimer's disease
- Clinical
- External
- Function
- Molecule
- P67
- Search
- Siglec-3
- Siglec3
- Chromosome
- Gene
- Location
- Bp
myeloid
- P67
- Pfizer
- Receptor
- Siglec-3
- Siglec3
- Sialic
- Gemtuzumab
- Ozogamicin

Connections between topic areas Semantic bridges

For CD33, one of the stronger structural bridges in this analysis connects CD33 with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

CD33 — Clinical significance · splits 17 ⟂ 11

CD33 — Overview · splits 21 ⟂ 7

CD33 — Structure · splits 24 ⟂ 4

CD33 — Alzheimer's disease · splits 25 ⟂ 3

Map overview Semantic statistics

CD33

Nodes28

Edges27

Triples118

Avg. degree1.93

Density0.071429

Components1

Source & methodology

TTTA analyzes the structure around CD33 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Clinical significance, Structure & Alzheimer's disease, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — CD33 · EN edition · Analysis: TopicsToTalkAbout