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Paracetamol

Paracetamol, or acetaminophen, is an analgesic and antipyretic agent used to treat fever and mild to moderate pain. It is a widely available over-the-counter drug sold generically or under various brand names, including Tylenol and Panadol.

History, Community, Culture & Applications

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Key facts & relationships

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
N02BE01 (WHO) N02BE51 (WHO) N02BE71 (WHO)
Bioavailability
63–89%: 73
CAS Number
103-90-2
ChEBI
CHEBI:46195

Topics to explore

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Overview

Medical uses

Use in pregnancy and breastfeeding

Adverse effects

Overdose

Interactions

Pharmacology

Chemistry

History

Society and culture

Veterinary use

Advanced semantic analysis

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Map overview Semantic statistics

Paracetamol

Nodes249
Edges248
Triples221
Avg. degree1.99
Density0.008032
Components1

How this topic connects Entity context

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Paracetamol

Top relations

has effect · 18
Paracetamol → According, After, American, Drug Administration, FDA, Food, French, Gastrointestinal, However, Hypotension, In, Increase, Intravenous, IV, Johnson, Other, Rechallenge, Stevens
related to Pregnancy · 18
Paracetamol → ADHD, Drug Administration, EMA, European Medicines Agency, FDA, Food, Healthcare, However, In, Large, Medicines, MHRA, Regulatory, Regulatory Agency, Some, Untreated, WHO, World Health Organization
related to history · 17
Paracetamol → Acetanilide, Antifebrin, Bayer, But, Cahn, Charles Gerhardt, Fe3, French, Harmon Northrop Morse, Hepp, In, Johns Hopkins University, Joseph, Mering, Some, The, Von Mering
related to Naming · 15
Paracetamol → APAP, Australian Approved Name, Both, British Approved Name, Canadian, Co, Frederick Stearns, Japanese Accepted Name, McNeil Laboratories, N-acetyl-p-aminophenol, The, United States, United States Adopted Name, WHO, World Health Organization
related to Available forms · 11
Paracetamol → Another, As, Australia, BAN, British Approved Name, February, In, Intravenous, Ofirmev, Panadeine, United States
related to Interactions · 11
Paracetamol → By, Cmax, Medications, NAPQI, On, Out, Pharmacokinetics, Prokinetic, St John's, The, There
related to Pharmacodynamics · 10
Paracetamol → AM404, CNS, COX, COX-1, COX-2, N-arachidonoylphenolamine, NSAIDs, Supporting, This, Under
related to Pharmacokinetics · 9
Paracetamol → After, Food, Furthermore, In, Its, Paracetamol's, Protein, The, Thus
related to Fever · 7
Paracetamol → As, For, However, In, It, Overall, The
Solubility in water · 6
Paracetamol → 10.97 g/kg (15 °C), 12.78 g/kg (20 °C), 7.21 g/kg (0 °C), 8.21 g/kg (5 °C), 9.44 g/kg (10 °C), ~14 mg/ml (20 °C)

Important terminology Word statistics

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Important terminology

pain liver use used ibuprofen may fever drug overdose effects analgesic combination also acute dose available effect treatment toxicity united

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Paracetamol3D model (JSmol)Interactive image1.00infobox
ParacetamolAHFS/Drugs.comMonograph1.00infobox
ParacetamolATC codeN02BE01 (WHO) N02BE51 (WHO) N02BE71 (WHO)1.00infobox
ParacetamolBioavailability63–89%: 731.00infobox
ParacetamolCAS Number103-90-21.00infobox
ParacetamolChEBICHEBI:461951.00infobox
ParacetamolChEMBLChEMBL1121.00infobox
ParacetamolChemSpider19061.00infobox
ParacetamolCompTox Dashboard (EPA)DTXSID20200061.00infobox
ParacetamolDensity1.293 g/cm31.00infobox
ParacetamolDrug classAnalgesic;1.00infobox
ParacetamolDrug classantipyretic1.00infobox
ParacetamolDrugBankDB003161.00infobox
ParacetamolECHA InfoCard100.002.8701.00infobox
ParacetamolElimination half-life1.9–2.5 hours1.00infobox
ParacetamolExcretionKidney1.00infobox
ParacetamolFormulaC8H9NO21.00infobox
ParacetamolIUPHAR/BPS52391.00infobox
ParacetamolKEGGD002171.00infobox
ParacetamolLegal statusAU: S4 (Prescription only) OTC, and unscheduled1.00infobox
ParacetamolLegal statusCA: OTC / Rx-only1.00infobox
ParacetamolLegal statusUK: General sales list (GSL, OTC)1.00infobox
ParacetamolLegal statusUS: OTC / Rx-only1.00infobox
ParacetamolLegal statusCN: OTC1.00infobox
ParacetamolLicense dataUS DailyMed: Acetaminophen1.00infobox
ParacetamolMedlinePlusa6810041.00infobox
ParacetamolMelting point169 °C (336 °F)1.00infobox
ParacetamolMetabolismPredominantly in the liver1.00infobox
ParacetamolMetabolitesAPAP gluc, APAP sulfate, APAP GSH, APAP cys, AM404, NAPQI1.00infobox
ParacetamolMolar mass151.165 g·mol−11.00infobox

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