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CD14

CD14 (cluster of differentiation 14) is a surface membrane protein made mostly by macrophages as part of the innate immune system. It helps to detect bacteria in the body by binding lipopolysaccharide (LPS), a pathogen-associated molecular pattern (PAMP). It is highly expressed on monocytes and macrophages, and at lower levels on neutrophils and…

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Aliases
CD14, entrez:929, CD14 molecule
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4GLP
Band
5q31.3 · 18 B2|18 19.46 cM
Bgee
monocyte · granulocyte · right lobe of liver · right coronary artery · blood
BioGPS
More reference expression data
Chr.
Chromosome 5 (human) · Chromosome 18 (mouse)

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Function

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Differentiation

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Map overview Semantic statistics

CD14

Nodes32
Edges31
Triples146
Avg. degree1.94
Density0.0625
Components1

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CD14

Top relations

Gene ontology · 57
CD14 → anchored component of external side of plasma membrane, anchored component of membrane, apoptotic process, apoptotic signaling pathway, cell surface, cell surface receptor signaling pathway, cellular response to diacyl bacterial lipopeptide, cellular response to lipopolysaccharide, cellular response to lipoteichoic acid, cellular response to triacyl bacterial lipopeptide, endosome membrane, external side of plasma membrane, extracellular exosome, extracellular region, extracellular space, Golgi apparatus, I-kappaB kinase/NF-kappaB signaling, immune system process, inflammatory response, innate immune response
Bgee · 19
CD14 → ankle joint, blood, cervix, endothelial cell of lymphatic vessel, gallbladder, granulocyte, Ileal epithelium, lactiferous gland, left adrenal cortex, left adrenal gland, left colon, monocyte, right adrenal gland, right coronary artery, right lobe of liver, right lung lobe, stroma of bone marrow, submandibular gland, synovial joint
RNA expression pattern · 19
CD14 → ankle joint, blood, cervix, endothelial cell of lymphatic vessel, gallbladder, granulocyte, Ileal epithelium, lactiferous gland, left adrenal cortex, left adrenal gland, left colon, monocyte, right adrenal gland, right coronary artery, right lobe of liver, right lung lobe, stroma of bone marrow, submandibular gland, synovial joint
related to External links · 12
CD14 → Antigens, Human CD14, Medicine Medical Subject Headings, MeSH, Monocyte, National Library, Overview, P08571, PDB, PDBe-KB, UCSC Genome Browser, UniProt
related to Function · 9
CD14 → Although LPS, Cluster, Gram-negative, Gram-positive, LBP, LPS, MD-2, TLR, Toll-like
related to Tissue distribution · 3
CD14 → It, LPS-responsiveness, The
Band · 2
CD14 → 18 B2|18 19.46 cM, 5q31.3
Chr. · 2
CD14 → Chromosome 18 (mouse), Chromosome 5 (human)
End · 2
CD14 → 140,633,700 bp, 36,859,851 bp
related to Differentiation · 2
CD14 → GM-CSF, IL-4

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Important terminology

human bp chr band differentiation lipopolysaccharide chromosome macrophages membrane protein expressed gene location lps cells scd14 mcd14 soluble monocytes external

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
CD14AliasesCD14, entrez:929, CD14 molecule1.00infobox
CD14Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4GLP1.00infobox
CD14Band5q31.31.00infobox
CD14Band18 B2|18 19.46 cM1.00infobox
CD14Bgeemonocyte1.00infobox
CD14Bgeegranulocyte1.00infobox
CD14Bgeeright lobe of liver1.00infobox
CD14Bgeeright coronary artery1.00infobox
CD14Bgeeblood1.00infobox
CD14Bgeeleft adrenal gland1.00infobox
CD14Bgeeleft adrenal cortex1.00infobox
CD14Bgeeright adrenal gland1.00infobox
CD14Bgeesynovial joint1.00infobox
CD14Bgeegallbladder1.00infobox
CD14Bgeelactiferous gland1.00infobox
CD14Bgeeankle joint1.00infobox
CD14Bgeestroma of bone marrow1.00infobox
CD14Bgeeendothelial cell of lymphatic vessel1.00infobox
CD14BgeeIleal epithelium1.00infobox
CD14Bgeecervix1.00infobox
CD14Bgeeright lung lobe1.00infobox
CD14Bgeeleft colon1.00infobox
CD14Bgeesubmandibular gland1.00infobox
CD14BioGPSMore reference expression data1.00infobox
CD14Chr.Chromosome 5 (human)1.00infobox
CD14Chr.Chromosome 18 (mouse)1.00infobox
CD14DatabasesNCBI: entry; OMA: entry1.00infobox
CD14End140,633,700 bp1.00infobox
CD14End36,859,851 bp1.00infobox
CD14EnsemblENSG000001704581.00infobox

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