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CD14: Art, Function & Differentiation
CD14 (cluster of differentiation 14) is a surface membrane protein made mostly by macrophages as part of the innate immune system. It helps to detect bacteria in the body by binding lipopolysaccharide (LPS), a pathogen-associated molecular pattern (PAMP). It is highly expressed on monocytes and macrophages, and at lower levels on neutrophils and…
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CD14 topic overview
The analysis highlights Art, Function and Differentiation as prominent areas in the source structure around CD14.
Related topics
26
Source areas
5
Connected nodes
31
Extracted relationships
146
Concept neighborhoods
17
Bridge connections
31
What this topic covers Research coverage
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Overview · 12 topics
Function · 6 topics
Differentiation · 4 topics
Tissue distribution · 3 topics
Interactions · 1 topics
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
Key facts & relationships
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Aliases
CD14, entrez:929, CD14 molecule
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4GLP
Band
5q31.3 · 18 B2|18 19.46 cM
Bgee
monocyte · granulocyte · right lobe of liver · right coronary artery · blood
BioGPS
More reference expression data
Chr.
Chromosome 5 (human) · Chromosome 18 (mouse)
Explore all related topics Closing gaps
A structured outline of related entities, concepts and subtopics. Open any item to build a new map centered on it.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
How CD14 connects Entity context
Entity context groups extracted connections by relationship type. Counts show recurrence in the analyzed source; the examples are research signals, not claims about importance.
The extracted context around CD14 shows recurring relationship patterns in the source. For example, CD14 → anchored component of external side of plasma membrane, anchored component of membrane, apoptotic process, apoptotic signaling pathway, cell surface, cell surface receptor signaling pathway, cellular response to diacyl bacterial lipopeptide, cellular response to lipopolysaccharide, cellular response to lipoteichoic acid, cellular response to triacyl bacterial lipopeptide, endosome membrane, external side of plasma membrane, extracellular exosome, extracellular region, extracellular space, Golgi apparatus, I-kappaB kinase/NF-kappaB signaling, immune system process, inflammatory response, innate immune response Another extracted example is CD14 → ankle joint, blood, cervix, endothelial cell of lymphatic vessel, gallbladder, granulocyte, Ileal epithelium, lactiferous gland, left adrenal cortex, left adrenal gland, left colon, monocyte, right adrenal gland, right coronary artery, right lobe of liver, right lung lobe, stroma of bone marrow, submandibular gland, synovial joint. Use these groups to spot repeated connection types before inspecting the individual relationships.
CD14
Top relations
Gene ontology· 57
CD14 → anchored component of external side of plasma membrane, anchored component of membrane, apoptotic process, apoptotic signaling pathway, cell surface, cell surface receptor signaling pathway, cellular response to diacyl bacterial lipopeptide, cellular response to lipopolysaccharide, cellular response to lipoteichoic acid, cellular response to triacyl bacterial lipopeptide, endosome membrane, external side of plasma membrane, extracellular exosome, extracellular region, extracellular space, Golgi apparatus, I-kappaB kinase/NF-kappaB signaling, immune system process, inflammatory response, innate immune response
Bgee· 19
CD14 → ankle joint, blood, cervix, endothelial cell of lymphatic vessel, gallbladder, granulocyte, Ileal epithelium, lactiferous gland, left adrenal cortex, left adrenal gland, left colon, monocyte, right adrenal gland, right coronary artery, right lobe of liver, right lung lobe, stroma of bone marrow, submandibular gland, synovial joint
RNA expression pattern· 19
CD14 → ankle joint, blood, cervix, endothelial cell of lymphatic vessel, gallbladder, granulocyte, Ileal epithelium, lactiferous gland, left adrenal cortex, left adrenal gland, left colon, monocyte, right adrenal gland, right coronary artery, right lobe of liver, right lung lobe, stroma of bone marrow, submandibular gland, synovial joint
related to External links· 12
CD14 → Antigens, Human CD14, Medicine Medical Subject Headings, MeSH, Monocyte, National Library, Overview, P08571, PDB, PDBe-KB, UCSC Genome Browser, UniProt
Relationships are represented as Subject → Predicate → Object triples. Confidence describes extraction strength, not the real-world importance of a relationship; lower-confidence rows may be contextual rather than explicit.
TTTA extracted 146 structured relationships around CD14. Examples in this analysis include CD14 → Aliases → CD14, entrez:929, CD14 molecule and CD14 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4GLP. The table shows each extracted connection, where it came from and its confidence.
Subject
Predicate
Object
Confidence
Src
CD14
Aliases
CD14, entrez:929, CD14 molecule
1.00
infobox
CD14
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4GLP
1.00
infobox
CD14
Band
5q31.3
1.00
infobox
CD14
Band
18 B2|18 19.46 cM
1.00
infobox
CD14
Bgee
monocyte
1.00
infobox
CD14
Bgee
granulocyte
1.00
infobox
CD14
Bgee
right lobe of liver
1.00
infobox
CD14
Bgee
right coronary artery
1.00
infobox
CD14
Bgee
blood
1.00
infobox
CD14
Bgee
left adrenal gland
1.00
infobox
CD14
Bgee
left adrenal cortex
1.00
infobox
CD14
Bgee
right adrenal gland
1.00
infobox
CD14
Bgee
synovial joint
1.00
infobox
CD14
Bgee
gallbladder
1.00
infobox
CD14
Bgee
lactiferous gland
1.00
infobox
CD14
Bgee
ankle joint
1.00
infobox
CD14
Bgee
stroma of bone marrow
1.00
infobox
CD14
Bgee
endothelial cell of lymphatic vessel
1.00
infobox
CD14
Bgee
Ileal epithelium
1.00
infobox
CD14
Bgee
cervix
1.00
infobox
CD14
Bgee
right lung lobe
1.00
infobox
CD14
Bgee
left colon
1.00
infobox
CD14
Bgee
submandibular gland
1.00
infobox
CD14
BioGPS
More reference expression data
1.00
infobox
CD14
Chr.
Chromosome 5 (human)
1.00
infobox
CD14
Chr.
Chromosome 18 (mouse)
1.00
infobox
CD14
Databases
NCBI: entry; OMA: entry
1.00
infobox
CD14
End
140,633,700 bp
1.00
infobox
CD14
End
36,859,851 bp
1.00
infobox
CD14
Ensembl
ENSG00000170458
1.00
infobox
No triples extracted yet.
Related concept clusters Concept neighborhoods
Concept neighborhoods group terms that sit near one another in the extracted graph. They are useful for discovering adjacent language and context, but proximity does not by itself imply a factual relationship.
The concept neighborhoods around CD14 bring nearby vocabulary together. In this analysis, examples include Differentiation, Human and Protein. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
CD14
Differentiation
Human
Protein
Acid
Lipoteichoic
Mcd14
Membrane
Receptor
Soluble
Gene
Location
Lps
cd14
Differentiation
Human
Protein
Acid
Lipoteichoic
Mcd14
Membrane
Receptor
Soluble
Gene
Location
Lps
cluster of differentiation
Pdb
Entrez
External
Function
Immune
Innate
Surface
System
Uniprot
Acid
Dendritic
Lipopolysaccharide
membrane protein
Anchored
Immune
Innate
Surface
System
Protein
Lps
Binding
Entrez
External
Function
Mouse
innate immune system
Immune
Innate
Surface
System
Membrane
Protein
Anchored
Binding
Entrez
External
Function
Mouse
lipopolysaccharide
Pattern
Acid
Lipoteichoic
Molecular
Receptor
Lps
Anchored
Entrez
External
Function
Mouse
Surface
lipopolysaccharide-binding protein
Immune
Innate
Surface
System
Lps
Anchored
Binding
Entrez
External
Function
Mouse
Pattern
lipoteichoic acid
Lipoteichoic
Lipopolysaccharide
Molecular
Receptor
Lps
Anchored
Binding
Entrez
External
Function
Immune
Innate
Connections between topic areas Semantic bridges
Semantic bridges connect parts of the graph that would otherwise be more separate. A bridge is a structural signal in this analysis, not a claim that the two topic areas are equivalent.
For CD14, one of the stronger structural bridges in this analysis connects CD14 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
Number of nodes, edges, triples, density and central hubs. Use it to gauge the size and connectivity of the map.
CD14
Nodes32
Edges31
Triples146
Avg. degree1.94
Density0.0625
Components1
Source & methodology
TTTA analyzes the structure around CD14 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Art, Function & Differentiation, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — CD14 · EN edition · Analysis: TopicsToTalkAbout
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