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Interleukin-1 receptor antagonist: Clinical significance, Function & Overview

The interleukin-1 receptor antagonist (IL-1RA) is a protein that in humans is encoded by the IL1RN gene.

Language: English [EN]
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Interleukin-1 receptor antagonist topic overview

The analysis highlights Clinical significance, Function and Overview as prominent areas in the source structure around Interleukin-1 receptor antagonist.

Related topics
20
Source areas
3
Connected nodes
23
Extracted relationships
95
Concept neighborhoods
12
Bridge connections
23

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Clinical significance · 13 topics
Overview · 4 topics
Function · 3 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
IL1RN, DIRA, ICIL-1RA, IL-1RN, IL-1ra, IL-1ra3, IL1F3, IL1RA, IRAP, MVCD4, interleukin 1 receptor antagonist
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1ILR, 1ILT, 1IRA, 1IRP, 2IRT
Band
2q14.1 · 2 A3|2 16.36 cM
Bgee
buccal mucosa cell · palpebral conjunctiva · mucosa of pharynx · gums · oral cavity
BioGPS
More reference expression data
Chr.
Chromosome 2 (human) · Chromosome 2 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Interleukin-1 receptor antagonist connects Entity context

The extracted context around Interleukin-1 receptor antagonist shows recurring relationship patterns in the source. For example, Interleukin-1 receptor antagonist → acute-phase response, cellular response to lipopolysaccharide, cytokine activity, cytokine-mediated signaling pathway, cytoplasm, extracellular exosome, extracellular region, extracellular space, fever generation, immune response, inflammatory response, insulin secretion, interleukin-1 receptor antagonist activity, interleukin-1 receptor binding, interleukin-1 type I receptor antagonist activity, interleukin-1 type II receptor antagonist activity, interleukin-1, type I receptor binding, interleukin-1, type II receptor binding, interleukin-1-mediated signaling pathway, intracellular anatomical structure Another extracted example is Interleukin-1 receptor antagonist → amniotic fluid, body of tongue, buccal mucosa cell, conjunctival fornix, esophagus, gingival epithelium, granulocyte, gums, left colon, lip, lumbar subsegment of spinal cord, mucosa of pharynx, oral cavity, palpebral conjunctiva, periodontal fiber, skin of abdomen, skin of back, skin of external ear, stroma of bone marrow. Use these groups to spot repeated connection types before inspecting the individual relationships.

Interleukin-1 receptor antagonist

Top relations

Gene ontology · 33
Interleukin-1 receptor antagonist → acute-phase response, cellular response to lipopolysaccharide, cytokine activity, cytokine-mediated signaling pathway, cytoplasm, extracellular exosome, extracellular region, extracellular space, fever generation, immune response, inflammatory response, insulin secretion, interleukin-1 receptor antagonist activity, interleukin-1 receptor binding, interleukin-1 type I receptor antagonist activity, interleukin-1 type II receptor antagonist activity, interleukin-1, type I receptor binding, interleukin-1, type II receptor binding, interleukin-1-mediated signaling pathway, intracellular anatomical structure
Bgee · 19
Interleukin-1 receptor antagonist → amniotic fluid, body of tongue, buccal mucosa cell, conjunctival fornix, esophagus, gingival epithelium, granulocyte, gums, left colon, lip, lumbar subsegment of spinal cord, mucosa of pharynx, oral cavity, palpebral conjunctiva, periodontal fiber, skin of abdomen, skin of back, skin of external ear, stroma of bone marrow
RNA expression pattern · 19
Interleukin-1 receptor antagonist → amniotic fluid, body of tongue, buccal mucosa cell, conjunctival fornix, esophagus, gingival epithelium, granulocyte, gums, left colon, lip, lumbar subsegment of spinal cord, mucosa of pharynx, oral cavity, palpebral conjunctiva, periodontal fiber, skin of abdomen, skin of back, skin of external ear, stroma of bone marrow
Band · 2
Interleukin-1 receptor antagonist → 2 A3|2 16.36 cM, 2q14.1
Chr. · 2
Interleukin-1 receptor antagonist → Chromosome 2 (human), Chromosome 2 (mouse)
End · 2
Interleukin-1 receptor antagonist → 113,134,016 bp, 24,241,506 bp
Aliases · 1
Interleukin-1 receptor antagonist → IL1RN, DIRA, ICIL-1RA, IL-1RN, IL-1ra, IL-1ra3, IL1F3, IL1RA, IRAP, MVCD4, interleukin 1 receptor antagonist
Available structures · 1
Interleukin-1 receptor antagonist → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1ILR, 1ILT, 1IRA, 1IRP, 2IRT
BioGPS · 1
Interleukin-1 receptor antagonist → More reference expression data
Databases · 1
Interleukin-1 receptor antagonist → NCBI: entry; OMA: entry

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

il-1ra receptor gene antagonist bp interleukin human il1rn chr band chromosome interleukin-1 protein il-1 external inflammatory cell location cytokine called

Interleukin-1 receptor antagonist relationships Subject–Predicate–Object triples

TTTA extracted 95 structured relationships around Interleukin-1 receptor antagonist. Examples in this analysis include Interleukin-1 receptor antagonist → Aliases → IL1RN, DIRA, ICIL-1RA, IL-1RN, IL-1ra, IL-1ra3, IL1F3, IL1RA, IRAP, MVCD4, interleukin 1 receptor antagonist and Interleukin-1 receptor antagonist → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1ILR, 1ILT, 1IRA, 1IRP, 2IRT. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Interleukin-1 receptor antagonistAliasesIL1RN, DIRA, ICIL-1RA, IL-1RN, IL-1ra, IL-1ra3, IL1F3, IL1RA, IRAP, MVCD4, interleukin 1 receptor antagonist1.00infobox
Interleukin-1 receptor antagonistAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1ILR, 1ILT, 1IRA, 1IRP, 2IRT1.00infobox
Interleukin-1 receptor antagonistBand2q14.11.00infobox
Interleukin-1 receptor antagonistBand2 A3|2 16.36 cM1.00infobox
Interleukin-1 receptor antagonistBgeebuccal mucosa cell1.00infobox
Interleukin-1 receptor antagonistBgeepalpebral conjunctiva1.00infobox
Interleukin-1 receptor antagonistBgeemucosa of pharynx1.00infobox
Interleukin-1 receptor antagonistBgeegums1.00infobox
Interleukin-1 receptor antagonistBgeeoral cavity1.00infobox
Interleukin-1 receptor antagonistBgeegingival epithelium1.00infobox
Interleukin-1 receptor antagonistBgeebody of tongue1.00infobox
Interleukin-1 receptor antagonistBgeeperiodontal fiber1.00infobox
Interleukin-1 receptor antagonistBgeeamniotic fluid1.00infobox
Interleukin-1 receptor antagonistBgeeskin of abdomen1.00infobox
Interleukin-1 receptor antagonistBgeegranulocyte1.00infobox
Interleukin-1 receptor antagonistBgeestroma of bone marrow1.00infobox
Interleukin-1 receptor antagonistBgeelip1.00infobox
Interleukin-1 receptor antagonistBgeeesophagus1.00infobox
Interleukin-1 receptor antagonistBgeelumbar subsegment of spinal cord1.00infobox
Interleukin-1 receptor antagonistBgeeleft colon1.00infobox
Interleukin-1 receptor antagonistBgeeskin of back1.00infobox
Interleukin-1 receptor antagonistBgeeskin of external ear1.00infobox
Interleukin-1 receptor antagonistBgeeconjunctival fornix1.00infobox
Interleukin-1 receptor antagonistBioGPSMore reference expression data1.00infobox
Interleukin-1 receptor antagonistChr.Chromosome 2 (human)1.00infobox
Interleukin-1 receptor antagonistChr.Chromosome 2 (mouse)1.00infobox
Interleukin-1 receptor antagonistDatabasesNCBI: entry; OMA: entry1.00infobox
Interleukin-1 receptor antagonistEnd113,134,016 bp1.00infobox
Interleukin-1 receptor antagonistEnd24,241,506 bp1.00infobox
Interleukin-1 receptor antagonistEnsemblENSG000001366891.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Interleukin-1 receptor antagonist bring nearby vocabulary together. In this analysis, examples include Family, Il1rn and Receptor. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Interleukin-1 receptor antagonist
    • Family
    • Il1rn
    • Receptor
    • Cell
    • Antagonist
    • Interleukin-1
    • Gene
    • Protein
    • Il-1ra
    • Interleukin
    • Treatment
    • Used
  • interleukin-1 receptor antagonist
    • Receptor
    • Interleukin
    • Family
    • Il1rn
    • Cell
    • Antagonist
    • Interleukin-1
    • Protein
    • Gene
    • External
    • Function
    • Search
  • gene
    • Il1rn
    • Chromosome
    • Location
    • Interleukin-1
    • Receptor
    • Bp
    • Chr
    • Human
    • A3
    • Cytokine
    • End
    • External
  • interleukin-1 receptor
    • Family
    • Il1rn
    • Receptor
    • Cell
    • Antagonist
    • Gene
    • Protein
    • Il-1ra
    • Search
    • Interleukin
    • Location
    • Treatment
  • interleukin 1
    • Receptor
    • Protein
    • External
    • Function
    • Search
    • Immune
    • Location
    • Treatment
    • Used
    • Inflammatory
    • Interleukin-1
    • Bp
  • deficiency of the interleukin-1–receptor antagonist
    • Receptor
    • Interleukin
    • Family
    • Il1rn
    • Cell
    • Antagonist
    • Interleukin-1
    • Protein
    • Gene
    • External
    • Function
    • Search
  • squamous cell carcinoma
    • Family
    • Interleukin-1
    • Human
    • Il-1ra
    • A3
    • Cytokine
    • End
    • External
    • Function
    • Interleukin
    • Mouse
    • Search
  • protein
    • Immune
    • Interleukin
    • Inflammatory
    • Receptor
    • A3
    • Cytokine
    • End
    • External
    • Family
    • Function
    • Mouse
    • Search

Connections between topic areas Semantic bridges

For Interleukin-1 receptor antagonist, one of the stronger structural bridges in this analysis connects Interleukin-1 receptor antagonist with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Interleukin-1 receptor antagonistClinical significance · splits 10 ⟂ 14
Interleukin-1 receptor antagonistOverview · splits 19 ⟂ 5
Interleukin-1 receptor antagonistFunction · splits 20 ⟂ 4

Map overview Semantic statistics

Interleukin-1 receptor antagonist

Nodes24
Edges23
Triples95
Avg. degree1.92
Density0.083333
Components1

Source & methodology

TTTA analyzes the structure around Interleukin-1 receptor antagonist to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Clinical significance, Function & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Interleukin-1 receptor antagonist · EN edition · Analysis: TopicsToTalkAbout

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