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Protein phosphorylation: Characters & History

Protein phosphorylation is a reversible post-translational modification of proteins in which an amino acid residue is phosphorylated by a protein kinase by the addition of a covalently bound phosphate group. Phosphorylation alters the structural conformation of a protein, causing it to become activated, deactivated, or otherwise modifying its function.…

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Protein phosphorylation topic overview

The analysis highlights Characters and History as prominent areas in the source structure around Protein phosphorylation.

Related topics
122
Source areas
10
Connected nodes
132
Extracted relationships
85
Concept neighborhoods
39
Bridge connections
132

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Mechanisms and functions of phosphorylation · 32 topics
Overview · 21 topics
History · 20 topics
Sites · 19 topics
Detection and characterization · 7 topics
Pathology · 7 topics
Receptor tyrosine kinases · 7 topics
Kinases · 5 topics
Abundance · 2 topics
Evolution · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

History

Abundance

Mechanisms and functions of phosphorylation

Kinases

Receptor tyrosine kinases

Sites

Detection and characterization

Evolution

Pathology

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Protein phosphorylation connects Entity context

The extracted context around Protein phosphorylation shows recurring relationship patterns in the source. For example, Protein phosphorylation → CDK, CDKs, Conversely, However, In, It, Most, Positioning, Protein, Some, Targets, The, There, These, While CDK Another extracted example is Protein phosphorylation → Abnormal, Alzheimer, Alzheimer's, Association, In Alzheimer's, MAP1, MAP2, MAPs, Parkinson's, Phosphatases PP1, PP2A, PP2B, PP2C, Tau, The. Use these groups to spot repeated connection types before inspecting the individual relationships.

Protein phosphorylation

Top relations

related to Evolution · 15
Protein phosphorylation → CDK, CDKs, Conversely, However, In, It, Most, Positioning, Protein, Some, Targets, The, There, These, While CDK
related to Pathology · 15
Protein phosphorylation → Abnormal, Alzheimer, Alzheimer's, Association, In Alzheimer's, MAP1, MAP2, MAPs, Parkinson's, Phosphatases PP1, PP2A, PP2B, PP2C, Tau, The
related to Kinases · 12
Protein phosphorylation → Histidine, However, In, OH, Once, Phosphorylation, Ser, The, Thr, Tyr, Tyrosine, Within
related to Comparisons between eukaryotes and prokaryotes · 10
Protein phosphorylation → Compared, DNA, Hanks-type, In, It, Protein, PTSs, These, Whether, While
related to Non-canonical phosphorylation on His, Asp, Cys, Glu, Arg and Lys in human cells · 6
Protein phosphorylation → Due, HeLa, Ser, Thr, Tyr, Widespread
is a · 1
Protein phosphorylation → reversible post-translational modification of proteins in which an amino acid residue is phosphorylated by a protein kinase by the addition of a covalently bound phosphate group

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

phosphorylation protein proteins phosphorylated tyrosine serine sites kinases kinase cell signaling threonine eukaryotes histidine bacteria amino eukaryotic α-synuclein enzyme residues

Protein phosphorylation relationships Subject–Predicate–Object triples

TTTA extracted 85 structured relationships around Protein phosphorylation. Examples in this analysis include Protein phosphorylation → is a → reversible post-translational modification of proteins in which an amino acid residue is phosphorylated by a protein kinase by the addition of a covalently bound phosphate group and p53 contain multiple phosphorylation sites → instance of → Some proteins. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Protein phosphorylationis areversible post-translational modification of proteins in which an amino acid residue is phosphorylated by a protein kinase by the addition of a covalently bound phosphate group0.90text
p53 contain multiple phosphorylation sitesinstance ofSome proteins0.80text
facilitating complexinstance ofSome proteins0.80text
multi-level regulationinstance ofSome proteins0.80text
phosphoproteomicsinstance ofGlobal approaches0.80text
the study of phosphorylated proteinsinstance ofGlobal approaches0.80text
which is a sub-branch of proteomicsinstance ofGlobal approaches0.80text
combined with mass spectrometry-based proteomicsinstance ofGlobal approaches0.80text
have been utilised to identifyinstance ofGlobal approaches0.80text
quantify dynamic changes in phosphorylated proteins over timeinstance ofGlobal approaches0.80text
transcriptioninstance ofit has a negative impact on several fundamental biological processes0.80text
replicationinstance ofit has a negative impact on several fundamental biological processes0.80text

Related concept clusters Concept neighborhoods

The concept neighborhoods around Protein phosphorylation bring nearby vocabulary together. In this analysis, examples include Protein, Kinase and Phosphorylated. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Protein phosphorylation
    • Protein
    • Kinase
    • Phosphorylated
    • Kinases
    • Signaling
    • Proteins
    • Cells
    • Threonine
    • Bacteria
    • Function
    • Sites
    • Amino
  • protein phosphorylation
    • Protein
    • Proteins
    • Sites
    • Kinase
    • Tyrosine
    • Phosphorylated
    • Kinases
    • Serine
    • Signaling
    • Cells
    • Eukaryotes
    • Cell
  • proteins
    • Sites
    • Kinases
    • Residues
    • Bacteria
    • However
    • Eukaryotic
    • Tyrosine
    • Cell
    • Arginine
    • Known
    • Interactions
    • Pathway
  • phosphorylated
    • Proteins
    • Protein
    • Serine
    • However
    • Histidine
    • Kinase
    • Human
    • Phosphorylation
    • Sites
    • Tyrosine
    • Also
    • Group
  • kinase
    • Enzyme
    • Tyrosine
    • Protein
    • Signaling
    • Pathway
    • Phosphorylated
    • Found
    • Serine
    • Phosphorylation
    • Group
    • Many
    • Structure
  • tyrosine
    • Threonine
    • Serine
    • Eukaryotes
    • Kinase
    • Histidine
    • Phosphorylation
    • Kinases
    • Residues
    • Signaling
    • Occurs
    • Enzyme
    • Protein
  • arginine
    • Human
    • Cells
    • Interactions
    • Occurs
    • Histidine
    • Threonine
    • Residues
    • Bacteria
    • Cell
    • Disease
    • Serine
    • However
  • protein kinases
    • Phosphatases
    • Kinase
    • Phosphorylated
    • Tyrosine
    • Eukaryotic
    • Kinases
    • Protein
    • Eukaryotes
    • Proteins
    • Signaling
    • Cells
    • Also

Connections between topic areas Semantic bridges

For Protein phosphorylation, one of the stronger structural bridges in this analysis connects Protein phosphorylation with Mechanisms and functions of phosphorylation. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Protein phosphorylationMechanisms and functions of phosphorylation · splits 100 ⟂ 33
Protein phosphorylationOverview · splits 111 ⟂ 22
Protein phosphorylationHistory · splits 112 ⟂ 21
Protein phosphorylationSites · splits 113 ⟂ 20
Protein phosphorylationReceptor tyrosine kinases · splits 125 ⟂ 8
Protein phosphorylationDetection and characterization · splits 125 ⟂ 8
Protein phosphorylationPathology · splits 125 ⟂ 8
Protein phosphorylationKinases · splits 127 ⟂ 6
Protein phosphorylationAbundance · splits 130 ⟂ 3
Protein phosphorylationEvolution · splits 130 ⟂ 3

Map overview Semantic statistics

Protein phosphorylation

Nodes133
Edges132
Triples85
Avg. degree1.99
Density0.015038
Components1

Source & methodology

TTTA analyzes the structure around Protein phosphorylation to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Characters & History, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Protein phosphorylation · EN edition · Analysis: TopicsToTalkAbout

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