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CD163: Applications & Research

CD163 (Cluster of Differentiation 163) is a protein that in humans is encoded by the CD163 gene. CD163 is the high affinity scavenger receptor for the hemoglobin-haptoglobin complex and in the absence of haptoglobin - with lower affinity - for hemoglobin alone. It also is a marker of cells from the monocyte/macrophage lineage. CD163 functions as innate…

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CD163 topic overview

The analysis highlights Applications and Research as prominent areas in the source structure around CD163.

Related topics
32
Source areas
6
Connected nodes
38
Extracted relationships
94
Concept neighborhoods
13
Bridge connections
38

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Clinical significance · 15 topics
Overview · 10 topics
Differences between mouse and human · 3 topics
Interactions · 2 topics
Animal studies · 1 topics
Structure · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
CD163, M130, MM130, SCARI1, CD163 molecule
Band
12p13.31 · 6|6 F2
Bgee
right lung · gastric mucosa · lower lobe of lung · right adrenal cortex · spleen
BioGPS
More reference expression data
Chr.
Chromosome 12 (human) · Chromosome 6 (mouse)
Databases
NCBI: entry; OMA: entry

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Clinical significance

Differences between mouse and human

Animal studies

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How CD163 connects Entity context

The extracted context around CD163 shows recurring relationship patterns in the source. For example, CD163 → ankle, aortic valve, ascending aorta, gastric mucosa, intercostal muscle, left adrenal cortex, left uterine tube, lower lobe of lung, lumbar spinal ganglion, monocyte, pericardium, right adrenal cortex, right coronary artery, right lung, sciatic nerve, skin of external ear, spleen, stroma of bone marrow, tunica adventitia of aorta, white adipose tissue Another extracted example is CD163 → acute-phase response, endocytic vesicle membrane, external side of plasma membrane, extracellular region, inflammatory response, integral component of membrane, integral component of plasma membrane, membrane, plasma membrane, protein binding, receptor-mediated endocytosis, scavenger receptor activity. Use these groups to spot repeated connection types before inspecting the individual relationships.

CD163

Top relations

Bgee · 20
CD163 → ankle, aortic valve, ascending aorta, gastric mucosa, intercostal muscle, left adrenal cortex, left uterine tube, lower lobe of lung, lumbar spinal ganglion, monocyte, pericardium, right adrenal cortex, right coronary artery, right lung, sciatic nerve, skin of external ear, spleen, stroma of bone marrow, tunica adventitia of aorta, white adipose tissue
RNA expression pattern · 20
CD163 → ankle, aortic valve, ascending aorta, gastric mucosa, intercostal muscle, left adrenal cortex, left uterine tube, lower lobe of lung, lumbar spinal ganglion, monocyte, pericardium, right adrenal cortex, right coronary artery, right lung, sciatic nerve, skin of external ear, spleen, stroma of bone marrow, tunica adventitia of aorta, white adipose tissue
Gene ontology · 12
CD163 → acute-phase response, endocytic vesicle membrane, external side of plasma membrane, extracellular region, inflammatory response, integral component of membrane, integral component of plasma membrane, membrane, plasma membrane, protein binding, receptor-mediated endocytosis, scavenger receptor activity
related to Clinical significance · 8
CD163 → ADAM17, ANCA, CNS, Gaucher's, HIV, Hodgkin, It, The
related to External links · 5
CD163 → Human CD163, Medicine Medical Subject Headings, MeSH, National Library, UCSC Genome Browser
related to Differences between mouse and human · 4
CD163 → ADAM17, Arg-Ser-Ser-Arg, Differences, Human CD163
related to Animal studies · 3
CD163 → Pigs, Porcine Reproductive, Respiratory Syndrome
Band · 2
CD163 → 12p13.31, 6|6 F2
Chr. · 2
CD163 → Chromosome 12 (human), Chromosome 6 (mouse)
End · 2
CD163 → 124,307,486 bp, 7,503,893 bp

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

human bp gene receptor chr band mouse chromosome 12 location scd163 protein also external scavenger humans monocyte hemoglobin lower macrophage

CD163 relationships Subject–Predicate–Object triples

TTTA extracted 94 structured relationships around CD163. Examples in this analysis include CD163 → Aliases → CD163, M130, MM130, SCARI1, CD163 molecule and CD163 → Band → 12p13.31. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
CD163AliasesCD163, M130, MM130, SCARI1, CD163 molecule1.00infobox
CD163Band12p13.311.00infobox
CD163Band6|6 F21.00infobox
CD163Bgeeright lung1.00infobox
CD163Bgeegastric mucosa1.00infobox
CD163Bgeelower lobe of lung1.00infobox
CD163Bgeeright adrenal cortex1.00infobox
CD163Bgeespleen1.00infobox
CD163Bgeeleft adrenal cortex1.00infobox
CD163Bgeemonocyte1.00infobox
CD163Bgeeleft uterine tube1.00infobox
CD163Bgeeright coronary artery1.00infobox
CD163Bgeepericardium1.00infobox
CD163Bgeestroma of bone marrow1.00infobox
CD163Bgeelumbar spinal ganglion1.00infobox
CD163Bgeeaortic valve1.00infobox
CD163Bgeeskin of external ear1.00infobox
CD163Bgeeascending aorta1.00infobox
CD163Bgeesciatic nerve1.00infobox
CD163Bgeewhite adipose tissue1.00infobox
CD163Bgeeintercostal muscle1.00infobox
CD163Bgeeankle1.00infobox
CD163Bgeetunica adventitia of aorta1.00infobox
CD163BioGPSMore reference expression data1.00infobox
CD163Chr.Chromosome 12 (human)1.00infobox
CD163Chr.Chromosome 6 (mouse)1.00infobox
CD163DatabasesNCBI: entry; OMA: entry1.00infobox
CD163End7,503,893 bp1.00infobox
CD163End124,307,486 bp1.00infobox
CD163EnsemblENSG000001775751.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around CD163 bring nearby vocabulary together. In this analysis, examples include Gene, Human and Protein. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • CD163
    • Gene
    • Human
    • Protein
    • Location
    • Mouse
    • Receptor
    • Adam17
    • Affinity
    • Alone
    • Cluster
    • Complex
    • Differences
  • cd163
    • Gene
    • Human
    • Protein
    • Location
    • Mouse
    • Receptor
    • Adam17
    • Affinity
    • Alone
    • Cluster
    • Complex
    • Differences
  • scavenger receptor
    • Lower
    • Receptor
    • Scavenger
    • Membrane
    • Scd163
    • Affinity
    • Alone
    • Complex
    • End
    • Expressed
    • External
    • Hemoglobin
  • differences between mouse and human
    • Studies
    • Chromosome
    • Location
    • Human
    • Mouse
    • Bp
    • Chr
    • End
    • External
    • Band
    • Adam17
    • Humans
  • gene
    • Location
    • Human
    • Chromosome
    • Mouse
    • Bp
    • Chr
    • End
    • External
    • Protein
    • Band
    • Differences
    • Expressed
  • animal studies
    • Differences
    • Adam17
    • External
    • Humans
    • Shedding
    • Significance
    • Also
    • Scd163
    • Chromosome
    • Location
    • Mouse
    • Bp
  • adam17
    • Shedding
    • Scd163
    • Differences
    • Humans
    • Macrophage
    • Membrane
    • Studies
    • Also
    • Cd163
    • Receptor
  • clinical significance
    • Expressed
    • External
    • Studies
    • Chromosome
    • Location
    • Bp
    • Chr

Connections between topic areas Semantic bridges

For CD163, one of the stronger structural bridges in this analysis connects CD163 with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
CD163 — Clinical significance · splits 23 ⟂ 16
CD163 — Overview · splits 28 ⟂ 11
CD163 — Differences between mouse and human · splits 35 ⟂ 4
CD163 — Interactions · splits 36 ⟂ 3

Map overview Semantic statistics

CD163

Nodes39
Edges38
Triples94
Avg. degree1.95
Density0.051282
Components1

Source & methodology

TTTA analyzes the structure around CD163 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Applications & Research, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — CD163 · EN edition · Analysis: TopicsToTalkAbout

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