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Telomerase reverse transcriptase: Measurement, Regulation & Clinical significance

Telomerase reverse transcriptase (abbreviated to TERT, or hTERT in humans) is a catalytic subunit of the enzyme telomerase, which, together with the telomerase RNA component (TERC), comprises the most important unit of the telomerase complex.

Language: English [EN]
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Telomerase reverse transcriptase topic overview

The analysis highlights Measurement, Regulation and Clinical significance as prominent areas in the source structure around Telomerase reverse transcriptase.

Related topics
145
Source areas
7
Connected nodes
152
Extracted relationships
176
Concept neighborhoods
35
Bridge connections
152

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Clinical significance · 41 topics
Medical implications · 41 topics
Regulation · 22 topics
Overview · 12 topics
Stem cells · 11 topics
Function · 9 topics
Interactions · 9 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

2.7.7.49
Aliases
TERT, CMM9, DKCA2, DKCB4, EST2, PFBMFT1, TCS1, TP2, TRT, hEST2, hTRT, telomerase reverse transcriptase, HTERT
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2BCK, 4B18, 4MNQ
Band
5p15.33 · 13 C1|13 40.12 cM
Bgee
stromal cell of endometrium · thymus · cardia · tongue · vein
BioGPS
More reference expression data

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Regulation

Stem cells

Clinical significance

Medical implications

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Telomerase reverse transcriptase connects Entity context

The extracted context around Telomerase reverse transcriptase shows recurring relationship patterns in the source. For example, Telomerase reverse transcriptase → beta-catenin-TCF complex assembly, cellular response to hypoxia, chaperone binding, chromosome, cytoplasm, cytosol, DNA binding, DNA biosynthetic process, DNA strand elongation, establishment of protein localization to telomere, identical protein binding, metal ion binding, mitochondrial nucleoid, mitochondrion, mitochondrion organization, negative regulation of apoptotic process, negative regulation of cellular senescence, negative regulation of endothelial cell apoptotic process, negative regulation of extrinsic apoptotic signaling pathway in absence of ligand, negative regulation of gene expression Another extracted example is Telomerase reverse transcriptase → cardia, condyle, epithelium of small intestine, external globus pallidus, fossa, genital tubercle, medullary collecting duct, mucosa of pharynx, otic vesicle, Paneth cell, pars reticulata, primary oocyte, pylorus, secondary oocyte, stromal cell of endometrium, superior surface of tongue, tail of embryo, thymus, tongue, vein. Use these groups to spot repeated connection types before inspecting the individual relationships.

Telomerase reverse transcriptase

Top relations

Gene ontology · 74
Telomerase reverse transcriptase → beta-catenin-TCF complex assembly, cellular response to hypoxia, chaperone binding, chromosome, cytoplasm, cytosol, DNA binding, DNA biosynthetic process, DNA strand elongation, establishment of protein localization to telomere, identical protein binding, metal ion binding, mitochondrial nucleoid, mitochondrion, mitochondrion organization, negative regulation of apoptotic process, negative regulation of cellular senescence, negative regulation of endothelial cell apoptotic process, negative regulation of extrinsic apoptotic signaling pathway in absence of ligand, negative regulation of gene expression
Bgee · 20
Telomerase reverse transcriptase → cardia, condyle, epithelium of small intestine, external globus pallidus, fossa, genital tubercle, medullary collecting duct, mucosa of pharynx, otic vesicle, Paneth cell, pars reticulata, primary oocyte, pylorus, secondary oocyte, stromal cell of endometrium, superior surface of tongue, tail of embryo, thymus, tongue, vein
RNA expression pattern · 20
Telomerase reverse transcriptase → cardia, condyle, epithelium of small intestine, external globus pallidus, fossa, genital tubercle, medullary collecting duct, mucosa of pharynx, otic vesicle, Paneth cell, pars reticulata, primary oocyte, pylorus, secondary oocyte, stromal cell of endometrium, superior surface of tongue, tail of embryo, thymus, tongue, vein
related to Interactions · 8
Telomerase reverse transcriptase → HSP90AA1, Ku70, Ku80, MCRS1, Nucleolin, PAWR, PINX1, Telomerase
related to Function · 7
Telomerase reverse transcriptase → Alternative, Alternatively, RNA, Studies, Telomerase, The, TTAGGG
Band · 2
Telomerase reverse transcriptase → 13 C1|13 40.12 cM, 5p15.33
Chr. · 2
Telomerase reverse transcriptase → Chromosome 13 (mouse), Chromosome 5 (human)
End · 2
Telomerase reverse transcriptase → 1,295,068 bp, 73,797,962 bp
2.7.7.49 · 1
Telomerase reverse transcriptase → ↗
Aliases · 1
Telomerase reverse transcriptase → TERT, CMM9, DKCA2, DKCB4, EST2, PFBMFT1, TCS1, TP2, TRT, hEST2, hTRT, telomerase reverse transcriptase, HTERT

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

cells telomerase htert stem gene tert cancer activity telomeres cell telomere human ips rna also expression associated somatic promoter apoptosis

Telomerase reverse transcriptase relationships Subject–Predicate–Object triples

TTTA extracted 176 structured relationships around Telomerase reverse transcriptase. Examples in this analysis include Telomerase reverse transcriptase → 2.7.7.49 → ↗ and Telomerase reverse transcriptase → Aliases → TERT, CMM9, DKCA2, DKCB4, EST2, PFBMFT1, TCS1, TP2, TRT, hEST2, hTRT, telomerase reverse transcriptase, HTERT. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Telomerase reverse transcriptase2.7.7.491.00infobox
Telomerase reverse transcriptaseAliasesTERT, CMM9, DKCA2, DKCB4, EST2, PFBMFT1, TCS1, TP2, TRT, hEST2, hTRT, telomerase reverse transcriptase, HTERT1.00infobox
Telomerase reverse transcriptaseAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2BCK, 4B18, 4MNQ1.00infobox
Telomerase reverse transcriptaseBand5p15.331.00infobox
Telomerase reverse transcriptaseBand13 C1|13 40.12 cM1.00infobox
Telomerase reverse transcriptaseBgeestromal cell of endometrium1.00infobox
Telomerase reverse transcriptaseBgeethymus1.00infobox
Telomerase reverse transcriptaseBgeecardia1.00infobox
Telomerase reverse transcriptaseBgeetongue1.00infobox
Telomerase reverse transcriptaseBgeevein1.00infobox
Telomerase reverse transcriptaseBgeemucosa of pharynx1.00infobox
Telomerase reverse transcriptaseBgeeexternal globus pallidus1.00infobox
Telomerase reverse transcriptaseBgeepylorus1.00infobox
Telomerase reverse transcriptaseBgeesuperior surface of tongue1.00infobox
Telomerase reverse transcriptaseBgeepars reticulata1.00infobox
Telomerase reverse transcriptaseBgeePaneth cell1.00infobox
Telomerase reverse transcriptaseBgeeprimary oocyte1.00infobox
Telomerase reverse transcriptaseBgeeepithelium of small intestine1.00infobox
Telomerase reverse transcriptaseBgeesecondary oocyte1.00infobox
Telomerase reverse transcriptaseBgeemedullary collecting duct1.00infobox
Telomerase reverse transcriptaseBgeetail of embryo1.00infobox
Telomerase reverse transcriptaseBgeecondyle1.00infobox
Telomerase reverse transcriptaseBgeefossa1.00infobox
Telomerase reverse transcriptaseBgeegenital tubercle1.00infobox
Telomerase reverse transcriptaseBgeeotic vesicle1.00infobox
Telomerase reverse transcriptaseBioGPSMore reference expression data1.00infobox
Telomerase reverse transcriptaseChr.Chromosome 5 (human)1.00infobox
Telomerase reverse transcriptaseChr.Chromosome 13 (mouse)1.00infobox
Telomerase reverse transcriptaseDatabasesNCBI: entry; OMA: entry1.00infobox
Telomerase reverse transcriptaseEnd1,295,068 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Telomerase reverse transcriptase bring nearby vocabulary together. In this analysis, examples include Activity, Enzyme and Cells. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Telomerase reverse transcriptase
    • Activity
    • Enzyme
    • Cells
    • Htert
    • Cell
    • Bp
    • Chr
    • Chromosome
    • Telomerase
    • Transcriptase
    • Cancer
    • Tert
  • telomerase reverse transcriptase
    • Transcriptase
    • Component
    • Activity
    • Rna
    • Enzyme
    • Cells
    • Htert
    • Protein
    • Cell
    • Human
    • Bp
    • Chr
  • enzyme
    • Reverse
    • Transcriptase
    • Complex
    • Component
    • Rna
    • Bp
    • Chr
    • Chromosome
    • Dna
    • Regulation
    • Specific
    • Tert
  • telomerase
    • Activity
    • Cells
    • Htert
    • Cell
    • Transcriptase
    • Cancer
    • Tert
    • Also
    • Human
    • Rna
    • Ips
    • Gene
  • telomerase rna component
    • Complex
    • Component
    • Reverse
    • Rna
    • Transcriptase
    • Activity
    • Cells
    • Gene
    • Htert
    • Enzyme
    • Cell
    • Associated
  • dna
    • Associated
    • Band
    • Bp
    • Chr
    • Chromosome
    • Enzyme
    • Mrna
    • Regulation
    • Tert
    • Apoptosis
    • Specific
    • Transcription
  • cells
    • Htert
    • Stem
    • Telomerase
    • Telomeres
    • Ips
    • Cancer
    • Cell
    • Activity
    • Somatic
    • Apoptosis
    • Tert
    • Over-expression
  • reverse transcriptase
    • Transcriptase
    • Component
    • Rna
    • Enzyme
    • Protein
    • Human
    • Bp
    • Chr
    • Chromosome
    • Tert
    • Complex
    • Gene

Connections between topic areas Semantic bridges

For Telomerase reverse transcriptase, one of the stronger structural bridges in this analysis connects Telomerase reverse transcriptase with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Telomerase reverse transcriptaseClinical significance · splits 111 ⟂ 42
Telomerase reverse transcriptaseMedical implications · splits 111 ⟂ 42
Telomerase reverse transcriptaseRegulation · splits 130 ⟂ 23
Telomerase reverse transcriptaseOverview · splits 140 ⟂ 13
Telomerase reverse transcriptaseStem cells · splits 141 ⟂ 12
Telomerase reverse transcriptaseFunction · splits 143 ⟂ 10
Telomerase reverse transcriptaseInteractions · splits 143 ⟂ 10

Map overview Semantic statistics

Telomerase reverse transcriptase

Nodes153
Edges152
Triples176
Avg. degree1.99
Density0.013072
Components1

Source & methodology

TTTA analyzes the structure around Telomerase reverse transcriptase to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Measurement, Regulation & Clinical significance, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Telomerase reverse transcriptase · EN edition · Analysis: TopicsToTalkAbout

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