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MEN1

Menin is a protein that in humans is encoded by the MEN1 gene. Menin is a putative tumor suppressor associated with multiple endocrine neoplasia type 1 (MEN-1 syndrome) and has autosomal dominant inheritance. Variations in the MEN1 gene can cause pituitary adenomas, hyperparathyroidism, pancreatic neuroendocrine tumors, gastrinoma, and adrenocortical…

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Aliases
MEN1, MEAI, SCG2, menin 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3U84, 3U85, 3U86, 3U88, 4GPQ, 4GQ3, 4GQ4, 4I80, 4OG3, 4OG4, 4OG5, 4OG6, 4OG7, 4OG8, 4X5Y, 4X5Z, 5DDF, 5DD9,…
Band
11q13.1 · 19|19 A
Bgee
granulocyte · right hemisphere of cerebellum · right adrenal gland · ganglionic eminence · ventricular zone
BioGPS
More reference expression data
Chr.
Chromosome 11 (human) · Chromosome 19 (mouse)

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Role in cancer

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Map overview Semantic statistics

MEN1

Nodes46
Edges45
Triples166
Avg. degree1.96
Density0.043478
Components1

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MEN1

Top relations

Gene ontology · 57
MEN1 → beta-catenin-TCF complex assembly, brain development, cellular response to DNA damage stimulus, cellular response to glucose stimulus, cellular response to peptide hormone stimulus, chromatin, chromatin binding, chromatin organization, cleavage furrow, cytoplasm, cytosol, decidualization, DNA binding, DNA repair, double-stranded DNA binding, endoplasmic reticulum lumen, four-way junction DNA binding, histone lysine methylation, histone methyltransferase complex, histone-lysine N-methyltransferase activity
Bgee · 18
MEN1 → adrenal gland, epiblast, ganglionic eminence, genital tubercle, granulocyte, left adrenal gland, mesencephalon, mucosa of transverse colon, neural tube, right adrenal cortex, right adrenal gland, right hemisphere of cerebellum, right lobe of liver, right lobe of thyroid gland, striatum of neuraxis, tail of embryo, ventricular zone, yolk sac
RNA expression pattern · 18
MEN1 → adrenal gland, epiblast, ganglionic eminence, genital tubercle, granulocyte, left adrenal gland, mesencephalon, mucosa of transverse colon, neural tube, right adrenal cortex, right adrenal gland, right hemisphere of cerebellum, right lobe of liver, right lobe of thyroid gland, striatum of neuraxis, tail of embryo, ventricular zone, yolk sac
related to External links · 13
MEN1 → Archived, GeneReviews/NIH/NCBI/UW, Medicine Medical Subject Headings, Menin, MeSH, Multiple Endocrine Neoplasia Type, National Library, O00255, Overview, PDB, PDBe-KB, UniProt, Wayback MachineMEN1
related to Role in cancer · 11
MEN1 → As, Consequently, Frameshift, Insulinomas, MEN-1, Menin, Missense, Most, Studies, Such, These
related to Clinical implications · 7
MEN1 → Ellison, In, MEN2A, Pancreatic, The MEN1, While, Zollinger
related to Interactions · 6
MEN1 → FANCD2, GFAP, JunD, MLL, NFKB1, RPA2
related to history · 5
MEN1 → In, Karolinska Institute, Stockholm, The, Uppsala University Hospital
Band · 2
MEN1 → 11q13.1, 19|19 A
Chr. · 2
MEN1 → Chromosome 11 (human), Chromosome 19 (mouse)

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Important terminology

gene menin protein mutations chromosome bp human tumors 11 two chr band tumor pituitary suppressor endocrine also pancreatic function nucleus

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
MEN1AliasesMEN1, MEAI, SCG2, menin 11.00infobox
MEN1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3U84, 3U85, 3U86, 3U88, 4GPQ, 4GQ3, 4GQ4, 4I80, 4OG3, 4OG4, 4OG5, 4OG6, 4OG7, 4OG8, 4X5Y, 4X5Z, 5DDF, 5DD9,…1.00infobox
MEN1Band11q13.11.00infobox
MEN1Band19|19 A1.00infobox
MEN1Bgeegranulocyte1.00infobox
MEN1Bgeeright hemisphere of cerebellum1.00infobox
MEN1Bgeeright adrenal gland1.00infobox
MEN1Bgeeganglionic eminence1.00infobox
MEN1Bgeeventricular zone1.00infobox
MEN1Bgeemucosa of transverse colon1.00infobox
MEN1Bgeeright adrenal cortex1.00infobox
MEN1Bgeeright lobe of liver1.00infobox
MEN1Bgeeright lobe of thyroid gland1.00infobox
MEN1Bgeeleft adrenal gland1.00infobox
MEN1Bgeegenital tubercle1.00infobox
MEN1Bgeetail of embryo1.00infobox
MEN1Bgeeepiblast1.00infobox
MEN1Bgeeyolk sac1.00infobox
MEN1Bgeeadrenal gland1.00infobox
MEN1Bgeestriatum of neuraxis1.00infobox
MEN1Bgeemesencephalon1.00infobox
MEN1Bgeeneural tube1.00infobox
MEN1BioGPSMore reference expression data1.00infobox
MEN1Chr.Chromosome 11 (human)1.00infobox
MEN1Chr.Chromosome 19 (mouse)1.00infobox
MEN1DatabasesNCBI: entry; OMA: entry1.00infobox
MEN1End64,811,294 bp1.00infobox
MEN1End6,390,921 bp1.00infobox
MEN1EnsemblENSG000001338951.00infobox
MEN1Entrez42211.00infobox

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