MEN1

Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.

Map view:

Zoom: 100%

More settings

Connection length 100% Label size 100% Node size 100% Line width 100% Label width 100%

Export map as:

MEN1 topic overview

The analysis highlights History and Regions as prominent areas in the source structure around MEN1. 1 topic appears in more than one source area, which can help identify connections that are less obvious in a linear reading.

Related topics: 39
Source areas: 5
Connected nodes: 45
Extracted relationships: 166
Concept neighborhoods: 12
Bridge connections: 45

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Role in cancer · 17 topics

Overview · 9 topics

Interactions · 8 topics

History · 4 topics

Clinical implications · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases: MEN1, MEAI, SCG2, menin 1
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3U84, 3U85, 3U86, 3U88, 4GPQ, 4GQ3, 4GQ4, 4I80, 4OG3, 4OG4, 4OG5, 4OG6, 4OG7, 4OG8, 4X5Y, 4X5Z, 5DDF, 5DD9,…
Band: 11q13.1 · 19|19 A
Bgee: granulocyte · right hemisphere of cerebellum · right adrenal gland · ganglionic eminence · ventricular zone
BioGPS: More reference expression data
Chr.: Chromosome 11 (human) · Chromosome 19 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Protein
Gene
Tumor suppressor
Multiple endocrine neoplasia type 1
Nuclear localization signals Nuclear localization signal
JunD
Northern blots Northern blot
Alternative splicing
5' UTR

History

Clinical implications

Role in cancer

Germline Germline mutation
Somatic mutations Somatic mutation
Splice-site mutations Splice site mutation
Pathology
Nonsense mutations Nonsense mutation
Nucleus Cell nucleus
Proteolytic degradation
Tumorigenesis
Knudson's "two-hit" model Knudson hypothesis
Tumor suppressor Tumor suppressor gene
Mitotic index
Ki67 Ki-67 (protein)
Revumenib
Bleximenib
Enzomenib
Icovamenib
Ziftomenib

Interactions

Interact Protein-protein interaction
FANCD2
GFAP Glial fibrillary acidic protein
JunD
NFKB1
MLL MLL (gene)
RPA2
VIM Vimentin

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How MEN1 connects Entity context

The extracted context around MEN1 shows recurring relationship patterns in the source. For example, MEN1 → beta-catenin-TCF complex assembly, brain development, cellular response to DNA damage stimulus, cellular response to glucose stimulus, cellular response to peptide hormone stimulus, chromatin, chromatin binding, chromatin organization, cleavage furrow, cytoplasm, cytosol, decidualization, DNA binding, DNA repair, double-stranded DNA binding, endoplasmic reticulum lumen, four-way junction DNA binding, histone lysine methylation, histone methyltransferase complex, histone-lysine N-methyltransferase activity Another extracted example is MEN1 → adrenal gland, epiblast, ganglionic eminence, genital tubercle, granulocyte, left adrenal gland, mesencephalon, mucosa of transverse colon, neural tube, right adrenal cortex, right adrenal gland, right hemisphere of cerebellum, right lobe of liver, right lobe of thyroid gland, striatum of neuraxis, tail of embryo, ventricular zone, yolk sac. Use these groups to spot repeated connection types before inspecting the individual relationships.

Top relations

Gene ontology · 57

MEN1 → beta-catenin-TCF complex assembly, brain development, cellular response to DNA damage stimulus, cellular response to glucose stimulus, cellular response to peptide hormone stimulus, chromatin, chromatin binding, chromatin organization, cleavage furrow, cytoplasm, cytosol, decidualization, DNA binding, DNA repair, double-stranded DNA binding, endoplasmic reticulum lumen, four-way junction DNA binding, histone lysine methylation, histone methyltransferase complex, histone-lysine N-methyltransferase activity

Bgee · 18

MEN1 → adrenal gland, epiblast, ganglionic eminence, genital tubercle, granulocyte, left adrenal gland, mesencephalon, mucosa of transverse colon, neural tube, right adrenal cortex, right adrenal gland, right hemisphere of cerebellum, right lobe of liver, right lobe of thyroid gland, striatum of neuraxis, tail of embryo, ventricular zone, yolk sac

RNA expression pattern · 18

related to External links · 13

MEN1 → Archived, GeneReviews/NIH/NCBI/UW, Medicine Medical Subject Headings, Menin, MeSH, Multiple Endocrine Neoplasia Type, National Library, O00255, Overview, PDB, PDBe-KB, UniProt, Wayback MachineMEN1

related to Role in cancer · 11

MEN1 → As, Consequently, Frameshift, Insulinomas, MEN-1, Menin, Missense, Most, Studies, Such, These

related to Clinical implications · 7

MEN1 → Ellison, In, MEN2A, Pancreatic, The MEN1, While, Zollinger

related to Interactions · 6

MEN1 → FANCD2, GFAP, JunD, MLL, NFKB1, RPA2

related to history · 5

MEN1 → In, Karolinska Institute, Stockholm, The, Uppsala University Hospital

Band · 2

MEN1 → 11q13.1, 19|19 A

Chr. · 2

MEN1 → Chromosome 11 (human), Chromosome 19 (mouse)

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gene menin protein mutations chromosome bp human tumors 11 two chr band tumor pituitary suppressor endocrine also pancreatic function nucleus

MEN1 relationships Subject–Predicate–Object triples

TTTA extracted 166 structured relationships around MEN1. Examples in this analysis include MEN1 → Aliases → MEN1, MEAI, SCG2, menin 1 and MEN1 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3U84, 3U85, 3U86, 3U88, 4GPQ, 4GQ3, 4GQ4, 4I80, 4OG3, 4OG4, 4OG5, 4OG6, 4OG7, 4OG8, 4X5Y, 4X5Z, 5DDF, 5DD9,…. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
MEN1	Aliases	MEN1, MEAI, SCG2, menin 1	1.00	infobox
MEN1	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3U84, 3U85, 3U86, 3U88, 4GPQ, 4GQ3, 4GQ4, 4I80, 4OG3, 4OG4, 4OG5, 4OG6, 4OG7, 4OG8, 4X5Y, 4X5Z, 5DDF, 5DD9,…	1.00	infobox
MEN1	Band	11q13.1	1.00	infobox
MEN1	Band	19\|19 A	1.00	infobox
MEN1	Bgee	granulocyte	1.00	infobox
MEN1	Bgee	right hemisphere of cerebellum	1.00	infobox
MEN1	Bgee	right adrenal gland	1.00	infobox
MEN1	Bgee	ganglionic eminence	1.00	infobox
MEN1	Bgee	ventricular zone	1.00	infobox
MEN1	Bgee	mucosa of transverse colon	1.00	infobox
MEN1	Bgee	right adrenal cortex	1.00	infobox
MEN1	Bgee	right lobe of liver	1.00	infobox
MEN1	Bgee	right lobe of thyroid gland	1.00	infobox
MEN1	Bgee	left adrenal gland	1.00	infobox
MEN1	Bgee	genital tubercle	1.00	infobox
MEN1	Bgee	tail of embryo	1.00	infobox
MEN1	Bgee	epiblast	1.00	infobox
MEN1	Bgee	yolk sac	1.00	infobox
MEN1	Bgee	adrenal gland	1.00	infobox
MEN1	Bgee	striatum of neuraxis	1.00	infobox
MEN1	Bgee	mesencephalon	1.00	infobox
MEN1	Bgee	neural tube	1.00	infobox
MEN1	BioGPS	More reference expression data	1.00	infobox
MEN1	Chr.	Chromosome 11 (human)	1.00	infobox
MEN1	Chr.	Chromosome 19 (mouse)	1.00	infobox
MEN1	Databases	NCBI: entry; OMA: entry	1.00	infobox
MEN1	End	64,811,294 bp	1.00	infobox
MEN1	End	6,390,921 bp	1.00	infobox
MEN1	Ensembl	ENSG00000133895	1.00	infobox
MEN1	Entrez	4221	1.00	infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around MEN1 bring nearby vocabulary together. In this analysis, examples include Gene, Mutations and Sporadic. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

MEN1
- Gene
- Mutations
- Sporadic
- Pituitary
- Tumors
- Menin
- Adenomas
- Cells
- Pancreatic
- Human
- Chromosome
- Tumor
men1
- Gene
- Mutations
- Sporadic
- Pituitary
- Tumors
- Menin
- Adenomas
- Cells
- Pancreatic
- Human
- Chromosome
- Tumor
gene
- Men1
- Chromosome
- Human
- Tumors
- Mutations
- Protein
- Location
- Function
- Sporadic
- Bp
- Chr
- Suppressor
multiple endocrine neoplasia type 1
- Endocrine
- Human
- Type
- Men-1
- Syndrome
- Tumor
- Location
- Nucleus
- Protein
- Associated
- Band
- Cell
chromosome 11
- Bp
- Human
- Location
- Band
- Gene
- Men1
- Nucleus
- Type
- Cell
- Function
- May
- Men-1
nucleus
- Cell
- Location
- Protein
- Shown
- Type
- Band
- Function
- May
- Pancreatic
- Bp
- Chr
- Human
tumor suppressor
- Tumor
- Function
- Shown
- Type
- May
- Syndrome
- Also
- Cell
- Cells
- Mutations
- Protein
somatic mutations
- Proteins
- Sporadic
- Protein
- Nucleus
- Suppressor
- Pituitary
- Tumor
- Tumors

Connections between topic areas Semantic bridges

For MEN1, one of the stronger structural bridges in this analysis connects MEN1 with Role in cancer. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

MEN1 — Role in cancer · splits 28 ⟂ 18

MEN1 — Overview · splits 36 ⟂ 10

MEN1 — Interactions · splits 37 ⟂ 9

MEN1 — History · splits 41 ⟂ 5

MEN1 — Clinical implications · splits 43 ⟂ 3

Map overview Semantic statistics

MEN1

Nodes46

Edges45

Triples166

Avg. degree1.96

Density0.043478

Components1

Source & methodology

TTTA analyzes the structure around MEN1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History & Regions, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — MEN1 · EN edition · Analysis: TopicsToTalkAbout