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Telomere

A telomere (/ˈtɛləmɪər, ˈtiːlə-/; from Ancient Greek τέλος (télos) 'end' and μέρος (méros) 'part') is a region of repetitive nucleotide sequences associated with specialized proteins at the ends of linear chromosomes (see Sequences). Telomeres are a widespread genetic feature most commonly found in eukaryotes. In most or even all species possessing them…

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Overview

Discovery

Structure and function

Shortening

Lengthening

Sequences

Research on disease risk

Measurement

In wildlife

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Map overview Semantic statistics

Telomere

Nodes96
Edges95
Triples174
Avg. degree1.98
Density0.020833
Components1

How this topic connects Entity context

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Telomere

Top relations

measured by · 22
Telomere → Amongst, Flow FISH, Flow-FISH, Length, Nature Protocols, One, PCR, Real-Time PCR, Several, T/S, Telomere-to-Single Copy Gene, Telomerecat, Telomeres, TelSeq, Terminal Restriction Fragment, There, These, Tools, TRF, WALTER
related to Discovery · 19
Telomere → According, Alexey Olovnikov, Barbara McClintock, Building, DNA, DNA-polymerase, Drosophila, Furthermore, Greek, He, Hermann Joseph Muller, In, It, Leonard Hayflick's, Muller, Olovnikov, Painter, Soviet, The
related to Telomere ends and shelterin · 18
Telomere → At, DNA, DNA-polymerases, G-quadruplexes, In, POT1, RAP1, Should, T-loop, The T-loop, There, This, TIN2, TPP1, TRF1, TRF2, TTAGGG, Watson-Crick
related to Lengthening · 14
Telomere → Geron Corporation, Geron's, Hayflick, In, Leach's, Leonard Hayflick, Michael, Oceanodroma, Science, Significant, Telomerase, The, Two, West
related to End replication problem · 13
Telomere → DNA, DNA-Pol, DNA-polymerase, During DNA, If, It, On, Originally, RNA, Telomeres, The, They, This
related to Length · 13
Telomere → At, D-loop, DNA, Eukaryotic, Here, However, Multiple, T-loop, T-loops, Telomeres, The, These, This
related to External links · 11
Telomere → Beginning Nobel Lecture, Carol GreiderDNA Ends, Consequences, Elizabeth Blackburn, End Nobel Lecture, Jack Szostak, Just, Telomerase, Telomere Dysfunction Nobel Lecture, Telomeres, The Means
related to Oxidative damage · 11
Telomere → Apart, Despite, DNA, In, LIBCSP, Long Island Breast Cancer, Population-based, ROS, Study Project, There, These
related to In wildlife · 9
Telomere → Age, During, For, In, Metazoa, Most, Phylogeny, Studies, They
related to Telomerase · 7
Telomere → ATP, DNA, In, Many, Telomerase, The, This

Important terminology Word statistics

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Important terminology

telomeres dna length ends telomerase replication chromosomes cell sequences end shortening cells associated species proteins aging stress strand linear cancer

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
germ lineinstance ofcould extend telomeres in immortal tissues0.80text
cancer cellsinstance ofcould extend telomeres in immortal tissues0.80text
stem cellsinstance ofcould extend telomeres in immortal tissues0.80text
most cancer cell linesinstance ofand immortal cell populations0.80text
an enzyme might be activated to prevent the shortening of DNA termini with each cell division.In 1975instance ofand immortal cell populations0.80text
DNA-polymerasesinstance ofG-quadruplexes present an obstacle for enzymes0.80text
are thus thought to be involved in the regulation of replicationinstance ofG-quadruplexes present an obstacle for enzymes0.80text
transcription.TelomeraseMany organisms have a ribonucleoprotein enzyme called telomeraseinstance ofG-quadruplexes present an obstacle for enzymes0.80text
which carries out the task of adding repetitive nucleotide sequences to the ends of the DNAinstance ofG-quadruplexes present an obstacle for enzymes0.80text
embryonic stem cellsinstance ofsome types of stem cells0.80text
and certain white blood cellsinstance ofsome types of stem cells0.80text
transcriptioninstance ofG-quadruplexes present an obstacle for enzymes0.80text

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