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An epigenetic clock is an analytical method used as a biomarker of aging to estimate "biological age." The method relies on age-related modifications to DNA that occur over time and regulate how genes are expressed. Many epigenetic clocks are based on the analysis of DNA methylation, measuring the accumulation of methyl groups to CpG regions of DNA…
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| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| Epigenetic clock | is a | analytical method used as a biomarker of aging to estimate | 0.90 | text |
| smoking | instance of | This was thanks to the incorporation not only of epigenetic variants such as DNA methylation but also environmental variants | 0.80 | text |
| age-related clinical phenotypes | instance of | This was thanks to the incorporation not only of epigenetic variants such as DNA methylation but also environmental variants | 0.80 | text |
| CD4 T cells | instance of | as well as in individual cell types | 0.80 | text |
| CD14 monocytes | instance of | as well as in individual cell types | 0.80 | text |
| glial cells | instance of | as well as in individual cell types | 0.80 | text |
| neurons | instance of | as well as in individual cell types | 0.80 | text |
| immortalized B cells | instance of | as well as in individual cell types | 0.80 | text |
| mesenchymal stromal cells | instance of | as well as in individual cell types | 0.80 | text |
| DNA damage | instance of | suggests that cellular senescence is a state that cells are forced into as a result of external pressures | 0.80 | text |
| ectopic oncogene expression | instance of | suggests that cellular senescence is a state that cells are forced into as a result of external pressures | 0.80 | text |
| exhaustive proliferation of cells to replenish those eliminated by external/environmental factors | instance of | suggests that cellular senescence is a state that cells are forced into as a result of external pressures | 0.80 | text |
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