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Epigenetic clock

An epigenetic clock is an analytical method used as a biomarker of aging to estimate "biological age." The method relies on age-related modifications to DNA that occur over time and regulate how genes are expressed. Many epigenetic clocks are based on the analysis of DNA methylation, measuring the accumulation of methyl groups to CpG regions of DNA…

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Overview

History

Most robustly age associated loci

Relationship to a cause of biological aging

Motivation for biological clocks

Properties of Horvath's clock

Applications of epigenetic clocks

Biological mechanism behind the epigenetic clock

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Map overview Semantic statistics

Epigenetic clock

Nodes101
Edges100
Triples158
Avg. degree1.98
Density0.019802
Components1

How this topic connects Entity context

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Epigenetic clock

Top relations

related to history · 21
Epigenetic clock → Bocklandt, California, CpGs, DNA, Eric Vilain, Hannum, Horvath, Horvath's, IEAA, Illumina DNA, Intrinsic Epigenetic Age Acceleration, Kang Zhang, San Diego, Shortly, Steve Horvath, Sven Bocklandt, The, This, Trey Ideker, UCLA
related to Cellular senescence versus epigenetic aging · 14
Epigenetic clock → Although, Baker, Consistent, DNA, DNA-damaging, However, Induction, It, OIS, RS, The, Therefore, These, This
related to HIV and SIV infection · 13
Epigenetic clock → AIDS, An, But, DNA, HIV, HIV-1, HLA, Human Immunodeficiency Virus-1, Infection, PBMCs, Simian Immunodeficiency Virus, SIVmac, These
related to Possible explanation 2: Unrepaired DNA damages · 10
Epigenetic clock → Accumulation, CpG, DNA, During, Endogenous DNA, H2O2, In, Similar, These, This
related to Properties of Horvath's clock · 10
Epigenetic clock → CpG, DNA, Estimated, Horvath's, It, Organismal, Salient, Similarly, Since, The
related to Epigenetic clock theory of aging · 9
Epigenetic clock → At, Axel Schumacher, Biological, DNA, DNAm, In, Kenneth Raj, Steve Horvath, The
related to Relationship to a cause of biological aging · 9
Epigenetic clock → CpG, CpGs, DNA, Horvath, However, It, On, Rather, The
related to Effect of sex and race/ethnicity · 8
Epigenetic clock → But, DNAm, For, Hispanic, Hispanics, Men, The, Tsimané
related to Statistical approach · 8
Epigenetic clock → CpG, CpGs, DNAm, Elastic, Horvath, Illumina, The, Using
related to Obesity and metabolic syndrome · 7
Epigenetic clock → BMI, C-reactive, Conversely, DNA, HDL, Other, The

Important terminology Word statistics

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Important terminology

age epigenetic aging dna clock blood acceleration methylation associated clocks cancer tissues tissue cells biological chronological based cellular senescence found

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Epigenetic clockis aanalytical method used as a biomarker of aging to estimate0.90text
smokinginstance ofThis was thanks to the incorporation not only of epigenetic variants such as DNA methylation but also environmental variants0.80text
age-related clinical phenotypesinstance ofThis was thanks to the incorporation not only of epigenetic variants such as DNA methylation but also environmental variants0.80text
CD4 T cellsinstance ofas well as in individual cell types0.80text
CD14 monocytesinstance ofas well as in individual cell types0.80text
glial cellsinstance ofas well as in individual cell types0.80text
neuronsinstance ofas well as in individual cell types0.80text
immortalized B cellsinstance ofas well as in individual cell types0.80text
mesenchymal stromal cellsinstance ofas well as in individual cell types0.80text
DNA damageinstance ofsuggests that cellular senescence is a state that cells are forced into as a result of external pressures0.80text
ectopic oncogene expressioninstance ofsuggests that cellular senescence is a state that cells are forced into as a result of external pressures0.80text
exhaustive proliferation of cells to replenish those eliminated by external/environmental factorsinstance ofsuggests that cellular senescence is a state that cells are forced into as a result of external pressures0.80text

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