Research any topic before you write.

Find related topics. | Discover entities. | See connections. | Build a topical map.

Epigenetic clock: History, Applications & Regions

An epigenetic clock is an analytical method used as a biomarker of aging to estimate "biological age." The method relies on age-related modifications to DNA that occur over time and regulate how genes are expressed. Many epigenetic clocks are based on the analysis of DNA methylation, measuring the accumulation of methyl groups to CpG regions of DNA…

Language: English [EN]
Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.
100%
More settings
100% 100% 100% 100% 100%

Epigenetic clock topic overview

The analysis highlights History, Applications and Regions as prominent areas in the source structure around Epigenetic clock.

Related topics
92
Source areas
8
Connected nodes
100
Extracted relationships
158
Concept neighborhoods
32
Bridge connections
100

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Applications of epigenetic clocks · 30 topics
Properties of Horvath's clock · 20 topics
History · 12 topics
Motivation for biological clocks · 10 topics
Overview · 9 topics
Most robustly age associated loci · 6 topics
Relationship to a cause of biological aging · 3 topics
Biological mechanism behind the epigenetic clock · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

History

Most robustly age associated loci

Relationship to a cause of biological aging

Motivation for biological clocks

Properties of Horvath's clock

Applications of epigenetic clocks

Biological mechanism behind the epigenetic clock

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Epigenetic clock connects Entity context

The extracted context around Epigenetic clock shows recurring relationship patterns in the source. For example, Epigenetic clock → Bocklandt, California, CpGs, DNA, Eric Vilain, Hannum, Horvath, Horvath's, IEAA, Illumina DNA, Intrinsic Epigenetic Age Acceleration, Kang Zhang, San Diego, Shortly, Steve Horvath, Sven Bocklandt, The, This, Trey Ideker, UCLA Another extracted example is Epigenetic clock → Although, Baker, Consistent, DNA, DNA-damaging, However, Induction, It, OIS, RS, The, Therefore, These, This. Use these groups to spot repeated connection types before inspecting the individual relationships.

Epigenetic clock

Top relations

related to history · 21
Epigenetic clock → Bocklandt, California, CpGs, DNA, Eric Vilain, Hannum, Horvath, Horvath's, IEAA, Illumina DNA, Intrinsic Epigenetic Age Acceleration, Kang Zhang, San Diego, Shortly, Steve Horvath, Sven Bocklandt, The, This, Trey Ideker, UCLA
related to Cellular senescence versus epigenetic aging · 14
Epigenetic clock → Although, Baker, Consistent, DNA, DNA-damaging, However, Induction, It, OIS, RS, The, Therefore, These, This
related to HIV and SIV infection · 13
Epigenetic clock → AIDS, An, But, DNA, HIV, HIV-1, HLA, Human Immunodeficiency Virus-1, Infection, PBMCs, Simian Immunodeficiency Virus, SIVmac, These
related to Possible explanation 2: Unrepaired DNA damages · 10
Epigenetic clock → Accumulation, CpG, DNA, During, Endogenous DNA, H2O2, In, Similar, These, This
related to Properties of Horvath's clock · 10
Epigenetic clock → CpG, DNA, Estimated, Horvath's, It, Organismal, Salient, Similarly, Since, The
related to Epigenetic clock theory of aging · 9
Epigenetic clock → At, Axel Schumacher, Biological, DNA, DNAm, In, Kenneth Raj, Steve Horvath, The
related to Relationship to a cause of biological aging · 9
Epigenetic clock → CpG, CpGs, DNA, Horvath, However, It, On, Rather, The
related to Effect of sex and race/ethnicity · 8
Epigenetic clock → But, DNAm, For, Hispanic, Hispanics, Men, The, Tsimané
related to Statistical approach · 8
Epigenetic clock → CpG, CpGs, DNAm, Elastic, Horvath, Illumina, The, Using
related to Obesity and metabolic syndrome · 7
Epigenetic clock → BMI, C-reactive, Conversely, DNA, HDL, Other, The

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

age epigenetic aging dna clock blood acceleration methylation associated clocks cancer tissues tissue cells biological chronological based cellular senescence found

Epigenetic clock relationships Subject–Predicate–Object triples

TTTA extracted 158 structured relationships around Epigenetic clock. Examples in this analysis include Epigenetic clock → is a → analytical method used as a biomarker of aging to estimate and smoking → instance of → This was thanks to the incorporation not only of epigenetic variants such as DNA methylation but also environmental variants. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Epigenetic clockis aanalytical method used as a biomarker of aging to estimate0.90text
smokinginstance ofThis was thanks to the incorporation not only of epigenetic variants such as DNA methylation but also environmental variants0.80text
age-related clinical phenotypesinstance ofThis was thanks to the incorporation not only of epigenetic variants such as DNA methylation but also environmental variants0.80text
CD4 T cellsinstance ofas well as in individual cell types0.80text
CD14 monocytesinstance ofas well as in individual cell types0.80text
glial cellsinstance ofas well as in individual cell types0.80text
neuronsinstance ofas well as in individual cell types0.80text
immortalized B cellsinstance ofas well as in individual cell types0.80text
mesenchymal stromal cellsinstance ofas well as in individual cell types0.80text
DNA damageinstance ofsuggests that cellular senescence is a state that cells are forced into as a result of external pressures0.80text
ectopic oncogene expressioninstance ofsuggests that cellular senescence is a state that cells are forced into as a result of external pressures0.80text
exhaustive proliferation of cells to replenish those eliminated by external/environmental factorsinstance ofsuggests that cellular senescence is a state that cells are forced into as a result of external pressures0.80text

Related concept clusters Concept neighborhoods

The concept neighborhoods around Epigenetic clock bring nearby vocabulary together. In this analysis, examples include Epigenetic, Blood and Age. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Epigenetic clock
    • Epigenetic
    • Blood
    • Age
    • Acceleration
    • Dna
    • Aging
    • Associated
    • Clocks
    • Cellular
    • Tissue
    • Effect
    • Methylation
  • epigenetic clock
    • Epigenetic
    • Blood
    • Age
    • Acceleration
    • Dna
    • Aging
    • Associated
    • Horvath
    • Cellular
    • Tissue
    • Clocks
    • Based
  • biomarker of aging
    • Biological
    • Cellular
    • Senescence
    • Epigenetic
    • Accelerated
    • Clock
    • Associated
    • Dna
    • Blood
    • Clocks
    • Ages
    • Effect
  • dna
    • Methylation
    • Epigenetic
    • Used
    • Horvath
    • Cellular
    • Senescence
    • Clocks
    • Years
    • Cell
    • Cells
    • Acceleration
    • Blood
  • epigenetic
    • Blood
    • Age
    • Acceleration
    • Dna
    • Aging
    • Associated
    • Clocks
    • Cellular
    • Tissue
    • Methylation
    • Based
    • Found
  • dna methylation
    • Methylation
    • Epigenetic
    • Used
    • Horvath
    • Cellular
    • Senescence
    • Levels
    • Also
    • Clocks
    • Years
    • Cell
    • Tissues
  • aging theories
    • Biological
    • Cellular
    • Senescence
    • Epigenetic
    • Accelerated
    • Clock
    • Associated
    • Dna
    • Blood
    • Clocks
    • Ages
    • Effect
  • theories of biological aging
    • Biological
    • Clocks
    • Expected
    • Cellular
    • Senescence
    • Epigenetic
    • Accelerated
    • Cell
    • Clock
    • Associated
    • Dna
    • Blood

Connections between topic areas Semantic bridges

For Epigenetic clock, one of the stronger structural bridges in this analysis connects Epigenetic clock with Applications of epigenetic clocks. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Epigenetic clockApplications of epigenetic clocks · splits 70 ⟂ 31
Epigenetic clockProperties of Horvath's clock · splits 80 ⟂ 21
Epigenetic clockHistory · splits 88 ⟂ 13
Epigenetic clockMotivation for biological clocks · splits 90 ⟂ 11
Epigenetic clockOverview · splits 91 ⟂ 10
Epigenetic clockMost robustly age associated loci · splits 94 ⟂ 7
Epigenetic clockRelationship to a cause of biological aging · splits 97 ⟂ 4
Epigenetic clockBiological mechanism behind the epigenetic clock · splits 98 ⟂ 3

Map overview Semantic statistics

Epigenetic clock

Nodes101
Edges100
Triples158
Avg. degree1.98
Density0.019802
Components1

Source & methodology

TTTA analyzes the structure around Epigenetic clock to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Applications & Regions, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Epigenetic clock · EN edition · Analysis: TopicsToTalkAbout

For writers, content strategists, SEOs, marketers and creators — from quick topic research to advanced semantic analysis.