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GSK-3

Glycogen synthase kinase 3 (GSK-3) is a serine/threonine protein kinase that mediates the addition of phosphate molecules onto serine and threonine amino acid residues. First discovered in 1980 as a regulatory kinase for its namesake, glycogen synthase (GS), GSK-3 has since been identified as a protein kinase for over 100 different proteins in a variety…

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AlphaFold
IPR039192
Available protein structures:
IPR039192
CDD
cd14137
InterPro
IPR039192
PDB
IPR039192
Symbol
STKc_GSK3

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Overview

Mechanism

Glycogen synthase

Function

Disease relevance

Inhibitors

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Map overview Semantic statistics

GSK-3

Nodes119
Edges118
Triples69
Avg. degree1.98
Density0.016807
Components1

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GSK-3

Top relations

related to Famotidine · 14
GSK-3 → AR-A014418, Ellison, Famotidine, GERD, GSK-3β, H2, H2-receptor, It, LEU-188, PRO-136, Strong, The, VAL, Zollinger
related to Disease relevance · 9
GSK-3 → Alzheimer's, Due, Elements, GSK-3's, Inhibition, Rev-ErbA, T2DM, The, There
related to Function · 7
GSK-3 → After, C-terminal, CK2, However, In, IRS1, Phosphorylation
related to Lithium · 6
GSK-3 → Also, Alzheimer's, GS, In, It, Lithium
related to Naproxen and Cromolyn · 6
GSK-3 → ARA014418, Both, C-peptide, GSK-3β, Naproxen, To
related to Pyrimidine derivatives · 4
GSK-3 → ATP-binding, GSK-3β, Pyrimidine, Some
related to Benefits of GSK-3β inhibitors · 3
GSK-3 → Alzheimer's, GSK-3β, In
related to Mechanism · 3
GSK-3 → ATP, C-terminal, The
is a · 2
GSK-3 → only type of glycogen synthase kinase named and recognized, serine/threonine protein kinase that phosphorylate either threonine or serine
AlphaFold · 1
GSK-3 → IPR039192

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Important terminology

glycogen also gsk-3β glucose phosphorylation synthase activity kinase inhibitors shown cancer effects serine gsk3 protein inhibition disease insulin apoptosis residues

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
GSK-3AlphaFoldIPR0391921.00infobox
GSK-3Available protein structures:IPR0391921.00infobox
GSK-3CDDcd141371.00infobox
GSK-3InterProIPR0391921.00infobox
GSK-3PDBIPR0391921.00infobox
GSK-3SymbolSTKc_GSK31.00infobox
GSK-3is aserine/threonine protein kinase that phosphorylate either threonine or serine0.90text
GSK-3is aonly type of glycogen synthase kinase named and recognized0.90text
insulininstance ofIt is active in resting cells and is inhibited by several hormones0.80text
endothelial growth factorinstance ofIt is active in resting cells and is inhibited by several hormones0.80text
and platelet-derived growth factorinstance ofIt is active in resting cells and is inhibited by several hormones0.80text
p53instance ofGSK-3 can promote apoptosis by both activating pro-apoptotic factors0.80text

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