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HDAC3

Histone deacetylase 3 is an enzyme encoded by the HDAC3 gene in both humans and mice.

Interactions, Function & Inhibitors

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3.5.1.98
Aliases
HDAC3, HD3, RPD3, RPD3-2, histone deacetylase 3
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4A69
Band
n/a · 18 19.81 cM|18 B3
Bgee
right hemisphere of cerebellum · right adrenal cortex · left adrenal gland · left adrenal cortex · skin of leg
BioGPS
More reference expression data

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Overview

Function

Role in intestinal homeostasis

Inhibitors

Interactions

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Map overview Semantic statistics

HDAC3

Nodes54
Edges53
Triples168
Avg. degree1.96
Density0.037037
Components1

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HDAC3

Top relations

Gene ontology · 49
HDAC3 → cellular response to fluid shear stress, chromatin binding, chromatin organization, circadian regulation of gene expression, circadian rhythm, cyclin binding, cytoplasm, cytosol, enzyme binding, Golgi apparatus, histone deacetylase activity, histone deacetylase binding, histone deacetylase complex, histone deacetylation, histone H3 deacetylation, histone H4 deacetylation, hydrolase activity, mitotic spindle, NAD-dependent histone deacetylase activity (H3-K14 specific), negative regulation of apoptotic process
related to Interactions · 26
HDAC3 → CBFA2T3, CCND1, GATA1, GATA2, GPS2, GTF2I, HDAC4, HDAC5, HDAC7A, HDAC9, MAP3K7IP2, MAPK11, NCOR1, NCOR2, PMLRBBP4, PPARD, PPARG, RELA, RP, RUNX2
Bgee · 20
HDAC3 → anterior pituitary, genital tubercle, granulocyte, left adrenal cortex, left adrenal gland, lip, muscle of thigh, neural tube, primary visual cortex, right adrenal cortex, right hemisphere of cerebellum, right lobe of thyroid gland, right ovary, skin of abdomen, skin of leg, spermatocyte, superior frontal gyrus, tail of embryo, ventricular zone, yolk sac
RNA expression pattern · 20
HDAC3 → anterior pituitary, genital tubercle, granulocyte, left adrenal cortex, left adrenal gland, lip, muscle of thigh, neural tube, primary visual cortex, right adrenal cortex, right hemisphere of cerebellum, right lobe of thyroid gland, right ovary, skin of abdomen, skin of leg, spermatocyte, superior frontal gyrus, tail of embryo, ventricular zone, yolk sac
related to Function · 10
HDAC3 → Class, DNA, HDACs, Histones, It, NCOR, NCOR2, Posttranslational, SMRT, Unlike
related to Role in intestinal homeostasis · 9
HDAC3 → Although, Histone, However, IEC, IECs, In, Paneth, Studies, These
related to External links · 6
HDAC3 → Medicine, Medicine Medical Subject Headings, MeSH, National Library, This, United States National Library
Band · 2
HDAC3 → 18 19.81 cM|18 B3, n/a
Chr. · 2
HDAC3 → Chromosome 18 (mouse), Chromosome 5 (human)
End · 2
HDAC3 → 141,636,870 bp, 38,088,069 bp

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Important terminology

histone bp gene human deacetylase chr band mice chromosome intestinal enzyme function location chromatin activity mouse expression protein external commensal

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
HDAC33.5.1.981.00infobox
HDAC3AliasesHDAC3, HD3, RPD3, RPD3-2, histone deacetylase 31.00infobox
HDAC3Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4A691.00infobox
HDAC3Bandn/a1.00infobox
HDAC3Band18 19.81 cM|18 B31.00infobox
HDAC3Bgeeright hemisphere of cerebellum1.00infobox
HDAC3Bgeeright adrenal cortex1.00infobox
HDAC3Bgeeleft adrenal gland1.00infobox
HDAC3Bgeeleft adrenal cortex1.00infobox
HDAC3Bgeeskin of leg1.00infobox
HDAC3Bgeegranulocyte1.00infobox
HDAC3Bgeeskin of abdomen1.00infobox
HDAC3Bgeeanterior pituitary1.00infobox
HDAC3Bgeeright ovary1.00infobox
HDAC3Bgeeright lobe of thyroid gland1.00infobox
HDAC3Bgeespermatocyte1.00infobox
HDAC3Bgeeventricular zone1.00infobox
HDAC3Bgeegenital tubercle1.00infobox
HDAC3Bgeetail of embryo1.00infobox
HDAC3Bgeesuperior frontal gyrus1.00infobox
HDAC3Bgeemuscle of thigh1.00infobox
HDAC3Bgeelip1.00infobox
HDAC3Bgeeyolk sac1.00infobox
HDAC3Bgeeprimary visual cortex1.00infobox
HDAC3Bgeeneural tube1.00infobox
HDAC3BioGPSMore reference expression data1.00infobox
HDAC3Chr.Chromosome 5 (human)1.00infobox
HDAC3Chr.Chromosome 18 (mouse)1.00infobox
HDAC3DatabasesNCBI: entry; OMA: entry1.00infobox
HDAC3End141,636,870 bp1.00infobox

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