Transcription factor II B

Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.

Map view:

Zoom: 100%

More settings

Connection length 100% Label size 100% Node size 100% Line width 100% Label width 100%

Export map as:

Transcription factor II B topic overview

The analysis highlights Structure, Phosphorylation and Clinical significance as prominent areas in the source structure around Transcription factor II B.

Related topics: 45
Source areas: 6
Connected nodes: 51
Extracted relationships: 105
Concept neighborhoods: 19
Bridge connections: 51

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Structure · 11 topics

Clinical significance · 8 topics

Overview · 8 topics

Phosphorylation · 8 topics

Mechanism of action · 7 topics

Similarities in other transcription complexes · 3 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

2.3.1.48: ↗
Aliases: GTF2B, TF2B, TFIIB, general transcription factor IIB
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1C9B, 1DL6, 1RLY, 1RO4, 1TFB, 1VOL, 2PHG, 5IY7, 5IYA, 5IY6, 5IY9, 5IYB, 5IYD, 5IY8, 5IYC
Band: 1p22.2 · 3|3 H1
Bgee: oocyte · secondary oocyte · Achilles tendon · gingival epithelium · epithelium of nasopharynx
BioGPS: More reference expression data

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

General transcription factor
RNA polymerase II
Preinitiation complex Transcription preinitiation complex
Transcription Transcription (genetics)
Nucleus Cell nucleus
TATA-binding protein
Archaeal transcription factor B
Sigma factors Sigma factor

Structure

Polypeptide Peptide
Amino acids
C-terminal C-terminus
Amino terminal N-terminus
Protein-protein interactions Protein-protein interaction
Transcription factor IID
RPB1 POLR2A
Protein-DNA interactions Protein-DNA interaction
B recognition element
Promoter element Response element
TATA element TATA box

Mechanism of action

Phosphodiester bond
Abortive transcripts Abortive initiation
Active site
Dissociation Dissociation (chemistry)
NTPs Nucleoside triphosphate
Magnesium ion Magnesium
Yeast

Phosphorylation

Phosphorylated Phosphorylation
Serine
TFIIH
Kinase
Mammalian Mammal
Cell cycle
Polyadenylation
CstF-64 Cleavage stimulation factor

Similarities in other transcription complexes

Clinical significance

In vitro
Herpes simplex virus
Cyclin A
Replication Viral replication
Cyclins Cyclin
Polyglutamine tract
Neurodegenerative diseases Neurodegeneration
Brain

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Transcription factor II B connects Entity context

The extracted context around Transcription factor II B shows recurring relationship patterns in the source. For example, Transcription factor II B → acetyltransferase activity, acyltransferase activity, chromosome, DNA binding, DNA-templated transcription, initiation, histone acetylation, histone acetyltransferase activity, metal ion binding, nuclear body, nucleoplasm, nucleus, positive regulation by host of viral transcription, positive regulation of core promoter binding, positive regulation of transcription initiation from RNA polymerase II promoter, positive regulation of viral transcription, promoter-specific chromatin binding, protein acetylation, protein binding, protein-DNA complex, regulation of transcription, DNA-templated Another extracted example is Transcription factor II B → Achilles tendon, bone marrow, epithelium of nasopharynx, facial motor nucleus, gingival epithelium, islet of Langerhans, jejunum, medial ganglionic eminence, mucosa of sigmoid colon, olfactory zone of nasal mucosa, oocyte, palpebral conjunctiva, Paneth cell, primary oocyte, primitive streak, secondary oocyte, spermatid, spermatocyte, zygote. Use these groups to spot repeated connection types before inspecting the individual relationships.

Top relations

Gene ontology · 41

Transcription factor II B → acetyltransferase activity, acyltransferase activity, chromosome, DNA binding, DNA-templated transcription, initiation, histone acetylation, histone acetyltransferase activity, metal ion binding, nuclear body, nucleoplasm, nucleus, positive regulation by host of viral transcription, positive regulation of core promoter binding, positive regulation of transcription initiation from RNA polymerase II promoter, positive regulation of viral transcription, promoter-specific chromatin binding, protein acetylation, protein binding, protein-DNA complex, regulation of transcription, DNA-templated

Bgee · 19

Transcription factor II B → Achilles tendon, bone marrow, epithelium of nasopharynx, facial motor nucleus, gingival epithelium, islet of Langerhans, jejunum, medial ganglionic eminence, mucosa of sigmoid colon, olfactory zone of nasal mucosa, oocyte, palpebral conjunctiva, Paneth cell, primary oocyte, primitive streak, secondary oocyte, spermatid, spermatocyte, zygote

RNA expression pattern · 19

Band · 2

Transcription factor II B → 1p22.2, 3|3 H1

Chr. · 2

Transcription factor II B → Chromosome 1 (human), Chromosome 3 (mouse)

End · 2

Transcription factor II B → 142,489,367 bp, 88,891,944 bp

2.3.1.48 · 1

Transcription factor II B → ↗

Aliases · 1

Transcription factor II B → GTF2B, TF2B, TFIIB, general transcription factor IIB

Available structures · 1

Transcription factor II B → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1C9B, 1DL6, 1RLY, 1RO4, 1TFB, 1VOL, 2PHG, 5IY7, 5IYA, 5IY6, 5IY9, 5IYB, 5IYD, 5IY8, 5IYC

BioGPS · 1

Transcription factor II B → More reference expression data

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

tfiib rna transcription polymerase ii dna reader factor linker site complex gene bp found formation initiation binding chr human chromosome

Transcription factor II B relationships Subject–Predicate–Object triples

TTTA extracted 105 structured relationships around Transcription factor II B. Examples in this analysis include Transcription factor II B → 2.3.1.48 → ↗ and Transcription factor II B → Aliases → GTF2B, TF2B, TFIIB, general transcription factor IIB. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
Transcription factor II B	2.3.1.48	↗	1.00	infobox
Transcription factor II B	Aliases	GTF2B, TF2B, TFIIB, general transcription factor IIB	1.00	infobox
Transcription factor II B	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1C9B, 1DL6, 1RLY, 1RO4, 1TFB, 1VOL, 2PHG, 5IY7, 5IYA, 5IY6, 5IY9, 5IYB, 5IYD, 5IY8, 5IYC	1.00	infobox
Transcription factor II B	Band	1p22.2	1.00	infobox
Transcription factor II B	Band	3\|3 H1	1.00	infobox
Transcription factor II B	Bgee	oocyte	1.00	infobox
Transcription factor II B	Bgee	secondary oocyte	1.00	infobox
Transcription factor II B	Bgee	Achilles tendon	1.00	infobox
Transcription factor II B	Bgee	gingival epithelium	1.00	infobox
Transcription factor II B	Bgee	epithelium of nasopharynx	1.00	infobox
Transcription factor II B	Bgee	bone marrow	1.00	infobox
Transcription factor II B	Bgee	islet of Langerhans	1.00	infobox
Transcription factor II B	Bgee	olfactory zone of nasal mucosa	1.00	infobox
Transcription factor II B	Bgee	mucosa of sigmoid colon	1.00	infobox
Transcription factor II B	Bgee	palpebral conjunctiva	1.00	infobox
Transcription factor II B	Bgee	primary oocyte	1.00	infobox
Transcription factor II B	Bgee	zygote	1.00	infobox
Transcription factor II B	Bgee	spermatocyte	1.00	infobox
Transcription factor II B	Bgee	spermatid	1.00	infobox
Transcription factor II B	Bgee	medial ganglionic eminence	1.00	infobox
Transcription factor II B	Bgee	primitive streak	1.00	infobox
Transcription factor II B	Bgee	Paneth cell	1.00	infobox
Transcription factor II B	Bgee	jejunum	1.00	infobox
Transcription factor II B	Bgee	facial motor nucleus	1.00	infobox
Transcription factor II B	BioGPS	More reference expression data	1.00	infobox
Transcription factor II B	Chr.	Chromosome 1 (human)	1.00	infobox
Transcription factor II B	Chr.	Chromosome 3 (mouse)	1.00	infobox
Transcription factor II B	Databases	NCBI: entry; OMA: entry	1.00	infobox
Transcription factor II B	End	88,891,944 bp	1.00	infobox
Transcription factor II B	End	142,489,367 bp	1.00	infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Transcription factor II B bring nearby vocabulary together. In this analysis, examples include Tfiib, Factor and Transcription. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

Transcription factor II B
- Tfiib
- Factor
- Transcription
- Rna
- Ii
- Polymerase
- Dna
- Initiation
- Formation
- Gene
- Binding
- General
transcription factor ii b
- Polymerase
- Rna
- Tfiib
- General
- Factor
- Transcription
- Ii
- Dna
- Initiation
- Complex
- Gene
- Formation
general transcription factor
- Tfiib
- General
- Chromosome
- Human
- Phosphorylation
- Factor
- Transcription
- Rna
- Bp
- Chr
- Ii
- Polymerase
rna polymerase ii
- Polymerase
- Rna
- Tfiib
- Transcription
- Dna
- Site
- Reader
- Complex
- Active
- Linker
- Binding
- Formation
preinitiation complex
- Open
- Formation
- General
- Protein
- Ii
- Dna
- Pic
- Rna
- Binding
- Initiation
- Polymerase
- Gene
transcription
- Tfiib
- Factor
- Rna
- Ii
- Polymerase
- Dna
- Initiation
- Formation
- Gene
- General
- Phosphorylation
- Pic
archaeal transcription factor b
- Tfiib
- General
- Factor
- Transcription
- Rna
- Ii
- Polymerase
- Dna
- Initiation
- Gene
- Formation
- Chromosome
transcription factor iid
- Tfiib
- General
- Factor
- Transcription
- Rna
- Ii
- Polymerase
- Dna
- Initiation
- Gene
- Formation
- Chromosome

Connections between topic areas Semantic bridges

For Transcription factor II B, one of the stronger structural bridges in this analysis connects Transcription factor II B with Structure. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

Transcription factor II B — Structure · splits 40 ⟂ 12

Transcription factor II B — Overview · splits 43 ⟂ 9

Transcription factor II B — Phosphorylation · splits 43 ⟂ 9

Transcription factor II B — Clinical significance · splits 43 ⟂ 9

Transcription factor II B — Mechanism of action · splits 44 ⟂ 8

Transcription factor II B — Similarities in other transcription complexes · splits 48 ⟂ 4

Map overview Semantic statistics

Transcription factor II B

Nodes52

Edges51

Triples105

Avg. degree1.96

Density0.038462

Components1

Source & methodology

TTTA analyzes the structure around Transcription factor II B to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Structure, Phosphorylation & Clinical significance, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Transcription factor II B · EN edition · Analysis: TopicsToTalkAbout