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ETHE1: Function, Clinical significance & Interactions

Protein ETHE1, mitochondrial, also known as "ethylmalonic encephalopathy 1 protein" and "persulfide dioxygenase", is a protein that in humans is encoded by the ETHE1 gene located on chromosome 19.

Language: English [EN]
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ETHE1 topic overview

The analysis highlights Function, Clinical significance and Interactions as prominent areas in the source structure around ETHE1.

Related topics
22
Source areas
4
Connected nodes
26
Extracted relationships
90
Concept neighborhoods
16
Bridge connections
26

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 12 topics
Clinical significance · 6 topics
Interactions · 2 topics
Overview · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

1.13.11.18
Aliases
ETHE1, HSCO, YF13H12, persulfide dioxygenase, ETHE1 persulfide dioxygenase
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4CHL
Band
19q13.31 · 7|7 A3
Bgee
mucosa of transverse colon · mucosa of ileum · rectum · mucosa of sigmoid colon · stromal cell of endometrium
BioGPS
More reference expression data

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Clinical significance

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How ETHE1 connects Entity context

The extracted context around ETHE1 shows recurring relationship patterns in the source. For example, ETHE1 → body of stomach, duodenum, epithelium of stomach, gastric mucosa, granulocyte, human kidney, left colon, left lobe of liver, minor salivary glands, mucosa of ileum, mucosa of pharynx, mucosa of sigmoid colon, mucosa of transverse colon, mucous cell of stomach, proximal tubule, pyloric antrum, rectum, right kidney, stromal cell of endometrium Another extracted example is ETHE1 → cytoplasm, dioxygenase activity, glutathione metabolic process, hydrogen sulfide metabolic process, hydrolase activity, acting on ester bonds, iron ion binding, metal ion binding, mitochondrial matrix, mitochondrion, nucleoplasm, nucleus, oxidoreductase activity, sulfide oxidation, using sulfide:quinone oxidoreductase, sulfur dioxygenase activity. Use these groups to spot repeated connection types before inspecting the individual relationships.

ETHE1

Top relations

Bgee · 19
ETHE1 → body of stomach, duodenum, epithelium of stomach, gastric mucosa, granulocyte, human kidney, left colon, left lobe of liver, minor salivary glands, mucosa of ileum, mucosa of pharynx, mucosa of sigmoid colon, mucosa of transverse colon, mucous cell of stomach, proximal tubule, pyloric antrum, rectum, right kidney, stromal cell of endometrium
RNA expression pattern · 19
ETHE1 → body of stomach, duodenum, epithelium of stomach, gastric mucosa, granulocyte, human kidney, left colon, left lobe of liver, minor salivary glands, mucosa of ileum, mucosa of pharynx, mucosa of sigmoid colon, mucosa of transverse colon, mucous cell of stomach, proximal tubule, pyloric antrum, rectum, right kidney, stromal cell of endometrium
Gene ontology · 14
ETHE1 → cytoplasm, dioxygenase activity, glutathione metabolic process, hydrogen sulfide metabolic process, hydrolase activity, acting on ester bonds, iron ion binding, metal ion binding, mitochondrial matrix, mitochondrion, nucleoplasm, nucleus, oxidoreductase activity, sulfide oxidation, using sulfide:quinone oxidoreductase, sulfur dioxygenase activity
related to Clinical significance · 5
ETHE1 → Decrease, However, Mouse, Mutations, Patients
related to Function · 3
ETHE1 → Sulfur, The ETHE1, This
Band · 2
ETHE1 → 19q13.31, 7|7 A3
Chr. · 2
ETHE1 → Chromosome 19 (human), Chromosome 7 (mouse)
End · 2
ETHE1 → 24,308,350 bp, 43,527,230 bp
1.13.11.18 · 1
ETHE1 → ↗
Aliases · 1
ETHE1 → ETHE1, HSCO, YF13H12, persulfide dioxygenase, ETHE1 persulfide dioxygenase

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gene bp human dioxygenase chromosome 19 protein chr band sulfide thought activity mouse hydrogen mitochondrial location function sulfur glutathione also

ETHE1 relationships Subject–Predicate–Object triples

TTTA extracted 90 structured relationships around ETHE1. Examples in this analysis include ETHE1 → 1.13.11.18 → ↗ and ETHE1 → Aliases → ETHE1, HSCO, YF13H12, persulfide dioxygenase, ETHE1 persulfide dioxygenase. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
ETHE11.13.11.181.00infobox
ETHE1AliasesETHE1, HSCO, YF13H12, persulfide dioxygenase, ETHE1 persulfide dioxygenase1.00infobox
ETHE1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4CHL1.00infobox
ETHE1Band19q13.311.00infobox
ETHE1Band7|7 A31.00infobox
ETHE1Bgeemucosa of transverse colon1.00infobox
ETHE1Bgeemucosa of ileum1.00infobox
ETHE1Bgeerectum1.00infobox
ETHE1Bgeemucosa of sigmoid colon1.00infobox
ETHE1Bgeestromal cell of endometrium1.00infobox
ETHE1Bgeegranulocyte1.00infobox
ETHE1Bgeemucosa of pharynx1.00infobox
ETHE1Bgeeduodenum1.00infobox
ETHE1Bgeeminor salivary glands1.00infobox
ETHE1Bgeebody of stomach1.00infobox
ETHE1Bgeeleft colon1.00infobox
ETHE1Bgeegastric mucosa1.00infobox
ETHE1Bgeepyloric antrum1.00infobox
ETHE1Bgeemucous cell of stomach1.00infobox
ETHE1Bgeeepithelium of stomach1.00infobox
ETHE1Bgeeright kidney1.00infobox
ETHE1Bgeeleft lobe of liver1.00infobox
ETHE1Bgeehuman kidney1.00infobox
ETHE1Bgeeproximal tubule1.00infobox
ETHE1BioGPSMore reference expression data1.00infobox
ETHE1Chr.Chromosome 19 (human)1.00infobox
ETHE1Chr.Chromosome 7 (mouse)1.00infobox
ETHE1DatabasesNCBI: entry; OMA: entry1.00infobox
ETHE1End43,527,230 bp1.00infobox
ETHE1End24,308,350 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around ETHE1 bring nearby vocabulary together. In this analysis, examples include Dioxygenase, Protein and Thought. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • ETHE1
    • Dioxygenase
    • Protein
    • Thought
    • Gene
    • Encephalopathy
    • Ethylmalonic
    • Glutathione
    • Mitochondrial
    • Activity
    • Chromosome
    • Sulfide
    • Iron
  • ethe1
    • Dioxygenase
    • Protein
    • Thought
    • Gene
    • Encephalopathy
    • Ethylmalonic
    • Glutathione
    • Mitochondrial
    • Activity
    • Chromosome
    • Sulfide
    • Iron
  • gene
    • Chromosome
    • Location
    • Human
    • Bp
    • Chr
    • Protein
    • End
    • Expressed
    • Liver
    • Persulfide
    • Search
    • Function
  • mitochondrial matrix
    • Matrix
    • Mitochondrial
    • Sulfur
    • Protein
    • Dioxygenase
    • Chromosome
    • Metabolic
    • Mitochondrion
    • Search
    • Gene
    • End
    • Expressed
  • sulfur dioxygenase
    • Mitochondrial
    • Ethe1
    • Activity
    • Chromosome
    • Protein
    • Sulfide
    • Catabolism
    • Gene
    • Matrix
    • Mitochondrion
    • Persulfide
    • Search
  • function
    • Search
    • Location
    • Sulfur
    • Activity
    • Human
    • Bp
    • Chr
    • Gene
    • End
    • Expressed
    • Iron
    • Liver
  • glutathione
    • Iron
    • Hydrogen
    • Protein
    • Sulfide
    • Thought
    • Liver
    • Matrix
    • Metabolic
    • Mitochondrion
    • Search
    • Substrate
    • Location
  • hydrogen sulfide
    • Sulfide
    • Metabolic
    • Mitochondrion
    • Catabolism
    • Glutathione
    • Thought
    • Iron
    • Liver
    • Matrix
    • Search
    • Substrate
    • Location

Connections between topic areas Semantic bridges

For ETHE1, one of the stronger structural bridges in this analysis connects ETHE1 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
ETHE1Function · splits 14 ⟂ 13
ETHE1Clinical significance · splits 20 ⟂ 7
ETHE1Overview · splits 24 ⟂ 3
ETHE1Interactions · splits 24 ⟂ 3

Map overview Semantic statistics

ETHE1

Nodes27
Edges26
Triples90
Avg. degree1.93
Density0.074074
Components1

Source & methodology

TTTA analyzes the structure around ETHE1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Clinical significance & Interactions, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — ETHE1 · EN edition · Analysis: TopicsToTalkAbout

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