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Nuclear receptor co-repressor 2: Regions, Interactions & Function

The nuclear receptor co-repressor 2 (NCOR2) is a transcriptional coregulatory protein that contains several nuclear receptor-interacting domains. In addition, NCOR2 appears to recruit histone deacetylases to DNA promoter regions. Hence NCOR2 assists nuclear receptors in the down regulation of target gene expression. NCOR2 is also referred to as a…

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Nuclear receptor co-repressor 2 topic overview

The analysis highlights Regions, Interactions and Function as prominent areas in the source structure around Nuclear receptor co-repressor 2.

Related topics
37
Source areas
5
Connected nodes
42
Extracted relationships
97
Concept neighborhoods
10
Bridge connections
42

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Interactions · 28 topics
Overview · 4 topics
Function · 3 topics
Discovery · 1 topics
Family · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
NCOR2, CTG26, N-CoR2, SMAP270, SMRT, SMRTE, SMRTE-tau, TNRC14, TRAC, TRAC-1, TRAC1, nuclear receptor corepressor 2
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2RT5, 4OAR, 2L5G, 2LTP, 1KKQ, 3R2A, 2ODD, 4A69, 3R29, 1XC5, 1R2B,%%s1KKQ, 1R2B, 1XC5, 2GPV, 2LTP, 3R29, 3R2…
Band
12q24.31 · 5|5 G1.1
Bgee
sural nerve · anterior pituitary · canal of the cervix · parotid gland · right ovary
BioGPS
More reference expression data
Chr.
Chromosome 12 (human) · Chromosome 5 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Family

Discovery

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Nuclear receptor co-repressor 2 connects Entity context

The extracted context around Nuclear receptor co-repressor 2 shows recurring relationship patterns in the source. For example, Nuclear receptor co-repressor 2 → chromatin, chromatin binding, DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, estrous cycle, glucocorticoid receptor binding, histone deacetylase binding, histone deacetylase complex, lactation, membrane, negative regulation of androgen receptor signaling pathway, negative regulation of production of miRNAs involved in gene silencing by miRNA, negative regulation of transcription by RNA polymerase II, negative regulation of transcription, DNA-templated, Notch binding, nuclear body, nuclear matrix, nuclear receptor binding, nucleoplasm, nucleus Another extracted example is Nuclear receptor co-repressor 2 → anterior pituitary, body of uterus, CA3 field, canal of the cervix, dentate gyrus of hippocampal formation granule cell, genital tubercle, left ovary, left uterine tube, lip, muscle of thigh, parotid gland, perirhinal cortex, primary visual cortex, right hemisphere of cerebellum, right ovary, Rostral migratory stream, superior frontal gyrus, sural nerve, ventricular zone. Use these groups to spot repeated connection types before inspecting the individual relationships.

Nuclear receptor co-repressor 2

Top relations

Gene ontology · 34
Nuclear receptor co-repressor 2 → chromatin, chromatin binding, DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, estrous cycle, glucocorticoid receptor binding, histone deacetylase binding, histone deacetylase complex, lactation, membrane, negative regulation of androgen receptor signaling pathway, negative regulation of production of miRNAs involved in gene silencing by miRNA, negative regulation of transcription by RNA polymerase II, negative regulation of transcription, DNA-templated, Notch binding, nuclear body, nuclear matrix, nuclear receptor binding, nucleoplasm, nucleus
Bgee · 19
Nuclear receptor co-repressor 2 → anterior pituitary, body of uterus, CA3 field, canal of the cervix, dentate gyrus of hippocampal formation granule cell, genital tubercle, left ovary, left uterine tube, lip, muscle of thigh, parotid gland, perirhinal cortex, primary visual cortex, right hemisphere of cerebellum, right ovary, Rostral migratory stream, superior frontal gyrus, sural nerve, ventricular zone
RNA expression pattern · 19
Nuclear receptor co-repressor 2 → anterior pituitary, body of uterus, CA3 field, canal of the cervix, dentate gyrus of hippocampal formation granule cell, genital tubercle, left ovary, left uterine tube, lip, muscle of thigh, parotid gland, perirhinal cortex, primary visual cortex, right hemisphere of cerebellum, right ovary, Rostral migratory stream, superior frontal gyrus, sural nerve, ventricular zone
Band · 2
Nuclear receptor co-repressor 2 → 12q24.31, 5|5 G1.1
Chr. · 2
Nuclear receptor co-repressor 2 → Chromosome 12 (human), Chromosome 5 (mouse)
End · 2
Nuclear receptor co-repressor 2 → 124,567,589 bp, 125,179,219 bp
related to Interactions · 2
Nuclear receptor co-repressor 2 → ARBCL6C-FosC-junHDAC1HDAC3HDAC4HDAC5HDAC10MeCP2NR4A1POU2F1PPARDPGRPMLRBPJRELARUNX1T1RARASIN3ASNW1SPENSRFTBL1XTHRBVDRZBTB16, Nuclear
Aliases · 1
Nuclear receptor co-repressor 2 → NCOR2, CTG26, N-CoR2, SMAP270, SMRT, SMRTE, SMRTE-tau, TNRC14, TRAC, TRAC-1, TRAC1, nuclear receptor corepressor 2
Available structures · 1
Nuclear receptor co-repressor 2 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2RT5, 4OAR, 2L5G, 2LTP, 1KKQ, 3R2A, 2ODD, 4A69, 3R29, 1XC5, 1R2B,%%s1KKQ, 1R2B, 1XC5, 2GPV, 2LTP, 3R29, 3R2…
BioGPS · 1
Nuclear receptor co-repressor 2 → More reference expression data

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

ncor2 nuclear bp human smrt chr band receptor protein gene chromosome 12 corepressor histone dna trac-1 location co-repressor coregulatory receptors

Nuclear receptor co-repressor 2 relationships Subject–Predicate–Object triples

TTTA extracted 97 structured relationships around Nuclear receptor co-repressor 2. Examples in this analysis include Nuclear receptor co-repressor 2 → Aliases → NCOR2, CTG26, N-CoR2, SMAP270, SMRT, SMRTE, SMRTE-tau, TNRC14, TRAC, TRAC-1, TRAC1, nuclear receptor corepressor 2 and Nuclear receptor co-repressor 2 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2RT5, 4OAR, 2L5G, 2LTP, 1KKQ, 3R2A, 2ODD, 4A69, 3R29, 1XC5, 1R2B,%%s1KKQ, 1R2B, 1XC5, 2GPV, 2LTP, 3R29, 3R2…. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Nuclear receptor co-repressor 2AliasesNCOR2, CTG26, N-CoR2, SMAP270, SMRT, SMRTE, SMRTE-tau, TNRC14, TRAC, TRAC-1, TRAC1, nuclear receptor corepressor 21.00infobox
Nuclear receptor co-repressor 2Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2RT5, 4OAR, 2L5G, 2LTP, 1KKQ, 3R2A, 2ODD, 4A69, 3R29, 1XC5, 1R2B,%%s1KKQ, 1R2B, 1XC5, 2GPV, 2LTP, 3R29, 3R2…1.00infobox
Nuclear receptor co-repressor 2Band12q24.311.00infobox
Nuclear receptor co-repressor 2Band5|5 G1.11.00infobox
Nuclear receptor co-repressor 2Bgeesural nerve1.00infobox
Nuclear receptor co-repressor 2Bgeeanterior pituitary1.00infobox
Nuclear receptor co-repressor 2Bgeecanal of the cervix1.00infobox
Nuclear receptor co-repressor 2Bgeeparotid gland1.00infobox
Nuclear receptor co-repressor 2Bgeeright ovary1.00infobox
Nuclear receptor co-repressor 2Bgeeleft ovary1.00infobox
Nuclear receptor co-repressor 2Bgeeleft uterine tube1.00infobox
Nuclear receptor co-repressor 2Bgeebody of uterus1.00infobox
Nuclear receptor co-repressor 2Bgeemuscle of thigh1.00infobox
Nuclear receptor co-repressor 2Bgeeright hemisphere of cerebellum1.00infobox
Nuclear receptor co-repressor 2Bgeesuperior frontal gyrus1.00infobox
Nuclear receptor co-repressor 2Bgeeprimary visual cortex1.00infobox
Nuclear receptor co-repressor 2Bgeelip1.00infobox
Nuclear receptor co-repressor 2BgeeRostral migratory stream1.00infobox
Nuclear receptor co-repressor 2BgeeCA3 field1.00infobox
Nuclear receptor co-repressor 2Bgeeventricular zone1.00infobox
Nuclear receptor co-repressor 2Bgeegenital tubercle1.00infobox
Nuclear receptor co-repressor 2Bgeedentate gyrus of hippocampal formation granule cell1.00infobox
Nuclear receptor co-repressor 2Bgeeperirhinal cortex1.00infobox
Nuclear receptor co-repressor 2BioGPSMore reference expression data1.00infobox
Nuclear receptor co-repressor 2Chr.Chromosome 12 (human)1.00infobox
Nuclear receptor co-repressor 2Chr.Chromosome 5 (mouse)1.00infobox
Nuclear receptor co-repressor 2DatabasesNCBI: entry; OMA: entry1.00infobox
Nuclear receptor co-repressor 2End124,567,589 bp1.00infobox
Nuclear receptor co-repressor 2End125,179,219 bp1.00infobox
Nuclear receptor co-repressor 2EnsemblENSG000001964981.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Nuclear receptor co-repressor 2 bring nearby vocabulary together. In this analysis, examples include Receptor, Co-repressor and Nuclear. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Nuclear receptor co-repressor 2
    • Receptor
    • Co-repressor
    • Nuclear
    • Corepressor
    • Gene
    • Protein
    • Ncor2
    • Human
    • Contains
    • Domains
    • Expression
    • Function
  • nuclear receptor co-repressor 2
    • Receptor
    • Co-repressor
    • Corepressor
    • Nuclear
    • Protein
    • Gene
    • Human
    • Function
    • Ncor2
    • Receptor-interacting
    • Search
    • Several
  • transcriptional coregulatory
    • Contains
    • Domains
    • Receptor-interacting
    • Several
    • Coregulatory
    • Transcriptional
    • Protein
    • Transcription
    • Corepressor
    • Receptor
    • Ncor2
    • End
  • nuclear receptor
    • Receptor
    • Co-repressor
    • Corepressor
    • Protein
    • Gene
    • Human
    • Function
    • Ncor2
    • Receptor-interacting
    • Search
    • Several
    • Transcriptional
  • histone deacetylases
    • Dna
    • Deacetylases
    • Histone
    • Transcription
    • Protein
    • Ncor2
    • Smrt
    • End
    • Expression
    • Function
    • Mouse
    • Receptor-interacting
  • corepressor
    • Function
    • Receptor
    • Search
    • Nuclear
    • Smrt
    • Location
    • Transcription
    • Chromosome
    • Gene
    • Ncor2
    • Bp
    • Chr
  • nuclear receptor co-repressor 1
    • Receptor
    • Co-repressor
    • Corepressor
    • Nuclear
    • Protein
    • Gene
    • Human
    • Function
    • Ncor2
    • Receptor-interacting
    • Search
    • Several
  • function
    • Search
    • Location
    • Chromosome
    • Corepressor
    • Gene
    • Bp
    • Chr
    • Human
    • Receptor
    • End
    • Mouse
    • Nuclear

Connections between topic areas Semantic bridges

For Nuclear receptor co-repressor 2, one of the stronger structural bridges in this analysis connects Nuclear receptor co-repressor 2 with Interactions. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Nuclear receptor co-repressor 2Interactions · splits 14 ⟂ 29
Nuclear receptor co-repressor 2Overview · splits 38 ⟂ 5
Nuclear receptor co-repressor 2Function · splits 39 ⟂ 4

Map overview Semantic statistics

Nuclear receptor co-repressor 2

Nodes43
Edges42
Triples97
Avg. degree1.95
Density0.046512
Components1

Source & methodology

TTTA analyzes the structure around Nuclear receptor co-repressor 2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Regions, Interactions & Function, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Nuclear receptor co-repressor 2 · EN edition · Analysis: TopicsToTalkAbout

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