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CD31: Role of CD31 in diseases, Function & Tissue distribution

Platelet endothelial cell adhesion molecule (PECAM-1) also known as cluster of differentiation 31 (CD31) is a protein that in humans is encoded by the PECAM1 gene found on chromosome17q23.3. PECAM-1 plays a key role in removing aged neutrophils from the body.

Language: English [EN]
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CD31 topic overview

The analysis highlights Role of CD31 in diseases, Function and Tissue distribution as prominent areas in the source structure around CD31.

Related topics
48
Source areas
5
Connected nodes
53
Extracted relationships
130
Concept neighborhoods
15
Bridge connections
53

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Role of CD31 in diseases · 19 topics
Function · 15 topics
Tissue distribution · 7 topics
Overview · 5 topics
Structure · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
PECAM1, CD31, CD31/EndoCAM, GPIIA', PECA1, PECAM-1, endoCAM, platelet and endothelial cell adhesion molecule 1, PCAM-1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2KY5, 5C14
Band
17q23.3 · 11|11 E1
Bgee
tendon of biceps brachii · visceral pleura · lower lobe of lung · pericardium · right lung
BioGPS
More reference expression data
Chr.
Chromosome 17 (human) · Chromosome 11 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Tissue distribution

Function

Role of CD31 in diseases

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How CD31 connects Entity context

The extracted context around CD31 shows recurring relationship patterns in the source. For example, CD31 → angiogenesis, cell adhesion, cell junction, cell periphery, cell recognition, cell-cell adhesion via plasma-membrane adhesion molecules, cell-cell contact zone, cytoplasm, diapedesis, endothelial cell migration, endothelial cell morphogenesis, endothelial cell-matrix adhesion, external side of plasma membrane, extracellular exosome, extracellular matrix organization, extracellular space, glomerular endothelium development, homophilic cell adhesion via plasma membrane adhesion molecules, integral component of membrane, leukocyte cell-cell adhesion Another extracted example is CD31 → aortic valve, ascending aorta, digastric muscle, epithelium of colon, glomerular capillary, left lung, left lung lobe, lower lobe of lung, mesenteric lymph nodes, monocyte, muscle of thigh, parietal pleura, pericardium, right lung, right lung lobe, tendon of biceps brachii, upper lobe of left lung, upper lobe of lung, vasculature of trunk, visceral pleura. Use these groups to spot repeated connection types before inspecting the individual relationships.

CD31

Top relations

Gene ontology · 39
CD31 → angiogenesis, cell adhesion, cell junction, cell periphery, cell recognition, cell-cell adhesion via plasma-membrane adhesion molecules, cell-cell contact zone, cytoplasm, diapedesis, endothelial cell migration, endothelial cell morphogenesis, endothelial cell-matrix adhesion, external side of plasma membrane, extracellular exosome, extracellular matrix organization, extracellular space, glomerular endothelium development, homophilic cell adhesion via plasma membrane adhesion molecules, integral component of membrane, leukocyte cell-cell adhesion
Bgee · 20
CD31 → aortic valve, ascending aorta, digastric muscle, epithelium of colon, glomerular capillary, left lung, left lung lobe, lower lobe of lung, mesenteric lymph nodes, monocyte, muscle of thigh, parietal pleura, pericardium, right lung, right lung lobe, tendon of biceps brachii, upper lobe of left lung, upper lobe of lung, vasculature of trunk, visceral pleura
RNA expression pattern · 20
CD31 → aortic valve, ascending aorta, digastric muscle, epithelium of colon, glomerular capillary, left lung, left lung lobe, lower lobe of lung, mesenteric lymph nodes, monocyte, muscle of thigh, parietal pleura, pericardium, right lung, right lung lobe, tendon of biceps brachii, upper lobe of left lung, upper lobe of lung, vasculature of trunk, visceral pleura
related to Function · 4
CD31 → CD38, PECAM-1, T-cells, The
related to Immunohistochemistry · 4
CD31 → In, It, Malignant, This
Band · 2
CD31 → 11|11 E1, 17q23.3
Chr. · 2
CD31 → Chromosome 11 (mouse), Chromosome 17 (human)
End · 2
CD31 → 106,641,454 bp, 64,413,776 bp
related to Tissue distribution · 2
CD31 → Kupffer, NK
Aliases · 1
CD31 → PECAM1, CD31, CD31/EndoCAM, GPIIA', PECA1, PECAM-1, endoCAM, platelet and endothelial cell adhesion molecule 1, PCAM-1

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

pecam-1 endothelial cell protein adhesion bp gene leukocyte human interactions chr angiogenesis band pecam1 neutrophils domain high cells found platelet

CD31 relationships Subject–Predicate–Object triples

TTTA extracted 130 structured relationships around CD31. Examples in this analysis include CD31 → Aliases → PECAM1, CD31, CD31/EndoCAM, GPIIA', PECA1, PECAM-1, endoCAM, platelet and endothelial cell adhesion molecule 1, PCAM-1 and CD31 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2KY5, 5C14. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
CD31AliasesPECAM1, CD31, CD31/EndoCAM, GPIIA', PECA1, PECAM-1, endoCAM, platelet and endothelial cell adhesion molecule 1, PCAM-11.00infobox
CD31Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2KY5, 5C141.00infobox
CD31Band17q23.31.00infobox
CD31Band11|11 E11.00infobox
CD31Bgeetendon of biceps brachii1.00infobox
CD31Bgeevisceral pleura1.00infobox
CD31Bgeelower lobe of lung1.00infobox
CD31Bgeepericardium1.00infobox
CD31Bgeeright lung1.00infobox
CD31Bgeeparietal pleura1.00infobox
CD31Bgeemonocyte1.00infobox
CD31Bgeeupper lobe of lung1.00infobox
CD31Bgeeepithelium of colon1.00infobox
CD31Bgeeupper lobe of left lung1.00infobox
CD31Bgeeright lung lobe1.00infobox
CD31Bgeeleft lung1.00infobox
CD31Bgeeleft lung lobe1.00infobox
CD31Bgeevasculature of trunk1.00infobox
CD31Bgeemesenteric lymph nodes1.00infobox
CD31Bgeemuscle of thigh1.00infobox
CD31Bgeeascending aorta1.00infobox
CD31Bgeeaortic valve1.00infobox
CD31Bgeeglomerular capillary1.00infobox
CD31Bgeedigastric muscle1.00infobox
CD31BioGPSMore reference expression data1.00infobox
CD31Chr.Chromosome 17 (human)1.00infobox
CD31Chr.Chromosome 11 (mouse)1.00infobox
CD31DatabasesNCBI: entry; OMA: entry1.00infobox
CD31End64,413,776 bp1.00infobox
CD31End106,641,454 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around CD31 bring nearby vocabulary together. In this analysis, examples include Cells, Immunohistochemistry and Endothelial. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • CD31
    • Cells
    • Immunohistochemistry
    • Endothelial
    • Molecule
    • Pecam1
    • Platelet
    • Found
    • Gene
    • Cell
    • External
    • Endothelium
    • Role
  • cd31
    • Cells
    • Immunohistochemistry
    • Endothelial
    • Molecule
    • Pecam1
    • Platelet
    • Found
    • Gene
    • Cell
    • External
    • Endothelium
    • Role
  • protein
    • Adhesion
    • Molecules
    • Pecam1
    • Platelet
    • Angiogenesis
    • Found
    • Homophilic
    • Domain
    • Gene
    • Leukocyte
    • Cell
    • External
  • gene
    • Location
    • Pecam1
    • Human
    • Mouse
    • Chromosome
    • Platelet
    • Bp
    • Chr
    • External
    • Atherosclerosis
    • Band
    • Molecule
  • endothelial cells
    • Cell
    • Cd31
    • Cells
    • Endothelial
    • Adhesion
    • Platelet
    • Immunohistochemistry
    • Molecule
    • Pecam1
    • Found
    • Gene
    • Pecam-1
  • angiogenesis
    • External
    • Leukocyte
    • Chromosome
    • Location
    • Pecam1
    • Platelet
    • Bp
    • Chr
    • Human
    • Gene
    • Protein
    • Cell
  • cell signaling
    • Endothelial
    • Platelet
    • Role
    • Adhesion
    • Molecule
    • Pecam1
    • Gene
    • External
    • Pecam-1
    • Chromosome
    • Location
    • Angiogenesis
  • role of cd31 in diseases
    • Cells
    • Immunohistochemistry
    • Endothelial
    • Signaling
    • Molecule
    • Pecam1
    • Platelet
    • Found
    • Gene
    • Location
    • Cell
    • External

Connections between topic areas Semantic bridges

For CD31, one of the stronger structural bridges in this analysis connects CD31 with Role of CD31 in diseases. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
CD31Role of CD31 in diseases · splits 34 ⟂ 20
CD31Function · splits 38 ⟂ 16
CD31Tissue distribution · splits 46 ⟂ 8
CD31Overview · splits 48 ⟂ 6
CD31Structure · splits 51 ⟂ 3

Map overview Semantic statistics

CD31

Nodes54
Edges53
Triples130
Avg. degree1.96
Density0.037037
Components1

Source & methodology

TTTA analyzes the structure around CD31 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Role of CD31 in diseases, Function & Tissue distribution, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — CD31 · EN edition · Analysis: TopicsToTalkAbout

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