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SOCS3

Suppressor of cytokine signaling 3 (SOCS3 or SOCS-3) is a protein that in humans is encoded by the SOCS3 gene. This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling.

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Aliases
SOCS3, ATOD4, CIS3, Cish3, SOCS-3, SSI-3, SSI3, suppressor of cytokine signaling 3
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2BBU, 2HMH, 2JZ3, 4GL9
Band
17q25.3 · 11|11 E2
Bgee
gastric mucosa · left uterine tube · vena cava · gallbladder · saphenous vein
BioGPS
More reference expression data
Chr.
Chromosome 17 (human) · Chromosome 11 (mouse)

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Function

Interactions

Regulation

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Map overview Semantic statistics

SOCS3

Nodes29
Edges28
Triples113
Avg. degree1.93
Density0.068966
Components1

How this topic connects Entity context

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SOCS3

Top relations

Gene ontology · 34
SOCS3 → 1-phosphatidylinositol-3-kinase regulator activity, branching involved in labyrinthine layer morphogenesis, cellular response to leukemia inhibitory factor, cytokine-mediated signaling pathway, cytoplasm, cytosol, interleukin-6-mediated signaling pathway, intracellular anatomical structure, intracellular signal transduction, negative regulation of apoptotic process, negative regulation of inflammatory response, negative regulation of insulin receptor signaling pathway, negative regulation of protein kinase activity, negative regulation of receptor signaling pathway via JAK-STAT, negative regulation of signal transduction, negative regulation of tyrosine phosphorylation of STAT protein, phosphatidylinositol 3-kinase complex, phosphatidylinositol phosphate biosynthetic process, phosphotyrosine residue binding, placenta blood vessel development
Bgee · 20
SOCS3 → ciliary body, decidua, external carotid artery, gallbladder, gastric mucosa, gastrula, granulocyte, internal carotid artery, islet of Langerhans, lactiferous duct, left uterine tube, lower lobe of lung, lumbar spinal ganglion, mesenteric lymph nodes, pericardium, saphenous vein, seminal vesicula, stroma of bone marrow, upper lobe of left lung, vena cava
RNA expression pattern · 20
SOCS3 → ciliary body, decidua, external carotid artery, gallbladder, gastric mucosa, gastrula, granulocyte, internal carotid artery, islet of Langerhans, lactiferous duct, left uterine tube, lower lobe of lung, lumbar spinal ganglion, mesenteric lymph nodes, pericardium, saphenous vein, seminal vesicula, stroma of bone marrow, upper lobe of left lung, vena cava
related to Function · 9
SOCS3 → Epo, For, GCSF, IFN, IL-6, IL10, IL6, Leptin, The
related to Interactions · 5
SOCS3 → Erythropoietin, Glycoprotein, Insulin-like, Janus, PTPN11
Band · 2
SOCS3 → 11|11 E2, 17q25.3
Chr. · 2
SOCS3 → Chromosome 11 (mouse), Chromosome 17 (human)
End · 2
SOCS3 → 117,860,873 bp, 78,360,077 bp
Aliases · 1
SOCS3 → SOCS3, ATOD4, CIS3, Cish3, SOCS-3, SSI-3, SSI3, suppressor of cytokine signaling 3
Available structures · 1
SOCS3 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2BBU, 2HMH, 2JZ3, 4GL9

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Important terminology

gene signaling bp cytokine chr human band insulin chromosome 17 protein suppressor socs mouse negative location function regulation ssi family

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
SOCS3AliasesSOCS3, ATOD4, CIS3, Cish3, SOCS-3, SSI-3, SSI3, suppressor of cytokine signaling 31.00infobox
SOCS3Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2BBU, 2HMH, 2JZ3, 4GL91.00infobox
SOCS3Band17q25.31.00infobox
SOCS3Band11|11 E21.00infobox
SOCS3Bgeegastric mucosa1.00infobox
SOCS3Bgeeleft uterine tube1.00infobox
SOCS3Bgeevena cava1.00infobox
SOCS3Bgeegallbladder1.00infobox
SOCS3Bgeesaphenous vein1.00infobox
SOCS3Bgeepericardium1.00infobox
SOCS3Bgeeseminal vesicula1.00infobox
SOCS3Bgeeupper lobe of left lung1.00infobox
SOCS3Bgeelower lobe of lung1.00infobox
SOCS3Bgeelactiferous duct1.00infobox
SOCS3Bgeestroma of bone marrow1.00infobox
SOCS3Bgeelumbar spinal ganglion1.00infobox
SOCS3Bgeegranulocyte1.00infobox
SOCS3Bgeedecidua1.00infobox
SOCS3Bgeeinternal carotid artery1.00infobox
SOCS3Bgeemesenteric lymph nodes1.00infobox
SOCS3Bgeegastrula1.00infobox
SOCS3Bgeeislet of Langerhans1.00infobox
SOCS3Bgeeexternal carotid artery1.00infobox
SOCS3Bgeeciliary body1.00infobox
SOCS3BioGPSMore reference expression data1.00infobox
SOCS3Chr.Chromosome 17 (human)1.00infobox
SOCS3Chr.Chromosome 11 (mouse)1.00infobox
SOCS3DatabasesNCBI: entry; OMA: entry1.00infobox
SOCS3End78,360,077 bp1.00infobox
SOCS3End117,860,873 bp1.00infobox

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