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JAK-STAT signaling pathway

The JAK-STAT signaling pathway is a chain of interactions between proteins in a cell, and is involved in processes such as immunity, cell division, cell death, and tumor formation. The pathway communicates information from chemical signals outside of a cell to the cell nucleus, resulting in the activation of genes through the process of transcription.…

Measurement, Structure of JAKs and STATs & Mechanism

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Overview

Structure of JAKs and STATs

Mechanism

Role in cytokine receptor signalling

Role in development

Regulation

Clinical significance

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JAK-STAT signaling pathway

Nodes163
Edges162
Triples12
Avg. degree1.99
Density0.01227
Components1

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JAK-STAT signaling pathway

Top relations

is a · 1
JAK-STAT signaling pathway → chain of interactions between proteins in a cell

Important terminology Word statistics

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Important terminology

signalling stats jak-stat jaks also pathway proteins transcription stat stat3 shp-1 genes cell tyrosine protein stat5 shp-2 sh2 called receptors

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
JAK-STAT signaling pathwayis achain of interactions between proteins in a cell0.90text
immunityinstance ofand is involved in processes0.80text
cell divisioninstance ofand is involved in processes0.80text
cell deathinstance ofand is involved in processes0.80text
and tumor formationinstance ofand is involved in processes0.80text
CBPinstance ofSTATs are capable of recruiting co-activators0.80text
p300instance ofSTATs are capable of recruiting co-activators0.80text
and these co-activators increase the rate of transcription of target genesinstance ofSTATs are capable of recruiting co-activators0.80text
BCL2instance ofas it can allow the transcription of genes0.80text
c-Mycinstance ofas it can allow the transcription of genes0.80text
which are involved in cell division.Mutations in JAK2 can lead to leukaemiainstance ofas it can allow the transcription of genes0.80text
lymphomainstance ofas it can allow the transcription of genes0.80text

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