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Interleukin 4

The interleukin 4 (IL4, IL-4) is a cytokine that induces differentiation of naive helper T cells (Th0 cells) to Th2 cells. Upon activation by IL-4, Th2 cells subsequently produce additional IL-4 in a positive feedback loop. IL-4 is produced primarily by mast cells, Th2 cells, eosinophils and basophils. It is closely related and has functions similar to…

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Aliases
IL4, Interleukin 4, IGG1 induction factor, B-cell IgG differentiation factor, B-cell stimulatory factor 1, B-cell growth factor 1, Il4, lymphocyte stimulatory factor 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1BBN, 1BCN, 1CYL, 1HIJ, 1HIK, 1HZI, 1IAR, 1ITI, 1ITL, 1ITM, 1RCB, 2B8U, 2B8X, 2B8Y, 2B8Z, 2B90, 2B91, 2CYK,…
Band
5q31.1 · 11 B1.3|11 31.97 cM
Bgee
oocyte · secondary oocyte · testicle · gonad · right uterine tube
BioGPS
n/a
Chr.
Chromosome 5 (human) · Chromosome 11 (mouse)

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Interleukin 4

Nodes62
Edges61
Triples140
Avg. degree1.97
Density0.032258
Components1

How this topic connects Entity context

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Interleukin 4

Top relations

Gene ontology · 47
Interleukin 4 → activation of Janus kinase activity, B cell activation, B cell differentiation, cholesterol metabolic process, cytokine activity, cytokine receptor binding, cytokine-mediated signaling pathway, dendritic cell differentiation, extracellular region, extracellular space, growth factor activity, immune response, interleukin-4 receptor binding, myeloid dendritic cell differentiation, negative regulation of apoptotic process, negative regulation of complement-dependent cytotoxicity, negative regulation of endothelial cell apoptotic process, negative regulation of epithelial cell migration, negative regulation of neuroinflammatory response, negative regulation of osteoclast differentiation
Bgee · 19
Interleukin 4 → anterior pituitary, bone marrow cell, dentate gyrus of hippocampal formation granule cell, embryo, gonad, lens, monocyte, morula, neural layer of retina, olfactory zone of nasal mucosa, oocyte, primary visual cortex, right coronary artery, right uterine tube, secondary oocyte, spermatocyte, superior frontal gyrus, testicle, ventricular zone
RNA expression pattern · 19
Interleukin 4 → anterior pituitary, bone marrow cell, dentate gyrus of hippocampal formation granule cell, embryo, gonad, lens, monocyte, morula, neural layer of retina, olfactory zone of nasal mucosa, oocyte, primary visual cortex, right coronary artery, right uterine tube, secondary oocyte, spermatocyte, superior frontal gyrus, testicle, ventricular zone
related to Function · 10
Interleukin 4 → IFNγ, IgE, II, IL-12, IL-4, Interleukin, It, MHC, Overproduction, Th1
related to Allergic diseases · 8
Interleukin 4 → Allergic, Asthma, IgE, IL-4, Interleukin, Th2, These, VCAM-1
Band · 2
Interleukin 4 → 11 B1.3|11 31.97 cM, 5q31.1
Chr. · 2
Interleukin 4 → Chromosome 11 (mouse), Chromosome 5 (human)
End · 2
Interleukin 4 → 132,018,370 bp, 53,509,496 bp
Aliases · 1
Interleukin 4 → IL4, Interleukin 4, IGG1 induction factor, B-cell IgG differentiation factor, B-cell stimulatory factor 1, B-cell growth factor 1, Il4, lymphocyte stimulatory factor 1
Available structures · 1
Interleukin 4 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1BBN, 1BCN, 1CYL, 1HIJ, 1HIK, 1HZI, 1IAR, 1ITI, 1ITL, 1ITM, 1RCB, 2B8U, 2B8X, 2B8Y, 2B8Z, 2B90, 2B91, 2CYK,…

Important terminology Word statistics

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Important terminology

il-4 cells human th2 bp cell type chr band interleukin il-13 receptor receptors differentiation chromosome cytokine production inflammation gene interleukin-4

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Interleukin 4AliasesIL4, Interleukin 4, IGG1 induction factor, B-cell IgG differentiation factor, B-cell stimulatory factor 1, B-cell growth factor 1, Il4, lymphocyte stimulatory factor 11.00infobox
Interleukin 4Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1BBN, 1BCN, 1CYL, 1HIJ, 1HIK, 1HZI, 1IAR, 1ITI, 1ITL, 1ITM, 1RCB, 2B8U, 2B8X, 2B8Y, 2B8Z, 2B90, 2B91, 2CYK,…1.00infobox
Interleukin 4Band5q31.11.00infobox
Interleukin 4Band11 B1.3|11 31.97 cM1.00infobox
Interleukin 4Bgeeoocyte1.00infobox
Interleukin 4Bgeesecondary oocyte1.00infobox
Interleukin 4Bgeetesticle1.00infobox
Interleukin 4Bgeegonad1.00infobox
Interleukin 4Bgeeright uterine tube1.00infobox
Interleukin 4Bgeemonocyte1.00infobox
Interleukin 4Bgeeanterior pituitary1.00infobox
Interleukin 4Bgeeright coronary artery1.00infobox
Interleukin 4Bgeeolfactory zone of nasal mucosa1.00infobox
Interleukin 4Bgeebone marrow cell1.00infobox
Interleukin 4Bgeeneural layer of retina1.00infobox
Interleukin 4Bgeesuperior frontal gyrus1.00infobox
Interleukin 4Bgeespermatocyte1.00infobox
Interleukin 4Bgeeprimary visual cortex1.00infobox
Interleukin 4Bgeelens1.00infobox
Interleukin 4Bgeeembryo1.00infobox
Interleukin 4Bgeedentate gyrus of hippocampal formation granule cell1.00infobox
Interleukin 4Bgeeventricular zone1.00infobox
Interleukin 4Bgeemorula1.00infobox
Interleukin 4BioGPSn/a1.00infobox
Interleukin 4Chr.Chromosome 5 (human)1.00infobox
Interleukin 4Chr.Chromosome 11 (mouse)1.00infobox
Interleukin 4DatabasesNCBI: entry; OMA: entry1.00infobox
Interleukin 4End132,018,370 bp1.00infobox
Interleukin 4End53,509,496 bp1.00infobox
Interleukin 4EnsemblENSG000001135201.00infobox

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