Research any topic before you write.
Find related topics. | Discover entities. | See connections. | Build a topical map.
The interleukin 4 (IL4, IL-4) is a cytokine that induces differentiation of naive helper T cells (Th0 cells) to Th2 cells. Upon activation by IL-4, Th2 cells subsequently produce additional IL-4 in a positive feedback loop. IL-4 is produced primarily by mast cells, Th2 cells, eosinophils and basophils. It is closely related and has functions similar to…
The analysis highlights Research, Function and Clinical significance as prominent areas in the source structure around Interleukin 4.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around Interleukin 4 shows recurring relationship patterns in the source. For example, Interleukin 4 → activation of Janus kinase activity, B cell activation, B cell differentiation, cholesterol metabolic process, cytokine activity, cytokine receptor binding, cytokine-mediated signaling pathway, dendritic cell differentiation, extracellular region, extracellular space, growth factor activity, immune response, interleukin-4 receptor binding, myeloid dendritic cell differentiation, negative regulation of apoptotic process, negative regulation of complement-dependent cytotoxicity, negative regulation of endothelial cell apoptotic process, negative regulation of epithelial cell migration, negative regulation of neuroinflammatory response, negative regulation of osteoclast differentiation Another extracted example is Interleukin 4 → anterior pituitary, bone marrow cell, dentate gyrus of hippocampal formation granule cell, embryo, gonad, lens, monocyte, morula, neural layer of retina, olfactory zone of nasal mucosa, oocyte, primary visual cortex, right coronary artery, right uterine tube, secondary oocyte, spermatocyte, superior frontal gyrus, testicle, ventricular zone. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
il-4 cells human th2 bp cell type chr band interleukin il-13 receptor receptors differentiation chromosome cytokine production inflammation gene interleukin-4
TTTA extracted 140 structured relationships around Interleukin 4. Examples in this analysis include Interleukin 4 → Aliases → IL4, Interleukin 4, IGG1 induction factor, B-cell IgG differentiation factor, B-cell stimulatory factor 1, B-cell growth factor 1, Il4, lymphocyte stimulatory factor 1 and Interleukin 4 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1BBN, 1BCN, 1CYL, 1HIJ, 1HIK, 1HZI, 1IAR, 1ITI, 1ITL, 1ITM, 1RCB, 2B8U, 2B8X, 2B8Y, 2B8Z, 2B90, 2B91, 2CYK,…. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| Interleukin 4 | Aliases | IL4, Interleukin 4, IGG1 induction factor, B-cell IgG differentiation factor, B-cell stimulatory factor 1, B-cell growth factor 1, Il4, lymphocyte stimulatory factor 1 | 1.00 | infobox |
| Interleukin 4 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1BBN, 1BCN, 1CYL, 1HIJ, 1HIK, 1HZI, 1IAR, 1ITI, 1ITL, 1ITM, 1RCB, 2B8U, 2B8X, 2B8Y, 2B8Z, 2B90, 2B91, 2CYK,… | 1.00 | infobox |
| Interleukin 4 | Band | 5q31.1 | 1.00 | infobox |
| Interleukin 4 | Band | 11 B1.3|11 31.97 cM | 1.00 | infobox |
| Interleukin 4 | Bgee | oocyte | 1.00 | infobox |
| Interleukin 4 | Bgee | secondary oocyte | 1.00 | infobox |
| Interleukin 4 | Bgee | testicle | 1.00 | infobox |
| Interleukin 4 | Bgee | gonad | 1.00 | infobox |
| Interleukin 4 | Bgee | right uterine tube | 1.00 | infobox |
| Interleukin 4 | Bgee | monocyte | 1.00 | infobox |
| Interleukin 4 | Bgee | anterior pituitary | 1.00 | infobox |
| Interleukin 4 | Bgee | right coronary artery | 1.00 | infobox |
| Interleukin 4 | Bgee | olfactory zone of nasal mucosa | 1.00 | infobox |
| Interleukin 4 | Bgee | bone marrow cell | 1.00 | infobox |
| Interleukin 4 | Bgee | neural layer of retina | 1.00 | infobox |
| Interleukin 4 | Bgee | superior frontal gyrus | 1.00 | infobox |
| Interleukin 4 | Bgee | spermatocyte | 1.00 | infobox |
| Interleukin 4 | Bgee | primary visual cortex | 1.00 | infobox |
| Interleukin 4 | Bgee | lens | 1.00 | infobox |
| Interleukin 4 | Bgee | embryo | 1.00 | infobox |
| Interleukin 4 | Bgee | dentate gyrus of hippocampal formation granule cell | 1.00 | infobox |
| Interleukin 4 | Bgee | ventricular zone | 1.00 | infobox |
| Interleukin 4 | Bgee | morula | 1.00 | infobox |
| Interleukin 4 | BioGPS | n/a | 1.00 | infobox |
| Interleukin 4 | Chr. | Chromosome 5 (human) | 1.00 | infobox |
| Interleukin 4 | Chr. | Chromosome 11 (mouse) | 1.00 | infobox |
| Interleukin 4 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| Interleukin 4 | End | 132,018,370 bp | 1.00 | infobox |
| Interleukin 4 | End | 53,509,496 bp | 1.00 | infobox |
| Interleukin 4 | Ensembl | ENSG00000113520 | 1.00 | infobox |
The concept neighborhoods around Interleukin 4 bring nearby vocabulary together. In this analysis, examples include Factor, Ige and Location. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For Interleukin 4, one of the stronger structural bridges in this analysis connects Interleukin 4 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around Interleukin 4 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Research, Function & Clinical significance, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — Interleukin 4 · EN edition · Analysis: TopicsToTalkAbout