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Interleukin 4: Research, Function & Clinical significance

The interleukin 4 (IL4, IL-4) is a cytokine that induces differentiation of naive helper T cells (Th0 cells) to Th2 cells. Upon activation by IL-4, Th2 cells subsequently produce additional IL-4 in a positive feedback loop. IL-4 is produced primarily by mast cells, Th2 cells, eosinophils and basophils. It is closely related and has functions similar to…

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Interleukin 4 topic overview

The analysis highlights Research, Function and Clinical significance as prominent areas in the source structure around Interleukin 4.

Related topics
53
Source areas
8
Connected nodes
61
Extracted relationships
140
Concept neighborhoods
22
Bridge connections
61

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 21 topics
Clinical significance · 13 topics
Structure · 6 topics
Overview · 5 topics
Discovery · 3 topics
Animal studies · 2 topics
Receptor · 2 topics
Evolution · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
IL4, Interleukin 4, IGG1 induction factor, B-cell IgG differentiation factor, B-cell stimulatory factor 1, B-cell growth factor 1, Il4, lymphocyte stimulatory factor 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1BBN, 1BCN, 1CYL, 1HIJ, 1HIK, 1HZI, 1IAR, 1ITI, 1ITL, 1ITM, 1RCB, 2B8U, 2B8X, 2B8Y, 2B8Z, 2B90, 2B91, 2CYK,…
Band
5q31.1 · 11 B1.3|11 31.97 cM
Bgee
oocyte · secondary oocyte · testicle · gonad · right uterine tube
BioGPS
n/a
Chr.
Chromosome 5 (human) · Chromosome 11 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Receptor

Structure

Evolution

Discovery

Animal studies

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Interleukin 4 connects Entity context

The extracted context around Interleukin 4 shows recurring relationship patterns in the source. For example, Interleukin 4 → activation of Janus kinase activity, B cell activation, B cell differentiation, cholesterol metabolic process, cytokine activity, cytokine receptor binding, cytokine-mediated signaling pathway, dendritic cell differentiation, extracellular region, extracellular space, growth factor activity, immune response, interleukin-4 receptor binding, myeloid dendritic cell differentiation, negative regulation of apoptotic process, negative regulation of complement-dependent cytotoxicity, negative regulation of endothelial cell apoptotic process, negative regulation of epithelial cell migration, negative regulation of neuroinflammatory response, negative regulation of osteoclast differentiation Another extracted example is Interleukin 4 → anterior pituitary, bone marrow cell, dentate gyrus of hippocampal formation granule cell, embryo, gonad, lens, monocyte, morula, neural layer of retina, olfactory zone of nasal mucosa, oocyte, primary visual cortex, right coronary artery, right uterine tube, secondary oocyte, spermatocyte, superior frontal gyrus, testicle, ventricular zone. Use these groups to spot repeated connection types before inspecting the individual relationships.

Interleukin 4

Top relations

Gene ontology · 47
Interleukin 4 → activation of Janus kinase activity, B cell activation, B cell differentiation, cholesterol metabolic process, cytokine activity, cytokine receptor binding, cytokine-mediated signaling pathway, dendritic cell differentiation, extracellular region, extracellular space, growth factor activity, immune response, interleukin-4 receptor binding, myeloid dendritic cell differentiation, negative regulation of apoptotic process, negative regulation of complement-dependent cytotoxicity, negative regulation of endothelial cell apoptotic process, negative regulation of epithelial cell migration, negative regulation of neuroinflammatory response, negative regulation of osteoclast differentiation
Bgee · 19
Interleukin 4 → anterior pituitary, bone marrow cell, dentate gyrus of hippocampal formation granule cell, embryo, gonad, lens, monocyte, morula, neural layer of retina, olfactory zone of nasal mucosa, oocyte, primary visual cortex, right coronary artery, right uterine tube, secondary oocyte, spermatocyte, superior frontal gyrus, testicle, ventricular zone
RNA expression pattern · 19
Interleukin 4 → anterior pituitary, bone marrow cell, dentate gyrus of hippocampal formation granule cell, embryo, gonad, lens, monocyte, morula, neural layer of retina, olfactory zone of nasal mucosa, oocyte, primary visual cortex, right coronary artery, right uterine tube, secondary oocyte, spermatocyte, superior frontal gyrus, testicle, ventricular zone
related to Function · 10
Interleukin 4 → IFNγ, IgE, II, IL-12, IL-4, Interleukin, It, MHC, Overproduction, Th1
related to Allergic diseases · 8
Interleukin 4 → Allergic, Asthma, IgE, IL-4, Interleukin, Th2, These, VCAM-1
Band · 2
Interleukin 4 → 11 B1.3|11 31.97 cM, 5q31.1
Chr. · 2
Interleukin 4 → Chromosome 11 (mouse), Chromosome 5 (human)
End · 2
Interleukin 4 → 132,018,370 bp, 53,509,496 bp
Aliases · 1
Interleukin 4 → IL4, Interleukin 4, IGG1 induction factor, B-cell IgG differentiation factor, B-cell stimulatory factor 1, B-cell growth factor 1, Il4, lymphocyte stimulatory factor 1
Available structures · 1
Interleukin 4 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1BBN, 1BCN, 1CYL, 1HIJ, 1HIK, 1HZI, 1IAR, 1ITI, 1ITL, 1ITM, 1RCB, 2B8U, 2B8X, 2B8Y, 2B8Z, 2B90, 2B91, 2CYK,…

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

il-4 cells human th2 bp cell type chr band interleukin il-13 receptor receptors differentiation chromosome cytokine production inflammation gene interleukin-4

Interleukin 4 relationships Subject–Predicate–Object triples

TTTA extracted 140 structured relationships around Interleukin 4. Examples in this analysis include Interleukin 4 → Aliases → IL4, Interleukin 4, IGG1 induction factor, B-cell IgG differentiation factor, B-cell stimulatory factor 1, B-cell growth factor 1, Il4, lymphocyte stimulatory factor 1 and Interleukin 4 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1BBN, 1BCN, 1CYL, 1HIJ, 1HIK, 1HZI, 1IAR, 1ITI, 1ITL, 1ITM, 1RCB, 2B8U, 2B8X, 2B8Y, 2B8Z, 2B90, 2B91, 2CYK,…. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Interleukin 4AliasesIL4, Interleukin 4, IGG1 induction factor, B-cell IgG differentiation factor, B-cell stimulatory factor 1, B-cell growth factor 1, Il4, lymphocyte stimulatory factor 11.00infobox
Interleukin 4Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1BBN, 1BCN, 1CYL, 1HIJ, 1HIK, 1HZI, 1IAR, 1ITI, 1ITL, 1ITM, 1RCB, 2B8U, 2B8X, 2B8Y, 2B8Z, 2B90, 2B91, 2CYK,…1.00infobox
Interleukin 4Band5q31.11.00infobox
Interleukin 4Band11 B1.3|11 31.97 cM1.00infobox
Interleukin 4Bgeeoocyte1.00infobox
Interleukin 4Bgeesecondary oocyte1.00infobox
Interleukin 4Bgeetesticle1.00infobox
Interleukin 4Bgeegonad1.00infobox
Interleukin 4Bgeeright uterine tube1.00infobox
Interleukin 4Bgeemonocyte1.00infobox
Interleukin 4Bgeeanterior pituitary1.00infobox
Interleukin 4Bgeeright coronary artery1.00infobox
Interleukin 4Bgeeolfactory zone of nasal mucosa1.00infobox
Interleukin 4Bgeebone marrow cell1.00infobox
Interleukin 4Bgeeneural layer of retina1.00infobox
Interleukin 4Bgeesuperior frontal gyrus1.00infobox
Interleukin 4Bgeespermatocyte1.00infobox
Interleukin 4Bgeeprimary visual cortex1.00infobox
Interleukin 4Bgeelens1.00infobox
Interleukin 4Bgeeembryo1.00infobox
Interleukin 4Bgeedentate gyrus of hippocampal formation granule cell1.00infobox
Interleukin 4Bgeeventricular zone1.00infobox
Interleukin 4Bgeemorula1.00infobox
Interleukin 4BioGPSn/a1.00infobox
Interleukin 4Chr.Chromosome 5 (human)1.00infobox
Interleukin 4Chr.Chromosome 11 (mouse)1.00infobox
Interleukin 4DatabasesNCBI: entry; OMA: entry1.00infobox
Interleukin 4End132,018,370 bp1.00infobox
Interleukin 4End53,509,496 bp1.00infobox
Interleukin 4EnsemblENSG000001135201.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Interleukin 4 bring nearby vocabulary together. In this analysis, examples include Factor, Ige and Location. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Interleukin 4
    • Factor
    • Ige
    • Location
    • Chromosome
    • Gene
    • Growth
    • Bp
    • Chr
    • Receptor
    • Cell
    • Human
    • Th2
  • interleukin 4
    • Factor
    • Ige
    • Location
    • Chromosome
    • Gene
    • Growth
    • Bp
    • Chr
    • Receptor
    • Cell
    • Human
    • Th2
  • cytokine
    • Interleukin
    • Differentiation
    • Ige
    • Cell
    • Il4
    • Th2
    • Type
    • Activation
    • Factor
    • Functions
    • Location
    • Mouse
  • th0 cells
    • Th2
    • Il-4
    • Production
    • Activation
    • Cell
    • Differentiation
    • Cytokine
    • Found
    • Growth
    • Immune
    • Interleukin
    • Macrophages
  • th2 cells
    • Th2
    • Il-4
    • Production
    • Activation
    • Cell
    • Differentiation
    • Cytokine
    • Found
    • Growth
    • Immune
    • Interleukin
    • Macrophages
  • b cell
    • Ige
    • Mouse
    • Type
    • Cytokine
    • Immune
    • Interleukin
    • Production
    • Cells
    • Human
    • Th2
    • Differentiation
    • Factor
  • t cell
    • Ige
    • Mouse
    • Type
    • Cytokine
    • Immune
    • Interleukin
    • Production
    • Cells
    • Human
    • Th2
    • Differentiation
    • Factor
  • plasma cells
    • Th2
    • Il-4
    • Production
    • Activation
    • Cell
    • Differentiation
    • Cytokine
    • Found
    • Growth
    • Immune
    • Interleukin
    • Macrophages

Connections between topic areas Semantic bridges

For Interleukin 4, one of the stronger structural bridges in this analysis connects Interleukin 4 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Interleukin 4Function · splits 40 ⟂ 22
Interleukin 4Clinical significance · splits 48 ⟂ 14
Interleukin 4Structure · splits 55 ⟂ 7
Interleukin 4Overview · splits 56 ⟂ 6
Interleukin 4Discovery · splits 58 ⟂ 4
Interleukin 4Receptor · splits 59 ⟂ 3
Interleukin 4Animal studies · splits 59 ⟂ 3

Map overview Semantic statistics

Interleukin 4

Nodes62
Edges61
Triples140
Avg. degree1.97
Density0.032258
Components1

Source & methodology

TTTA analyzes the structure around Interleukin 4 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Research, Function & Clinical significance, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Interleukin 4 · EN edition · Analysis: TopicsToTalkAbout

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