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Signal transducer and activator of transcription 4 (STAT4) is a transcription factor belonging to the STAT protein family, composed of STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6. STAT proteins are key activators of gene transcription which bind to DNA in response to cytokine gradient. STAT proteins are a common part of Janus kinase (JAK)-…
The analysis highlights Art, Disease and Structure as prominent areas in the source structure around STAT4.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around STAT4 shows recurring relationship patterns in the source. For example, STAT4 → cytokine-mediated signaling pathway, cytoplasm, cytosol, defense response, DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, identical protein binding, interleukin-12-mediated signaling pathway, interleukin-21-mediated signaling pathway, interleukin-23-mediated signaling pathway, interleukin-35-mediated signaling pathway, nucleoplasm, nucleus, positive regulation of transcription by RNA polymerase II, protein binding, receptor signaling pathway via JAK-STAT, regulation of cell population proliferation, regulation of transcription, DNA-templated Another extracted example is STAT4 → blood, cardiac muscle tissue of right atrium, granulocyte, left testis, mesenteric lymph nodes, middle temporal gyrus, pituitary gland, primary oocyte, right auricle of heart, right frontal lobe, right testis, secondary oocyte, seminiferous tubule, sperm, spermatid, spermatocyte, spleen, zygote. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
cells human bp transcription stat il-12 binding gene chr band ifn-γ production signalling response cytokines stat1 phosphorylation proteins chromosome genes
TTTA extracted 173 structured relationships around STAT4. Examples in this analysis include STAT4 → Aliases → STAT4, SLEB11, signal transducer and activator of transcription 4 and STAT4 → Band → 2q32.2-q32.3. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| STAT4 | Aliases | STAT4, SLEB11, signal transducer and activator of transcription 4 | 1.00 | infobox |
| STAT4 | Band | 2q32.2-q32.3 | 1.00 | infobox |
| STAT4 | Band | 1 C1.1|1 26.67 cM | 1.00 | infobox |
| STAT4 | Bgee | granulocyte | 1.00 | infobox |
| STAT4 | Bgee | sperm | 1.00 | infobox |
| STAT4 | Bgee | middle temporal gyrus | 1.00 | infobox |
| STAT4 | Bgee | blood | 1.00 | infobox |
| STAT4 | Bgee | right auricle of heart | 1.00 | infobox |
| STAT4 | Bgee | cardiac muscle tissue of right atrium | 1.00 | infobox |
| STAT4 | Bgee | left testis | 1.00 | infobox |
| STAT4 | Bgee | right testis | 1.00 | infobox |
| STAT4 | Bgee | pituitary gland | 1.00 | infobox |
| STAT4 | Bgee | right frontal lobe | 1.00 | infobox |
| STAT4 | Bgee | spermatid | 1.00 | infobox |
| STAT4 | Bgee | seminiferous tubule | 1.00 | infobox |
| STAT4 | Bgee | spermatocyte | 1.00 | infobox |
| STAT4 | Bgee | mesenteric lymph nodes | 1.00 | infobox |
| STAT4 | Bgee | zygote | 1.00 | infobox |
| STAT4 | Bgee | spleen | 1.00 | infobox |
| STAT4 | Bgee | primary oocyte | 1.00 | infobox |
| STAT4 | Bgee | secondary oocyte | 1.00 | infobox |
| STAT4 | BioGPS | n/a | 1.00 | infobox |
| STAT4 | Chr. | Chromosome 2 (human) | 1.00 | infobox |
| STAT4 | Chr. | Chromosome 1 (mouse) | 1.00 | infobox |
| STAT4 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| STAT4 | End | 191,151,596 bp | 1.00 | infobox |
| STAT4 | End | 52,146,348 bp | 1.00 | infobox |
| STAT4 | Ensembl | ENSG00000138378 | 1.00 | infobox |
| STAT4 | Entrez | 6775 | 1.00 | infobox |
| STAT4 | External IDs | OMIM: 600558; MGI: 103062; GeneCards: STAT4 | 1.00 | infobox |
The concept neighborhoods around STAT4 bring nearby vocabulary together. In this analysis, examples include Cells, Cytokines and Disease. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For STAT4, one of the stronger structural bridges in this analysis connects STAT4 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around STAT4 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Art, Disease & Structure, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — STAT4 · EN edition · Analysis: TopicsToTalkAbout