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STAT4

Signal transducer and activator of transcription 4 (STAT4) is a transcription factor belonging to the STAT protein family, composed of STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6. STAT proteins are key activators of gene transcription which bind to DNA in response to cytokine gradient. STAT proteins are a common part of Janus kinase (JAK)-…

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Aliases
STAT4, SLEB11, signal transducer and activator of transcription 4
Band
2q32.2-q32.3 · 1 C1.1|1 26.67 cM
Bgee
granulocyte · sperm · middle temporal gyrus · blood · right auricle of heart
BioGPS
n/a
Chr.
Chromosome 2 (human) · Chromosome 1 (mouse)
Databases
NCBI: entry; OMA: entry

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Overview

Structure

Expression

Cytokines activating STAT4

Inhibitors of STAT4 signalling pathways

Target genes

Disease

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Map overview Semantic statistics

STAT4

Nodes53
Edges52
Triples173
Avg. degree1.96
Density0.037736
Components1

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STAT4

Top relations

Gene ontology · 24
STAT4 → cytokine-mediated signaling pathway, cytoplasm, cytosol, defense response, DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, identical protein binding, interleukin-12-mediated signaling pathway, interleukin-21-mediated signaling pathway, interleukin-23-mediated signaling pathway, interleukin-35-mediated signaling pathway, nucleoplasm, nucleus, positive regulation of transcription by RNA polymerase II, protein binding, receptor signaling pathway via JAK-STAT, regulation of cell population proliferation, regulation of transcription, DNA-templated
Bgee · 18
STAT4 → blood, cardiac muscle tissue of right atrium, granulocyte, left testis, mesenteric lymph nodes, middle temporal gyrus, pituitary gland, primary oocyte, right auricle of heart, right frontal lobe, right testis, secondary oocyte, seminiferous tubule, sperm, spermatid, spermatocyte, spleen, zygote
RNA expression pattern · 18
STAT4 → blood, cardiac muscle tissue of right atrium, granulocyte, left testis, mesenteric lymph nodes, middle temporal gyrus, pituitary gland, primary oocyte, right auricle of heart, right frontal lobe, right testis, secondary oocyte, seminiferous tubule, sperm, spermatid, spermatocyte, spleen, zygote
related to IL-23 · 18
STAT4 → Additionally, DC, During, Gram-positive/negative, IL, IL-12, IL-23, IL-23/STAT4, IL12β1, IL18, IL2, IL21, IL23R, IL35, Monocytes, Receptor, Th17, The
related to IL-12 · 14
STAT4 → Binding, IFNγ, IL-12, IL-12R, IL12Rβ1, IL12Rβ2, JAK2, NK, Pro-inflammatory, Runx1, Runx3, Th1, The, TYK2
related to Inhibitors of STAT4 signalling pathways · 14
STAT4 → E3, IL12, IL6, In, JAK-STAT, JAK/STAT, Other, PAIS, PTP, SLIM, SOCSs, STAT, STAT-interacting LIM, STAT4-DNA
related to Structure · 14
STAT4 → C-terminal, Dalton, DNA, DNA-binding, GAS, Human, IFN-γ, N-terminal, SH2, Src, STAT, STAT1, STATs, The
related to IFNα and IFNβ · 11
STAT4 → During, IFN, IFNAR, IFNAR1, IFNAR2, IFNα, IFNα IFNβ, In, NK, Secreted, STAT1
related to Disease · 8
STAT4 → EAE, High, Intronic, Moreover, SD, Sjögren's, SLE, SNP
related to Target genes · 6
STAT4 → IFN-γ, IL12rβ2, IL18R1, IL18RAP, MYD88, TNF

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Important terminology

cells human bp transcription stat il-12 binding gene chr band ifn-γ production signalling response cytokines stat1 phosphorylation proteins chromosome genes

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
STAT4AliasesSTAT4, SLEB11, signal transducer and activator of transcription 41.00infobox
STAT4Band2q32.2-q32.31.00infobox
STAT4Band1 C1.1|1 26.67 cM1.00infobox
STAT4Bgeegranulocyte1.00infobox
STAT4Bgeesperm1.00infobox
STAT4Bgeemiddle temporal gyrus1.00infobox
STAT4Bgeeblood1.00infobox
STAT4Bgeeright auricle of heart1.00infobox
STAT4Bgeecardiac muscle tissue of right atrium1.00infobox
STAT4Bgeeleft testis1.00infobox
STAT4Bgeeright testis1.00infobox
STAT4Bgeepituitary gland1.00infobox
STAT4Bgeeright frontal lobe1.00infobox
STAT4Bgeespermatid1.00infobox
STAT4Bgeeseminiferous tubule1.00infobox
STAT4Bgeespermatocyte1.00infobox
STAT4Bgeemesenteric lymph nodes1.00infobox
STAT4Bgeezygote1.00infobox
STAT4Bgeespleen1.00infobox
STAT4Bgeeprimary oocyte1.00infobox
STAT4Bgeesecondary oocyte1.00infobox
STAT4BioGPSn/a1.00infobox
STAT4Chr.Chromosome 2 (human)1.00infobox
STAT4Chr.Chromosome 1 (mouse)1.00infobox
STAT4DatabasesNCBI: entry; OMA: entry1.00infobox
STAT4End191,151,596 bp1.00infobox
STAT4End52,146,348 bp1.00infobox
STAT4EnsemblENSG000001383781.00infobox
STAT4Entrez67751.00infobox
STAT4External IDsOMIM: 600558; MGI: 103062; GeneCards: STAT41.00infobox

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