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STAT4: Art, Disease & Structure

Signal transducer and activator of transcription 4 (STAT4) is a transcription factor belonging to the STAT protein family, composed of STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6. STAT proteins are key activators of gene transcription which bind to DNA in response to cytokine gradient. STAT proteins are a common part of Janus kinase (JAK)-…

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STAT4 topic overview

The analysis highlights Art, Disease and Structure as prominent areas in the source structure around STAT4.

Related topics
45
Source areas
7
Connected nodes
52
Extracted relationships
173
Concept neighborhoods
23
Bridge connections
52

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 12 topics
Disease · 9 topics
Structure · 8 topics
Target genes · 7 topics
Expression · 5 topics
Cytokines activating STAT4 · 3 topics
Inhibitors of STAT4 signalling pathways · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
STAT4, SLEB11, signal transducer and activator of transcription 4
Band
2q32.2-q32.3 · 1 C1.1|1 26.67 cM
Bgee
granulocyte · sperm · middle temporal gyrus · blood · right auricle of heart
BioGPS
n/a
Chr.
Chromosome 2 (human) · Chromosome 1 (mouse)
Databases
NCBI: entry; OMA: entry

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Expression

Cytokines activating STAT4

Inhibitors of STAT4 signalling pathways

Target genes

Disease

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How STAT4 connects Entity context

The extracted context around STAT4 shows recurring relationship patterns in the source. For example, STAT4 → cytokine-mediated signaling pathway, cytoplasm, cytosol, defense response, DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, identical protein binding, interleukin-12-mediated signaling pathway, interleukin-21-mediated signaling pathway, interleukin-23-mediated signaling pathway, interleukin-35-mediated signaling pathway, nucleoplasm, nucleus, positive regulation of transcription by RNA polymerase II, protein binding, receptor signaling pathway via JAK-STAT, regulation of cell population proliferation, regulation of transcription, DNA-templated Another extracted example is STAT4 → blood, cardiac muscle tissue of right atrium, granulocyte, left testis, mesenteric lymph nodes, middle temporal gyrus, pituitary gland, primary oocyte, right auricle of heart, right frontal lobe, right testis, secondary oocyte, seminiferous tubule, sperm, spermatid, spermatocyte, spleen, zygote. Use these groups to spot repeated connection types before inspecting the individual relationships.

STAT4

Top relations

Gene ontology · 24
STAT4 → cytokine-mediated signaling pathway, cytoplasm, cytosol, defense response, DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, identical protein binding, interleukin-12-mediated signaling pathway, interleukin-21-mediated signaling pathway, interleukin-23-mediated signaling pathway, interleukin-35-mediated signaling pathway, nucleoplasm, nucleus, positive regulation of transcription by RNA polymerase II, protein binding, receptor signaling pathway via JAK-STAT, regulation of cell population proliferation, regulation of transcription, DNA-templated
Bgee · 18
STAT4 → blood, cardiac muscle tissue of right atrium, granulocyte, left testis, mesenteric lymph nodes, middle temporal gyrus, pituitary gland, primary oocyte, right auricle of heart, right frontal lobe, right testis, secondary oocyte, seminiferous tubule, sperm, spermatid, spermatocyte, spleen, zygote
RNA expression pattern · 18
STAT4 → blood, cardiac muscle tissue of right atrium, granulocyte, left testis, mesenteric lymph nodes, middle temporal gyrus, pituitary gland, primary oocyte, right auricle of heart, right frontal lobe, right testis, secondary oocyte, seminiferous tubule, sperm, spermatid, spermatocyte, spleen, zygote
related to IL-23 · 18
STAT4 → Additionally, DC, During, Gram-positive/negative, IL, IL-12, IL-23, IL-23/STAT4, IL12β1, IL18, IL2, IL21, IL23R, IL35, Monocytes, Receptor, Th17, The
related to IL-12 · 14
STAT4 → Binding, IFNγ, IL-12, IL-12R, IL12Rβ1, IL12Rβ2, JAK2, NK, Pro-inflammatory, Runx1, Runx3, Th1, The, TYK2
related to Inhibitors of STAT4 signalling pathways · 14
STAT4 → E3, IL12, IL6, In, JAK-STAT, JAK/STAT, Other, PAIS, PTP, SLIM, SOCSs, STAT, STAT-interacting LIM, STAT4-DNA
related to Structure · 14
STAT4 → C-terminal, Dalton, DNA, DNA-binding, GAS, Human, IFN-γ, N-terminal, SH2, Src, STAT, STAT1, STATs, The
related to IFNα and IFNβ · 11
STAT4 → During, IFN, IFNAR, IFNAR1, IFNAR2, IFNα, IFNα IFNβ, In, NK, Secreted, STAT1
related to Disease · 8
STAT4 → EAE, High, Intronic, Moreover, SD, Sjögren's, SLE, SNP
related to Target genes · 6
STAT4 → IFN-γ, IL12rβ2, IL18R1, IL18RAP, MYD88, TNF

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

cells human bp transcription stat il-12 binding gene chr band ifn-γ production signalling response cytokines stat1 phosphorylation proteins chromosome genes

STAT4 relationships Subject–Predicate–Object triples

TTTA extracted 173 structured relationships around STAT4. Examples in this analysis include STAT4 → Aliases → STAT4, SLEB11, signal transducer and activator of transcription 4 and STAT4 → Band → 2q32.2-q32.3. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
STAT4AliasesSTAT4, SLEB11, signal transducer and activator of transcription 41.00infobox
STAT4Band2q32.2-q32.31.00infobox
STAT4Band1 C1.1|1 26.67 cM1.00infobox
STAT4Bgeegranulocyte1.00infobox
STAT4Bgeesperm1.00infobox
STAT4Bgeemiddle temporal gyrus1.00infobox
STAT4Bgeeblood1.00infobox
STAT4Bgeeright auricle of heart1.00infobox
STAT4Bgeecardiac muscle tissue of right atrium1.00infobox
STAT4Bgeeleft testis1.00infobox
STAT4Bgeeright testis1.00infobox
STAT4Bgeepituitary gland1.00infobox
STAT4Bgeeright frontal lobe1.00infobox
STAT4Bgeespermatid1.00infobox
STAT4Bgeeseminiferous tubule1.00infobox
STAT4Bgeespermatocyte1.00infobox
STAT4Bgeemesenteric lymph nodes1.00infobox
STAT4Bgeezygote1.00infobox
STAT4Bgeespleen1.00infobox
STAT4Bgeeprimary oocyte1.00infobox
STAT4Bgeesecondary oocyte1.00infobox
STAT4BioGPSn/a1.00infobox
STAT4Chr.Chromosome 2 (human)1.00infobox
STAT4Chr.Chromosome 1 (mouse)1.00infobox
STAT4DatabasesNCBI: entry; OMA: entry1.00infobox
STAT4End191,151,596 bp1.00infobox
STAT4End52,146,348 bp1.00infobox
STAT4EnsemblENSG000001383781.00infobox
STAT4Entrez67751.00infobox
STAT4External IDsOMIM: 600558; MGI: 103062; GeneCards: STAT41.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around STAT4 bring nearby vocabulary together. In this analysis, examples include Cells, Cytokines and Disease. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • STAT4
    • Cells
    • Cytokines
    • Disease
    • Stat1
    • Genes
    • Pathway
    • Signalling
    • Transcription
    • Binding
    • Phosphorylation
    • Ifn-γ
    • Il-23
  • stat4
    • Cells
    • Cytokines
    • Disease
    • Stat1
    • Genes
    • Pathway
    • Signalling
    • Transcription
    • Binding
    • Phosphorylation
    • Ifn-γ
    • Il-23
  • transcription factor
    • Activator
    • Factor
    • Signal
    • Transcription
    • Gene
    • Protein
    • Stat1
    • Dna
    • Expression
    • Location
    • Chromosome
    • Response
  • stat protein
    • Proteins
    • Signal
    • Activity
    • Stat1
    • Activated
    • Pathway
    • Pathways
    • Response
    • Stat
    • Transcription
    • Binding
    • Mouse
  • gene duplication
    • Location
    • Chromosome
    • Bp
    • Chr
    • Human
    • Mouse
    • Transcription
    • Dna
    • Expression
    • Signal
    • Band
    • Response
  • expression
    • Location
    • Signal
    • Activity
    • Chromosome
    • Gene
    • Pathways
    • Bp
    • Chr
    • Genes
    • Human
    • Signalling
    • Transcription
  • cytokines activating stat4
    • Ifn-γ
    • Pathways
    • Genes
    • Il-12
    • Signalling
    • Cells
    • Cytokines
    • Disease
    • Stat1
    • Stat4
    • Pathway
    • Transcription
  • inhibitors of stat4 signalling pathways
    • Pathways
    • Signalling
    • Expression
    • Activated
    • Activity
    • Cytokines
    • Ifnα
    • Proteins
    • Il-12
    • Il-23
    • Production
    • Stat

Connections between topic areas Semantic bridges

For STAT4, one of the stronger structural bridges in this analysis connects STAT4 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
STAT4Overview · splits 40 ⟂ 13
STAT4Disease · splits 43 ⟂ 10
STAT4Structure · splits 44 ⟂ 9
STAT4Target genes · splits 45 ⟂ 8
STAT4Expression · splits 47 ⟂ 6
STAT4Cytokines activating STAT4 · splits 49 ⟂ 4

Map overview Semantic statistics

STAT4

Nodes53
Edges52
Triples173
Avg. degree1.96
Density0.037736
Components1

Source & methodology

TTTA analyzes the structure around STAT4 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Art, Disease & Structure, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — STAT4 · EN edition · Analysis: TopicsToTalkAbout

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