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SUMO protein: Function, Role in Human Pathology & Overview
In molecular biology, SUMO (Small Ubiquitin-like MOdifier) proteins are a family of small proteins that are covalently attached to and detached from other proteins in cells to modify their function. This process is called SUMOylation (pronounced soo-muh-lā-shun and sometimes written sumoylation). SUMOylation is a post-translational modification involved…
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SUMO protein topic overview
The analysis highlights Function, Role in Human Pathology and Overview as prominent areas in the source structure around SUMO protein.
Related topics
79
Source areas
8
Connected nodes
87
Extracted relationships
89
Concept neighborhoods
28
Bridge connections
87
What this topic covers Research coverage
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Overview · 23 topics
Function · 16 topics
Role in Human Pathology · 13 topics
Prediction of SUMO attachment · 7 topics
Structure · 7 topics
SUMO attachment (SUMOylation) · 5 topics
DeSUMOylation · 4 topics
Role in protein purification · 4 topics
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
Key facts & relationships
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Explore all related topics Closing gaps
A structured outline of related entities, concepts and subtopics. Open any item to build a new map centered on it.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
How SUMO protein connects Entity context
Entity context groups extracted connections by relationship type. Counts show recurrence in the analyzed source; the examples are research signals, not claims about importance.
The extracted context around SUMO protein shows recurring relationship patterns in the source. For example, SUMO protein → Among, As, At, During, GeneRIFs, Glutamine, II, In, One, Proline, RanGAP1, Serine, SUMO, SUMO-1, SUMO-2, SUMO-2/3, SUMO-3, SUMO-4, SUMO1, SUMO2 Another extracted example is SUMO protein → Beyond, DNA, DNA-binding, EMT, Here, HIF-1α, Hippel-Lindau, In, IκB, Li-Fraumeni, MDM2, MMPs, Mouse Double Minute, NF-κB, One, RING, SMT3IP1/SENP3, SUMO, SUMOylated, SUMOylation. Use these groups to spot repeated connection types before inspecting the individual relationships.
SUMO protein
Top relations
related to Function· 26
SUMO protein → Among, As, At, During, GeneRIFs, Glutamine, II, In, One, Proline, RanGAP1, Serine, SUMO, SUMO-1, SUMO-2, SUMO-2/3, SUMO-3, SUMO-4, SUMO1, SUMO2
SUMO protein relationships Subject–Predicate–Object triples
Relationships are represented as Subject → Predicate → Object triples. Confidence describes extraction strength, not the real-world importance of a relationship; lower-confidence rows may be contextual rather than explicit.
TTTA extracted 89 structured relationships around SUMO protein. Examples in this analysis include NEDD 8 → instance of → as it is for the other ubiquitin-like proteins and Cdc48 may then dissociate the SUMOylated → instance of → segregases. The table shows each extracted connection, where it came from and its confidence.
Subject
Predicate
Object
Confidence
Src
NEDD 8
instance of
as it is for the other ubiquitin-like proteins
0.80
text
Cdc48 may then dissociate the SUMOylated
instance of
segregases
0.80
text
ubiquitinated target from its bound protein
instance of
segregases
0.80
text
yeast lies in their potential to inform scientists in the research
instance of
This may be beneficial in some circumstances as it supports the breakdown of accumulated waste products.The importance of these studies in models
0.80
text
development of precise biomedical interventions that can translate to the improvement of human health in an array of clinical aspects
instance of
This may be beneficial in some circumstances as it supports the breakdown of accumulated waste products.The importance of these studies in models
0.80
text
SUMO or MBP
instance of
In order to purify such proteins it may be necessary to fuse the protein of interest with a solubility tag
0.80
text
Ulp1 peptidase
instance of
SUMO can later be cleaved from the protein of interest using a SUMO-specific protease
0.80
text
SUMO protein
related to DeSUMOylation
SUMO
0.60
section
SUMO protein
related to DeSUMOylation
Specific
0.60
section
SUMO protein
related to DeSUMOylation
SENP
0.60
section
SUMO protein
related to DeSUMOylation
Ulp1
0.60
section
SUMO protein
related to DeSUMOylation
Ulp2
0.60
section
No triples extracted yet.
Related concept clusters Concept neighborhoods
Concept neighborhoods group terms that sit near one another in the extracted graph. They are useful for discovering adjacent language and context, but proximity does not by itself imply a factual relationship.
The concept neighborhoods around SUMO protein bring nearby vocabulary together. In this analysis, examples include Proteins, Protein and Sumo. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
SUMO protein
Proteins
Protein
Sumo
Protease
Amino
Human
Ubiquitin
Yeast
Ubiquitin-like
Sumo-1
Ulp2
Modification
sumo protein
Proteins
Protein
Sumo
Protease
May
Amino
Sumoylation
Human
Ubiquitin
Yeast
Target
Ubiquitin-like
proteins
Sumo
Ubiquitin-like
Protein
Target
Human
Binding
Sumoylation
Disease
E3
Ubiquitin
Sumo2
Many
ubiquitin-like protein
Family
Ubiquitin
Sumo
Proteins
May
Sumoylation
Acids
Cells
Target
Motif
Sumo1
Sumo2
human genome
Sumo1
Sumo2
Yeast
Proteins
Sumo
Binding
Motif
Sites
One
Protease
Amino
Protein
maltose-binding protein
Sumo
Proteins
May
Sumoylation
Ubiquitin
Target
Ubiquitin-like
Case
Disease
Shown
Protease
Yeast
prediction of sumo attachment
Proteins
Protein
Protease
Amino
Human
Ubiquitin
Yeast
Ubiquitin-like
Sumo-1
Ulp2
Modification
Target
sumo attachment (sumoylation)
Proteins
Protein
Protease
Many
Sites
Amino
Human
P53
Ubiquitin
Yeast
One
Ubiquitin-like
Connections between topic areas Semantic bridges
Semantic bridges connect parts of the graph that would otherwise be more separate. A bridge is a structural signal in this analysis, not a claim that the two topic areas are equivalent.
For SUMO protein, one of the stronger structural bridges in this analysis connects SUMO protein with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
Min side: 3
SUMO protein — Overview· splits 64 ⟂ 24SUMO protein — Function· splits 71 ⟂ 17SUMO protein — Role in Human Pathology· splits 74 ⟂ 14SUMO protein — Structure· splits 80 ⟂ 8SUMO protein — Prediction of SUMO attachment· splits 80 ⟂ 8SUMO protein — SUMO attachment (SUMOylation)· splits 82 ⟂ 6SUMO protein — DeSUMOylation· splits 83 ⟂ 5SUMO protein — Role in protein purification· splits 83 ⟂ 5
Map overview Semantic statistics
Number of nodes, edges, triples, density and central hubs. Use it to gauge the size and connectivity of the map.
SUMO protein
Nodes88
Edges87
Triples89
Avg. degree1.98
Density0.022727
Components1
Source & methodology
TTTA analyzes the structure around SUMO protein to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Role in Human Pathology & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
