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STAT2

Signal transducer and activator of transcription 2 is a protein that in humans is encoded by the STAT2 gene. It is a member of the STAT protein family. This protein is critical to the biological response of type I interferons (IFNs). It functions as a transcription factor downstream of type I interferons. STAT2 sequence identity between mouse and human…

Interactions, Function & STAT2 deficiency

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Interactions

7 related topics

Function

3 related topics

STAT2 deficiency

1 related topics

Overview

10 related topics

Key facts & relationships

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Aliases
STAT2, ISGF-3, P113, STAT113, IMD44, signal transducer and activator of transcription 2, PTORCH3
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2KA4
Band
12q13.3 · 10 D3|10 76.5 cM
Bgee
granulocyte · stromal cell of endometrium · monocyte · sural nerve · pituitary gland
BioGPS
More reference expression data
Chr.
Chromosome 12 (human) · Chromosome 10 (mouse)

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Overview

Function

Interactions

STAT2 deficiency

Advanced semantic analysis

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Map overview Semantic statistics

STAT2

Nodes26
Edges25
Triples149
Avg. degree1.92
Density0.076923
Components1

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STAT2

Top relations

Gene ontology · 29
STAT2 → cytokine-mediated signaling pathway, cytoplasm, cytosol, defense response, defense response to virus, DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, identical protein binding, nucleoplasm, nucleus, plasma membrane, positive regulation of transcription by RNA polymerase II, protein binding, receptor signaling pathway via JAK-STAT, regulation of cell population proliferation, regulation of mitochondrial fission, regulation of protein phosphorylation, regulation of transcription by RNA polymerase II
related to Function · 25
STAT2 → DNA, EP300/CREBBP, IFN, IFN-alpha, IFN-stimulated, IFN-α, Immunodeficiency, In, IRF9, ISGF-3, ISRE, ISRE-driven, Ly-6C, MHC, Mutations, MX, OAS, P300/CBP, PKR, RNA
related to Knockout mice · 21
STAT2 → Additionally, Arginase-1, DNV, IFN-α, IFN-γ, In, Indiana, M1, M1/M2, M2, MCMV, STAT, STAT1, The, Therefore, These, This, Vesicular, VSV, WT
Bgee · 19
STAT2 → anterior pituitary, canal of the cervix, cerebellar cortex, epithelium of small intestine, genital tubercle, granulocyte, lumbar spinal ganglion, monocyte, mucous cell of stomach, neural layer of retina, pituitary gland, right lobe of liver, right ovary, stromal cell of endometrium, superior frontal gyrus, sural nerve, tendon of biceps brachii, thymus, zygote
RNA expression pattern · 19
STAT2 → anterior pituitary, canal of the cervix, cerebellar cortex, epithelium of small intestine, genital tubercle, granulocyte, lumbar spinal ganglion, monocyte, mucous cell of stomach, neural layer of retina, pituitary gland, right lobe of liver, right ovary, stromal cell of endometrium, superior frontal gyrus, sural nerve, tendon of biceps brachii, thymus, zygote
related to External links · 8
STAT2 → Factor, FactorBookSTAT2 This, Medicine, Medicine Medical Subject Headings, MeSH, National Library, Transcription, United States National Library
related to Interactions · 5
STAT2 → CREB-binding, IFNAR1IFNAR2, IRF9, MED14, SMARCA4
Band · 2
STAT2 → 10 D3|10 76.5 cM, 12q13.3
Chr. · 2
STAT2 → Chromosome 10 (mouse), Chromosome 12 (human)
End · 2
STAT2 → 128,128,718 bp, 56,360,167 bp

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Important terminology

protein human response gene type viral transcription knockout patients bp deficiency mice infection ifn chr band ar mouse infections chromosome

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
STAT2AliasesSTAT2, ISGF-3, P113, STAT113, IMD44, signal transducer and activator of transcription 2, PTORCH31.00infobox
STAT2Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2KA41.00infobox
STAT2Band12q13.31.00infobox
STAT2Band10 D3|10 76.5 cM1.00infobox
STAT2Bgeegranulocyte1.00infobox
STAT2Bgeestromal cell of endometrium1.00infobox
STAT2Bgeemonocyte1.00infobox
STAT2Bgeesural nerve1.00infobox
STAT2Bgeepituitary gland1.00infobox
STAT2Bgeeanterior pituitary1.00infobox
STAT2Bgeeright ovary1.00infobox
STAT2Bgeeright lobe of liver1.00infobox
STAT2Bgeetendon of biceps brachii1.00infobox
STAT2Bgeecanal of the cervix1.00infobox
STAT2Bgeelumbar spinal ganglion1.00infobox
STAT2Bgeeneural layer of retina1.00infobox
STAT2Bgeeepithelium of small intestine1.00infobox
STAT2Bgeecerebellar cortex1.00infobox
STAT2Bgeethymus1.00infobox
STAT2Bgeezygote1.00infobox
STAT2Bgeegenital tubercle1.00infobox
STAT2Bgeemucous cell of stomach1.00infobox
STAT2Bgeesuperior frontal gyrus1.00infobox
STAT2BioGPSMore reference expression data1.00infobox
STAT2Chr.Chromosome 12 (human)1.00infobox
STAT2Chr.Chromosome 10 (mouse)1.00infobox
STAT2DatabasesNCBI: entry; OMA: entry1.00infobox
STAT2End56,360,167 bp1.00infobox
STAT2End128,128,718 bp1.00infobox
STAT2EnsemblENSG000001705811.00infobox

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