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PTPRC: Applications, Function & Interactions
Protein tyrosine phosphatase, receptor type, C also known as PTPRC is an enzyme that, in humans, is encoded by the PTPRC gene. PTPRC is also known as CD45 antigen (CD stands for cluster of differentiation), which was originally called leukocyte common antigen (LCA).
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PTPRC topic overview
The analysis highlights Applications, Function and Interactions as prominent areas in the source structure around PTPRC.
Related topics
50
Source areas
6
Connected nodes
56
Extracted relationships
106
Concept neighborhoods
21
Bridge connections
56
What this topic covers Research coverage
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Function · 20 topics
Overview · 10 topics
Clinical importance · 6 topics
Interactions · 6 topics
Use as a congenic marker · 5 topics
Isoforms · 3 topics
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
Key facts & relationships
High-confidence facts extracted from structured source data. Use them as anchors for further research.
3.1.3.48
↗
Aliases
PTPRC, B220, CD45, CD45R, GP180, L-CA, LCA, LY5, T200, protein tyrosine phosphatase, receptor type C, protein tyrosine phosphatase receptor type C
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1YGU, 1YGR, 5FMV, 5FN6, 5FN7
A structured outline of related entities, concepts and subtopics. Open any item to build a new map centered on it.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
How PTPRC connects Entity context
Entity context groups extracted connections by relationship type. Counts show recurrence in the analyzed source; the examples are research signals, not claims about importance.
The extracted context around PTPRC shows recurring relationship patterns in the source. For example, PTPRC → B cell proliferation, B cell receptor signaling pathway, bone marrow development, cell cycle phase transition, cell surface, cell surface receptor signaling pathway, defense response to virus, dephosphorylation, external side of plasma membrane, extracellular exosome, focal adhesion, hematopoietic progenitor cell differentiation, hydrolase activity, integral component of membrane, integral component of plasma membrane, membrane, membrane raft, negative regulation of cell adhesion involved in substrate-bound cell migration, negative regulation of cytokine-mediated signaling pathway, negative regulation of protein kinase activity Another extracted example is PTPRC → appendix, blood, bone marrow, bone marrow cell, epithelium of nasopharynx, granulocyte, lymph node, mesenteric lymph nodes, monocyte, Paneth cell, right lung, spleen, stroma of bone marrow, submandibular gland, thymus, tibiofemoral joint. Use these groups to spot repeated connection types before inspecting the individual relationships.
PTPRC
Top relations
Gene ontology· 43
PTPRC → B cell proliferation, B cell receptor signaling pathway, bone marrow development, cell cycle phase transition, cell surface, cell surface receptor signaling pathway, defense response to virus, dephosphorylation, external side of plasma membrane, extracellular exosome, focal adhesion, hematopoietic progenitor cell differentiation, hydrolase activity, integral component of membrane, integral component of plasma membrane, membrane, membrane raft, negative regulation of cell adhesion involved in substrate-bound cell migration, negative regulation of cytokine-mediated signaling pathway, negative regulation of protein kinase activity
Bgee· 16
PTPRC → appendix, blood, bone marrow, bone marrow cell, epithelium of nasopharynx, granulocyte, lymph node, mesenteric lymph nodes, monocyte, Paneth cell, right lung, spleen, stroma of bone marrow, submandibular gland, thymus, tibiofemoral joint
RNA expression pattern· 16
PTPRC → appendix, blood, bone marrow, bone marrow cell, epithelium of nasopharynx, granulocyte, lymph node, mesenteric lymph nodes, monocyte, Paneth cell, right lung, spleen, stroma of bone marrow, submandibular gland, thymus, tibiofemoral joint
is a· 3
PTPRC → critical enzyme involved in regulating immune cell function, enzyme that, transmembrane protein tyrosine phosphatase expressed on the surface of all nucleated hematopoietic cells
PTPRC → PTPRC, B220, CD45, CD45R, GP180, L-CA, LCA, LY5, T200, protein tyrosine phosphatase, receptor type C, protein tyrosine phosphatase receptor type C
Important terminology
Frequent words and multi-word phrases across the lead, headings, infobox and body. Useful for terminology coverage.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
Relationships are represented as Subject → Predicate → Object triples. Confidence describes extraction strength, not the real-world importance of a relationship; lower-confidence rows may be contextual rather than explicit.
TTTA extracted 106 structured relationships around PTPRC. Examples in this analysis include PTPRC → 3.1.3.48 → ↗ and PTPRC → Aliases → PTPRC, B220, CD45, CD45R, GP180, L-CA, LCA, LY5, T200, protein tyrosine phosphatase, receptor type C, protein tyrosine phosphatase receptor type C. The table shows each extracted connection, where it came from and its confidence.
Subject
Predicate
Object
Confidence
Src
PTPRC
3.1.3.48
↗
1.00
infobox
PTPRC
Aliases
PTPRC, B220, CD45, CD45R, GP180, L-CA, LCA, LY5, T200, protein tyrosine phosphatase, receptor type C, protein tyrosine phosphatase receptor type C
1.00
infobox
PTPRC
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1YGU, 1YGR, 5FMV, 5FN6, 5FN7
Concept neighborhoods group terms that sit near one another in the extracted graph. They are useful for discovering adjacent language and context, but proximity does not by itself imply a factual relationship.
The concept neighborhoods around PTPRC bring nearby vocabulary together. In this analysis, examples include Tyrosine, Function and External. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
PTPRC
Tyrosine
Function
External
Receptor
Location
Transmembrane
Type
Antigen
Chromosome
Differentiation
Hematopoietic
Involved
ptprc
Tyrosine
Function
External
Receptor
Location
Transmembrane
Type
Antigen
Chromosome
Differentiation
Hematopoietic
Involved
gene
Location
Receptor
Chromosome
Bp
Chr
Human
Protein
Phosphatase
Tyrosine
External
Ptprc
Function
antigen
Receptor
Differentiation
Family
Extracellular
Known
Signaling
Ptprc
External
Function
Functions
Location
Transmembrane
cluster of differentiation
Signaling
Known
Ptprc
External
Cell
Activation
Function
Location
Transmembrane
Band
Chromosome
Family
hematopoietic cells
Transmembrane
Family
Extracellular
Human
Phosphatase
Tyrosine
Ptprc
Receptor
Cells
Hematopoietic
Protein
External
protein tyrosine phosphatase
Phosphatase
Tyrosine
Ptprc
Protein
External
Gene
Receptor
Enzyme
Function
Location
Transmembrane
Type
receptor type ptp
Type
Antigen
Family
Extracellular
Signaling
Tyrosine
External
Isoforms
Ptprc
Function
Functions
Location
Connections between topic areas Semantic bridges
Semantic bridges connect parts of the graph that would otherwise be more separate. A bridge is a structural signal in this analysis, not a claim that the two topic areas are equivalent.
For PTPRC, one of the stronger structural bridges in this analysis connects PTPRC with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
Number of nodes, edges, triples, density and central hubs. Use it to gauge the size and connectivity of the map.
PTPRC
Nodes57
Edges56
Triples106
Avg. degree1.96
Density0.035088
Components1
Source & methodology
TTTA analyzes the structure around PTPRC to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Applications, Function & Interactions, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — PTPRC · EN edition · Analysis: TopicsToTalkAbout
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