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USP20: Function, Structure & Overview

Ubiquitin carboxyl-terminal hydrolase 20 is an enzyme that in humans is encoded by the USP20 gene.

Language: English [EN]
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USP20 topic overview

The analysis highlights Function, Structure and Overview as prominent areas in the source structure around USP20.

Related topics
23
Source areas
4
Connected nodes
27
Extracted relationships
117
Concept neighborhoods
21
Bridge connections
27

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 11 topics
Function · 9 topics
Structure · 2 topics
Regulation · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3.4.19.12
Aliases
USP20, LSFR3A, VDU2, hVDU2, ubiquitin specific peptidase 20
Band
9q34.11 · 2|2 B
Bgee
granulocyte · anterior pituitary · right lobe of thyroid gland · right hemisphere of cerebellum · left lobe of thyroid gland
BioGPS
More reference expression data
Chr.
Chromosome 9 (human) · Chromosome 2 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Function

Regulation

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How USP20 connects Entity context

The extracted context around USP20 shows recurring relationship patterns in the source. For example, USP20 → centrosome, cysteine-type endopeptidase activity, cysteine-type peptidase activity, cytoplasm, cytoskeleton, cytosol, endocytosis, G protein-coupled receptor binding, hydrolase activity, metal ion binding, microtubule organizing center, peptidase activity, perinuclear region of cytoplasm, protein binding, protein deubiquitination, protein K48-linked deubiquitination, protein K63-linked deubiquitination, proteolysis, regulation of G protein-coupled receptor signaling pathway, thiol-dependent deubiquitinase Another extracted example is USP20 → anterior pituitary, ascending aorta, dentate gyrus of hippocampal formation granule cell, Descending thoracic aorta, dorsal tegmental nucleus, dorsomedial hypothalamic nucleus, gastric mucosa, granulocyte, habenula, left lobe of thyroid gland, lumbar spinal ganglion, muscle layer of sigmoid colon, paraventricular nucleus of hypothalamus, right frontal lobe, right hemisphere of cerebellum, right kidney, right lobe of thyroid gland, spermatid, spermatocyte, subiculum. Use these groups to spot repeated connection types before inspecting the individual relationships.

USP20

Top relations

Gene ontology · 22
USP20 → centrosome, cysteine-type endopeptidase activity, cysteine-type peptidase activity, cytoplasm, cytoskeleton, cytosol, endocytosis, G protein-coupled receptor binding, hydrolase activity, metal ion binding, microtubule organizing center, peptidase activity, perinuclear region of cytoplasm, protein binding, protein deubiquitination, protein K48-linked deubiquitination, protein K63-linked deubiquitination, proteolysis, regulation of G protein-coupled receptor signaling pathway, thiol-dependent deubiquitinase
Bgee · 20
USP20 → anterior pituitary, ascending aorta, dentate gyrus of hippocampal formation granule cell, Descending thoracic aorta, dorsal tegmental nucleus, dorsomedial hypothalamic nucleus, gastric mucosa, granulocyte, habenula, left lobe of thyroid gland, lumbar spinal ganglion, muscle layer of sigmoid colon, paraventricular nucleus of hypothalamus, right frontal lobe, right hemisphere of cerebellum, right kidney, right lobe of thyroid gland, spermatid, spermatocyte, subiculum
RNA expression pattern · 20
USP20 → anterior pituitary, ascending aorta, dentate gyrus of hippocampal formation granule cell, Descending thoracic aorta, dorsal tegmental nucleus, dorsomedial hypothalamic nucleus, gastric mucosa, granulocyte, habenula, left lobe of thyroid gland, lumbar spinal ganglion, muscle layer of sigmoid colon, paraventricular nucleus of hypothalamus, right frontal lobe, right hemisphere of cerebellum, right kidney, right lobe of thyroid gland, spermatid, spermatocyte, subiculum
related to Function · 11
USP20 → DUBs, JAB1/MPN/MOV34, JAMM/MPN, Machado-Joseph, MJD, OTU, The, This, UCH, USP, Zn
related to Structure · 5
USP20 → C-terminal DUSP, DUB, It, N-terminal Zf UBP, USP33
related to Hypoxia inducible factor 1α · 4
USP20 → HIF1α, Hippel-Lindau, The, This
related to Thyronine deiodinase type 2 · 4
USP20 → D2, Deubiquitination, T3, T4
related to Regulation · 3
USP20 → HIF1α, In, This
Band · 2
USP20 → 2|2 B, 9q34.11
Chr. · 2
USP20 → Chromosome 2 (mouse), Chromosome 9 (human)

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

protein ubiquitin cysteine gene bp receptor enzyme chr human band chromosome histidine degradation hif1α factor 20 residue d2 known thyronine

USP20 relationships Subject–Predicate–Object triples

TTTA extracted 117 structured relationships around USP20. Examples in this analysis include USP20 → 3.4.19.12 → ↗ and USP20 → Aliases → USP20, LSFR3A, VDU2, hVDU2, ubiquitin specific peptidase 20. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
USP203.4.19.121.00infobox
USP20AliasesUSP20, LSFR3A, VDU2, hVDU2, ubiquitin specific peptidase 201.00infobox
USP20Band9q34.111.00infobox
USP20Band2|2 B1.00infobox
USP20Bgeegranulocyte1.00infobox
USP20Bgeeanterior pituitary1.00infobox
USP20Bgeeright lobe of thyroid gland1.00infobox
USP20Bgeeright hemisphere of cerebellum1.00infobox
USP20Bgeeleft lobe of thyroid gland1.00infobox
USP20Bgeeright frontal lobe1.00infobox
USP20Bgeeascending aorta1.00infobox
USP20Bgeegastric mucosa1.00infobox
USP20Bgeemuscle layer of sigmoid colon1.00infobox
USP20BgeeDescending thoracic aorta1.00infobox
USP20Bgeespermatid1.00infobox
USP20Bgeelumbar spinal ganglion1.00infobox
USP20Bgeespermatocyte1.00infobox
USP20Bgeehabenula1.00infobox
USP20Bgeedentate gyrus of hippocampal formation granule cell1.00infobox
USP20Bgeedorsomedial hypothalamic nucleus1.00infobox
USP20Bgeesubiculum1.00infobox
USP20Bgeeright kidney1.00infobox
USP20Bgeeparaventricular nucleus of hypothalamus1.00infobox
USP20Bgeedorsal tegmental nucleus1.00infobox
USP20BioGPSMore reference expression data1.00infobox
USP20Chr.Chromosome 9 (human)1.00infobox
USP20Chr.Chromosome 2 (mouse)1.00infobox
USP20DatabasesNCBI: entry; OMA: entry1.00infobox
USP20End129,881,828 bp1.00infobox
USP20End30,913,598 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around USP20 bring nearby vocabulary together. In this analysis, examples include Receptor, Degradation and Regulation. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • enzyme
    • Deiodinase
    • Thyronine
    • Type
    • Gene
    • Usp20
    • Cysteine
    • Ubiquitin
    • Adrenergic
    • Β2
    • Also
    • Catalytic
  • deubiquitinating enzyme
    • Deiodinase
    • Thyronine
    • Type
    • Gene
    • Usp20
    • Cysteine
    • Ubiquitin
    • Adrenergic
    • Β2
    • Also
    • Catalytic
  • adrenergic receptor
    • Β2
    • Deiodinase
    • Thyronine
    • Type
    • Factor
    • Receptor
    • Usp20
    • Location
    • Regulation
    • Chromosome
    • Human
    • Known
  • ubiquitin
    • Bond
    • Dubs
    • Isopeptide
    • Residue
    • Glycine
    • Lysine
    • Protein
    • Gene
    • Histidine
    • Usp20
    • Cysteine
    • Adrenergic
  • von hippel-lindau tumour suppressor protein
    • Bond
    • Isopeptide
    • Residue
    • Cysteine
    • Ubiquitin
    • Usp20
    • Glycine
    • Lysine
    • Proteolysis
    • Dubs
    • Histidine
    • Mouse
  • hypoxia-inducible factor 1α
    • Factor
    • Adrenergic
    • Β2
    • Deiodinase
    • Hif1α
    • Thyronine
    • Type
    • Receptor
    • Known
    • Location
    • Regulation
  • thyronine deiodinase type 2
    • Deiodinase
    • Thyronine
    • Type
    • Adrenergic
    • Β2
    • D2
    • Factor
    • Enzyme
    • Receptor
    • Known
    • Location
  • gene
    • Location
    • Chromosome
    • Human
    • Bp
    • Chr
    • Mouse
    • Regulation
    • Band
    • Receptor
    • Ubiquitin
    • Adrenergic
    • Proteolysis

Connections between topic areas Semantic bridges

For USP20, one of the stronger structural bridges in this analysis connects USP20 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
USP20Overview · splits 16 ⟂ 12
USP20Function · splits 18 ⟂ 10
USP20Structure · splits 25 ⟂ 3

Map overview Semantic statistics

USP20

Nodes28
Edges27
Triples117
Avg. degree1.93
Density0.071429
Components1

Source & methodology

TTTA analyzes the structure around USP20 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Structure & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — USP20 · EN edition · Analysis: TopicsToTalkAbout

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