Proteasome subunit alpha type-7 also known as 20S proteasome subunit alpha-4 is a protein that in humans is encoded by the PSMA7 gene. This protein is one of the 17 essential subunits (alpha subunits 1–7, constitutive beta subunits 1–7, and inducible subunits including beta1i, beta2i, beta5i) that contributes to the complete assembly of 20S proteasome…
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PSMA7 topic overview
The analysis highlights Measurement, Clinical significance and Interactions as prominent areas in the source structure around PSMA7.
Related topics
62
Source areas
5
Connected nodes
67
Extracted relationships
119
Concept neighborhoods
11
Bridge connections
67
What this topic covers Research coverage
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Clinical significance · 53 topics
Interactions · 3 topics
Function · 2 topics
Overview · 2 topics
Structure · 2 topics
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
Key facts & relationships
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4R3O, 4R67, 1IRU, 5A0Q
Band
20q13.33 · 2|2 H4
Bgee
gastrocnemius muscle · oocyte · right adrenal gland · left adrenal gland · left coronary artery
BioGPS
More reference expression data
Chr.
Chromosome 20 (human) · Chromosome 2 (mouse)
Explore all related topics Closing gaps
A structured outline of related entities, concepts and subtopics. Open any item to build a new map centered on it.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
How PSMA7 connects Entity context
Entity context groups extracted connections by relationship type. Counts show recurrence in the analyzed source; the examples are research signals, not claims about importance.
The extracted context around PSMA7 shows recurring relationship patterns in the source. For example, PSMA7 → anaphase-promoting complex-dependent catabolic process, antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent, cytoplasm, cytosol, endopeptidase activity, extracellular exosome, Fc-epsilon receptor signaling pathway, hydrolase activity, identical protein binding, interleukin-1-mediated signaling pathway, MAPK cascade, negative regulation of canonical Wnt signaling pathway, negative regulation of G2/M transition of mitotic cell cycle, NIK/NF-kappaB signaling, nucleoplasm, nucleus, peptidase activity, positive regulation of canonical Wnt signaling pathway, post-translational protein modification, postsynapse Another extracted example is PSMA7 → abdominal wall, apex of heart, blastocyst, embryo, endocardial cushion, epiblast, gastrocnemius muscle, left adrenal cortex, left adrenal gland, left coronary artery, mandibular prominence, maxillary prominence, morula, muscle of thigh, oocyte, right adrenal cortex, right adrenal gland, right lung, ventricular zone. Use these groups to spot repeated connection types before inspecting the individual relationships.
PSMA7
Top relations
Gene ontology· 45
PSMA7 → anaphase-promoting complex-dependent catabolic process, antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent, cytoplasm, cytosol, endopeptidase activity, extracellular exosome, Fc-epsilon receptor signaling pathway, hydrolase activity, identical protein binding, interleukin-1-mediated signaling pathway, MAPK cascade, negative regulation of canonical Wnt signaling pathway, negative regulation of G2/M transition of mitotic cell cycle, NIK/NF-kappaB signaling, nucleoplasm, nucleus, peptidase activity, positive regulation of canonical Wnt signaling pathway, post-translational protein modification, postsynapse
Bgee· 19
PSMA7 → abdominal wall, apex of heart, blastocyst, embryo, endocardial cushion, epiblast, gastrocnemius muscle, left adrenal cortex, left adrenal gland, left coronary artery, mandibular prominence, maxillary prominence, morula, muscle of thigh, oocyte, right adrenal cortex, right adrenal gland, right lung, ventricular zone
RNA expression pattern· 19
PSMA7 → abdominal wall, apex of heart, blastocyst, embryo, endocardial cushion, epiblast, gastrocnemius muscle, left adrenal cortex, left adrenal gland, left coronary artery, mandibular prominence, maxillary prominence, morula, muscle of thigh, oocyte, right adrenal cortex, right adrenal gland, right lung, ventricular zone
related to Expression· 6
PSMA7 → Isoelectric, Multiple, Proteasome, T1A, The, This
Relationships are represented as Subject → Predicate → Object triples. Confidence describes extraction strength, not the real-world importance of a relationship; lower-confidence rows may be contextual rather than explicit.
TTTA extracted 119 structured relationships around PSMA7. Examples in this analysis include PSMA7 → Aliases → PSMA7, C6, HSPC, RC6-1, XAPC7, HEL-S-276, proteasome subunit alpha 7, proteasome 20S subunit alpha 7 and PSMA7 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4R3O, 4R67, 1IRU, 5A0Q. The table shows each extracted connection, where it came from and its confidence.
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4R3O, 4R67, 1IRU, 5A0Q
1.00
infobox
PSMA7
Band
20q13.33
1.00
infobox
PSMA7
Band
2|2 H4
1.00
infobox
PSMA7
Bgee
gastrocnemius muscle
1.00
infobox
PSMA7
Bgee
oocyte
1.00
infobox
PSMA7
Bgee
right adrenal gland
1.00
infobox
PSMA7
Bgee
left adrenal gland
1.00
infobox
PSMA7
Bgee
left coronary artery
1.00
infobox
PSMA7
Bgee
apex of heart
1.00
infobox
PSMA7
Bgee
right adrenal cortex
1.00
infobox
PSMA7
Bgee
right lung
1.00
infobox
PSMA7
Bgee
left adrenal cortex
1.00
infobox
PSMA7
Bgee
muscle of thigh
1.00
infobox
PSMA7
Bgee
blastocyst
1.00
infobox
PSMA7
Bgee
embryo
1.00
infobox
PSMA7
Bgee
endocardial cushion
1.00
infobox
PSMA7
Bgee
morula
1.00
infobox
PSMA7
Bgee
ventricular zone
1.00
infobox
PSMA7
Bgee
maxillary prominence
1.00
infobox
PSMA7
Bgee
abdominal wall
1.00
infobox
PSMA7
Bgee
mandibular prominence
1.00
infobox
PSMA7
Bgee
epiblast
1.00
infobox
PSMA7
BioGPS
More reference expression data
1.00
infobox
PSMA7
Chr.
Chromosome 20 (human)
1.00
infobox
PSMA7
Chr.
Chromosome 2 (mouse)
1.00
infobox
PSMA7
Databases
NCBI: entry; OMA: entry
1.00
infobox
PSMA7
End
62,143,440 bp
1.00
infobox
PSMA7
End
179,684,226 bp
1.00
infobox
PSMA7
Ensembl
ENSG00000101182
1.00
infobox
No triples extracted yet.
Related concept clusters Concept neighborhoods
Concept neighborhoods group terms that sit near one another in the extracted graph. They are useful for discovering adjacent language and context, but proximity does not by itself imply a factual relationship.
The concept neighborhoods around PSMA7 bring nearby vocabulary together. In this analysis, examples include Location, Subunit and Tumor. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
protein
Psma7
Complex
Tumor
Function
Transcription
Type-7
Subunit
Assembly
Human
Proteolysis
Role
Ups
proteasome
Complex
Protein
20s
Alpha
Subunit
Function
Type-7
Assembly
Psma7
Gene
Clinical
Human
ubiquitin–proteasome system
Complex
Protein
20s
Alpha
Subunit
Function
Type-7
Assembly
Psma7
Gene
Clinical
Human
gene
Chromosome
Location
Psma7
Degradation
Expression
Transcription
Band
Bp
Chr
Human
Tumor
Function
PSMA7
Location
Subunit
Tumor
Associated
Expression
Function
Type-7
Bp
Chr
Human
Chromosome
Core
psma7
Location
Subunit
Tumor
Associated
Expression
Function
Type-7
Bp
Chr
Human
Chromosome
Core
function
Location
Bp
Chr
Human
Chromosome
Psma7
Proteasome
Gene
Tumor
Protein
Transcription
Band
clinical significance
Associated
Complex
Location
Proteasome
Expression
Function
Bp
Chr
Human
Proteasomes
Two
Chromosome
Connections between topic areas Semantic bridges
Semantic bridges connect parts of the graph that would otherwise be more separate. A bridge is a structural signal in this analysis, not a claim that the two topic areas are equivalent.
For PSMA7, one of the stronger structural bridges in this analysis connects PSMA7 with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
Number of nodes, edges, triples, density and central hubs. Use it to gauge the size and connectivity of the map.
PSMA7
Nodes68
Edges67
Triples119
Avg. degree1.97
Density0.029412
Components1
Source & methodology
TTTA analyzes the structure around PSMA7 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Measurement, Clinical significance & Interactions, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — PSMA7 · EN edition · Analysis: TopicsToTalkAbout
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