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Dopamine transporter

The dopamine transporter (DAT, also sodium-dependent dopamine transporter) is a membrane-spanning protein coded for in humans by the SLC6A3 gene (also known as DAT1), that pumps the neurotransmitter dopamine out of the synaptic cleft back into cytosol. In the cytosol, other transporters sequester the dopamine into vesicles for storage and later release.…

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Location and distribution

NigrostriatalMesolimbicMesocortical pathwayNucleiSubstantia nigra
20 related topics

Genetics and regulation

DAT1Rs28363170IntronNurr1Nuclear receptor
22 related topics

Ligands and modulators

NorepinephrineCatecholaminergic activity enhancersSelegilinePPAPBPAP
36 related topics

Mechanism

SymporterCo-transportNa+IonsCl−
19 related topics

Key facts & relationships

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Aliases
SLC6A3, solute carrier family 6 (neurotransmitter transporter), member 3, DAT, DAT1, PKDYS, solute carrier family 6 member 3, Dopamine transporter, PKDYS1
Band
5p15.33 · 13 C1|13 40.1 cM
Bgee
substantia nigra · testicle · gonad · left lobe of thyroid gland · right ovary
BioGPS
More reference expression data
Chr.
Chromosome 5 (human) · Chromosome 13 (mouse)
Databases
NCBI: entry; OMA: entry

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Overview

Function

Mechanism

Protein structure

Location and distribution

Genetics and regulation

Biological role and disorders

Pharmacology

Interactions

Ligands and modulators

Advanced semantic analysis

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Map overview Semantic statistics

Dopamine transporter

Nodes206
Edges205
Triples173
Avg. degree1.99
Density0.009709
Components1

How this topic connects Entity context

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Dopamine transporter

Top relations

Gene ontology · 51
Dopamine transporter → adenohypophysis development, ageing, axon, cell surface, cytoplasm, dopamine binding, dopamine biosynthetic process, dopamine catabolic process, dopamine transport, dopamine uptake, dopamine uptake involved in synaptic transmission, dopamine:sodium symporter activity, dopaminergic synapse, flotillin complex, integral component of membrane, integral component of plasma membrane, integral component of postsynaptic membrane, integral component of presynaptic membrane, lactation, locomotory behavior
Bgee · 19
Dopamine transporter → arcuate nucleus, body of uterus, canal of the cervix, central gray substance of midbrain, embryo, epithelium of lens, epithelium of small intestine, gonad, hypothalamus, left lobe of thyroid gland, left ovary, olfactory bulb, renal cortex, right lobe of thyroid gland, right ovary, substantia nigra, suprachiasmatic nucleus, testicle, ventral tegmental area
RNA expression pattern · 19
Dopamine transporter → arcuate nucleus, body of uterus, canal of the cervix, central gray substance of midbrain, embryo, epithelium of lens, epithelium of small intestine, gonad, hypothalamus, left lobe of thyroid gland, left ovary, olfactory bulb, renal cortex, right lobe of thyroid gland, right ovary, substantia nigra, suprachiasmatic nucleus, testicle, ventral tegmental area
related to External links · 16
Dopamine transporter → Associations, Clinical TrialsDopamine, Dopamine, Drosophila, Experiments, Medicine Medical Subject Headings, MeSH, National Library, Overview, PDB, PDBe-KB, Publications, Q7K4Y6, Sodium-dependent, Transporter, UniProt
related to Pharmacology · 13
Dopamine transporter → Amphetamine, CAMKIIα-mediated, Cocaine, DAT, DAT-coupled L-type, In, Once, Phosphorylated DAT, TAAR1, TAAR1-independent, The, VMAT2, When
related to Biological role and disorders · 10
Dopamine transporter → Additionally, ADHD, An, DAT, Data, Differences, The, These, This, VNTR
related to DAT–Cav coupling · 9
Dopamine transporter → As, CAMKII, CAMKII-mediated, Cav, Cav1, DAT, L-type, Preliminary, This
related to Protein structure · 9
Dopamine transporter → DAT, Drosophila, Further, GABA, The, These, TMD, TMDs, X-ray
related to Interactions · 4
Dopamine transporter → Alpha-synuclein, Dopamine, PICK1, Synaptogyrin-3
Band · 2
Dopamine transporter → 13 C1|13 40.1 cM, 5p15.33

Important terminology Word statistics

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Important terminology

dopamine dat transporter protein gene membrane also amphetamine reuptake human may chromosome bp disorders synaptic neurotransmitter slc6a3 sodium transport chr

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Dopamine transporterAliasesSLC6A3, solute carrier family 6 (neurotransmitter transporter), member 3, DAT, DAT1, PKDYS, solute carrier family 6 member 3, Dopamine transporter, PKDYS11.00infobox
Dopamine transporterBand5p15.331.00infobox
Dopamine transporterBand13 C1|13 40.1 cM1.00infobox
Dopamine transporterBgeesubstantia nigra1.00infobox
Dopamine transporterBgeetesticle1.00infobox
Dopamine transporterBgeegonad1.00infobox
Dopamine transporterBgeeleft lobe of thyroid gland1.00infobox
Dopamine transporterBgeeright ovary1.00infobox
Dopamine transporterBgeecanal of the cervix1.00infobox
Dopamine transporterBgeeleft ovary1.00infobox
Dopamine transporterBgeeright lobe of thyroid gland1.00infobox
Dopamine transporterBgeebody of uterus1.00infobox
Dopamine transporterBgeerenal cortex1.00infobox
Dopamine transporterBgeeventral tegmental area1.00infobox
Dopamine transporterBgeeembryo1.00infobox
Dopamine transporterBgeehypothalamus1.00infobox
Dopamine transporterBgeearcuate nucleus1.00infobox
Dopamine transporterBgeeepithelium of small intestine1.00infobox
Dopamine transporterBgeeepithelium of lens1.00infobox
Dopamine transporterBgeecentral gray substance of midbrain1.00infobox
Dopamine transporterBgeesuprachiasmatic nucleus1.00infobox
Dopamine transporterBgeeolfactory bulb1.00infobox
Dopamine transporterBioGPSMore reference expression data1.00infobox
Dopamine transporterChr.Chromosome 5 (human)1.00infobox
Dopamine transporterChr.Chromosome 13 (mouse)1.00infobox
Dopamine transporterDatabasesNCBI: entry; OMA: entry1.00infobox
Dopamine transporterEnd1,445,440 bp1.00infobox
Dopamine transporterEnd73,726,791 bp1.00infobox
Dopamine transporterEnsemblENSG00000142319 ENSG000002769961.00infobox
Dopamine transporterEntrez65311.00infobox

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