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Pemoline

Pemoline, formerly sold under the brand name Cylert among others, is a stimulant medication which was used in the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy. It has since been discontinued in most countries due to rare but serious liver toxicity. The medication was taken by mouth.

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Micromedex Detailed Consumer Information
ATC code
N06BA05 (WHO)
CAS Number
2152-34-3 N
ChEBI
CHEBI:7953 Y
ChEMBL
ChEMBL1177 Y

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Overview

Medical uses

Side effects

Overdose

Interactions

Pharmacology

Chemistry

History

Society and culture

Research

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Map overview Semantic statistics

Pemoline

Nodes94
Edges93
Triples131
Avg. degree1.98
Density0.021277
Components1

How this topic connects Entity context

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Pemoline

Top relations

related to history · 23
Pemoline → Abbott Laboratories, ADHD, Canada, Cases, Clinicians, December, Drug Administration, Drug Administration's MedWatch, FDA, FDA's, However, In, Japan, June, May, November, September, Serious, These, United Kingdom
related to Liver toxicity · 15
Pemoline → ADHD, Approximately, As, Because, Canada, FDA, However, Japan, On, Over, Rarely, Since, Some, There, United States
related to Names · 15
Pemoline → BANTooltip British Approved Name, Betanamin, Ceractiv, Cylert, Hyperilex, INNTooltip International Nonproprietary Name, Kethamed, Name, Ronyl, Stimul, Tamilan, Tradon, Tropocer, USANTooltip United States Adopted, Volital
related to Availability · 12
Pemoline → Argentina, Belgium, Canada, Germany, However, It, Japan, Luxembourg, Spain, Switzerland, United Kingdom, United States
related to Pharmacodynamics · 10
Pemoline → As, By, However, II, In, It, IV, Nonetheless, The, While
related to Legal status · 7
Pemoline → Convention, DEA ACSCN, IV, Psychotropic Substances, Schedule IV Non-Narcotic, Stimulant, Under
Legal status · 5
Pemoline → AU: S4 (Prescription only), BR: Class B1 (Psychoactive drugs), CA: Schedule IV, DE: Prescription only (Anlage III for higher doses), US: Schedule IV
related to Medical uses · 4
Pemoline → ADHD, It, The, This
related to Pharmacokinetics · 4
Pemoline → Peak, Steady-state, Studies, The
has effect · 2
Pemoline → It, Side

Important terminology Word statistics

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Important terminology

liver toxicity united states stimulant effects treatment used adhd narcolepsy due drug medication however available cases japan serious stimulants potential

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Pemoline3D model (JSmol)Interactive image1.00infobox
PemolineAHFS/Drugs.comMicromedex Detailed Consumer Information1.00infobox
PemolineATC codeN06BA05 (WHO)1.00infobox
PemolineCAS Number2152-34-3 N1.00infobox
PemolineChEBICHEBI:7953 Y1.00infobox
PemolineChEMBLChEMBL1177 Y1.00infobox
PemolineChemSpider4561 Y1.00infobox
PemolineChiralityRacemic mixture1.00infobox
PemolineCompTox Dashboard (EPA)DTXSID30234271.00infobox
PemolineDrug classStimulant; Dopamine reuptake inhibitor; Dopamine releasing agent1.00infobox
PemolineDrugBankDB01230 Y1.00infobox
PemolineECHA InfoCard100.016.7631.00infobox
PemolineElimination half-life7–12 hours1.00infobox
PemolineExcretionMainly urine1.00infobox
PemolineFormulaC9H8N2O21.00infobox
PemolineKEGGD00744 Y1.00infobox
PemolineLegal statusAU: S4 (Prescription only)1.00infobox
PemolineLegal statusBR: Class B1 (Psychoactive drugs)1.00infobox
PemolineLegal statusCA: Schedule IV1.00infobox
PemolineLegal statusDE: Prescription only (Anlage III for higher doses)1.00infobox
PemolineLegal statusUS: Schedule IV1.00infobox
PemolineMetabolismLiver1.00infobox
PemolineMetabolitesVarious1.00infobox
PemolineMolar mass176.175 g·mol−11.00infobox
PemolineOther namesPheniminooxazolidinone; Phenylisohydantoin; Phenylpseudohydantoin; Phenilone; 2-Imino-5-phenyl-4-oxazolidinone; 2-Amino-5-phenyl-1,3-oxazol-4(5H)-one1.00infobox
PemolineProtein binding≤50%1.00infobox
PemolinePubChem CID47231.00infobox
PemolineRoutes of administrationBy mouth1.00infobox
PemolineTrade namesCylert, others1.00infobox
PemolineUNII7GAQ2332NK1.00infobox

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