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MPTP

MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) is an organic compound. It is classified as a tetrahydropyridine. It is of interest as a precursor to the monoaminergic neurotoxin MPP+, which causes permanent symptoms of Parkinson's disease by destroying dopaminergic neurons in the substantia nigra of the brain. It has been used to study disease…

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Overview

Toxicity

Discovery in illicit drug users

Contribution of MPTP to research into Parkinson's disease

Synthesis and uses

Analogues

In popular culture

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Map overview Semantic statistics

MPTP

Nodes88
Edges87
Triples96
Avg. degree1.98
Density0.022727
Components1

How this topic connects Entity context

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MPTP

Top relations

related to External links · 36
MPTP → Archived, Ballard, Bibcode, Chronic Parkinsonism, Contains, Erowid MPTP Vault, February, Frozen Addict, How, Humans Due, Ian, Irwin, James, JSTOR, June, Junkie's Brain Helps Parkinson's, Langston, March, Meperidine-Analog Synthesis, NOVA
related to Discovery in illicit drug users · 24
MPTP → After, An, Barry Kidston, California, In, Investigators, Kidston, Lewy, Lund University Hospital, Maryland, Mental Health, MPPP, National Institute, NIH, Parkinson's, Parkinsonism, Santa Clara County, Sweden, The, United States
related to In popular culture · 8
MPTP → In, Law, MPTP-induced Parkinson's, Neuromancer, Order, Parkinsonism, Stiff, William Gibson
related to Contribution of MPTP to research into Parkinson's disease · 7
MPTP → Knowledge, Langston, Mouse, MPTP-induced Parkinson's, Parkinson's, Parkinsonism, The
related to Toxicity · 7
MPTP → Injection, MAO-B, MPP, MPPP, Once, Parkinsonism, SNc
related to Analogues · 6
MPTP → Analogues, CH3-MPTP, HPP, HPTP, NH2-MPTP, The
related to Synthesis and uses · 6
MPTP → In, It, MPP, Parkinson-like, While, Ziering
causes · 2
MPTP → Parkinsonism in primates, rapid onset of Parkinsonism

Important terminology Word statistics

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Important terminology

parkinson's neurons disease mpp symptoms parkinsonism brain used effects mppp substantia nigra causes dopaminergic toxic cell langston may compound complex

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
MPTPcausesrapid onset of Parkinsonism0.90text
MPTPcausesParkinsonism in primates0.90text
MPTPrelated to AnaloguesAnalogues0.60section
MPTPrelated to AnaloguesNH2-MPTP0.60section
MPTPrelated to AnaloguesCH3-MPTP0.60section
MPTPrelated to AnaloguesThe0.60section
MPTPrelated to AnaloguesHPTP0.60section
MPTPrelated to AnaloguesHPP0.60section
MPTPrelated to Contribution of MPTP to research into Parkinson's diseaseLangston0.60section
MPTPrelated to Contribution of MPTP to research into Parkinson's diseaseParkinsonism0.60section
MPTPrelated to Contribution of MPTP to research into Parkinson's diseaseParkinson's0.60section
MPTPrelated to Contribution of MPTP to research into Parkinson's diseaseThe0.60section

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