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Paneth cell

Paneth cells are cells in the small intestine epithelium, alongside goblet cells, enterocytes, and enteroendocrine cells. Some can also be found in the cecum and appendix. They lie interspersed between intestinal stem cells in the intestinal glands (also called crypts of Lieberkühn) and under the large eosinophilic refractile granules that occupy most of…

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Location
Small intestine epithelium
FMA
62897
Latin
cellula panethensis
MeSH
D019879
TH
H3.04.03.0.00017

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Function

Clinical significance

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Map overview Semantic statistics

Paneth cell

Nodes97
Edges96
Triples118
Avg. degree1.98
Density0.020619
Components1

How this topic connects Entity context

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Paneth cell

Top relations

related to Epithelium maintenance · 16
Paneth cell → DLL1, DLL4, Frizzled, If Notum, Notch, Notch1, Notch2, Notum, Paneth, Recently, Tcf, They, Wnt, Wnt11, Wnt3a, Wnt9b
related to Antimicrobial secretions · 15
Paneth cell → Candida, DEFA5, DEFA6, Due, Escherichia, Gram, HD-5, HD-6, Human Paneth, Listeria, Paneth, Salmonella, The, These, This
related to Sensing microbiota · 14
Paneth cell → CpG-ODN, DNA, For, Gram, Gram-negative, Internalizing, MyD88-dependent, PAMPs, Paneth, Surprisingly, They, TLR, TLR4, TLR9
related to Zinc · 12
Paneth cell → Akkermansia, Dietary, HD5, In, It, Mice, Normally, Paneth, PC, Zinc, Zn, ZnT
related to Necrotizing enterocolitis · 11
Paneth cell → About, Bacteroidetes, Enterobacteriaceae, Firmicutes, It, Paneth, Proteobacteria, The, This, Thus, When
related to Clinical significance · 9
Paneth cell → Abnormal Paneth, Collectively, Crohn's, HD-5, HD-6, However, In, It, Paneth
related to Non-alcoholic fatty liver disease · 9
Paneth cell → Crohn's, Harryflintia, It, Muribaculaceae, Murine, Paneth, Panth, R-Spondin1, Whereas
related to Secretory autophagy · 9
Paneth cell → Crohn's, During, ER-Golgi, Golgi, In, LC3, Not, Paneth, Should
related to Structure · 6
Paneth cell → Furthermore, Like, Paneth, There, This, Unlike
related to Phagocytic function · 5
Paneth cell → Cesium-137, GI, Paneth, The, These

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Important terminology

paneth cells cell intestinal antimicrobial stem small epithelium secretory also intestine secretion bacteria function autophagy zinc bacterial disease granules defensins

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Paneth cellFMA628971.00infobox
Paneth cellLatincellula panethensis1.00infobox
Paneth cellLocationSmall intestine epithelium1.00infobox
Paneth cellMeSHD0198791.00infobox
Paneth cellTHH3.04.03.0.000171.00infobox
autophagyinstance ofseveral of the Crohn's disease-risk alleles are associated with Paneth cell dysfunction are involved in processes0.80text
the unfolded protein responseinstance ofseveral of the Crohn's disease-risk alleles are associated with Paneth cell dysfunction are involved in processes0.80text
and the regulation of mitochondrial function.It is believed that the dysfunction of Paneth cells compromises antimicrobial peptides leading to a microbiota composition shiftinstance ofseveral of the Crohn's disease-risk alleles are associated with Paneth cell dysfunction are involved in processes0.80text
and even dysbiosisinstance ofseveral of the Crohn's disease-risk alleles are associated with Paneth cell dysfunction are involved in processes0.80text
Paneth cellrelated to Antimicrobial secretionsThe0.60section
Paneth cellrelated to Antimicrobial secretionsPaneth0.60section
Paneth cellrelated to Antimicrobial secretionsThese0.60section

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