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Proto-oncogene c-KIT is the gene encoding the receptor tyrosine kinase protein known as tyrosine-protein kinase KIT, CD117 (cluster of differentiation 117) or mast/stem cell growth factor receptor (SCFR). Multiple transcript variants encoding different isoforms have been found for this gene. KIT was first described by the German biochemist Axel Ullrich…
The analysis highlights Standards, Role in cancer and Interactions as prominent areas in the source structure around KIT gene.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around KIT gene shows recurring relationship patterns in the source. For example, KIT gene → acrosomal vesicle, actin cytoskeleton reorganization, ATP binding, B cell differentiation, cell chemotaxis, cell differentiation, cell surface, cell-cell junction, cellular response to thyroid hormone stimulus, cytokine binding, cytokine-mediated signaling pathway, cytoplasm, cytoplasmic side of plasma membrane, dendritic cell cytokine production, detection of mechanical stimulus involved in sensory perception of sound, developmental pigmentation, digestive tract development, ectopic germ cell programmed cell death, embryonic hemopoiesis, epithelial cell proliferation Another extracted example is KIT gene → cardia, cerebellar vermis, decidua, dermis, epithelium of lactiferous gland, gastrula, gonad, lactiferous duct, lateral nuclear group of thalamus, liver parenchyma, lobe of cerebellum, muscle layer of urethra, parotid gland, primary oocyte, secondary oocyte, skin of hip, skin of thigh, visceral pleura, zygote. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
kit cell c-kit receptor cells stem gene also hematopoietic used cancer kinase bp mast human tyrosine mobilization signaling chr band
TTTA extracted 197 structured relationships around KIT gene. Examples in this analysis include KIT gene → 2.7.10.1 → ↗ and KIT gene → Aliases → KIT, C-Kit, CD117, PBT, SCFR, KIT proto-oncogene receptor tyrosine kinase, MASTC, KIT proto-oncogene, receptor tyrosine kinase. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| KIT gene | 2.7.10.1 | ↗ | 1.00 | infobox |
| KIT gene | Aliases | KIT, C-Kit, CD117, PBT, SCFR, KIT proto-oncogene receptor tyrosine kinase, MASTC, KIT proto-oncogene, receptor tyrosine kinase | 1.00 | infobox |
| KIT gene | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4U0I, 1PKG, 1T45, 1T46, 2E9W, 2EC8, 2VIF, 3G0E, 3G0F, 4HVS, 4K94, 4K9E, 4PGZ, 2IUH | 1.00 | infobox |
| KIT gene | Band | 4q12 | 1.00 | infobox |
| KIT gene | Band | 5 C3.3|5 39.55 cM | 1.00 | infobox |
| KIT gene | Bgee | lateral nuclear group of thalamus | 1.00 | infobox |
| KIT gene | Bgee | secondary oocyte | 1.00 | infobox |
| KIT gene | Bgee | skin of thigh | 1.00 | infobox |
| KIT gene | Bgee | epithelium of lactiferous gland | 1.00 | infobox |
| KIT gene | Bgee | gonad | 1.00 | infobox |
| KIT gene | Bgee | lactiferous duct | 1.00 | infobox |
| KIT gene | Bgee | cardia | 1.00 | infobox |
| KIT gene | Bgee | parotid gland | 1.00 | infobox |
| KIT gene | Bgee | skin of hip | 1.00 | infobox |
| KIT gene | Bgee | visceral pleura | 1.00 | infobox |
| KIT gene | Bgee | lobe of cerebellum | 1.00 | infobox |
| KIT gene | Bgee | cerebellar vermis | 1.00 | infobox |
| KIT gene | Bgee | primary oocyte | 1.00 | infobox |
| KIT gene | Bgee | zygote | 1.00 | infobox |
| KIT gene | Bgee | gastrula | 1.00 | infobox |
| KIT gene | Bgee | dermis | 1.00 | infobox |
| KIT gene | Bgee | liver parenchyma | 1.00 | infobox |
| KIT gene | Bgee | muscle layer of urethra | 1.00 | infobox |
| KIT gene | Bgee | decidua | 1.00 | infobox |
| KIT gene | BioGPS | n/a | 1.00 | infobox |
| KIT gene | Chr. | Chromosome 4 (human) | 1.00 | infobox |
| KIT gene | Chr. | Chromosome 5 (mouse) | 1.00 | infobox |
| KIT gene | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| KIT gene | End | 54,740,715 bp | 1.00 | infobox |
| KIT gene | End | 75,817,382 bp | 1.00 | infobox |
The concept neighborhoods around KIT gene bring nearby vocabulary together. In this analysis, examples include Encoding, Chromosome and Bp. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For KIT gene, one of the stronger structural bridges in this analysis connects KIT gene with Role in cancer. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around KIT gene to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Standards, Role in cancer & Interactions, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — KIT gene · EN edition · Analysis: TopicsToTalkAbout