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KIT gene: Standards, Role in cancer & Interactions

Proto-oncogene c-KIT is the gene encoding the receptor tyrosine kinase protein known as tyrosine-protein kinase KIT, CD117 (cluster of differentiation 117) or mast/stem cell growth factor receptor (SCFR). Multiple transcript variants encoding different isoforms have been found for this gene. KIT was first described by the German biochemist Axel Ullrich…

Language: English [EN]
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KIT gene topic overview

The analysis highlights Standards, Role in cancer and Interactions as prominent areas in the source structure around KIT gene.

Related topics
81
Source areas
7
Connected nodes
88
Extracted relationships
197
Concept neighborhoods
27
Bridge connections
88

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Interactions · 24 topics
Role in cancer · 24 topics
Cell surface marker · 14 topics
Function · 9 topics
Mobilization · 6 topics
Overview · 3 topics
Structure · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

2.7.10.1
Aliases
KIT, C-Kit, CD117, PBT, SCFR, KIT proto-oncogene receptor tyrosine kinase, MASTC, KIT proto-oncogene, receptor tyrosine kinase
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4U0I, 1PKG, 1T45, 1T46, 2E9W, 2EC8, 2VIF, 3G0E, 3G0F, 4HVS, 4K94, 4K9E, 4PGZ, 2IUH
Band
4q12 · 5 C3.3|5 39.55 cM
Bgee
lateral nuclear group of thalamus · secondary oocyte · skin of thigh · epithelium of lactiferous gland · gonad
BioGPS
n/a

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Structure

Cell surface marker

Mobilization

Role in cancer

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How KIT gene connects Entity context

The extracted context around KIT gene shows recurring relationship patterns in the source. For example, KIT gene → acrosomal vesicle, actin cytoskeleton reorganization, ATP binding, B cell differentiation, cell chemotaxis, cell differentiation, cell surface, cell-cell junction, cellular response to thyroid hormone stimulus, cytokine binding, cytokine-mediated signaling pathway, cytoplasm, cytoplasmic side of plasma membrane, dendritic cell cytokine production, detection of mechanical stimulus involved in sensory perception of sound, developmental pigmentation, digestive tract development, ectopic germ cell programmed cell death, embryonic hemopoiesis, epithelial cell proliferation Another extracted example is KIT gene → cardia, cerebellar vermis, decidua, dermis, epithelium of lactiferous gland, gastrula, gonad, lactiferous duct, lateral nuclear group of thalamus, liver parenchyma, lobe of cerebellum, muscle layer of urethra, parotid gland, primary oocyte, secondary oocyte, skin of hip, skin of thigh, visceral pleura, zygote. Use these groups to spot repeated connection types before inspecting the individual relationships.

KIT gene

Top relations

Gene ontology · 118
KIT gene → acrosomal vesicle, actin cytoskeleton reorganization, ATP binding, B cell differentiation, cell chemotaxis, cell differentiation, cell surface, cell-cell junction, cellular response to thyroid hormone stimulus, cytokine binding, cytokine-mediated signaling pathway, cytoplasm, cytoplasmic side of plasma membrane, dendritic cell cytokine production, detection of mechanical stimulus involved in sensory perception of sound, developmental pigmentation, digestive tract development, ectopic germ cell programmed cell death, embryonic hemopoiesis, epithelial cell proliferation
Bgee · 19
KIT gene → cardia, cerebellar vermis, decidua, dermis, epithelium of lactiferous gland, gastrula, gonad, lactiferous duct, lateral nuclear group of thalamus, liver parenchyma, lobe of cerebellum, muscle layer of urethra, parotid gland, primary oocyte, secondary oocyte, skin of hip, skin of thigh, visceral pleura, zygote
RNA expression pattern · 19
KIT gene → cardia, cerebellar vermis, decidua, dermis, epithelium of lactiferous gland, gastrula, gonad, lactiferous duct, lateral nuclear group of thalamus, liver parenchyma, lobe of cerebellum, muscle layer of urethra, parotid gland, primary oocyte, secondary oocyte, skin of hip, skin of thigh, visceral pleura, zygote
related to External links · 10
KIT gene → C-kit, Cancer TermsHuman KIT, KIT, Medicine Medical Subject Headings, MeSH, National Library, NCI Dictionary, Proteins, Proto-Oncogene, UCSC Genome Browser
Band · 2
KIT gene → 4q12, 5 C3.3|5 39.55 cM
Chr. · 2
KIT gene → Chromosome 4 (human), Chromosome 5 (mouse)
End · 2
KIT gene → 54,740,715 bp, 75,817,382 bp
2.7.10.1 · 1
KIT gene → ↗
Aliases · 1
KIT gene → KIT, C-Kit, CD117, PBT, SCFR, KIT proto-oncogene receptor tyrosine kinase, MASTC, KIT proto-oncogene, receptor tyrosine kinase
Available structures · 1
KIT gene → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4U0I, 1PKG, 1T45, 1T46, 2E9W, 2EC8, 2VIF, 3G0E, 3G0F, 4HVS, 4K94, 4K9E, 4PGZ, 2IUH

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

kit cell c-kit receptor cells stem gene also hematopoietic used cancer kinase bp mast human tyrosine mobilization signaling chr band

KIT gene relationships Subject–Predicate–Object triples

TTTA extracted 197 structured relationships around KIT gene. Examples in this analysis include KIT gene → 2.7.10.1 → ↗ and KIT gene → Aliases → KIT, C-Kit, CD117, PBT, SCFR, KIT proto-oncogene receptor tyrosine kinase, MASTC, KIT proto-oncogene, receptor tyrosine kinase. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
KIT gene2.7.10.11.00infobox
KIT geneAliasesKIT, C-Kit, CD117, PBT, SCFR, KIT proto-oncogene receptor tyrosine kinase, MASTC, KIT proto-oncogene, receptor tyrosine kinase1.00infobox
KIT geneAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4U0I, 1PKG, 1T45, 1T46, 2E9W, 2EC8, 2VIF, 3G0E, 3G0F, 4HVS, 4K94, 4K9E, 4PGZ, 2IUH1.00infobox
KIT geneBand4q121.00infobox
KIT geneBand5 C3.3|5 39.55 cM1.00infobox
KIT geneBgeelateral nuclear group of thalamus1.00infobox
KIT geneBgeesecondary oocyte1.00infobox
KIT geneBgeeskin of thigh1.00infobox
KIT geneBgeeepithelium of lactiferous gland1.00infobox
KIT geneBgeegonad1.00infobox
KIT geneBgeelactiferous duct1.00infobox
KIT geneBgeecardia1.00infobox
KIT geneBgeeparotid gland1.00infobox
KIT geneBgeeskin of hip1.00infobox
KIT geneBgeevisceral pleura1.00infobox
KIT geneBgeelobe of cerebellum1.00infobox
KIT geneBgeecerebellar vermis1.00infobox
KIT geneBgeeprimary oocyte1.00infobox
KIT geneBgeezygote1.00infobox
KIT geneBgeegastrula1.00infobox
KIT geneBgeedermis1.00infobox
KIT geneBgeeliver parenchyma1.00infobox
KIT geneBgeemuscle layer of urethra1.00infobox
KIT geneBgeedecidua1.00infobox
KIT geneBioGPSn/a1.00infobox
KIT geneChr.Chromosome 4 (human)1.00infobox
KIT geneChr.Chromosome 5 (mouse)1.00infobox
KIT geneDatabasesNCBI: entry; OMA: entry1.00infobox
KIT geneEnd54,740,715 bp1.00infobox
KIT geneEnd75,817,382 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around KIT gene bring nearby vocabulary together. In this analysis, examples include Encoding, Chromosome and Bp. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • KIT gene
    • Encoding
    • Chromosome
    • Bp
    • Chr
    • Cell
    • Kinase
    • Receptor
    • Mouse
    • Band
    • Role
    • Activity
    • Also
  • kit gene
    • Location
    • Human
    • Encoding
    • Chromosome
    • Bp
    • Chr
    • Cell
    • Tyrosine
    • External
    • Kinase
    • Mast
    • Receptor
  • receptor tyrosine kinase
    • Kinase
    • Tyrosine
    • Factor
    • Receptor
    • Activity
    • Protein
    • Stem
    • External
    • Cell
    • Gene
    • Chromosome
    • Differentiation
  • cluster of differentiation
    • Protein
    • Activity
    • Factor
    • Surface
    • Tyrosine
    • Cell
    • Kinase
    • Mast
    • Signaling
    • External
    • Gene
    • Stem
  • hematopoietic stem cells
    • Tyrosine
    • Hematopoietic
    • Expression
    • Prostate
    • Progenitors
    • Cells
    • Stem
    • Used
    • Levels
    • Mouse
    • Surface
    • Also
  • cancer
    • Expression
    • Location
    • Prostate
    • Proto-oncogene
    • Also
    • Human
    • Receptor
    • Gene
    • Cell
    • External
    • Kit
    • Cells
  • stem cell factor
    • Tyrosine
    • Stem
    • Kinase
    • Cells
    • Factor
    • Protein
    • Receptor
    • Kit
    • Mast
    • Activity
    • Differentiation
    • Hematopoietic
  • receptor tyrosine kinase iii family
    • Kinase
    • Tyrosine
    • Factor
    • Receptor
    • Activity
    • Protein
    • Stem
    • External
    • Cell
    • Gene
    • Chromosome
    • Differentiation

Connections between topic areas Semantic bridges

For KIT gene, one of the stronger structural bridges in this analysis connects KIT gene with Role in cancer. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
KIT geneRole in cancer · splits 64 ⟂ 25
KIT geneInteractions · splits 64 ⟂ 25
KIT geneCell surface marker · splits 74 ⟂ 15
KIT geneFunction · splits 79 ⟂ 10
KIT geneMobilization · splits 82 ⟂ 7
KIT geneOverview · splits 85 ⟂ 4

Map overview Semantic statistics

KIT gene

Nodes89
Edges88
Triples197
Avg. degree1.98
Density0.022472
Components1

Source & methodology

TTTA analyzes the structure around KIT gene to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Standards, Role in cancer & Interactions, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — KIT gene · EN edition · Analysis: TopicsToTalkAbout

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