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Programmed cell death protein 1

Programmed cell death protein 1 (PD-1) (CD279 cluster of differentiation 279) is a protein encoded in humans by the PDCD1 gene. PD-1 is a cell surface receptor on T cells and B cells that has a role in regulating the immune system's response to the cells of the human body by down-regulating the immune system and promoting self-tolerance by suppressing T…

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Aliases
PDCD1, CD279, PD-1, PD1, SLEB2, hPD-1, hPD-l, hSLE1, Programmed cell death 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2M2D, 3RRQ, 4ZQK
Band
2q37.3 · 1|1 D
Bgee
lymph node · granulocyte · spleen · right auricle of heart · appendix
BioGPS
More reference expression data
Chr.
Chromosome 2 (human) · Chromosome 1 (mouse)

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Programmed cell death protein 1

Nodes83
Edges82
Triples86
Avg. degree1.98
Density0.024096
Components1

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Programmed cell death protein 1

Top relations

Bgee · 17
Programmed cell death protein 1 → appendix, blood, cumulus cell, embryo, granulocyte, left ventricle, lymph node, mesenteric lymph nodes, mucosa of transverse colon, ovary, primary oocyte, right auricle of heart, spleen, thymus, tonsil, upper lobe of left lung, zygote
RNA expression pattern · 17
Programmed cell death protein 1 → appendix, blood, cumulus cell, embryo, granulocyte, left ventricle, lymph node, mesenteric lymph nodes, mucosa of transverse colon, ovary, primary oocyte, right auricle of heart, spleen, thymus, tonsil, upper lobe of left lung, zygote
Gene ontology · 16
Programmed cell death protein 1 → apoptotic process, external side of plasma membrane, humoral immune response, immune system process, integral component of membrane, membrane, multicellular organism development, negative regulation of apoptotic process, negative regulation of tolerance induction, plasma membrane, positive regulation of apoptotic process, positive regulation of T cell apoptotic process, protein binding, signal transducer activity, signal transduction, T cell costimulation
related to External links · 13
Programmed cell death protein 1 → Medicine, Medicine Medical Subject Headings, MeSH, National Library, Overview, PDB, PDBe-KB, PDCD1, Programmed, Q15116, This, UniProt, United States National Library
Band · 2
Programmed cell death protein 1 → 1|1 D, 2q37.3
Chr. · 2
Programmed cell death protein 1 → Chromosome 1 (mouse), Chromosome 2 (human)
End · 2
Programmed cell death protein 1 → 241,858,894 bp, 93,980,278 bp
Aliases · 1
Programmed cell death protein 1 → PDCD1, CD279, PD-1, PD1, SLEB2, hPD-1, hPD-l, hSLE1, Programmed cell death 1
Available structures · 1
Programmed cell death protein 1 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2M2D, 3RRQ, 4ZQK
BioGPS · 1
Programmed cell death protein 1 → More reference expression data

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Important terminology

pd-1 cell immune cancer pd-l1 cells tumor treatment gene human expressed system melanoma receptor bp expression response responses protein activity

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Programmed cell death protein 1AliasesPDCD1, CD279, PD-1, PD1, SLEB2, hPD-1, hPD-l, hSLE1, Programmed cell death 11.00infobox
Programmed cell death protein 1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2M2D, 3RRQ, 4ZQK1.00infobox
Programmed cell death protein 1Band2q37.31.00infobox
Programmed cell death protein 1Band1|1 D1.00infobox
Programmed cell death protein 1Bgeelymph node1.00infobox
Programmed cell death protein 1Bgeegranulocyte1.00infobox
Programmed cell death protein 1Bgeespleen1.00infobox
Programmed cell death protein 1Bgeeright auricle of heart1.00infobox
Programmed cell death protein 1Bgeeappendix1.00infobox
Programmed cell death protein 1Bgeeblood1.00infobox
Programmed cell death protein 1Bgeeleft ventricle1.00infobox
Programmed cell death protein 1Bgeemucosa of transverse colon1.00infobox
Programmed cell death protein 1Bgeeupper lobe of left lung1.00infobox
Programmed cell death protein 1Bgeetonsil1.00infobox
Programmed cell death protein 1Bgeeembryo1.00infobox
Programmed cell death protein 1Bgeethymus1.00infobox
Programmed cell death protein 1Bgeemesenteric lymph nodes1.00infobox
Programmed cell death protein 1Bgeezygote1.00infobox
Programmed cell death protein 1Bgeecumulus cell1.00infobox
Programmed cell death protein 1Bgeeprimary oocyte1.00infobox
Programmed cell death protein 1Bgeeovary1.00infobox
Programmed cell death protein 1BioGPSMore reference expression data1.00infobox
Programmed cell death protein 1Chr.Chromosome 2 (human)1.00infobox
Programmed cell death protein 1Chr.Chromosome 1 (mouse)1.00infobox
Programmed cell death protein 1DatabasesNCBI: entry; OMA: entry1.00infobox
Programmed cell death protein 1End241,858,894 bp1.00infobox
Programmed cell death protein 1End93,980,278 bp1.00infobox
Programmed cell death protein 1EnsemblENSG00000188389 ENSG000002769771.00infobox
Programmed cell death protein 1Entrez51331.00infobox
Programmed cell death protein 1External IDsOMIM: 600244; MGI: 104879; GeneCards: PDCD11.00infobox

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