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Macrophage colony-stimulating factor: Function, As a drug target & Clinical significance

The colony stimulating factor 1 (CSF1), also known as macrophage colony-stimulating factor (M-CSF), is a secreted cytokine which causes hematopoietic stem cells to differentiate into macrophages or other related cell types. Eukaryotic cells also produce M-CSF in order to combat intercellular viral infection. It is one of the three experimentally…

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Macrophage colony-stimulating factor topic overview

The analysis highlights Function, As a drug target and Clinical significance as prominent areas in the source structure around Macrophage colony-stimulating factor.

Related topics
24
Source areas
5
Connected nodes
29
Extracted relationships
132
Concept neighborhoods
11
Bridge connections
29

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 11 topics
Overview · 6 topics
As a drug target · 3 topics
Clinical significance · 2 topics
Interactions · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
CSF1, CSF-1, MCSF, colony stimulating factor 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1HMC, 3UEZ, 3UF2, 4ADF, 4FA8, 4WRL, 4WRM
Band
1p13.3 · 3 F2.3|3 46.83 cM
Bgee
gallbladder · subcutaneous adipose tissue · right coronary artery · apex of heart · left adrenal gland
BioGPS
More reference expression data
Chr.
Chromosome 1 (human) · Chromosome 3 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Clinical significance

As a drug target

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Macrophage colony-stimulating factor connects Entity context

The extracted context around Macrophage colony-stimulating factor shows recurring relationship patterns in the source. For example, Macrophage colony-stimulating factor → branching involved in mammary gland duct morphogenesis, cell differentiation, cell population proliferation, CSF1-CSF1R complex, cytokine activity, cytokine-mediated signaling pathway, developmental process involved in reproduction, endoplasmic reticulum lumen, extracellular region, extracellular space, growth factor activity, hemopoiesis, homeostasis of number of cells within a tissue, identical protein binding, immune system process, inflammatory response, innate immune response, integral component of membrane, macrophage colony-stimulating factor receptor binding, macrophage colony-stimulating factor signaling pathway Another extracted example is Macrophage colony-stimulating factor → ankle joint, aortic valve, apex of heart, ascending aorta, calvaria, cartilage tissue, endothelial cell of lymphatic vessel, gallbladder, left adrenal cortex, left adrenal gland, left coronary artery, mesenteric lymph nodes, right adrenal cortex, right adrenal gland, right coronary artery, secondary oocyte, stroma of bone marrow, subcutaneous adipose tissue, supraoptic nucleus, zygote. Use these groups to spot repeated connection types before inspecting the individual relationships.

Macrophage colony-stimulating factor

Top relations

Gene ontology · 56
Macrophage colony-stimulating factor → branching involved in mammary gland duct morphogenesis, cell differentiation, cell population proliferation, CSF1-CSF1R complex, cytokine activity, cytokine-mediated signaling pathway, developmental process involved in reproduction, endoplasmic reticulum lumen, extracellular region, extracellular space, growth factor activity, hemopoiesis, homeostasis of number of cells within a tissue, identical protein binding, immune system process, inflammatory response, innate immune response, integral component of membrane, macrophage colony-stimulating factor receptor binding, macrophage colony-stimulating factor signaling pathway
Bgee · 20
Macrophage colony-stimulating factor → ankle joint, aortic valve, apex of heart, ascending aorta, calvaria, cartilage tissue, endothelial cell of lymphatic vessel, gallbladder, left adrenal cortex, left adrenal gland, left coronary artery, mesenteric lymph nodes, right adrenal cortex, right adrenal gland, right coronary artery, secondary oocyte, stroma of bone marrow, subcutaneous adipose tissue, supraoptic nucleus, zygote
RNA expression pattern · 20
Macrophage colony-stimulating factor → ankle joint, aortic valve, apex of heart, ascending aorta, calvaria, cartilage tissue, endothelial cell of lymphatic vessel, gallbladder, left adrenal cortex, left adrenal gland, left coronary artery, mesenteric lymph nodes, right adrenal cortex, right adrenal gland, right coronary artery, secondary oocyte, stroma of bone marrow, subcutaneous adipose tissue, supraoptic nucleus, zygote
related to External links · 11
Macrophage colony-stimulating factor → Colony-Stimulating, Factor, Macrophage, Medicine Medical Subject Headings, MeSH, National Library, Overview, P09603, PDB, PDBe-KB, UniProt
Band · 2
Macrophage colony-stimulating factor → 1p13.3, 3 F2.3|3 46.83 cM
Chr. · 2
Macrophage colony-stimulating factor → Chromosome 1 (human), Chromosome 3 (mouse)
End · 2
Macrophage colony-stimulating factor → 107,667,785 bp, 109,930,992 bp
related to Interactions · 2
Macrophage colony-stimulating factor → Macrophage, PIK3R2
Aliases · 1
Macrophage colony-stimulating factor → CSF1, CSF-1, MCSF, colony stimulating factor 1
Available structures · 1
Macrophage colony-stimulating factor → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1HMC, 3UEZ, 3UF2, 4ADF, 4FA8, 4WRL, 4WRM

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

m-csf factor also bp macrophage colony-stimulating cell chr human band csf1 receptor involved development csf1r stimulating cells chromosome csf-1 gene

Macrophage colony-stimulating factor relationships Subject–Predicate–Object triples

TTTA extracted 132 structured relationships around Macrophage colony-stimulating factor. Examples in this analysis include Macrophage colony-stimulating factor → Aliases → CSF1, CSF-1, MCSF, colony stimulating factor 1 and Macrophage colony-stimulating factor → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1HMC, 3UEZ, 3UF2, 4ADF, 4FA8, 4WRL, 4WRM. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Macrophage colony-stimulating factorAliasesCSF1, CSF-1, MCSF, colony stimulating factor 11.00infobox
Macrophage colony-stimulating factorAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1HMC, 3UEZ, 3UF2, 4ADF, 4FA8, 4WRL, 4WRM1.00infobox
Macrophage colony-stimulating factorBand1p13.31.00infobox
Macrophage colony-stimulating factorBand3 F2.3|3 46.83 cM1.00infobox
Macrophage colony-stimulating factorBgeegallbladder1.00infobox
Macrophage colony-stimulating factorBgeesubcutaneous adipose tissue1.00infobox
Macrophage colony-stimulating factorBgeeright coronary artery1.00infobox
Macrophage colony-stimulating factorBgeeapex of heart1.00infobox
Macrophage colony-stimulating factorBgeeleft adrenal gland1.00infobox
Macrophage colony-stimulating factorBgeeleft coronary artery1.00infobox
Macrophage colony-stimulating factorBgeecartilage tissue1.00infobox
Macrophage colony-stimulating factorBgeeright adrenal gland1.00infobox
Macrophage colony-stimulating factorBgeeright adrenal cortex1.00infobox
Macrophage colony-stimulating factorBgeeleft adrenal cortex1.00infobox
Macrophage colony-stimulating factorBgeestroma of bone marrow1.00infobox
Macrophage colony-stimulating factorBgeeaortic valve1.00infobox
Macrophage colony-stimulating factorBgeeascending aorta1.00infobox
Macrophage colony-stimulating factorBgeemesenteric lymph nodes1.00infobox
Macrophage colony-stimulating factorBgeecalvaria1.00infobox
Macrophage colony-stimulating factorBgeeendothelial cell of lymphatic vessel1.00infobox
Macrophage colony-stimulating factorBgeeankle joint1.00infobox
Macrophage colony-stimulating factorBgeezygote1.00infobox
Macrophage colony-stimulating factorBgeesecondary oocyte1.00infobox
Macrophage colony-stimulating factorBgeesupraoptic nucleus1.00infobox
Macrophage colony-stimulating factorBioGPSMore reference expression data1.00infobox
Macrophage colony-stimulating factorChr.Chromosome 1 (human)1.00infobox
Macrophage colony-stimulating factorChr.Chromosome 3 (mouse)1.00infobox
Macrophage colony-stimulating factorDatabasesNCBI: entry; OMA: entry1.00infobox
Macrophage colony-stimulating factorEnd109,930,992 bp1.00infobox
Macrophage colony-stimulating factorEnd107,667,785 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Macrophage colony-stimulating factor bring nearby vocabulary together. In this analysis, examples include Colony-stimulating, Macrophage and Factor. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Macrophage colony-stimulating factor
    • Colony-stimulating
    • Macrophage
    • Factor
    • Cytokine
    • P09603
    • Uniprot
    • Csf1
    • M-csf
    • Role
    • Proliferation
    • Chr
    • Csf-1
  • macrophage colony-stimulating factor
    • Colony-stimulating
    • Macrophage
    • Factor
    • Csf1
    • Cytokine
    • P09603
    • Stimulating
    • Uniprot
    • Function
    • M-csf
    • Pdb
    • Role
  • cytokine
    • Function
    • Mouse
    • P09603
    • Uniprot
    • Macrophage
    • Activation
    • Bone
    • Differentiation
    • Factor
    • Growth
    • Hematopoietic
    • Location
  • hematopoietic stem cells
    • Cytokine
    • Macrophages
    • Bone
    • Differentiation
    • Growth
    • Hematopoietic
    • Involved
    • Proliferation
    • Csf1
    • Factor
    • M-csf
    • Cell
  • colony-stimulating factors
    • Macrophage
    • Factor
    • Cytokine
    • P09603
    • Uniprot
    • Csf1
    • Function
    • Mouse
    • Pdb
    • Activation
    • Bone
    • Described
  • colony stimulating factor 1 receptor
    • Colony
    • Stimulating
    • Colony-stimulating
    • Macrophage
    • Csf1r
    • Csf1
    • Macrophages
    • Factor
    • External
    • Growth
    • Cell
    • Involved
  • function
    • Location
    • Chromosome
    • Gene
    • Human
    • Bp
    • Chr
    • Mouse
    • P09603
    • Pdb
    • Uniprot
    • Activation
    • Bone
  • macrophages
    • Monocytes
    • Stimulating
    • Bone
    • Differentiation
    • Growth
    • Involved
    • Proliferation
    • Csf-1

Connections between topic areas Semantic bridges

For Macrophage colony-stimulating factor, one of the stronger structural bridges in this analysis connects Macrophage colony-stimulating factor with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Macrophage colony-stimulating factorFunction · splits 18 ⟂ 12
Macrophage colony-stimulating factorOverview · splits 23 ⟂ 7
Macrophage colony-stimulating factorAs a drug target · splits 26 ⟂ 4
Macrophage colony-stimulating factorClinical significance · splits 27 ⟂ 3
Macrophage colony-stimulating factorInteractions · splits 27 ⟂ 3

Map overview Semantic statistics

Macrophage colony-stimulating factor

Nodes30
Edges29
Triples132
Avg. degree1.93
Density0.066667
Components1

Source & methodology

TTTA analyzes the structure around Macrophage colony-stimulating factor to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, As a drug target & Clinical significance, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Macrophage colony-stimulating factor · EN edition · Analysis: TopicsToTalkAbout

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