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Stem cell factor

Stem cell factor (also known as SCF, KIT-ligand, KL, or steel factor) is a cytokine that binds to the c-KIT receptor (CD117). SCF can exist both as a transmembrane protein and a soluble protein. This cytokine plays an important role in hematopoiesis (formation of blood cells), spermatogenesis, and melanogenesis.

Role in hematopoiesis, Production & Role in development

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Role in hematopoiesis

6 related topics

Production

4 related topics

Role in development

3 related topics

Expression in mast cells

1 related topics

Key facts & relationships

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Aliases
KITLG, FPH2, FPHH, KL-1, Kitl, MGF, SCF, SF, SHEP7, DCUA, KIT ligand, DFNA69, SLF
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1EXZ, 1SCF, 2E9W
Band
12q21.32 · 10 D1|10 51.4 cM
Bgee
visceral pleura · cardia · lower lobe of lung · pylorus · lateral nuclear group of thalamus
BioGPS
More reference expression data
Chr.
Chromosome 12 (human) · Chromosome 10 (mouse)

Topics to explore

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Overview

Production

Role in development

Role in hematopoiesis

Expression in mast cells

C-KIT receptor

Clinical relevance

Interactions

Advanced semantic analysis

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Map overview Semantic statistics

Stem cell factor

Nodes33
Edges32
Triples113
Avg. degree1.94
Density0.060606
Components1

How this topic connects Entity context

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Stem cell factor

Top relations

Gene ontology · 40
Stem cell factor → cell adhesion, cell population proliferation, cell projection, cytokine activity, cytoplasm, cytoskeleton, ectopic germ cell programmed cell death, embryonic hemopoiesis, extracellular region, extracellular space, extrinsic apoptotic signaling pathway in absence of ligand, filopodium, growth factor activity, integral component of membrane, lamellipodium, male gonad development, MAPK cascade, membrane, negative regulation of apoptotic process, negative regulation of mast cell apoptotic process
Bgee · 20
Stem cell factor → cardia, cardiac muscle tissue of left ventricle, cerebellar vermis, dermis, endothelial cell, habenula, lateral geniculate nucleus, lateral nuclear group of thalamus, left lung lobe, lobe of cerebellum, lower lobe of lung, medial dorsal nucleus, medial geniculate nucleus, middle temporal gyrus, parietal pleura, pylorus, right lung, seminal vesicula, skin of hip, visceral pleura
RNA expression pattern · 20
Stem cell factor → cardia, cardiac muscle tissue of left ventricle, cerebellar vermis, dermis, endothelial cell, habenula, lateral geniculate nucleus, lateral nuclear group of thalamus, left lung lobe, lobe of cerebellum, lower lobe of lung, medial dorsal nucleus, medial geniculate nucleus, middle temporal gyrus, parietal pleura, pylorus, right lung, seminal vesicula, skin of hip, visceral pleura
related to Production · 8
Stem cell factor → Both, Cleavage, Figure, KIT, RNA, SCF, Sl, The
Band · 2
Stem cell factor → 10 D1|10 51.4 cM, 12q21.32
Chr. · 2
Stem cell factor → Chromosome 10 (mouse), Chromosome 12 (human)
End · 2
Stem cell factor → 88,580,851 bp, 99,936,278 bp
related to Interactions · 2
Stem cell factor → CD117, Stem
Aliases · 1
Stem cell factor → KITLG, FPH2, FPHH, KL-1, Kitl, MGF, SCF, SF, SHEP7, DCUA, KIT ligand, DFNA69, SLF
Available structures · 1
Stem cell factor → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1EXZ, 1SCF, 2E9W

Important terminology Word statistics

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Important terminology

scf cells c-kit hscs cell hematopoietic receptor mast also transmembrane role stem soluble bp human plays hematopoiesis expressed chr band

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Stem cell factorAliasesKITLG, FPH2, FPHH, KL-1, Kitl, MGF, SCF, SF, SHEP7, DCUA, KIT ligand, DFNA69, SLF1.00infobox
Stem cell factorAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1EXZ, 1SCF, 2E9W1.00infobox
Stem cell factorBand12q21.321.00infobox
Stem cell factorBand10 D1|10 51.4 cM1.00infobox
Stem cell factorBgeevisceral pleura1.00infobox
Stem cell factorBgeecardia1.00infobox
Stem cell factorBgeelower lobe of lung1.00infobox
Stem cell factorBgeepylorus1.00infobox
Stem cell factorBgeelateral nuclear group of thalamus1.00infobox
Stem cell factorBgeemiddle temporal gyrus1.00infobox
Stem cell factorBgeeparietal pleura1.00infobox
Stem cell factorBgeeendothelial cell1.00infobox
Stem cell factorBgeeskin of hip1.00infobox
Stem cell factorBgeeseminal vesicula1.00infobox
Stem cell factorBgeehabenula1.00infobox
Stem cell factorBgeeleft lung lobe1.00infobox
Stem cell factorBgeemedial geniculate nucleus1.00infobox
Stem cell factorBgeemedial dorsal nucleus1.00infobox
Stem cell factorBgeelateral geniculate nucleus1.00infobox
Stem cell factorBgeelobe of cerebellum1.00infobox
Stem cell factorBgeedermis1.00infobox
Stem cell factorBgeecerebellar vermis1.00infobox
Stem cell factorBgeecardiac muscle tissue of left ventricle1.00infobox
Stem cell factorBgeeright lung1.00infobox
Stem cell factorBioGPSMore reference expression data1.00infobox
Stem cell factorChr.Chromosome 12 (human)1.00infobox
Stem cell factorChr.Chromosome 10 (mouse)1.00infobox
Stem cell factorDatabasesNCBI: entry; OMA: entry1.00infobox
Stem cell factorEnd88,580,851 bp1.00infobox
Stem cell factorEnd99,936,278 bp1.00infobox

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