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Stem cell factor: Role in hematopoiesis, Production & Role in development

Stem cell factor (also known as SCF, KIT-ligand, KL, or steel factor) is a cytokine that binds to the c-KIT receptor (CD117). SCF can exist both as a transmembrane protein and a soluble protein. This cytokine plays an important role in hematopoiesis (formation of blood cells), spermatogenesis, and melanogenesis.

Language: English [EN]
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Stem cell factor topic overview

The analysis highlights Role in hematopoiesis, Production and Role in development as prominent areas in the source structure around Stem cell factor.

Related topics
24
Source areas
8
Connected nodes
32
Extracted relationships
113
Concept neighborhoods
18
Bridge connections
32

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 7 topics
Role in hematopoiesis · 6 topics
Production · 4 topics
Role in development · 3 topics
C-KIT receptor · 1 topics
Clinical relevance · 1 topics
Expression in mast cells · 1 topics
Interactions · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
KITLG, FPH2, FPHH, KL-1, Kitl, MGF, SCF, SF, SHEP7, DCUA, KIT ligand, DFNA69, SLF
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1EXZ, 1SCF, 2E9W
Band
12q21.32 · 10 D1|10 51.4 cM
Bgee
visceral pleura · cardia · lower lobe of lung · pylorus · lateral nuclear group of thalamus
BioGPS
More reference expression data
Chr.
Chromosome 12 (human) · Chromosome 10 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Production

Role in development

Role in hematopoiesis

Expression in mast cells

C-KIT receptor

Clinical relevance

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Stem cell factor connects Entity context

The extracted context around Stem cell factor shows recurring relationship patterns in the source. For example, Stem cell factor → cell adhesion, cell population proliferation, cell projection, cytokine activity, cytoplasm, cytoskeleton, ectopic germ cell programmed cell death, embryonic hemopoiesis, extracellular region, extracellular space, extrinsic apoptotic signaling pathway in absence of ligand, filopodium, growth factor activity, integral component of membrane, lamellipodium, male gonad development, MAPK cascade, membrane, negative regulation of apoptotic process, negative regulation of mast cell apoptotic process Another extracted example is Stem cell factor → cardia, cardiac muscle tissue of left ventricle, cerebellar vermis, dermis, endothelial cell, habenula, lateral geniculate nucleus, lateral nuclear group of thalamus, left lung lobe, lobe of cerebellum, lower lobe of lung, medial dorsal nucleus, medial geniculate nucleus, middle temporal gyrus, parietal pleura, pylorus, right lung, seminal vesicula, skin of hip, visceral pleura. Use these groups to spot repeated connection types before inspecting the individual relationships.

Stem cell factor

Top relations

Gene ontology · 40
Stem cell factor → cell adhesion, cell population proliferation, cell projection, cytokine activity, cytoplasm, cytoskeleton, ectopic germ cell programmed cell death, embryonic hemopoiesis, extracellular region, extracellular space, extrinsic apoptotic signaling pathway in absence of ligand, filopodium, growth factor activity, integral component of membrane, lamellipodium, male gonad development, MAPK cascade, membrane, negative regulation of apoptotic process, negative regulation of mast cell apoptotic process
Bgee · 20
Stem cell factor → cardia, cardiac muscle tissue of left ventricle, cerebellar vermis, dermis, endothelial cell, habenula, lateral geniculate nucleus, lateral nuclear group of thalamus, left lung lobe, lobe of cerebellum, lower lobe of lung, medial dorsal nucleus, medial geniculate nucleus, middle temporal gyrus, parietal pleura, pylorus, right lung, seminal vesicula, skin of hip, visceral pleura
RNA expression pattern · 20
Stem cell factor → cardia, cardiac muscle tissue of left ventricle, cerebellar vermis, dermis, endothelial cell, habenula, lateral geniculate nucleus, lateral nuclear group of thalamus, left lung lobe, lobe of cerebellum, lower lobe of lung, medial dorsal nucleus, medial geniculate nucleus, middle temporal gyrus, parietal pleura, pylorus, right lung, seminal vesicula, skin of hip, visceral pleura
related to Production · 8
Stem cell factor → Both, Cleavage, Figure, KIT, RNA, SCF, Sl, The
Band · 2
Stem cell factor → 10 D1|10 51.4 cM, 12q21.32
Chr. · 2
Stem cell factor → Chromosome 10 (mouse), Chromosome 12 (human)
End · 2
Stem cell factor → 88,580,851 bp, 99,936,278 bp
related to Interactions · 2
Stem cell factor → CD117, Stem
Aliases · 1
Stem cell factor → KITLG, FPH2, FPHH, KL-1, Kitl, MGF, SCF, SF, SHEP7, DCUA, KIT ligand, DFNA69, SLF
Available structures · 1
Stem cell factor → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1EXZ, 1SCF, 2E9W

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

scf cells c-kit hscs cell hematopoietic receptor mast also transmembrane role stem soluble bp human plays hematopoiesis expressed chr band

Stem cell factor relationships Subject–Predicate–Object triples

TTTA extracted 113 structured relationships around Stem cell factor. Examples in this analysis include Stem cell factor → Aliases → KITLG, FPH2, FPHH, KL-1, Kitl, MGF, SCF, SF, SHEP7, DCUA, KIT ligand, DFNA69, SLF and Stem cell factor → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1EXZ, 1SCF, 2E9W. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Stem cell factorAliasesKITLG, FPH2, FPHH, KL-1, Kitl, MGF, SCF, SF, SHEP7, DCUA, KIT ligand, DFNA69, SLF1.00infobox
Stem cell factorAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1EXZ, 1SCF, 2E9W1.00infobox
Stem cell factorBand12q21.321.00infobox
Stem cell factorBand10 D1|10 51.4 cM1.00infobox
Stem cell factorBgeevisceral pleura1.00infobox
Stem cell factorBgeecardia1.00infobox
Stem cell factorBgeelower lobe of lung1.00infobox
Stem cell factorBgeepylorus1.00infobox
Stem cell factorBgeelateral nuclear group of thalamus1.00infobox
Stem cell factorBgeemiddle temporal gyrus1.00infobox
Stem cell factorBgeeparietal pleura1.00infobox
Stem cell factorBgeeendothelial cell1.00infobox
Stem cell factorBgeeskin of hip1.00infobox
Stem cell factorBgeeseminal vesicula1.00infobox
Stem cell factorBgeehabenula1.00infobox
Stem cell factorBgeeleft lung lobe1.00infobox
Stem cell factorBgeemedial geniculate nucleus1.00infobox
Stem cell factorBgeemedial dorsal nucleus1.00infobox
Stem cell factorBgeelateral geniculate nucleus1.00infobox
Stem cell factorBgeelobe of cerebellum1.00infobox
Stem cell factorBgeedermis1.00infobox
Stem cell factorBgeecerebellar vermis1.00infobox
Stem cell factorBgeecardiac muscle tissue of left ventricle1.00infobox
Stem cell factorBgeeright lung1.00infobox
Stem cell factorBioGPSMore reference expression data1.00infobox
Stem cell factorChr.Chromosome 12 (human)1.00infobox
Stem cell factorChr.Chromosome 10 (mouse)1.00infobox
Stem cell factorDatabasesNCBI: entry; OMA: entry1.00infobox
Stem cell factorEnd88,580,851 bp1.00infobox
Stem cell factorEnd99,936,278 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Stem cell factor bring nearby vocabulary together. In this analysis, examples include Stem, Factor and Scf. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Stem cell factor
    • Stem
    • Factor
    • Scf
    • Niche
    • Hscs
    • Mast
    • Cytokine
    • Proliferation
    • Hematopoietic
    • Plays
    • Mice
    • Progenitor
  • stem cell factor
    • Stem
    • Cytokine
    • Factor
    • Scf
    • Survival
    • Niche
    • Hscs
    • Gene
    • Mast
    • Receptor
    • Band
    • Chromosome
  • cytokine
    • Factor
    • Stem
    • Gene
    • Band
    • Chromosome
    • Proliferation
    • Protein
    • Receptor
    • Bp
    • Chr
    • Development
    • Germ
  • transmembrane protein
    • Soluble
    • Scf
    • Forms
    • Protein
    • Transmembrane
    • Gene
    • Band
    • Chromosome
    • Proliferation
    • Bp
    • Chr
    • Development
  • soluble protein
    • Transmembrane
    • Forms
    • Soluble
    • Gene
    • Band
    • Chromosome
    • Proliferation
    • Role
    • Bp
    • Chr
    • Development
    • Germ
  • endothelial cells
    • Hematopoietic
    • Mast
    • Scf
    • Expressed
    • Progenitor
    • Hscs
    • Germ
    • Role
    • Receptor
    • Melanocytes
    • Important
    • Bone
  • hematopoietic stem cells
    • Progenitor
    • Hematopoietic
    • Mast
    • Scf
    • Expressed
    • Hscs
    • Germ
    • Role
    • Important
    • Receptor
    • Bone
    • Marrow
  • stem cell niche
    • Stem
    • Factor
    • Role
    • Scf
    • Survival
    • Niche
    • Hscs
    • Plays
    • Mast
    • Cytokine
    • Proliferation
    • Hematopoietic

Connections between topic areas Semantic bridges

For Stem cell factor, one of the stronger structural bridges in this analysis connects Stem cell factor with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Stem cell factorOverview · splits 25 ⟂ 8
Stem cell factorRole in hematopoiesis · splits 26 ⟂ 7
Stem cell factorProduction · splits 28 ⟂ 5
Stem cell factorRole in development · splits 29 ⟂ 4

Map overview Semantic statistics

Stem cell factor

Nodes33
Edges32
Triples113
Avg. degree1.94
Density0.060606
Components1

Source & methodology

TTTA analyzes the structure around Stem cell factor to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Role in hematopoiesis, Production & Role in development, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Stem cell factor · EN edition · Analysis: TopicsToTalkAbout

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