NFE2L2

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Explore the main themes, entities and connections around NFE2L2. Start with the topic map, then use the sections below for research and deeper semantic analysis.

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Structure

NFE2 NFE2L1 NFE2L3 Leucine zipper JUN

21 related topics

Target genes

Nqo1 Quinones Redox cycling Glutamate-cysteine ligase GCLC

39 related topics

Clinical relevance

NRF2 Dimethyl fumarate Biogen Idec Food and Drug Administration Phase III clinical trial

16 related topics

Localization and function

KEAP1 Cullin 3 Ubiquitination Proteasome Promoter region

5 related topics

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases: NFE2L2, NRF2, HEBP1, nuclear factor, erythroid 2 like 2, IMDDHH, Nrf-2, NFE2 like bZIP transcription factor 2
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2FLU, 2LZ1, 3ZGC, 4IFL
Band: 2q31.2 · 2 C3|2 44.75 cM
Bgee: epithelium of nasopharynx · mucosa of pharynx · oral cavity · bronchial epithelial cell · pylorus
BioGPS: More reference expression data
Chr.: Chromosome 2 (human) · Chromosome 2 (mouse)

Topics to explore

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Overview

Structure

Localization and function

Target genes

Clinical relevance

NRF2
Dimethyl fumarate
Biogen Idec
Food and Drug Administration
Phase III clinical trial Phases of clinical research
Multiple sclerosis
Monomethyl fumarate
Nicotinic acid
Agonists Agonist
Progressive multifocal leukoencephalopathy
Lymphopenia
Liver damage
Oltipraz
Neurotoxicity
Superoxide radicals Superoxide radical
MIND4-17 MIND4-17?action=edit&redlink=1

Interactions

Interact Protein-protein interaction
CREBBP CREB-binding protein
EIF2AK3
UBC Ubiquitin C

Advanced semantic analysis

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Map overview Semantic statistics

Nodes105

Edges104

Triples197

Avg. degree1.98

Density0.019048

Components1

How this topic connects Entity context

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NFE2L2

Top relations

Gene ontology · 65

NFE2L2 → aflatoxin catabolic process, ageing, cell redox homeostasis, cellular response to angiotensin, cellular response to fluid shear stress, cellular response to glucose starvation, cellular response to hydrogen peroxide, cellular response to hypoxia, cellular response to laminar fluid shear stress, cellular response to oxidative stress, cellular response to tumor necrosis factor, centrosome, chromatin, cytoplasm, cytosol, DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, endoplasmic reticulum unfolded protein response

related to Target genes · 37

NFE2L2 → Activation, After, An AREs, Both Gclc, Conversely, GCLC, GCLM, Glutamate-cysteine, GSH, GST, GSTs, Heme, HMOX1, HO-1, Important, INrf2, Keap1, Kelch-like ECH-associated, Mrps, Multidrug

Bgee · 20

NFE2L2 → bronchial epithelial cell, cardia, duodenum, epithelium of nasopharynx, epithelium of stomach, esophagus, germinal epithelium, granulocyte, human penis, jejunal mucosa, left lung lobe, mucosa of pharynx, mucous cell of stomach, oral cavity, pericardium, pyloric antrum, pylorus, respiratory epithelium, stroma of bone marrow, transitional epithelium of urinary bladder

RNA expression pattern · 20

related to Structure · 15

NFE2L2 → C-terminus, Cap, CNC, Collar, FOS, From, JUN, N-terminus, Neh, NFE2, NFE2L1, NFE2L3, NRF2, NRF2-ECH, They

related to Interactions · 8

NFE2L2 → C-jun, CREBBP, EIF2AK3, KEAP1, MAFF, MAFG, MAFK, UBC

related to External links · 6

NFE2L2 → Medicine, Medicine Medical Subject Headings, MeSH, National Library, This, United States National Library

Band · 2

NFE2L2 → 2 C3|2 44.75 cM, 2q31.2

Chr. · 2

NFE2L2 → Chromosome 2 (human), Chromosome 2 (mouse)

End · 2

NFE2L2 → 177,392,697 bp, 75,534,985 bp

Important terminology Word statistics

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Important terminology

nrf2 protein antioxidant transcription proteins keap1 human bp genes gene also oxidative bzip expression chr band shown factor glutathione response

Entity relationships Subject–Predicate–Object triples

Subject	Predicate	Object	Confidence	Src
NFE2L2	Aliases	NFE2L2, NRF2, HEBP1, nuclear factor, erythroid 2 like 2, IMDDHH, Nrf-2, NFE2 like bZIP transcription factor 2	1.00	infobox
NFE2L2	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2FLU, 2LZ1, 3ZGC, 4IFL	1.00	infobox
NFE2L2	Band	2q31.2	1.00	infobox
NFE2L2	Band	2 C3\|2 44.75 cM	1.00	infobox
NFE2L2	Bgee	epithelium of nasopharynx	1.00	infobox
NFE2L2	Bgee	mucosa of pharynx	1.00	infobox
NFE2L2	Bgee	oral cavity	1.00	infobox
NFE2L2	Bgee	bronchial epithelial cell	1.00	infobox
NFE2L2	Bgee	pylorus	1.00	infobox
NFE2L2	Bgee	cardia	1.00	infobox
NFE2L2	Bgee	pericardium	1.00	infobox
NFE2L2	Bgee	human penis	1.00	infobox
NFE2L2	Bgee	jejunal mucosa	1.00	infobox
NFE2L2	Bgee	germinal epithelium	1.00	infobox
NFE2L2	Bgee	transitional epithelium of urinary bladder	1.00	infobox
NFE2L2	Bgee	epithelium of stomach	1.00	infobox
NFE2L2	Bgee	mucous cell of stomach	1.00	infobox
NFE2L2	Bgee	pyloric antrum	1.00	infobox
NFE2L2	Bgee	left lung lobe	1.00	infobox
NFE2L2	Bgee	esophagus	1.00	infobox
NFE2L2	Bgee	duodenum	1.00	infobox
NFE2L2	Bgee	stroma of bone marrow	1.00	infobox
NFE2L2	Bgee	granulocyte	1.00	infobox
NFE2L2	Bgee	respiratory epithelium	1.00	infobox
NFE2L2	BioGPS	More reference expression data	1.00	infobox
NFE2L2	Chr.	Chromosome 2 (human)	1.00	infobox
NFE2L2	Chr.	Chromosome 2 (mouse)	1.00	infobox
NFE2L2	Databases	NCBI: entry; OMA: entry	1.00	infobox
NFE2L2	End	177,392,697 bp	1.00	infobox
NFE2L2	End	75,534,985 bp	1.00	infobox

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