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Chemokine (C-C motif) ligand 5 (also CCL5) is a protein which in humans is encoded by the CCL5 gene. The gene was discovered in 1990 by in situ hybridisation, and it is localised on the 17q11.2-q12 chromosome.
The analysis highlights Function, Clinical significance and Interactions as prominent areas in the source structure around CCL5.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around CCL5 shows recurring relationship patterns in the source. For example, CCL5 → activation of phospholipase D activity, calcium ion transport, CCR chemokine receptor binding, CCR1 chemokine receptor binding, CCR4 chemokine receptor binding, CCR5 chemokine receptor binding, cell-cell signaling, cellular calcium ion homeostasis, cellular response to fibroblast growth factor stimulus, cellular response to interferon-gamma, cellular response to interleukin-1, cellular response to organic cyclic compound, cellular response to tumor necrosis factor, chemoattractant activity, chemokine activity, chemokine receptor antagonist activity, chemokine receptor binding, chemokine-mediated signaling pathway, chemotaxis, cytokine activity Another extracted example is CCL5 → After, Akt, Akt/PKB, Although, An, B-cells, Bcl2, Beta-catenin, CC, CC-Chemokine-activated, CCL5/CCR5, CCR1, CCR3, CCR4, CCR5, CD8, CHAK, Cyclin, G-protein, GPCRs. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
chemokine protein also human gene ccr5 cells expressed bp cell rantes chromosome t-cells binding activation chr band surface receptor factor
TTTA extracted 195 structured relationships around CCL5. Examples in this analysis include CCL5 → Aliases → CCL5, D17S136E, RANTES, SCYA5, SIS-delta, SISd, TCP228, eoCP, C-C motif chemokine ligand 5 and CCL5 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1B3A, 1EQT, 1HRJ, 1RTN, 1RTO, 1U4L, 1U4M, 1U4P, 1U4R, 2L9H, 2VXW, 5CMD, 5DNF, 5COY. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| CCL5 | Aliases | CCL5, D17S136E, RANTES, SCYA5, SIS-delta, SISd, TCP228, eoCP, C-C motif chemokine ligand 5 | 1.00 | infobox |
| CCL5 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1B3A, 1EQT, 1HRJ, 1RTN, 1RTO, 1U4L, 1U4M, 1U4P, 1U4R, 2L9H, 2VXW, 5CMD, 5DNF, 5COY | 1.00 | infobox |
| CCL5 | Band | 17q12 | 1.00 | infobox |
| CCL5 | Band | 11 C|11 50.66 cM | 1.00 | infobox |
| CCL5 | Bgee | granulocyte | 1.00 | infobox |
| CCL5 | Bgee | monocyte | 1.00 | infobox |
| CCL5 | Bgee | blood | 1.00 | infobox |
| CCL5 | Bgee | lymph node | 1.00 | infobox |
| CCL5 | Bgee | spleen | 1.00 | infobox |
| CCL5 | Bgee | gallbladder | 1.00 | infobox |
| CCL5 | Bgee | duodenum | 1.00 | infobox |
| CCL5 | Bgee | epithelium of colon | 1.00 | infobox |
| CCL5 | Bgee | appendix | 1.00 | infobox |
| CCL5 | Bgee | bone marrow | 1.00 | infobox |
| CCL5 | Bgee | mesenteric lymph nodes | 1.00 | infobox |
| CCL5 | Bgee | superior surface of tongue | 1.00 | infobox |
| CCL5 | Bgee | thymus | 1.00 | infobox |
| CCL5 | Bgee | jejunum | 1.00 | infobox |
| CCL5 | Bgee | subcutaneous adipose tissue | 1.00 | infobox |
| CCL5 | Bgee | Paneth cell | 1.00 | infobox |
| CCL5 | Bgee | right lung | 1.00 | infobox |
| CCL5 | BioGPS | More reference expression data | 1.00 | infobox |
| CCL5 | Chr. | Chromosome 17 (human) | 1.00 | infobox |
| CCL5 | Chr. | Chromosome 11 (mouse) | 1.00 | infobox |
| CCL5 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| CCL5 | End | 35,880,793 bp | 1.00 | infobox |
| CCL5 | End | 83,421,344 bp | 1.00 | infobox |
| CCL5 | Ensembl | ENSG00000271503 ENSG00000274233 | 1.00 | infobox |
| CCL5 | Entrez | 6352 | 1.00 | infobox |
| CCL5 | External IDs | OMIM: 187011; MGI: 98262; GeneCards: CCL5 | 1.00 | infobox |
The concept neighborhoods around CCL5 bring nearby vocabulary together. In this analysis, examples include Chemokine, Gene and Human. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For CCL5, one of the stronger structural bridges in this analysis connects CCL5 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around CCL5 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Clinical significance & Interactions, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — CCL5 · EN edition · Analysis: TopicsToTalkAbout