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ETS2 is a gene that in humans is encoding the C-ETS2 protein. The protein encoded by this gene belongs to the ETS family of transcription factors. It has been found to play a key role in the development of inflammatory bowel disease.
The analysis highlights Regions, Interactions and Clinical significance as prominent areas in the source structure around ETS2.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
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The extracted context around ETS2 shows recurring relationship patterns in the source. For example, ETS2 → cell differentiation, cytosol, DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, ectodermal cell fate commitment, glucocorticoid receptor binding, mesoderm development, negative regulation of transcription by RNA polymerase II, nucleoplasm, nucleus, plasma membrane, positive regulation of transcription by RNA polymerase II, positive regulation of transcription, DNA-templated, primitive streak formation, protein binding, protein domain specific binding, regulation of transcription by RNA polymerase II, regulation of transcription, DNA-templated Another extracted example is ETS2 → conjunctival fornix, ectocervix, gastric mucosa, granulocyte, left lung lobe, mucosa of urinary bladder, olfactory zone of nasal mucosa, Paneth cell, rectum, right lung, right lung lobe, skin of abdomen, skin of back, skin of external ear, skin of leg, spleen, tail of embryo, thymus, upper lobe of left lung. Use these groups to spot repeated connection types before inspecting the individual relationships.
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gene bp chr human band chromosome 21 protein transcription external location mouse ets development inflammatory bowel disease factor search 824
TTTA extracted 91 structured relationships around ETS2. Examples in this analysis include ETS2 → Aliases → ETS2, ETS2IT1, ETS proto-oncogene 2, transcription factor and ETS2 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4BQA, 4MHV. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| ETS2 | Aliases | ETS2, ETS2IT1, ETS proto-oncogene 2, transcription factor | 1.00 | infobox |
| ETS2 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4BQA, 4MHV | 1.00 | infobox |
| ETS2 | Band | 21q22.2 | 1.00 | infobox |
| ETS2 | Band | 16 C4|16 56.64 cM | 1.00 | infobox |
| ETS2 | Bgee | skin of abdomen | 1.00 | infobox |
| ETS2 | Bgee | mucosa of urinary bladder | 1.00 | infobox |
| ETS2 | Bgee | skin of leg | 1.00 | infobox |
| ETS2 | Bgee | gastric mucosa | 1.00 | infobox |
| ETS2 | Bgee | rectum | 1.00 | infobox |
| ETS2 | Bgee | spleen | 1.00 | infobox |
| ETS2 | Bgee | upper lobe of left lung | 1.00 | infobox |
| ETS2 | Bgee | ectocervix | 1.00 | infobox |
| ETS2 | Bgee | olfactory zone of nasal mucosa | 1.00 | infobox |
| ETS2 | Bgee | right lung | 1.00 | infobox |
| ETS2 | Bgee | left lung lobe | 1.00 | infobox |
| ETS2 | Bgee | tail of embryo | 1.00 | infobox |
| ETS2 | Bgee | thymus | 1.00 | infobox |
| ETS2 | Bgee | Paneth cell | 1.00 | infobox |
| ETS2 | Bgee | granulocyte | 1.00 | infobox |
| ETS2 | Bgee | skin of external ear | 1.00 | infobox |
| ETS2 | Bgee | skin of back | 1.00 | infobox |
| ETS2 | Bgee | conjunctival fornix | 1.00 | infobox |
| ETS2 | Bgee | right lung lobe | 1.00 | infobox |
| ETS2 | BioGPS | More reference expression data | 1.00 | infobox |
| ETS2 | Chr. | Chromosome 21 (human) | 1.00 | infobox |
| ETS2 | Chr. | Chromosome 16 (mouse) | 1.00 | infobox |
| ETS2 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| ETS2 | End | 38,824,955 bp | 1.00 | infobox |
| ETS2 | End | 95,522,095 bp | 1.00 | infobox |
| ETS2 | Ensembl | ENSG00000157557 | 1.00 | infobox |
The concept neighborhoods around ETS2 bring nearby vocabulary together. In this analysis, examples include Chromosome, External and Factor. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For ETS2, one of the stronger structural bridges in this analysis connects ETS2 with Interactions. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around ETS2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Regions, Interactions & Clinical significance, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — ETS2 · EN edition · Analysis: TopicsToTalkAbout
