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IKBKB

IKK-β also known as inhibitor of nuclear factor kappa-B kinase subunit beta is a protein that in humans is encoded by the IKBKB (inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta) gene.

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Interactions

15 related topics

Function

14 related topics

Clinical significance

4 related topics

Overview

2 related topics

Key facts & relationships

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2.7.11.1
2.7.11.10
Aliases
IKBKB, IKK-beta, IKK2, IKKB, IMD15, NFKBIKB, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta, inhibitor of nuclear factor kappa B kinase subunit beta,…
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4KIK, 3BRT, 3BRV, 4E3C
Band
8p11.21 · 8|8 A2
Bgee
spleen · granulocyte · right lobe of thyroid gland · right uterine tube · skin of leg

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Overview

Function

Clinical significance

Interactions

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Map overview Semantic statistics

IKBKB

Nodes40
Edges39
Triples130
Avg. degree1.95
Density0.05
Components1

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IKBKB

Top relations

Gene ontology · 53
IKBKB → anatomical structure morphogenesis, antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent, ATP binding, CD40 receptor complex, cellular response to tumor necrosis factor, cortical actin cytoskeleton organization, cytoplasm, cytoplasmic side of plasma membrane, cytosol, Fc-epsilon receptor signaling pathway, I-kappaB kinase/NF-kappaB signaling, I-kappaB phosphorylation, identical protein binding, IkappaB kinase activity, IkappaB kinase complex, inflammatory response, innate immune response, interleukin-1-mediated signaling pathway, kinase activity, membrane
Bgee · 19
IKBKB → blood, crypt of lieberkuhn of small intestine, granulocyte, hair follicle, left lobe of thyroid gland, medullary collecting duct, mesenteric lymph nodes, minor salivary glands, molar, Paneth cell, right lobe of thyroid gland, right uterine tube, skin of abdomen, skin of leg, spleen, stroma of bone marrow, superior cervical ganglion, tonsil, vagina
RNA expression pattern · 19
IKBKB → blood, crypt of lieberkuhn of small intestine, granulocyte, hair follicle, left lobe of thyroid gland, medullary collecting duct, mesenteric lymph nodes, minor salivary glands, molar, Paneth cell, right lobe of thyroid gland, right uterine tube, skin of abdomen, skin of leg, spleen, stroma of bone marrow, superior cervical ganglion, tonsil, vagina
related to Interactions · 13
IKBKB → CDC37, CHUKCTNNB1, FANCA, HDAC9, IKBKGIRAK1, IKK-β, MAP3K14, NCOA3, NFKB1, NFKBIA, NFKBIB, PPM1B, TNFRSF1A
Band · 2
IKBKB → 8p11.21, 8|8 A2
Chr. · 2
IKBKB → Chromosome 8 (human), Chromosome 8 (mouse)
End · 2
IKBKB → 23,196,605 bp, 42,332,460 bp
2.7.11.1 · 1
IKBKB → ↗
2.7.11.10 · 1
IKBKB → ↗
Aliases · 1
IKBKB → IKBKB, IKK-beta, IKK2, IKKB, IMD15, NFKBIKB, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta, inhibitor of nuclear factor kappa B kinase subunit beta,…

Important terminology Word statistics

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Important terminology

bp chr human band ikk-β kinase gene inhibitor protein factor chromosome iκb nf-κb nuclear subunit location function activity also mouse

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
IKBKB2.7.11.11.00infobox
IKBKB2.7.11.101.00infobox
IKBKBAliasesIKBKB, IKK-beta, IKK2, IKKB, IMD15, NFKBIKB, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta, inhibitor of nuclear factor kappa B kinase subunit beta,…1.00infobox
IKBKBAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4KIK, 3BRT, 3BRV, 4E3C1.00infobox
IKBKBBand8p11.211.00infobox
IKBKBBand8|8 A21.00infobox
IKBKBBgeespleen1.00infobox
IKBKBBgeegranulocyte1.00infobox
IKBKBBgeeright lobe of thyroid gland1.00infobox
IKBKBBgeeright uterine tube1.00infobox
IKBKBBgeeskin of leg1.00infobox
IKBKBBgeeskin of abdomen1.00infobox
IKBKBBgeeminor salivary glands1.00infobox
IKBKBBgeeleft lobe of thyroid gland1.00infobox
IKBKBBgeetonsil1.00infobox
IKBKBBgeevagina1.00infobox
IKBKBBgeemesenteric lymph nodes1.00infobox
IKBKBBgeeblood1.00infobox
IKBKBBgeePaneth cell1.00infobox
IKBKBBgeecrypt of lieberkuhn of small intestine1.00infobox
IKBKBBgeehair follicle1.00infobox
IKBKBBgeemolar1.00infobox
IKBKBBgeemedullary collecting duct1.00infobox
IKBKBBgeesuperior cervical ganglion1.00infobox
IKBKBBgeestroma of bone marrow1.00infobox
IKBKBBioGPSMore reference expression data1.00infobox
IKBKBChr.Chromosome 8 (human)1.00infobox
IKBKBChr.Chromosome 8 (mouse)1.00infobox
IKBKBDatabasesNCBI: entry; OMA: entry1.00infobox
IKBKBEnd42,332,460 bp1.00infobox

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