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Interferon type I: Applications, Sources and functions & Mammalian types

The type-I interferons (IFN) are cytokines which play essential roles in inflammation, immunoregulation, tumor cells recognition, and T-cell responses. In the human genome, a cluster of thirteen functional IFN genes is located at the 9p21.3 cytoband over approximately 400 kb including coding genes for IFNα (IFNA1, IFNA2, IFNA4, IFNA5, IFNA6, IFNA7…

Language: English [EN]
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Interferon type I topic overview

The analysis highlights Applications, Sources and functions and Mammalian types as prominent areas in the source structure around Interferon type I.

Related topics
111
Source areas
7
Connected nodes
118
Extracted relationships
16
Concept neighborhoods
30
Bridge connections
118

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Mammalian types · 30 topics
In cancer · 22 topics
Sources and functions · 21 topics
Overview · 15 topics
Use in therapeutics · 9 topics
Non-mammalian types · 8 topics
Interferonopathies · 6 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

AlphaFold
IPR000471 · PF00143
Available protein structures:
IPR000471 · PF00143
CATH
1au1
CDD
cd00095
InterPro
IPR000471
PDB
1b5l :24-187 1ovi :24-185 2hie :24-186 1itf :24-186 1au1B:22-187 2hif :24-182 1wu3I:22-182 IPR000471 PF00143 (ECOD; PDBsum)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Sources and functions

Mammalian types

In cancer

Use in therapeutics

Interferonopathies

Non-mammalian types

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Interferon type I connects Entity context

The extracted context around Interferon type I shows recurring relationship patterns in the source. For example, Interferon type I → IPR000471, PF00143 Another extracted example is Interferon type I → 1au1. Use these groups to spot repeated connection types before inspecting the individual relationships.

Interferon type I

Top relations

AlphaFold · 2
Interferon type I → IPR000471, PF00143
Available protein structures: · 2
Interferon type I → IPR000471, PF00143
CATH · 1
Interferon type I → 1au1
CDD · 1
Interferon type I → cd00095
InterPro · 1
Interferon type I → IPR000471
PDB · 1
Interferon type I → 1b5l :24-187 1ovi :24-185 2hie :24-186 1itf :24-186 1au1B:22-187 2hif :24-182 1wu3I:22-182 IPR000471 PF00143 (ECOD; PDBsum)
Pfam · 1
Interferon type I → PF00143
PROSITE · 1
Interferon type I → PDOC00225
SCOP2 · 1
Interferon type I → 1au1 / SCOPe / SUPFAM
SMART · 1
Interferon type I → SM00076

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

type ifn ifn-α interferon genes ifns cancer types cluster multiple treatment cells cell found gene human also mammals species mammalian

Interferon type I relationships Subject–Predicate–Object triples

TTTA extracted 16 structured relationships around Interferon type I. Examples in this analysis include Interferon type I → AlphaFold → IPR000471 and Interferon type I → AlphaFold → PF00143. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Interferon type IAlphaFoldIPR0004711.00infobox
Interferon type IAlphaFoldPF001431.00infobox
Interferon type IAvailable protein structures:IPR0004711.00infobox
Interferon type IAvailable protein structures:PF001431.00infobox
Interferon type ICATH1au11.00infobox
Interferon type ICDDcd000951.00infobox
Interferon type IInterProIPR0004711.00infobox
Interferon type IPDB1b5l :24-187 1ovi :24-185 2hie :24-186 1itf :24-186 1au1B:22-187 2hif :24-182 1wu3I:22-182 IPR000471 PF00143 (ECOD; PDBsum)1.00infobox
Interferon type IPfamPF001431.00infobox
Interferon type IPROSITEPDOC002251.00infobox
Interferon type ISCOP21au1 / SCOPe / SUPFAM1.00infobox
Interferon type ISMARTSM000761.00infobox
Interferon type ISymbolInterferons1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Interferon type I bring nearby vocabulary together. In this analysis, examples include Type, Recombinant and Therapy. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • human genome
    • Functional
    • Ifn
    • Melanoma
    • Approved
    • Human
    • Also
    • Cluster
    • Ifnα
    • Interferon
    • Citation
    • Needed
    • Associated
  • cancer
    • Cluster
    • Gene
    • Therapy
    • Ifn
    • Associated
    • Types
    • Ifnα
    • Approved
    • Citation
    • Genome
    • Infection
    • Many
  • in cancer
    • Cluster
    • Gene
    • Therapy
    • Ifn
    • Associated
    • Types
    • Ifnα
    • Approved
    • Citation
    • Genome
    • Infection
    • Many
  • viral dna
    • Infection
    • Ifn-ω
    • Ifns
    • Ifn-α
    • Citation
    • Needed
    • Recombinant
    • Therapy
    • Associated
    • Human
    • Ifn-β
    • Mammalian
  • mammalian types
    • Pegylated
    • Multiple
    • Ifn-β
    • Ifn-ω
    • Gene
    • Melanoma
    • Many
    • Recombinant
    • Types
    • Treatment
    • Infection
    • Receptor
  • pegylated interferon alfa-2a
    • Melanoma
    • Types
    • Recombinant
    • Treatment
    • Type
    • Ifnα
    • Therapy
    • Ifn-α
    • Interferons
    • Pegylated
    • Infection
    • Associated
  • pegylated interferon alfa-2b
    • Melanoma
    • Types
    • Recombinant
    • Treatment
    • Type
    • Ifnα
    • Therapy
    • Ifn-α
    • Interferons
    • Pegylated
    • Infection
    • Associated
  • recombinant feline interferon omega
    • Treatment
    • Melanoma
    • Pegylated
    • Type
    • Types
    • Recombinant
    • Therapy
    • Ifnα
    • Viral
    • Ifn-α
    • Interferons
    • Infection

Connections between topic areas Semantic bridges

For Interferon type I, one of the stronger structural bridges in this analysis connects Interferon type I with Mammalian types. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Interferon type I — Mammalian types · splits 88 ⟂ 31
Interferon type I — In cancer · splits 96 ⟂ 23
Interferon type I — Sources and functions · splits 97 ⟂ 22
Interferon type I — Overview · splits 103 ⟂ 16
Interferon type I — Use in therapeutics · splits 109 ⟂ 10
Interferon type I — Non-mammalian types · splits 110 ⟂ 9
Interferon type I — Interferonopathies · splits 112 ⟂ 7

Map overview Semantic statistics

Interferon type I

Nodes119
Edges118
Triples16
Avg. degree1.98
Density0.016807
Components1

Source & methodology

TTTA analyzes the structure around Interferon type I to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Applications, Sources and functions & Mammalian types, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Interferon type I · EN edition · Analysis: TopicsToTalkAbout

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