Research any topic before you write.

Find related topics. | Discover entities. | See connections. | Build a topical map.

TRAF6: Interactions, Function & Overview

The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein mediates the signaling not only from the members of the TNF receptor superfamily, but also from the members of the Toll/IL-1…

Language: English [EN]
Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.
100%
More settings
100% 100% 100% 100% 100%

TRAF6 topic overview

The analysis highlights Interactions, Function and Overview as prominent areas in the source structure around TRAF6.

Related topics
38
Source areas
3
Connected nodes
41
Extracted relationships
174
Concept neighborhoods
16
Bridge connections
41

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Interactions · 19 topics
Function · 18 topics
Overview · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

2.3.2.27
Aliases
TRAF6, MGC:3310, RNF85, TNF receptor associated factor 6
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1LB4, 1LB5, 1LB6, 2ECI, 2JMD, 3HCS, 3HCT, 3HCU, 4Z8M
Band
11p12 · 2|2 E2
Bgee
secondary oocyte · endothelial cell · gonad · islet of Langerhans · Achilles tendon
BioGPS
More reference expression data

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How TRAF6 connects Entity context

The extracted context around TRAF6 shows recurring relationship patterns in the source. For example, TRAF6 → activation of NF-kappaB-inducing kinase activity, activation of protein kinase activity, animal organ morphogenesis, antigen processing and presentation of exogenous peptide antigen via MHC class II, bone remodeling, bone resorption, CD40 receptor complex, cell cortex, cell development, cellular response to cytokine stimulus, cellular response to DNA damage stimulus, cellular response to lipopolysaccharide, cytokine-mediated signaling pathway, cytoplasm, cytoplasmic side of plasma membrane, cytosol, endosome membrane, Fc-epsilon receptor signaling pathway, histone deacetylase binding, I-kappaB kinase/NF-kappaB signaling Another extracted example is TRAF6 → Achilles tendon, ascending aorta, condyle, endothelial cell, fossa, genital tubercle, gonad, granulocyte, Ileal epithelium, islet of Langerhans, lumbar spinal ganglion, lumbar subsegment of spinal cord, middle temporal gyrus, monocyte, popliteal artery, secondary oocyte, tail of embryo, testicle, thymus, ventricular zone. Use these groups to spot repeated connection types before inspecting the individual relationships.

TRAF6

Top relations

Gene ontology · 85
TRAF6 → activation of NF-kappaB-inducing kinase activity, activation of protein kinase activity, animal organ morphogenesis, antigen processing and presentation of exogenous peptide antigen via MHC class II, bone remodeling, bone resorption, CD40 receptor complex, cell cortex, cell development, cellular response to cytokine stimulus, cellular response to DNA damage stimulus, cellular response to lipopolysaccharide, cytokine-mediated signaling pathway, cytoplasm, cytoplasmic side of plasma membrane, cytosol, endosome membrane, Fc-epsilon receptor signaling pathway, histone deacetylase binding, I-kappaB kinase/NF-kappaB signaling
Bgee · 20
TRAF6 → Achilles tendon, ascending aorta, condyle, endothelial cell, fossa, genital tubercle, gonad, granulocyte, Ileal epithelium, islet of Langerhans, lumbar spinal ganglion, lumbar subsegment of spinal cord, middle temporal gyrus, monocyte, popliteal artery, secondary oocyte, tail of embryo, testicle, thymus, ventricular zone
RNA expression pattern · 20
TRAF6 → Achilles tendon, ascending aorta, condyle, endothelial cell, fossa, genital tubercle, gonad, granulocyte, Ileal epithelium, islet of Langerhans, lumbar spinal ganglion, lumbar subsegment of spinal cord, middle temporal gyrus, monocyte, popliteal artery, secondary oocyte, tail of embryo, testicle, thymus, ventricular zone
related to Interactions · 18
TRAF6 → ASK1, CD40, FHL2, HSPB2, IKBKG, IRAK1, IRAK2, MAP3K7IP2, MAP3K7PPP4C, RANK, SDCBP, Sequestosome, SIGIRR, TAB1, TAX1BP1, TNFAIP3, TNFRSF13B, UBE2N
related to External links · 3
TRAF6 → Medicine Medical Subject Headings, MeSH, National Library
Band · 2
TRAF6 → 11p12, 2|2 E2
Chr. · 2
TRAF6 → Chromosome 11 (human), Chromosome 2 (mouse)
End · 2
TRAF6 → 101,532,014 bp, 36,510,272 bp
2.3.2.27 · 1
TRAF6 → ↗
Aliases · 1
TRAF6 → TRAF6, MGC:3310, RNF85, TNF receptor associated factor 6

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

protein human bp chr band receptor chromosome 11 gene tnf location traf cd40 factor mouse associated signaling signal function external

TRAF6 relationships Subject–Predicate–Object triples

TTTA extracted 174 structured relationships around TRAF6. Examples in this analysis include TRAF6 → 2.3.2.27 → ↗ and TRAF6 → Aliases → TRAF6, MGC:3310, RNF85, TNF receptor associated factor 6. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
TRAF62.3.2.271.00infobox
TRAF6AliasesTRAF6, MGC:3310, RNF85, TNF receptor associated factor 61.00infobox
TRAF6Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1LB4, 1LB5, 1LB6, 2ECI, 2JMD, 3HCS, 3HCT, 3HCU, 4Z8M1.00infobox
TRAF6Band11p121.00infobox
TRAF6Band2|2 E21.00infobox
TRAF6Bgeesecondary oocyte1.00infobox
TRAF6Bgeeendothelial cell1.00infobox
TRAF6Bgeegonad1.00infobox
TRAF6Bgeeislet of Langerhans1.00infobox
TRAF6BgeeAchilles tendon1.00infobox
TRAF6Bgeemiddle temporal gyrus1.00infobox
TRAF6Bgeetesticle1.00infobox
TRAF6Bgeeascending aorta1.00infobox
TRAF6Bgeemonocyte1.00infobox
TRAF6Bgeepopliteal artery1.00infobox
TRAF6BgeeIleal epithelium1.00infobox
TRAF6Bgeegenital tubercle1.00infobox
TRAF6Bgeetail of embryo1.00infobox
TRAF6Bgeelumbar subsegment of spinal cord1.00infobox
TRAF6Bgeelumbar spinal ganglion1.00infobox
TRAF6Bgeegranulocyte1.00infobox
TRAF6Bgeethymus1.00infobox
TRAF6Bgeeventricular zone1.00infobox
TRAF6Bgeecondyle1.00infobox
TRAF6Bgeefossa1.00infobox
TRAF6BioGPSMore reference expression data1.00infobox
TRAF6Chr.Chromosome 11 (human)1.00infobox
TRAF6Chr.Chromosome 2 (mouse)1.00infobox
TRAF6DatabasesNCBI: entry; OMA: entry1.00infobox
TRAF6End36,510,272 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around TRAF6 bring nearby vocabulary together. In this analysis, examples include Ubiquitin, Irak1 and Ube2n. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • traf
    • Associated
    • Signal
    • Receptor
    • Tnf
    • Human
    • Traf6
    • Activation
    • Activity
    • End
    • Enzyme
    • Factor
    • Function
  • tnf receptor associated factor
    • Activity
    • Enzyme
    • Function
    • Receptor
    • Search
    • Tnf
    • Factor
    • Gene
    • Location
    • Chromosome
    • Signal
    • Traf
  • cd40
    • Ubiquitin
    • Traf6
    • Activation
    • End
    • Enzyme
    • Factor
    • Function
    • Identical
    • Il-1
    • Irak1
    • Kinase
    • Mouse
  • protein kinases
    • Signaling
    • Activation
    • Il-1
    • Kinase
    • Nf-kappab
    • Pathway
    • Response
    • Cd40
    • Signal
    • Traf
    • Receptor
    • Tnf
  • ubiquitin c
    • Cd40
    • Traf6
    • Activation
    • Activity
    • End
    • Enzyme
    • Factor
    • Function
    • Identical
    • Irak1
    • Kinase
    • Mouse
  • function
    • Activity
    • Enzyme
    • Factor
    • Search
    • Associated
    • Gene
    • Location
    • Chromosome
    • Receptor
    • Tnf
    • Bp
    • Chr
  • tnf receptor superfamily
    • Receptor
    • Tnf
    • Search
    • Gene
    • Location
    • Signal
    • Signaling
    • Traf
    • Traf6
    • Activation
    • End
    • Identical
  • ikappab kinase
    • Nf-kappab
    • Pathway
    • Response
    • Signal
    • Identical
    • Mouse
    • Search
    • Ubiquitin
    • Protein
    • Location
    • Signaling
    • Traf

Connections between topic areas Semantic bridges

For TRAF6, one of the stronger structural bridges in this analysis connects TRAF6 with Interactions. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
TRAF6Interactions · splits 22 ⟂ 20
TRAF6Function · splits 23 ⟂ 19

Map overview Semantic statistics

TRAF6

Nodes42
Edges41
Triples174
Avg. degree1.95
Density0.047619
Components1

Source & methodology

TTTA analyzes the structure around TRAF6 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Interactions, Function & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — TRAF6 · EN edition · Analysis: TopicsToTalkAbout

For writers, content strategists, SEOs, marketers and creators — from quick topic research to advanced semantic analysis.