Research any topic before you write.

Find related topics. | Discover entities. | See connections. | Build a topical map.

Toll-like receptor 8

Toll-like receptor 8 is a protein that in humans is encoded by the TLR8 gene. TLR8 has also been designated as CD288 (cluster of differentiation 288). It is a member of the toll-like receptor (TLR) family.

Function, Clinical significance & Overview

Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.

Research this topic

Explore the main themes, entities and connections around Toll-like receptor 8. Start with the topic map, then use the sections below for research and deeper semantic analysis.

Explore this topic

Start with a few of the strongest sections from the source topic. These are research directions, not a list of keywords you must use.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
TLR8, CD288, toll like receptor 8, hIMD98
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3W3G, 3W3J, 3W3K, 3W3L, 3W3M, 3W3N, 3WN4, 4QBZ, 4QC0, 4R07, 4R08, 4R09, 4R0A, 4R6A, 5AWB, 5AWD, 5HDH, 5AWA
Band
Xp22.2 · X|X F5
Bgee
monocyte · blood · granulocyte · visceral pleura · trabecular bone
BioGPS
More reference expression data
Chr.
X chromosome (human) · X chromosome (mouse)

Topics to explore

Browse the full topic structure. Each item opens a new analysis centered on that subject.

Overview

Function

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

Map overview Semantic statistics

Toll-like receptor 8

Nodes20
Edges19
Triples109
Avg. degree1.9
Density0.1
Components1

How this topic connects Entity context

See the strongest relationship patterns around the current topic before diving into the raw triples.

Toll-like receptor 8

Top relations

Gene ontology · 35
Toll-like receptor 8 → cellular response to mechanical stimulus, defense response to virus, DNA binding, double-stranded RNA binding, endolysosome membrane, endoplasmic reticulum membrane, endosome membrane, external side of plasma membrane, Golgi membrane, I-kappaB kinase/NF-kappaB signaling, identical protein binding, immune response, immune system process, immunoglobulin mediated immune response, inflammatory response, innate immune response, integral component of membrane, integral component of plasma membrane, membrane, microglial cell activation
Bgee · 18
Toll-like receptor 8 → appendix, blastocyst, blood, bone marrow, calvaria, embryo, esophagus, granulocyte, lower lobe of lung, monocyte, muscle of thigh, parietal pleura, secondary oocyte, spleen, stroma of bone marrow, trabecular bone, visceral pleura, zygote
RNA expression pattern · 18
Toll-like receptor 8 → appendix, blastocyst, blood, bone marrow, calvaria, embryo, esophagus, granulocyte, lower lobe of lung, monocyte, muscle of thigh, parietal pleura, secondary oocyte, spleen, stroma of bone marrow, trabecular bone, visceral pleura, zygote
related to External links · 9
Toll-like receptor 8 → Human Toll-like, Medicine Medical Subject Headings, MeSH, National Library, PDB, PDBe-KB, Receptor, TLR8, Toll-Like
Band · 2
Toll-like receptor 8 → Xp22.2, X|X F5
Chr. · 2
Toll-like receptor 8 → X chromosome (human), X chromosome (mouse)
End · 2
Toll-like receptor 8 → 12,923,169 bp, 166,047,325 bp
Aliases · 1
Toll-like receptor 8 → TLR8, CD288, toll like receptor 8, hIMD98
Available structures · 1
Toll-like receptor 8 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3W3G, 3W3J, 3W3K, 3W3L, 3W3M, 3W3N, 3WN4, 4QBZ, 4QC0, 4R07, 4R08, 4R09, 4R0A, 4R6A, 5AWB, 5AWD, 5HDH, 5AWA
BioGPS · 1
Toll-like receptor 8 → More reference expression data

Important terminology Word statistics

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

tlr8 receptor bp human gene toll-like chr band chromosome rna function humans protein external single-stranded activation location also family mouse

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Toll-like receptor 8AliasesTLR8, CD288, toll like receptor 8, hIMD981.00infobox
Toll-like receptor 8Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3W3G, 3W3J, 3W3K, 3W3L, 3W3M, 3W3N, 3WN4, 4QBZ, 4QC0, 4R07, 4R08, 4R09, 4R0A, 4R6A, 5AWB, 5AWD, 5HDH, 5AWA1.00infobox
Toll-like receptor 8BandXp22.21.00infobox
Toll-like receptor 8BandX|X F51.00infobox
Toll-like receptor 8Bgeemonocyte1.00infobox
Toll-like receptor 8Bgeeblood1.00infobox
Toll-like receptor 8Bgeegranulocyte1.00infobox
Toll-like receptor 8Bgeevisceral pleura1.00infobox
Toll-like receptor 8Bgeetrabecular bone1.00infobox
Toll-like receptor 8Bgeebone marrow1.00infobox
Toll-like receptor 8Bgeespleen1.00infobox
Toll-like receptor 8Bgeeappendix1.00infobox
Toll-like receptor 8Bgeeparietal pleura1.00infobox
Toll-like receptor 8Bgeelower lobe of lung1.00infobox
Toll-like receptor 8Bgeezygote1.00infobox
Toll-like receptor 8Bgeeembryo1.00infobox
Toll-like receptor 8Bgeestroma of bone marrow1.00infobox
Toll-like receptor 8Bgeesecondary oocyte1.00infobox
Toll-like receptor 8Bgeecalvaria1.00infobox
Toll-like receptor 8Bgeeesophagus1.00infobox
Toll-like receptor 8Bgeemuscle of thigh1.00infobox
Toll-like receptor 8Bgeeblastocyst1.00infobox
Toll-like receptor 8BioGPSMore reference expression data1.00infobox
Toll-like receptor 8Chr.X chromosome (human)1.00infobox
Toll-like receptor 8Chr.X chromosome (mouse)1.00infobox
Toll-like receptor 8DatabasesNCBI: entry; OMA: entry1.00infobox
Toll-like receptor 8End12,923,169 bp1.00infobox
Toll-like receptor 8End166,047,325 bp1.00infobox
Toll-like receptor 8EnsemblENSG000001019161.00infobox
Toll-like receptor 8Entrez513111.00infobox

Related concept clusters Concept neighborhoods

These clusters group vocabulary that occurs around closely connected concepts in the source material.

    Connections between topic areas Semantic bridges

    Bridges can reveal useful research angles that are easy to miss in a flat list of related terms.

    Min side: 3
    For writers, content strategists, SEOs, marketers and creators — from quick topic research to advanced semantic analysis.