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Short hairpin RNA

A short hairpin RNA or small hairpin RNA (shRNA/Hairpin Vector) is an artificial RNA molecule with a tight hairpin turn that can be used to silence target gene expression via RNA interference (RNAi). Expression of shRNA in cells is typically accomplished by delivery of plasmids or through viral or bacterial vectors. shRNA is an advantageous mediator of…

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Applications in gene therapy

Lipoplex (LP)Wiskott–Aldrich syndrome
2 related topics

Delivery

Escherichia coliAdeno-associated virusesAdenovirusesLentiviruses
4 related topics

Mechanism of action

DroshaDicerRNA-induced silencing complex
3 related topics

Overview

RNARNA interferenceExpressionPlasmidsVectors
10 related topics

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Delivery

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Applications in gene therapy

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Short hairpin RNA

Nodes24
Edges23
Triples2
Avg. degree1.92
Density0.083333
Components1

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Important terminology

shrna expression cells vector used gene viral delivery vectors however therapy risc bacterial using polymerase plasmids applications rna developed target

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SubjectPredicateObjectConfidenceSrc
U6instance ofpolymerase III promoters0.80text
H1 were usedinstance ofpolymerase III promoters0.80text

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