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PRKCE: Standards, Structure & Function

Protein kinase C epsilon type (PKCε) is an enzyme that in humans is encoded by the PRKCE gene. PKCε is an isoform of the large PKC family of protein kinases that play many roles in different tissues. In cardiac muscle cells, PKCε regulates muscle contraction through its actions at sarcomeric proteins, and PKCε modulates cardiac cell metabolism through…

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PRKCE topic overview

The analysis highlights Standards, Structure and Function as prominent areas in the source structure around PRKCE.

Related topics
120
Source areas
5
Connected nodes
125
Extracted relationships
160
Concept neighborhoods
28
Bridge connections
125

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 46 topics
Structure · 29 topics
Clinical significance · 22 topics
Overview · 13 topics
Substrates and interactions · 10 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

2.7.11.13
Aliases
PRKCE, PKCE, nPKC-epsilon, protein kinase C epsilon
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2WH0
Band
2p21 · 17|17 E4
Bgee
buccal mucosa cell · sural nerve · lateral nuclear group of thalamus · parietal lobe · postcentral gyrus
BioGPS
More reference expression data

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Function

Clinical significance

Substrates and interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How PRKCE connects Entity context

The extracted context around PRKCE shows recurring relationship patterns in the source. For example, PRKCE → 14-3-3 protein binding, actin monomer binding, apoptotic process, ATP binding, calcium-independent protein kinase C activity, cell adhesion, cell cycle, cell division, cell periphery, cellular response to ethanol, cellular response to hypoxia, cellular response to prostaglandin E stimulus, cytoplasm, cytoskeleton, cytosol, endoplasmic reticulum, enzyme activator activity, enzyme binding, ethanol binding, Fc-gamma receptor signaling pathway involved in phagocytosis Another extracted example is PRKCE → C-kinase, C1, C2, Ensembl ID, ENSG00000171132, Human PRKCE, It, PKC, PKC-δ, PKCε, Q02156, RACK, RACK/RACK2, RACK1, Receptors, Serine-729, The, The PKC, Threonine-566, Threonine-710. Use these groups to spot repeated connection types before inspecting the individual relationships.

PRKCE

Top relations

Gene ontology · 71
PRKCE → 14-3-3 protein binding, actin monomer binding, apoptotic process, ATP binding, calcium-independent protein kinase C activity, cell adhesion, cell cycle, cell division, cell periphery, cellular response to ethanol, cellular response to hypoxia, cellular response to prostaglandin E stimulus, cytoplasm, cytoskeleton, cytosol, endoplasmic reticulum, enzyme activator activity, enzyme binding, ethanol binding, Fc-gamma receptor signaling pathway involved in phagocytosis
related to Structure · 21
PRKCE → C-kinase, C1, C2, Ensembl ID, ENSG00000171132, Human PRKCE, It, PKC, PKC-δ, PKCε, Q02156, RACK, RACK/RACK2, RACK1, Receptors, Serine-729, The, The PKC, Threonine-566, Threonine-710
Bgee · 20
PRKCE → anterior amygdaloid area, buccal mucosa cell, dentate gyrus, dentate gyrus of hippocampal formation granule cell, entorhinal cortex, hippocampus proper, lateral nuclear group of thalamus, lateral septal nucleus, medial dorsal nucleus, middle temporal gyrus, olfactory tubercle, parietal lobe, postcentral gyrus, prefrontal cortex, right lung, sperm, subiculum, superior frontal gyrus, sural nerve, ventromedial nucleus
RNA expression pattern · 20
PRKCE → anterior amygdaloid area, buccal mucosa cell, dentate gyrus, dentate gyrus of hippocampal formation granule cell, entorhinal cortex, hippocampus proper, lateral nuclear group of thalamus, lateral septal nucleus, medial dorsal nucleus, middle temporal gyrus, olfactory tubercle, parietal lobe, postcentral gyrus, prefrontal cortex, right lung, sperm, subiculum, superior frontal gyrus, sural nerve, ventromedial nucleus
Band · 2
PRKCE → 17|17 E4, 2p21
Chr. · 2
PRKCE → Chromosome 17 (mouse), Chromosome 2 (human)
End · 2
PRKCE → 46,187,990 bp, 86,965,347 bp
2.7.11.13 · 1
PRKCE → ↗
Aliases · 1
PRKCE → PRKCE, PKCE, nPKC-epsilon, protein kinase C epsilon
Available structures · 1
PRKCE → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2WH0

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

pkcε protein cardiac pkc phosphorylation also mitochondrial kinase cardioprotection gene studies human function ctni preconditioning hypertrophy following bp isoform mitochondria

PRKCE relationships Subject–Predicate–Object triples

TTTA extracted 160 structured relationships around PRKCE. Examples in this analysis include PRKCE → 2.7.11.13 → ↗ and PRKCE → Aliases → PRKCE, PKCE, nPKC-epsilon, protein kinase C epsilon. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
PRKCE2.7.11.131.00infobox
PRKCEAliasesPRKCE, PKCE, nPKC-epsilon, protein kinase C epsilon1.00infobox
PRKCEAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2WH01.00infobox
PRKCEBand2p211.00infobox
PRKCEBand17|17 E41.00infobox
PRKCEBgeebuccal mucosa cell1.00infobox
PRKCEBgeesural nerve1.00infobox
PRKCEBgeelateral nuclear group of thalamus1.00infobox
PRKCEBgeeparietal lobe1.00infobox
PRKCEBgeepostcentral gyrus1.00infobox
PRKCEBgeeright lung1.00infobox
PRKCEBgeemiddle temporal gyrus1.00infobox
PRKCEBgeesperm1.00infobox
PRKCEBgeesuperior frontal gyrus1.00infobox
PRKCEBgeeentorhinal cortex1.00infobox
PRKCEBgeeanterior amygdaloid area1.00infobox
PRKCEBgeesubiculum1.00infobox
PRKCEBgeelateral septal nucleus1.00infobox
PRKCEBgeeolfactory tubercle1.00infobox
PRKCEBgeedentate gyrus1.00infobox
PRKCEBgeeprefrontal cortex1.00infobox
PRKCEBgeehippocampus proper1.00infobox
PRKCEBgeedentate gyrus of hippocampal formation granule cell1.00infobox
PRKCEBgeeventromedial nucleus1.00infobox
PRKCEBgeemedial dorsal nucleus1.00infobox
PRKCEBioGPSMore reference expression data1.00infobox
PRKCEChr.Chromosome 2 (human)1.00infobox
PRKCEChr.Chromosome 17 (mouse)1.00infobox
PRKCEDatabasesNCBI: entry; OMA: entry1.00infobox
PRKCEEnd46,187,990 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around PRKCE bring nearby vocabulary together. In this analysis, examples include Gene, Bp and Chr. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • gene
    • Prkce
    • Bp
    • Chr
    • Human
    • Protein
    • Kinase
    • Band
    • Hypertrophy
    • Activation
    • Family
    • Function
    • Pkc
  • cardiac muscle
    • Muscle
    • Sarcomeric
    • Modulates
    • Hypertrophy
    • Sarcomeres
    • Pkcε
    • Mitochondria
    • Ctni
    • Function
    • Studies
    • Injury
    • Prkce
  • cardioprotection
    • Injury
    • Mitochondrial
    • Involved
    • Translocation
    • Hypertrophy
    • Targets
    • Following
    • Kinase
    • Pkcε
    • Prkce
    • Bp
    • Chr
  • cardiac hypertrophy
    • Muscle
    • Hypertrophy
    • Injury
    • Sarcomeres
    • Pkcε
    • Mitochondria
    • Ctni
    • Kinase
    • Studies
    • Prkce
    • Sarcomeric
    • Protein
  • kinase
    • Prkce
    • Protein
    • Epsilon
    • Gene
    • Bp
    • Chr
    • Human
    • Hypertrophy
    • Involved
    • Function
    • Cardioprotection
    • Phosphorylation
  • gene expression
    • Prkce
    • Bp
    • Chr
    • Human
    • Protein
    • Kinase
    • Band
    • Hypertrophy
    • Activation
    • Family
    • Function
    • Pkc
  • mitochondrial potassium-sensitive atp channel (mitok(atp))
    • Activation
    • Following
    • Atp
    • Mitochondrial
    • Involved
    • Phosphorylation
    • Translocation
    • Shown
    • Pkcε
    • Cardiomyocytes
    • Preconditioning
    • Prkce
  • cardiac troponin t (ctnt)
    • Muscle
    • Hypertrophy
    • Sarcomeres
    • Pkcε
    • Mitochondria
    • Ctni
    • Studies
    • Injury
    • Sarcomeric
    • Modulates
    • Function
    • Cardioprotection

Connections between topic areas Semantic bridges

For PRKCE, one of the stronger structural bridges in this analysis connects PRKCE with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
PRKCEFunction · splits 79 ⟂ 47
PRKCEStructure · splits 96 ⟂ 30
PRKCEClinical significance · splits 103 ⟂ 23
PRKCEOverview · splits 112 ⟂ 14
PRKCESubstrates and interactions · splits 115 ⟂ 11

Map overview Semantic statistics

PRKCE

Nodes126
Edges125
Triples160
Avg. degree1.98
Density0.015873
Components1

Source & methodology

TTTA analyzes the structure around PRKCE to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Standards, Structure & Function, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — PRKCE · EN edition · Analysis: TopicsToTalkAbout

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