Apelin

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Apelin topic overview

The analysis highlights Art, Physiological functions and Discovery as prominent areas in the source structure around Apelin.

Related topics: 60
Source areas: 4
Connected nodes: 64
Extracted relationships: 178
Concept neighborhoods: 17
Bridge connections: 64

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Physiological functions · 44 topics

Overview · 7 topics

Discovery · 5 topics

Biosynthesis · 4 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases: APLN, APEL, XNPEP2, apelin
Band: Xq26.1 · X|X A4
Bgee: C1 segment · substantia nigra · subthalamic nucleus · testicle · hypothalamus
BioGPS: n/a
Chr.: X chromosome (human) · X chromosome (mouse)
Databases: NCBI: entry; OMA: entry

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Discovery

Biosynthesis

Physiological functions

Receptor Receptor (biology)
Blood pressure
Angiogenesis
Hypotensive
Endothelial cells
Nitric oxide
Angiotensin II
Angiogenic
Signal transduction
Extracellular signal-regulated kinases
Protein kinase B
S6 kinase Ribosomal s6 kinase
Phosphorylation
Genetic knockout
Embryonic development
Cardiomyocytes
Contractility
Chronic liver disease
Hypothalamic Hypothalamus
Antidiuretic Diuresis
Hormone
Vasopressin
Diuretic
Adipocytes Adipocyte
Insulin
Gastro-intestinal tract
Stomach
Pancreas
Colon Colon (anatomy)
Parietal cells
Glycemia Blood sugar
Muscle regeneration Myosatellite cell
Cellular proliferation
Differentiation Cellular differentiation
Longevity therapeutics Life extension
BGE-105
Muscle protein synthesis Muscle protein synthesis?action=edit&redlink=1
Double-blind Double-blind trial
Placebo-controlled Placebo-controlled trial
Phase 1b trial Phases of clinical research
Ventilators Mechanical ventilation
Intensive care unit
Diaphragm atrophy Diaphragm atrophy?action=edit&redlink=1
Critical illness myopathy

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Apelin connects Entity context

The extracted context around Apelin shows recurring relationship patterns in the source. For example, Apelin → angiogenesis, apelin receptor binding, apelin receptor signaling pathway, coronary vasculature development, drinking behavior, extracellular region, extracellular space, feeding behavior, G protein-coupled receptor binding, G protein-coupled receptor signaling pathway, gastrulation, hormone activity, immune response, lactation, multicellular organism development, negative regulation of blood pressure, negative regulation of fibroblast growth factor receptor signaling pathway, negative regulation of gene expression, negative regulation of vascular associated smooth muscle cell proliferation, negative regulation of vasoconstriction Another extracted example is Apelin → amygdala, C1 segment, digastric muscle, entorhinal cortex, epiblast, external globus pallidus, hypothalamus, Ileal epithelium, inferior ganglion of vagus nerve, lateral nuclear group of thalamus, left lung, lumbar subsegment of spinal cord, pericardium, right lung, right ventricle, stroma of bone marrow, substantia nigra, subthalamic nucleus, testicle, ventral tegmental area. Use these groups to spot repeated connection types before inspecting the individual relationships.

Top relations

Gene ontology · 38

Apelin → angiogenesis, apelin receptor binding, apelin receptor signaling pathway, coronary vasculature development, drinking behavior, extracellular region, extracellular space, feeding behavior, G protein-coupled receptor binding, G protein-coupled receptor signaling pathway, gastrulation, hormone activity, immune response, lactation, multicellular organism development, negative regulation of blood pressure, negative regulation of fibroblast growth factor receptor signaling pathway, negative regulation of gene expression, negative regulation of vascular associated smooth muscle cell proliferation, negative regulation of vasoconstriction

Bgee · 20

Apelin → amygdala, C1 segment, digastric muscle, entorhinal cortex, epiblast, external globus pallidus, hypothalamus, Ileal epithelium, inferior ganglion of vagus nerve, lateral nuclear group of thalamus, left lung, lumbar subsegment of spinal cord, pericardium, right lung, right ventricle, stroma of bone marrow, substantia nigra, subthalamic nucleus, testicle, ventral tegmental area

RNA expression pattern · 20

related to Muscle aging · 16

Apelin → AMPK-dependent, BGE-105, BioAge, By, Cedric Dray, Each, Finally, ICU, In, Moreover, Muscle, Phase, Philippe Valet, Such, They, This

related to External links · 14

Apelin → APLN, Archived, Basic, Clinical Pharmacology, Human APLN, International Union, Ion Channels, IUPHAR Database, Medicine Medical Subject Headings, MeSH, National Library, Receptors, Retrieved, UCSC Genome Browser

related to Vascular · 10

Apelin → Akt, ERKs, Genetic, II, NO, PKB, Studies, The, This, Vascular

related to Biosynthesis · 7

Apelin → After, C-ter, However, N-terminal, Recently, The, This

related to Discovery · 7

Apelin → APLNR, Bruno Reversade, Elabela, Gunma University, In, Masahiko Fujino, Takeda Pharmaceutical Company

related to Digestive · 5

Apelin → In, Its, Recently, The, This

related to Cardiac · 4

Apelin → Aged, It, Its, The

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

receptor also human muscle gene expressed cells bp expression blood cell chr band peptide apln chromosome brain heart location hormone

Apelin relationships Subject–Predicate–Object triples

TTTA extracted 178 structured relationships around Apelin. Examples in this analysis include Apelin → Aliases → APLN, APEL, XNPEP2, apelin and Apelin → Band → Xq26.1. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
Apelin	Aliases	APLN, APEL, XNPEP2, apelin	1.00	infobox
Apelin	Band	Xq26.1	1.00	infobox
Apelin	Band	X\|X A4	1.00	infobox
Apelin	Bgee	C1 segment	1.00	infobox
Apelin	Bgee	substantia nigra	1.00	infobox
Apelin	Bgee	subthalamic nucleus	1.00	infobox
Apelin	Bgee	testicle	1.00	infobox
Apelin	Bgee	hypothalamus	1.00	infobox
Apelin	Bgee	lateral nuclear group of thalamus	1.00	infobox
Apelin	Bgee	amygdala	1.00	infobox
Apelin	Bgee	inferior ganglion of vagus nerve	1.00	infobox
Apelin	Bgee	external globus pallidus	1.00	infobox
Apelin	Bgee	ventral tegmental area	1.00	infobox
Apelin	Bgee	lumbar subsegment of spinal cord	1.00	infobox
Apelin	Bgee	Ileal epithelium	1.00	infobox
Apelin	Bgee	pericardium	1.00	infobox
Apelin	Bgee	stroma of bone marrow	1.00	infobox
Apelin	Bgee	epiblast	1.00	infobox
Apelin	Bgee	right ventricle	1.00	infobox
Apelin	Bgee	right lung	1.00	infobox
Apelin	Bgee	left lung	1.00	infobox
Apelin	Bgee	entorhinal cortex	1.00	infobox
Apelin	Bgee	digastric muscle	1.00	infobox
Apelin	BioGPS	n/a	1.00	infobox
Apelin	Chr.	X chromosome (human)	1.00	infobox
Apelin	Chr.	X chromosome (mouse)	1.00	infobox
Apelin	Databases	NCBI: entry; OMA: entry	1.00	infobox
Apelin	End	129,654,956 bp	1.00	infobox
Apelin	End	47,123,730 bp	1.00	infobox
Apelin	Ensembl	ENSG00000171388	1.00	infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Apelin bring nearby vocabulary together. In this analysis, examples include Receptor, Cells and Muscle. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

Apelin
- Receptor
- Cells
- Muscle
- Expressed
- Gene
- Aged
- Cell
- Peptide
- Blood
- Endothelial
- Insulin
- Mice
apelin
- Receptor
- Cells
- Muscle
- Expressed
- Gene
- Aged
- Cell
- Peptide
- Blood
- Endothelial
- Insulin
- Mice
blood pressure
- Pressure
- Vascular
- Control
- Endothelial
- Activation
- Receptor
- Levels
- Proliferation
- Protein
- Signal
- Cell
- Expression
muscle regeneration
- Aged
- Cells
- Receptor
- Expression
- External
- Vascular
- Chromosome
- Location
- Mice
- Proliferation
- Protein
- Bp
muscle protein synthesis
- Aged
- Proliferation
- Signal
- Cells
- Receptor
- Expression
- External
- Vascular
- Chromosome
- Location
- Mice
- Protein
endothelial cells
- Proliferation
- Protein
- Signal
- Cells
- Endothelial
- Muscle
- Receptor
- Expressed
- External
- Hormone
- Vascular
- Heart
hormone
- Secretion
- Peptide
- Vascular
- Levels
- Location
- Pressure
- Proliferation
- Protein
- Signal
- Human
- Muscle
- Receptor
parietal cells
- Endothelial
- Proliferation
- Muscle
- Receptor
- Expressed
- Heart
- Mice
- Protein
- Secretion
- Signal
- Aged
- Expression

Connections between topic areas Semantic bridges

For Apelin, one of the stronger structural bridges in this analysis connects Apelin with Physiological functions. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

Apelin — Physiological functions · splits 20 ⟂ 45

Apelin — Overview · splits 57 ⟂ 8

Apelin — Discovery · splits 59 ⟂ 6

Apelin — Biosynthesis · splits 60 ⟂ 5

Map overview Semantic statistics

Apelin

Nodes65

Edges64

Triples178

Avg. degree1.97

Density0.030769

Components1

Source & methodology

TTTA analyzes the structure around Apelin to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Art, Physiological functions & Discovery, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Apelin · EN edition · Analysis: TopicsToTalkAbout