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Apelin

Apelin (also known as APLN) is a peptide that in humans is encoded by the APLN gene. Apelin is one of two endogenous ligands for the G-protein-coupled APJ receptor that is expressed at the surface of some cell types. It is widely expressed in various organs such as the heart, lung, kidney, liver, adipose tissue, gastrointestinal tract, brain, adrenal…

Art, Physiological functions & Discovery

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Aliases
APLN, APEL, XNPEP2, apelin
Band
Xq26.1 · X|X A4
Bgee
C1 segment · substantia nigra · subthalamic nucleus · testicle · hypothalamus
BioGPS
n/a
Chr.
X chromosome (human) · X chromosome (mouse)
Databases
NCBI: entry; OMA: entry

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Discovery

Biosynthesis

Physiological functions

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Map overview Semantic statistics

Apelin

Nodes65
Edges64
Triples178
Avg. degree1.97
Density0.030769
Components1

How this topic connects Entity context

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Apelin

Top relations

Gene ontology · 38
Apelin → angiogenesis, apelin receptor binding, apelin receptor signaling pathway, coronary vasculature development, drinking behavior, extracellular region, extracellular space, feeding behavior, G protein-coupled receptor binding, G protein-coupled receptor signaling pathway, gastrulation, hormone activity, immune response, lactation, multicellular organism development, negative regulation of blood pressure, negative regulation of fibroblast growth factor receptor signaling pathway, negative regulation of gene expression, negative regulation of vascular associated smooth muscle cell proliferation, negative regulation of vasoconstriction
Bgee · 20
Apelin → amygdala, C1 segment, digastric muscle, entorhinal cortex, epiblast, external globus pallidus, hypothalamus, Ileal epithelium, inferior ganglion of vagus nerve, lateral nuclear group of thalamus, left lung, lumbar subsegment of spinal cord, pericardium, right lung, right ventricle, stroma of bone marrow, substantia nigra, subthalamic nucleus, testicle, ventral tegmental area
RNA expression pattern · 20
Apelin → amygdala, C1 segment, digastric muscle, entorhinal cortex, epiblast, external globus pallidus, hypothalamus, Ileal epithelium, inferior ganglion of vagus nerve, lateral nuclear group of thalamus, left lung, lumbar subsegment of spinal cord, pericardium, right lung, right ventricle, stroma of bone marrow, substantia nigra, subthalamic nucleus, testicle, ventral tegmental area
related to Muscle aging · 16
Apelin → AMPK-dependent, BGE-105, BioAge, By, Cedric Dray, Each, Finally, ICU, In, Moreover, Muscle, Phase, Philippe Valet, Such, They, This
related to External links · 14
Apelin → APLN, Archived, Basic, Clinical Pharmacology, Human APLN, International Union, Ion Channels, IUPHAR Database, Medicine Medical Subject Headings, MeSH, National Library, Receptors, Retrieved, UCSC Genome Browser
related to Vascular · 10
Apelin → Akt, ERKs, Genetic, II, NO, PKB, Studies, The, This, Vascular
related to Biosynthesis · 7
Apelin → After, C-ter, However, N-terminal, Recently, The, This
related to Discovery · 7
Apelin → APLNR, Bruno Reversade, Elabela, Gunma University, In, Masahiko Fujino, Takeda Pharmaceutical Company
related to Digestive · 5
Apelin → In, Its, Recently, The, This
related to Cardiac · 4
Apelin → Aged, It, Its, The

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Important terminology

receptor also human muscle gene expressed cells bp expression blood cell chr band peptide apln chromosome brain heart location hormone

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
ApelinAliasesAPLN, APEL, XNPEP2, apelin1.00infobox
ApelinBandXq26.11.00infobox
ApelinBandX|X A41.00infobox
ApelinBgeeC1 segment1.00infobox
ApelinBgeesubstantia nigra1.00infobox
ApelinBgeesubthalamic nucleus1.00infobox
ApelinBgeetesticle1.00infobox
ApelinBgeehypothalamus1.00infobox
ApelinBgeelateral nuclear group of thalamus1.00infobox
ApelinBgeeamygdala1.00infobox
ApelinBgeeinferior ganglion of vagus nerve1.00infobox
ApelinBgeeexternal globus pallidus1.00infobox
ApelinBgeeventral tegmental area1.00infobox
ApelinBgeelumbar subsegment of spinal cord1.00infobox
ApelinBgeeIleal epithelium1.00infobox
ApelinBgeepericardium1.00infobox
ApelinBgeestroma of bone marrow1.00infobox
ApelinBgeeepiblast1.00infobox
ApelinBgeeright ventricle1.00infobox
ApelinBgeeright lung1.00infobox
ApelinBgeeleft lung1.00infobox
ApelinBgeeentorhinal cortex1.00infobox
ApelinBgeedigastric muscle1.00infobox
ApelinBioGPSn/a1.00infobox
ApelinChr.X chromosome (human)1.00infobox
ApelinChr.X chromosome (mouse)1.00infobox
ApelinDatabasesNCBI: entry; OMA: entry1.00infobox
ApelinEnd129,654,956 bp1.00infobox
ApelinEnd47,123,730 bp1.00infobox
ApelinEnsemblENSG000001713881.00infobox

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