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MYL2

Myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MLC-2) also known as the regulatory light chain of myosin (RLC) is a protein that in humans is encoded by the MYL2 gene. This cardiac ventricular RLC isoform is distinct from that expressed in skeletal muscle (MYLPF), smooth muscle (MYL12B) and cardiac atrial muscle (MYL7).

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Function

21 related topics

Structure

3 related topics

Clinical significance

1 related topics

Overview

6 related topics

Key facts & relationships

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Aliases
MYL2, CMH10, MLC2, MLC-2s/v, myosin light chain 2, MFM12
Band
12q24.11 · 5|5 F
Bgee
right ventricle · apex of heart · thoracic diaphragm · Skeletal muscle tissue of biceps brachii · Skeletal muscle tissue of rectus abdominis
BioGPS
More reference expression data
Chr.
Chromosome 12 (human) · Chromosome 5 (mouse)
Databases
NCBI: entry; OMA: entry

Topics to explore

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Overview

Structure

Function

Clinical significance

  • FHC Hypertrophic cardiomyopathy

Advanced semantic analysis

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Map overview Semantic statistics

MYL2

Nodes36
Edges35
Triples126
Avg. degree1.94
Density0.055556
Components1

How this topic connects Entity context

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MYL2

Top relations

Gene ontology · 28
MYL2 → A band, actin cytoskeleton, actin monomer binding, calcium ion binding, cardiac muscle contraction, cardiac myofibril, cardiac myofibril assembly, cytoplasm, cytoskeleton, cytosol, development of the heart, heart contraction, heart morphogenesis, metal ion binding, muscle cell fate specification, muscle filament sliding, myofibril, myosin complex, myosin heavy chain binding, negative regulation of cell growth
related to Animal studies · 21
MYL2 → Altogether, Consistent, D166V, E12, FHC, FHC-associated MLC-2v, Furthermore, In, Loss, MLC-2, MLC-2v, MLC-2v R58Q, MLC2v, MLC2v Ser14Ala/Ser15Ala, MLCK, More, Ser14/Ser15, Similarly, The, These
Bgee · 19
MYL2 → ankle, aortic valve, apex of heart, atrioventricular valve, cardiac muscle tissue of left ventricle, deltoid muscle, endocardial cushion, glutes, interventricular septum, muscle of thigh, plantaris muscle, right ventricle, semi-lunar valve, Skeletal muscle tissue of biceps brachii, Skeletal muscle tissue of rectus abdominis, soleus muscle, thoracic diaphragm, tibialis anterior muscle, triceps brachii muscle
RNA expression pattern · 19
MYL2 → ankle, aortic valve, apex of heart, atrioventricular valve, cardiac muscle tissue of left ventricle, deltoid muscle, endocardial cushion, glutes, interventricular septum, muscle of thigh, plantaris muscle, right ventricle, semi-lunar valve, Skeletal muscle tissue of biceps brachii, Skeletal muscle tissue of rectus abdominis, soleus muscle, thoracic diaphragm, tibialis anterior muscle, triceps brachii muscle
related to Clinical significance · 19
MYL2 → A13T, D166V, E22K, F18L, FHC, Functional, IVS5-2-are, IVS5-2A, IVS6-1G, L103E, Mutations, N47K, N47K-have, P95A, R58Q, RLC, Ten FHC, The, Three
Band · 2
MYL2 → 12q24.11, 5|5 F
Chr. · 2
MYL2 → Chromosome 12 (human), Chromosome 5 (mouse)
End · 2
MYL2 → 110,921,443 bp, 122,113,472 bp
Aliases · 1
MYL2 → MYL2, CMH10, MLC2, MLC-2s/v, myosin light chain 2, MFM12
BioGPS · 1
MYL2 → More reference expression data

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Important terminology

cardiac phosphorylation myosin mlc-2v rlc muscle ventricular human chain studies light protein heart mouse role bp function also fhc chr

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
MYL2AliasesMYL2, CMH10, MLC2, MLC-2s/v, myosin light chain 2, MFM121.00infobox
MYL2Band12q24.111.00infobox
MYL2Band5|5 F1.00infobox
MYL2Bgeeright ventricle1.00infobox
MYL2Bgeeapex of heart1.00infobox
MYL2Bgeethoracic diaphragm1.00infobox
MYL2BgeeSkeletal muscle tissue of biceps brachii1.00infobox
MYL2BgeeSkeletal muscle tissue of rectus abdominis1.00infobox
MYL2Bgeemuscle of thigh1.00infobox
MYL2Bgeetibialis anterior muscle1.00infobox
MYL2Bgeeglutes1.00infobox
MYL2Bgeetriceps brachii muscle1.00infobox
MYL2Bgeedeltoid muscle1.00infobox
MYL2Bgeecardiac muscle tissue of left ventricle1.00infobox
MYL2Bgeeinterventricular septum1.00infobox
MYL2Bgeeatrioventricular valve1.00infobox
MYL2Bgeesoleus muscle1.00infobox
MYL2Bgeeplantaris muscle1.00infobox
MYL2Bgeeendocardial cushion1.00infobox
MYL2Bgeesemi-lunar valve1.00infobox
MYL2Bgeeaortic valve1.00infobox
MYL2Bgeeankle1.00infobox
MYL2BioGPSMore reference expression data1.00infobox
MYL2Chr.Chromosome 12 (human)1.00infobox
MYL2Chr.Chromosome 5 (mouse)1.00infobox
MYL2DatabasesNCBI: entry; OMA: entry1.00infobox
MYL2End110,921,443 bp1.00infobox
MYL2End122,113,472 bp1.00infobox
MYL2EnsemblENSG000001112451.00infobox
MYL2Entrez46331.00infobox

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