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TPM1

Tropomyosin alpha-1 chain is a protein that in humans is encoded by the TPM1 gene. This gene is a member of the tropomyosin (Tm) family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells.

Structure, Function & Clinical Significance

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Structure

5 related topics

Function

3 related topics

Clinical Significance

3 related topics

Overview

2 related topics

Key facts & relationships

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Aliases
TPM1, C15orf13, CMD1Y, CMH3, HTM-alpha, LVNC9, TMSA, HEL-S-265, tropomyosin 1 (alpha), tropomyosin 1
Band
15q22.2 · 9 C|9 36.27 cM
Bgee
myocardium of left ventricle · right ventricle · atrium · right auricle of heart · seminal vesicula
BioGPS
More reference expression data
Chr.
Chromosome 15 (human) · Chromosome 9 (mouse)
Databases
NCBI: entry; OMA: entry

Topics to explore

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Overview

Structure

Function

Clinical Significance

Advanced semantic analysis

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Map overview Semantic statistics

TPM1

Nodes18
Edges17
Triples121
Avg. degree1.89
Density0.111111
Components1

How this topic connects Entity context

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TPM1

Top relations

Gene ontology · 42
TPM1 → actin binding, actin cytoskeleton, actin filament, actin filament binding, actin filament organization, bleb, cardiac muscle contraction, cellular response to reactive oxygen species, cytoplasm, cytoskeletal protein binding, cytoskeleton, cytoskeleton organization, cytosol, filamentous actin, identical protein binding, in utero embryonic development, muscle contraction, muscle filament sliding, muscle thin filament tropomyosin, myofibril
Bgee · 20
TPM1 → ankle, aortic valve, apex of heart, ascending aorta, atrium, cardiac muscle tissue of right atrium, masseter muscle, medial head of gastrocnemius muscle, muscle layer of sigmoid colon, muscle of thigh, myocardium of left ventricle, right auricle of heart, right ventricle, saphenous vein, seminal vesicula, Skeletal muscle tissue of rectus abdominis, sternocleidomastoid muscle, tail of embryo, temporal muscle, triceps brachii muscle
RNA expression pattern · 20
TPM1 → ankle, aortic valve, apex of heart, ascending aorta, atrium, cardiac muscle tissue of right atrium, masseter muscle, medial head of gastrocnemius muscle, muscle layer of sigmoid colon, muscle of thigh, myocardium of left ventricle, right auricle of heart, right ventricle, saphenous vein, seminal vesicula, Skeletal muscle tissue of rectus abdominis, sternocleidomastoid muscle, tail of embryo, temporal muscle, triceps brachii muscle
related to External links · 9
TPM1 → COPaKB Archived, Familial Hypertrophic Cardiomyopathy OverviewOverview, Mass, P09493, PDB, PDBe-KB, Tropomyosin, UniProt, Wayback MachineGeneReviews/NIH/NCBI/UW
related to Structure · 6
TPM1 → Human, In, It, Tm, TPM2, TPM3
related to Clinical Significance · 4
TPM1 → HCM, LVNC, Mutations, N-terminal
Band · 2
TPM1 → 15q22.2, 9 C|9 36.27 cM
Chr. · 2
TPM1 → Chromosome 15 (human), Chromosome 9 (mouse)
End · 2
TPM1 → 63,071,915 bp, 66,956,688 bp
Aliases · 1
TPM1 → TPM1, C15orf13, CMD1Y, CMH3, HTM-alpha, LVNC9, TMSA, HEL-S-265, tropomyosin 1 (alpha), tropomyosin 1

Important terminology Word statistics

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Important terminology

actin tm human gene bp tropomyosin chr band protein muscle chromosome 15 myosin binding location state end cytoskeleton mouse cardiac

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
TPM1AliasesTPM1, C15orf13, CMD1Y, CMH3, HTM-alpha, LVNC9, TMSA, HEL-S-265, tropomyosin 1 (alpha), tropomyosin 11.00infobox
TPM1Band15q22.21.00infobox
TPM1Band9 C|9 36.27 cM1.00infobox
TPM1Bgeemyocardium of left ventricle1.00infobox
TPM1Bgeeright ventricle1.00infobox
TPM1Bgeeatrium1.00infobox
TPM1Bgeeright auricle of heart1.00infobox
TPM1Bgeeseminal vesicula1.00infobox
TPM1Bgeeapex of heart1.00infobox
TPM1Bgeecardiac muscle tissue of right atrium1.00infobox
TPM1BgeeSkeletal muscle tissue of rectus abdominis1.00infobox
TPM1Bgeesaphenous vein1.00infobox
TPM1Bgeemuscle layer of sigmoid colon1.00infobox
TPM1Bgeeankle1.00infobox
TPM1Bgeeaortic valve1.00infobox
TPM1Bgeemedial head of gastrocnemius muscle1.00infobox
TPM1Bgeetail of embryo1.00infobox
TPM1Bgeeascending aorta1.00infobox
TPM1Bgeemasseter muscle1.00infobox
TPM1Bgeemuscle of thigh1.00infobox
TPM1Bgeetriceps brachii muscle1.00infobox
TPM1Bgeetemporal muscle1.00infobox
TPM1Bgeesternocleidomastoid muscle1.00infobox
TPM1BioGPSMore reference expression data1.00infobox
TPM1Chr.Chromosome 15 (human)1.00infobox
TPM1Chr.Chromosome 9 (mouse)1.00infobox
TPM1DatabasesNCBI: entry; OMA: entry1.00infobox
TPM1End63,071,915 bp1.00infobox
TPM1End66,956,688 bp1.00infobox
TPM1EnsemblENSG000001404161.00infobox

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