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VDAC1

Voltage-dependent anion-selective channel 1 (VDAC-1) is a beta barrel protein that in humans is encoded by the VDAC1 gene located on chromosome 5. It forms an ion channel in the outer mitochondrial membrane (OMM) and also the outer cell membrane. In the OMM, it allows ATP to diffuse out of the mitochondria into the cytoplasm. In the cell membrane, it is…

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Aliases
VDAC1, PORIN, VDAC-1, voltage dependent anion channel 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2JK4, 2K4T
Band
11 B1.3|11 31.86 cM
Bgee
biceps brachii · Skeletal muscle tissue of biceps brachii · gastrocnemius muscle · muscle of thigh · Skeletal muscle tissue of rectus abdominis
BioGPS
More reference expression data
Chr.
Chromosome 11 (mouse)

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Map overview Semantic statistics

VDAC1

Nodes46
Edges45
Triples180
Avg. degree1.96
Density0.043478
Components1

How this topic connects Entity context

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VDAC1

Top relations

Gene ontology · 42
VDAC1 → anion channel activity, anion transmembrane transport, anion transport, apoptotic process, behavioral fear response, chemical synaptic transmission, epithelial cell differentiation, extracellular exosome, identical protein binding, inorganic anion transport, integral component of membrane, ion transport, learning, macroautophagy, membrane, membrane raft, mitochondrial calcium ion transmembrane transport, mitochondrial inner membrane, mitochondrial nucleoid, mitochondrial outer membrane
related to Structure · 21
VDAC1 → Additionally, C-terminus, DNA, E73, HK1, N-terminal, N-terminus, NMR, Nuclear Magnetic Resonance, One, Structural, The, These, This, This N-terminus, Two, VDAC, VDAC1's, VDAC2, VDAC3
Bgee · 19
VDAC1 → ankle, aortic valve, ascending aorta, biceps brachii, condyle, gastrocnemius muscle, glutes, jejunal mucosa, left ventricle, muscle of thigh, pineal gland, renal corpuscle, right ventricle, Skeletal muscle tissue of biceps brachii, Skeletal muscle tissue of rectus abdominis, sternocleidomastoid muscle, temporal muscle, thoracic diaphragm, vastus lateralis muscle
RNA expression pattern · 19
VDAC1 → ankle, aortic valve, ascending aorta, biceps brachii, condyle, gastrocnemius muscle, glutes, jejunal mucosa, left ventricle, muscle of thigh, pineal gland, renal corpuscle, right ventricle, Skeletal muscle tissue of biceps brachii, Skeletal muscle tissue of rectus abdominis, sternocleidomastoid muscle, temporal muscle, thoracic diaphragm, vastus lateralis muscle
related to Clinical significance · 17
VDAC1 → Amyloid, Aβ, Bcl-2, Bcl-xl, Because, Huntington's, In, In PD, Mcl-1, Moreover, OMM, ROS, The, These, VDAC-targeting, VDAC1's, While
related to Voltage gating · 13
VDAC1 → Alpha, At, ATP, ATP/second, Because, However, Its, N-terminal, N-terminus, Since, The, This, VDAC1's
related to External links · 9
VDAC1 → Medicine Medical Subject Headings, MeSH, National Library, Overview, P21796, PDB, PDBe-KB, UniProt, Voltage-dependent
related to Function · 8
VDAC1 → ATP, However, In, Of, OMM, ROS, TCA, VDAC
related to Oligomerization · 6
VDAC1 → AFM, Atomic Force Microscopy, Bcl-2, MPTP, The, VDACs
related to Interactions · 3
VDAC1 → ATP, It, Markov

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Important terminology

channel cell pore mitochondrial atp also ion protein transport calcium within membrane function voltage shown anion metabolism apoptosis expression proteins

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
VDAC1AliasesVDAC1, PORIN, VDAC-1, voltage dependent anion channel 11.00infobox
VDAC1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2JK4, 2K4T1.00infobox
VDAC1Band11 B1.3|11 31.86 cM1.00infobox
VDAC1Bgeebiceps brachii1.00infobox
VDAC1BgeeSkeletal muscle tissue of biceps brachii1.00infobox
VDAC1Bgeegastrocnemius muscle1.00infobox
VDAC1Bgeemuscle of thigh1.00infobox
VDAC1BgeeSkeletal muscle tissue of rectus abdominis1.00infobox
VDAC1Bgeejejunal mucosa1.00infobox
VDAC1Bgeevastus lateralis muscle1.00infobox
VDAC1Bgeeright ventricle1.00infobox
VDAC1Bgeeleft ventricle1.00infobox
VDAC1Bgeeglutes1.00infobox
VDAC1Bgeeaortic valve1.00infobox
VDAC1Bgeeascending aorta1.00infobox
VDAC1Bgeerenal corpuscle1.00infobox
VDAC1Bgeeankle1.00infobox
VDAC1Bgeetemporal muscle1.00infobox
VDAC1Bgeethoracic diaphragm1.00infobox
VDAC1Bgeecondyle1.00infobox
VDAC1Bgeesternocleidomastoid muscle1.00infobox
VDAC1Bgeepineal gland1.00infobox
VDAC1BioGPSMore reference expression data1.00infobox
VDAC1Chr.Chromosome 11 (mouse)1.00infobox
VDAC1DatabasesNCBI: entry; OMA: entry1.00infobox
VDAC1End52,389,397 bp1.00infobox
VDAC1EnsemblENSG000002135851.00infobox
VDAC1Entrez74161.00infobox
VDAC1External IDsOMIM: 604492; MGI: 106919; GeneCards: VDAC11.00infobox
VDAC1Gene location (Mouse)Gene location (Mouse)Chr.Chromosome 11 (mouse)Band11 B1.3|11 31.86 cMStart52,360,860 bpEnd52,389,397 bp1.00infobox

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