VDAC1

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VDAC1 topic overview

The analysis highlights Interactions, Clinical significance and Structure as prominent areas in the source structure around VDAC1.

Related topics: 40
Source areas: 5
Connected nodes: 45
Extracted relationships: 180
Concept neighborhoods: 16
Bridge connections: 45

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 14 topics

Interactions · 12 topics

Clinical significance · 6 topics

Structure · 5 topics

Function · 3 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases: VDAC1, PORIN, VDAC-1, voltage dependent anion channel 1
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2JK4, 2K4T
Band: 11 B1.3|11 31.86 cM
Bgee: biceps brachii · Skeletal muscle tissue of biceps brachii · gastrocnemius muscle · muscle of thigh · Skeletal muscle tissue of rectus abdominis
BioGPS: More reference expression data
Chr.: Chromosome 11 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

X-ray crystallography
Nuclear Magnetic Resonance (NMR) spectroscopy Nuclear magnetic resonance spectroscopy
Circular dichroism
N-terminus
Phospholipid bilayer Lipid bilayer

Function

Reactive oxygen species
Atomic Force Microscopy Atomic-force microscopy
Mitochondrial permeability transition pore

Clinical significance

Interactions

Markov state modeling approach Hidden Markov model
Interact Protein-protein interaction
BCL2-like 1 BCL2-like 1 (gene)
Bcl-2-associated X protein
DYNLT3
Gelsolin
PRKCE
HK1
Parkin Parkin (ligase)
ENOS ENOS?action=edit&redlink=1
ATP Adenosine triphosphate
GSK-3

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How VDAC1 connects Entity context

The extracted context around VDAC1 shows recurring relationship patterns in the source. For example, VDAC1 → anion channel activity, anion transmembrane transport, anion transport, apoptotic process, behavioral fear response, chemical synaptic transmission, epithelial cell differentiation, extracellular exosome, identical protein binding, inorganic anion transport, integral component of membrane, ion transport, learning, macroautophagy, membrane, membrane raft, mitochondrial calcium ion transmembrane transport, mitochondrial inner membrane, mitochondrial nucleoid, mitochondrial outer membrane Another extracted example is VDAC1 → Additionally, C-terminus, DNA, E73, HK1, N-terminal, N-terminus, NMR, Nuclear Magnetic Resonance, One, Structural, The, These, This, This N-terminus, Two, VDAC, VDAC1's, VDAC2, VDAC3. Use these groups to spot repeated connection types before inspecting the individual relationships.

Top relations

Gene ontology · 42

VDAC1 → anion channel activity, anion transmembrane transport, anion transport, apoptotic process, behavioral fear response, chemical synaptic transmission, epithelial cell differentiation, extracellular exosome, identical protein binding, inorganic anion transport, integral component of membrane, ion transport, learning, macroautophagy, membrane, membrane raft, mitochondrial calcium ion transmembrane transport, mitochondrial inner membrane, mitochondrial nucleoid, mitochondrial outer membrane

related to Structure · 21

VDAC1 → Additionally, C-terminus, DNA, E73, HK1, N-terminal, N-terminus, NMR, Nuclear Magnetic Resonance, One, Structural, The, These, This, This N-terminus, Two, VDAC, VDAC1's, VDAC2, VDAC3

Bgee · 19

VDAC1 → ankle, aortic valve, ascending aorta, biceps brachii, condyle, gastrocnemius muscle, glutes, jejunal mucosa, left ventricle, muscle of thigh, pineal gland, renal corpuscle, right ventricle, Skeletal muscle tissue of biceps brachii, Skeletal muscle tissue of rectus abdominis, sternocleidomastoid muscle, temporal muscle, thoracic diaphragm, vastus lateralis muscle

RNA expression pattern · 19

related to Clinical significance · 17

VDAC1 → Amyloid, Aβ, Bcl-2, Bcl-xl, Because, Huntington's, In, In PD, Mcl-1, Moreover, OMM, ROS, The, These, VDAC-targeting, VDAC1's, While

related to Voltage gating · 13

VDAC1 → Alpha, At, ATP, ATP/second, Because, However, Its, N-terminal, N-terminus, Since, The, This, VDAC1's

related to External links · 9

VDAC1 → Medicine Medical Subject Headings, MeSH, National Library, Overview, P21796, PDB, PDBe-KB, UniProt, Voltage-dependent

related to Function · 8

VDAC1 → ATP, However, In, Of, OMM, ROS, TCA, VDAC

related to Oligomerization · 6

VDAC1 → AFM, Atomic Force Microscopy, Bcl-2, MPTP, The, VDACs

related to Interactions · 3

VDAC1 → ATP, It, Markov

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

channel cell pore mitochondrial atp also ion protein transport calcium within membrane function voltage shown anion metabolism apoptosis expression proteins

VDAC1 relationships Subject–Predicate–Object triples

TTTA extracted 180 structured relationships around VDAC1. Examples in this analysis include VDAC1 → Aliases → VDAC1, PORIN, VDAC-1, voltage dependent anion channel 1 and VDAC1 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2JK4, 2K4T. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
VDAC1	Aliases	VDAC1, PORIN, VDAC-1, voltage dependent anion channel 1	1.00	infobox
VDAC1	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2JK4, 2K4T	1.00	infobox
VDAC1	Band	11 B1.3\|11 31.86 cM	1.00	infobox
VDAC1	Bgee	biceps brachii	1.00	infobox
VDAC1	Bgee	Skeletal muscle tissue of biceps brachii	1.00	infobox
VDAC1	Bgee	gastrocnemius muscle	1.00	infobox
VDAC1	Bgee	muscle of thigh	1.00	infobox
VDAC1	Bgee	Skeletal muscle tissue of rectus abdominis	1.00	infobox
VDAC1	Bgee	jejunal mucosa	1.00	infobox
VDAC1	Bgee	vastus lateralis muscle	1.00	infobox
VDAC1	Bgee	right ventricle	1.00	infobox
VDAC1	Bgee	left ventricle	1.00	infobox
VDAC1	Bgee	glutes	1.00	infobox
VDAC1	Bgee	aortic valve	1.00	infobox
VDAC1	Bgee	ascending aorta	1.00	infobox
VDAC1	Bgee	renal corpuscle	1.00	infobox
VDAC1	Bgee	ankle	1.00	infobox
VDAC1	Bgee	temporal muscle	1.00	infobox
VDAC1	Bgee	thoracic diaphragm	1.00	infobox
VDAC1	Bgee	condyle	1.00	infobox
VDAC1	Bgee	sternocleidomastoid muscle	1.00	infobox
VDAC1	Bgee	pineal gland	1.00	infobox
VDAC1	BioGPS	More reference expression data	1.00	infobox
VDAC1	Chr.	Chromosome 11 (mouse)	1.00	infobox
VDAC1	Databases	NCBI: entry; OMA: entry	1.00	infobox
VDAC1	End	52,389,397 bp	1.00	infobox
VDAC1	Ensembl	ENSG00000213585	1.00	infobox
VDAC1	Entrez	7416	1.00	infobox
VDAC1	External IDs	OMIM: 604492; MGI: 106919; GeneCards: VDAC1	1.00	infobox
VDAC1	Gene location (Mouse)	Gene location (Mouse)Chr.Chromosome 11 (mouse)Band11 B1.3\|11 31.86 cMStart52,360,860 bpEnd52,389,397 bp	1.00	infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around VDAC1 bring nearby vocabulary together. In this analysis, examples include Calcium, Shown and Ion. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

VDAC1
- Calcium
- Shown
- Ion
- Cell
- Proteins
- Function
- Also
- Mitochondrial
- Transport
- Gene
- Expression
- Interact
vdac1
- Calcium
- Shown
- Ion
- Cell
- Proteins
- Function
- Also
- Mitochondrial
- Transport
- Gene
- Expression
- Interact
outer mitochondrial membrane
- Regulation
- Mitochondrial
- Permeability
- Ros
- Mitochondrion
- Omm
- Structure
- Metabolism
- Apoptosis
- Anion
- Calcium
- Function
mitochondrial
- Regulation
- Permeability
- Ros
- Metabolism
- Omm
- Apoptosis
- Anion
- Function
- Protein
- Calcium
- Vdac1
- Pore
voltage-dependent anion channel
- Protein
- Anion
- Channel
- Voltage
- Function
- Bp
- Gene
- Voltage-dependent
- Regulation
- Ion
- Structure
- Vdac1
mitochondrial permeability transition pore
- Regulation
- Permeability
- Ros
- Alpha
- Metabolites
- Pore
- Metabolism
- Omm
- State
- Within
- Apoptosis
- Anion
bcl-2-associated x protein
- Voltage-dependent
- Anion
- Gene
- Expression
- Regulation
- Shown
- Mitochondrial
- Vdac1
- Cell
- Bp
- Interact
- Located
gene
- Bp
- Structure
- Anion
- Function
- Protein
- Expression
- Located
- Metabolic
- Mitochondrion
- Regulation
- Voltage-dependent
- Alpha

Connections between topic areas Semantic bridges

For VDAC1, one of the stronger structural bridges in this analysis connects VDAC1 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

VDAC1 — Overview · splits 31 ⟂ 15

VDAC1 — Interactions · splits 33 ⟂ 13

VDAC1 — Clinical significance · splits 39 ⟂ 7

VDAC1 — Structure · splits 40 ⟂ 6

VDAC1 — Function · splits 42 ⟂ 4

Map overview Semantic statistics

VDAC1

Nodes46

Edges45

Triples180

Avg. degree1.96

Density0.043478

Components1

Source & methodology

TTTA analyzes the structure around VDAC1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Interactions, Clinical significance & Structure, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — VDAC1 · EN edition · Analysis: TopicsToTalkAbout