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Desmin: Structure, Function & Clinical significance

Desmin is a protein that in humans is encoded by the DES gene. Desmin is a muscle-specific, type III intermediate filament that integrates the sarcolemma, Z disk, and nuclear membrane in sarcomeres and regulates sarcomere architecture.

Language: English [EN]
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Desmin topic overview

The analysis highlights Structure, Function and Clinical significance as prominent areas in the source structure around Desmin.

Related topics
31
Source areas
4
Connected nodes
35
Extracted relationships
122
Concept neighborhoods
18
Bridge connections
35

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Structure · 11 topics
Function · 9 topics
Overview · 6 topics
Clinical significance · 5 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
DES, CSM1, CSM2, LGMD2R, desmin, LGMD1D, CMD1F, CDCD3, LGMD1E
Band
2q35 · 1 C4|1 38.85 cM
Bgee
saphenous vein · apex of heart · gastrocnemius muscle · muscle of thigh · gastric mucosa
BioGPS
More reference expression data
Chr.
Chromosome 2 (human) · Chromosome 1 (mouse)
Databases
NCBI: entry; OMA: entry

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Function

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Desmin connects Entity context

The extracted context around Desmin shows recurring relationship patterns in the source. For example, Desmin → cardiac myofibril, cell-cell junction, contractile fiber, cytoplasm, cytoskeletal protein binding, cytoskeleton, cytoskeleton organization, cytosol, extracellular exosome, fascia adherens, identical protein binding, intercalated disc, intermediate filament, intermediate filament cytoskeleton, intermediate filament organization, membrane, muscle contraction, muscle filament sliding, neuromuscular junction, nucleus Another extracted example is Desmin → ankle, apex of heart, decidua, digastric muscle, esophagus, gastric mucosa, gastrocnemius muscle, gastrula, left ventricle, medial head of gastrocnemius muscle, muscle layer of sigmoid colon, muscle of thigh, myocardium of left ventricle, right auricle of heart, saphenous vein, sternocleidomastoid muscle, temporal muscle, thoracic diaphragm, triceps brachii muscle. Use these groups to spot repeated connection types before inspecting the individual relationships.

Desmin

Top relations

Gene ontology · 27
Desmin → cardiac myofibril, cell-cell junction, contractile fiber, cytoplasm, cytoskeletal protein binding, cytoskeleton, cytoskeleton organization, cytosol, extracellular exosome, fascia adherens, identical protein binding, intercalated disc, intermediate filament, intermediate filament cytoskeleton, intermediate filament organization, membrane, muscle contraction, muscle filament sliding, neuromuscular junction, nucleus
Bgee · 19
Desmin → ankle, apex of heart, decidua, digastric muscle, esophagus, gastric mucosa, gastrocnemius muscle, gastrula, left ventricle, medial head of gastrocnemius muscle, muscle layer of sigmoid colon, muscle of thigh, myocardium of left ventricle, right auricle of heart, saphenous vein, sternocleidomastoid muscle, temporal muscle, thoracic diaphragm, triceps brachii muscle
RNA expression pattern · 19
Desmin → ankle, apex of heart, decidua, digastric muscle, esophagus, gastric mucosa, gastrocnemius muscle, gastrula, left ventricle, medial head of gastrocnemius muscle, muscle layer of sigmoid colon, muscle of thigh, myocardium of left ventricle, right auricle of heart, saphenous vein, sternocleidomastoid muscle, temporal muscle, thoracic diaphragm, triceps brachii muscle
related to Function · 12
Desmin → Although, Cardiac, However, In, It, Since, The, These, This, Through, Z-disk, Z-disks
related to Clinical significance · 10
Desmin → A120D, DES, Desmin-related, DRM, Even, In, R127P, Some, The N-terminal, TURBT
related to External links · 7
Desmin → DES, GeneReviews/NIH/NCBI/UW, LOVD, Medicine Medical Subject Headings, MeSH, Myofibrillar MyopathyDesmin, National Library
related to Structure · 5
Desmin → DES, In, The, There, Z-discs
is a · 3
Desmin → muscle-specific, protein that in humans is encoded by the DES gene, subunit of intermediate filaments in cardiac muscle
Band · 2
Desmin → 1 C4|1 38.85 cM, 2q35
Chr. · 2
Desmin → Chromosome 1 (mouse), Chromosome 2 (human)

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

des gene muscle protein cardiac human bp chr band function sarcomere chromosome cell intermediate filament mitochondria may mutations mouse head

Desmin relationships Subject–Predicate–Object triples

TTTA extracted 122 structured relationships around Desmin. Examples in this analysis include Desmin → Aliases → DES, CSM1, CSM2, LGMD2R, desmin, LGMD1D, CMD1F, CDCD3, LGMD1E and Desmin → Band → 2q35. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
DesminAliasesDES, CSM1, CSM2, LGMD2R, desmin, LGMD1D, CMD1F, CDCD3, LGMD1E1.00infobox
DesminBand2q351.00infobox
DesminBand1 C4|1 38.85 cM1.00infobox
DesminBgeesaphenous vein1.00infobox
DesminBgeeapex of heart1.00infobox
DesminBgeegastrocnemius muscle1.00infobox
DesminBgeemuscle of thigh1.00infobox
DesminBgeegastric mucosa1.00infobox
DesminBgeeright auricle of heart1.00infobox
DesminBgeeleft ventricle1.00infobox
DesminBgeemyocardium of left ventricle1.00infobox
DesminBgeethoracic diaphragm1.00infobox
DesminBgeemuscle layer of sigmoid colon1.00infobox
DesminBgeegastrula1.00infobox
DesminBgeeankle1.00infobox
DesminBgeetriceps brachii muscle1.00infobox
DesminBgeetemporal muscle1.00infobox
DesminBgeeesophagus1.00infobox
DesminBgeemedial head of gastrocnemius muscle1.00infobox
DesminBgeedigastric muscle1.00infobox
DesminBgeesternocleidomastoid muscle1.00infobox
DesminBgeedecidua1.00infobox
DesminBioGPSMore reference expression data1.00infobox
DesminChr.Chromosome 2 (human)1.00infobox
DesminChr.Chromosome 1 (mouse)1.00infobox
DesminDatabasesNCBI: entry; OMA: entry1.00infobox
DesminEnd219,426,734 bp1.00infobox
DesminEnd75,345,223 bp1.00infobox
DesminEnsemblENSG000001750841.00infobox
DesminEntrez16741.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Desmin bring nearby vocabulary together. In this analysis, examples include Protein, Muscle and Function. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Desmin
    • Protein
    • Muscle
    • Function
    • Sarcomere
    • Gene
    • Des
    • Intermediate
    • May
    • Cardiac
    • Expressed
    • Filament
    • Filaments
  • desmin
    • Protein
    • Muscle
    • Function
    • Sarcomere
    • Gene
    • Des
    • Intermediate
    • May
    • Cardiac
    • Expressed
    • Filament
    • Filaments
  • gene
    • Location
    • Mouse
    • Chromosome
    • Bp
    • Chr
    • Human
    • Protein
    • Band
    • Function
    • External
    • Cytoplasm
    • Membrane
  • type iii intermediate filament
    • Membrane
    • Sarcolemma
    • Acids
    • Amino
    • Filaments
    • Head
    • Intermediate
    • Cytoplasm
    • Cardiac
    • Contraction
    • Important
    • Location
  • chromosome 2
    • Bp
    • Human
    • Location
    • Band
    • Gene
    • Mouse
    • External
    • Function
    • Des
    • Cytoplasm
    • Membrane
    • Sarcolemma
  • intermediate filaments
    • Membrane
    • Sarcolemma
    • Proteins
    • Filaments
    • Intermediate
    • Cytoplasm
    • Cardiac
    • Acids
    • Amino
    • Contraction
    • Location
    • Mouse
  • cardiac muscle
    • Tissue
    • Muscle
    • May
    • Cell
    • Sarcomere
    • Intermediate
    • Present
    • Differentiation
    • Mitochondria
    • Mutations
    • Des
    • Protein
  • function
    • Location
    • Chromosome
    • Expressed
    • Bp
    • Chr
    • Human
    • May
    • Gene
    • Protein
    • Cytoplasm
    • Membrane
    • Sarcolemma

Connections between topic areas Semantic bridges

For Desmin, one of the stronger structural bridges in this analysis connects Desmin with Structure. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
DesminStructure · splits 24 ⟂ 12
DesminFunction · splits 26 ⟂ 10
DesminOverview · splits 29 ⟂ 7
DesminClinical significance · splits 30 ⟂ 6

Map overview Semantic statistics

Desmin

Nodes36
Edges35
Triples122
Avg. degree1.94
Density0.055556
Components1

Source & methodology

TTTA analyzes the structure around Desmin to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Structure, Function & Clinical significance, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Desmin · EN edition · Analysis: TopicsToTalkAbout

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