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Cytochrome c oxidase: Genetic defects and disorders, Inhibition & Structure

The enzyme cytochrome c oxidase or Complex IV (was EC 1.9.3.1, now reclassified as a translocase EC 7.1.1.9) is a large transmembrane protein complex found in bacteria, archaea, and the mitochondria of eukaryotes, including humans.

Language: English [EN]
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Cytochrome c oxidase topic overview

The analysis highlights Genetic defects and disorders, Inhibition and Structure as prominent areas in the source structure around Cytochrome c oxidase.

Related topics
63
Source areas
8
Connected nodes
71
Extracted relationships
39
Concept neighborhoods
20
Bridge connections
71

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 17 topics
Genetic defects and disorders · 15 topics
Inhibition · 10 topics
Extramitochondrial and subcellular localizations · 8 topics
Structure · 8 topics
Assembly · 2 topics
Histochemistry · 2 topics
Biochemistry · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

BRENDA
enzyme data
CAS no.
9001-16-5
EC no.
1.9.3.1
ExPASy
NiceZyme view
Gene Ontology
AmiGO / QuickGO
KEGG
enzyme entry

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Assembly

Biochemistry

Inhibition

Extramitochondrial and subcellular localizations

Genetic defects and disorders

Histochemistry

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Cytochrome c oxidase connects Entity context

The extracted context around Cytochrome c oxidase shows recurring relationship patterns in the source. For example, Cytochrome c oxidase → Medicine Medical Subject Headings, Membranesfamilies/superfamily-4Cytochrome-c, MeSH, National Library, Oxidase, Proteins, Requires MDL Chime, Rice UniversityInteractive Molecular, The Cytochrome Oxidase, UMich Orientation Another extracted example is Cytochrome c oxidase → Additionally, Besides, Cytochrome, DNA, II, III, In, Of, The, This. Use these groups to spot repeated connection types before inspecting the individual relationships.

Cytochrome c oxidase

Top relations

related to External links · 10
Cytochrome c oxidase → Medicine Medical Subject Headings, Membranesfamilies/superfamily-4Cytochrome-c, MeSH, National Library, Oxidase, Proteins, Requires MDL Chime, Rice UniversityInteractive Molecular, The Cytochrome Oxidase, UMich Orientation
related to Extramitochondrial and subcellular localizations · 10
Cytochrome c oxidase → Additionally, Besides, Cytochrome, DNA, II, III, In, Of, The, This
see also · 4
Cytochrome c oxidase → Cytochrome, ICytochrome, IICytochrome, IIIHeme
BRENDA · 1
Cytochrome c oxidase → enzyme data
CAS no. · 1
Cytochrome c oxidase → 9001-16-5
EC no. · 1
Cytochrome c oxidase → 1.9.3.1
ExPASy · 1
Cytochrome c oxidase → NiceZyme view
Gene Ontology · 1
Cytochrome c oxidase → AmiGO / QuickGO
KEGG · 1
Cytochrome c oxidase → enzyme entry
MetaCyc · 1
Cytochrome c oxidase → metabolic pathway

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

cox enzyme cytochrome subunits oxygen assembly complex oxidase center two a3 binuclear cub reduced mitochondrial electron proteins form activity protons

Cytochrome c oxidase relationships Subject–Predicate–Object triples

TTTA extracted 39 structured relationships around Cytochrome c oxidase. Examples in this analysis include Cytochrome c oxidase → BRENDA → enzyme data and Cytochrome c oxidase → CAS no. → 9001-16-5. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Cytochrome c oxidaseBRENDAenzyme data1.00infobox
Cytochrome c oxidaseCAS no.9001-16-51.00infobox
Cytochrome c oxidaseEC no.1.9.3.11.00infobox
Cytochrome c oxidaseExPASyNiceZyme view1.00infobox
Cytochrome c oxidaseGene OntologyAmiGO / QuickGO1.00infobox
Cytochrome c oxidaseKEGGenzyme entry1.00infobox
Cytochrome c oxidaseMetaCycmetabolic pathway1.00infobox
Cytochrome c oxidaseNCBIproteins1.00infobox
Cytochrome c oxidasePDB structuresRCSB PDB PDBe PDBsum1.00infobox
Cytochrome c oxidasePMCarticles1.00infobox
Cytochrome c oxidasePubMedarticles1.00infobox
Cytochrome c oxidaseRheareactions1.00infobox
Cytochrome c oxidaseSearchSearchPMCarticlesPubMedarticlesNCBIproteins1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Cytochrome c oxidase bring nearby vocabulary together. In this analysis, examples include Oxidase, Binuclear and Center. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Cytochrome c oxidase
    • Oxidase
    • Binuclear
    • Center
    • Cub
    • A3
    • Electron
    • Two
    • Complex
    • Protons
    • Water
    • Reduced
    • Four
  • cytochrome c oxidase
    • Oxidase
    • Binuclear
    • Center
    • Cub
    • A3
    • Electron
    • Two
    • Complex
    • Protons
    • Mitochondrial
    • Water
    • Reduced
  • enzyme
    • Activity
    • Cox
    • State
    • Cyanide
    • Bind
    • Reduced
    • A3
    • Subunits
    • Membrane
    • Iii
    • Inhibition
    • Reducing
  • cytochrome c
    • Oxidase
    • Binuclear
    • Center
    • Cub
    • A3
    • Electron
    • Two
    • Complex
    • Protons
    • Water
    • Reduced
    • Four
  • cytochrome a3
    • Cub
    • Center
    • Oxidase
    • Binuclear
    • A3
    • Cytochrome
    • Reduced
    • Two
    • Reducing
    • Electron
    • Form
    • Complex
  • assembly
    • Mutations
    • Cox
    • Disorders
    • Proteins
    • Subunits
    • Structure
    • Mitochondrial
    • Complex
    • Membrane
    • Iv
    • Ii
    • Iii
  • electron transport chain
    • Binuclear
    • Center
    • Cub
    • A3
    • Protons
    • Water
    • Oxygen
    • Reduced
    • Two
    • Membrane
    • Four
    • Iii
  • oxygen
    • Cub
    • Electrons
    • Reducing
    • Water
    • Form
    • A3
    • Binuclear
    • Two
    • Center
    • Protons
    • Inhibition
    • Bind

Connections between topic areas Semantic bridges

For Cytochrome c oxidase, one of the stronger structural bridges in this analysis connects Cytochrome c oxidase with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Cytochrome c oxidaseOverview · splits 54 ⟂ 18
Cytochrome c oxidaseGenetic defects and disorders · splits 56 ⟂ 16
Cytochrome c oxidaseInhibition · splits 61 ⟂ 11
Cytochrome c oxidaseStructure · splits 63 ⟂ 9
Cytochrome c oxidaseExtramitochondrial and subcellular localizations · splits 63 ⟂ 9
Cytochrome c oxidaseAssembly · splits 69 ⟂ 3
Cytochrome c oxidaseHistochemistry · splits 69 ⟂ 3

Map overview Semantic statistics

Cytochrome c oxidase

Nodes72
Edges71
Triples39
Avg. degree1.97
Density0.027778
Components1

Source & methodology

TTTA analyzes the structure around Cytochrome c oxidase to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Genetic defects and disorders, Inhibition & Structure, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Cytochrome c oxidase · EN edition · Analysis: TopicsToTalkAbout

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