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Phorbol

Phorbol is a natural, plant-derived organic compound. It is a member of the tigliane family of diterpenes. Phorbol was first isolated in 1934 via the hydrolysis of croton oil, which is derived from the seeds of the purging croton, Croton tiglium. The structure of phorbol was determined in 1967. Various esters of phorbol have important biological…

History, Applications, Research & Standards

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History and source

EuphorbiaceaeThymelaeaceaeManchineelPolarSolvents
6 related topics

Total synthesis

Total synthesisEnantiopureAnalogsDerivatives3-carene
5 related topics

Mechanism of action

DiacylglycerolNF-κBIC50LD50
4 related topics

Overview

Organic compoundTiglianeDiterpenesHydrolysisCroton oil
13 related topics

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Overview

History and source

Mechanism of action

Total synthesis

Uses in biomedical research

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Map overview Semantic statistics

Phorbol

Nodes37
Edges36
Triples71
Avg. degree1.95
Density0.054054
Components1

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Phorbol

Top relations

related to Further reading · 30
Phorbol → Animals, Becker, Biological Activity, Discovery Marked, Francis, George, Goel, Gunjan, Harinder, International Journal, IUBMB Life, July, June, Kikkawa, Klaus, Makkar, November, October, Phorbol Esters, PKC
related to Mechanism of action · 13
Phorbol → Although, Diacylglycerol, IC50, LD50, NF-κB, PK, PKC, Symptoms, The, This, Thus, When, While
related to history · 11
Phorbol → Chinese, Contact, Croton, Euphorbiaceae, Hippomane, In, It, Its, New World, The, Thymelaeaceae
related to External links · 4
Phorbol → Medicine Medical Subject Headings, MeSH, National Library, Phorbols
related to Uses in biomedical research · 4
Phorbol → Because, For, T-cell, TPA
related to Total synthesis · 3
Phorbol → Previously, This, While
is a · 1
Phorbol → natural
related to Possible and purported medicinal uses · 1
Phorbol → The

Important terminology Word statistics

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Important terminology

esters pkc used derivatives oil tumor also synthesis natural tpa action research especially exposure needed pathways proliferation isolated croton seeds

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Phorbolis anatural0.90text
models of carcinogenesisinstance ofwhich is used as a biomedical research tool in contexts0.80text
severe paininstance ofContact with the tree or consumption of its fruit can lead to symptoms0.80text
swellinginstance ofContact with the tree or consumption of its fruit can lead to symptoms0.80text
the NF-κB pathwayinstance ofPKC is also involved in activation of inflammation pathways0.80text
Phorbolrelated to External linksPhorbols0.60section
Phorbolrelated to External linksNational Library0.60section
Phorbolrelated to External linksMedicine Medical Subject Headings0.60section
Phorbolrelated to External linksMeSH0.60section
Phorbolrelated to Further readingGoel0.60section
Phorbolrelated to Further readingGunjan0.60section
Phorbolrelated to Further readingMakkar0.60section

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